Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0673 | 0.3267 |
Leishmania major | hypothetical protein, conserved | 0.0017 | 0.007 | 0.0472 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.2554 | 0.2931 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1104 | 0.1267 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0039 | 0.0951 | 0.6421 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.0866 | 0.5844 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0052 | 0.1481 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0722 | 0.7591 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0951 | 0.1092 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0039 | 0.0951 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0231 | 0.8711 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1486 | 0.1706 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0019 | 0.0149 | 0.0721 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.0501 | 0.0575 |
Onchocerca volvulus | 0.0052 | 0.1481 | 0.1481 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0052 | 0.1486 | 0.6695 |
Loa Loa (eye worm) | bromodomain containing protein | 0.002 | 0.0176 | 0.0202 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0052 | 0.1481 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0231 | 0.8711 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0017 | 0.007 | 0.0315 |
Brugia malayi | AMP-binding enzyme family protein | 0.0052 | 0.1481 | 0.17 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0052 | 0.1481 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0052 | 0.1481 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0722 | 0.0829 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.0995 | 0.4829 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.0995 | 0.4829 |
Trypanosoma cruzi | ISWI complex protein | 0.0017 | 0.007 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0052 | 0.1481 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.0866 | 0.5844 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0951 | 0.1092 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0149 | 0.0669 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0052 | 0.1481 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0052 | 0.1481 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.0866 | 0.5844 |
Trypanosoma cruzi | ISWI complex protein | 0.0017 | 0.007 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1481 | 0.17 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0395 | 0.1916 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0309 | 0.1392 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0951 | 0.1092 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0722 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1481 | 0.17 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0052 | 0.1486 | 0.6695 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.121 | 0.1389 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0722 | 0.3506 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.1101 | 0.1263 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0951 | 0.1092 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0262 | 0.1178 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0052 | 0.1481 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0052 | 0.1486 | 0.7216 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0052 | 0.1481 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0052 | 0.1481 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0039 | 0.0951 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0262 | 0.127 |
Brugia malayi | AMP-binding enzyme family protein | 0.0052 | 0.1481 | 0.17 |
Mycobacterium ulcerans | hypothetical protein | 0.0052 | 0.1481 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1481 | 0.17 |
Brugia malayi | Bromodomain containing protein | 0.0083 | 0.2745 | 0.3152 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.222 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.206 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.206 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.0866 | 0.5844 |
Brugia malayi | AMP-binding enzyme family protein | 0.0052 | 0.1481 | 0.17 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0019 | 0.0149 | 0.0721 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0149 | 0.0669 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0309 | 0.0355 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0722 | 0.3252 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0039 | 0.0951 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0039 | 0.0951 | 0.6421 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0052 | 0.1481 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0052 | 0.1481 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0052 | 0.1481 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0722 | 0.3252 |
Onchocerca volvulus | 0.0033 | 0.0722 | 0.0722 | |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0052 | 0.1486 | 0.7216 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0395 | 0.1777 |
Trichomonas vaginalis | set domain proteins, putative | 0.0263 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.007 | 0.0315 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0262 | 0.127 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0052 | 0.1481 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0052 | 0.1481 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0951 | 0.1092 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1296 | 0.1487 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0395 | 0.1916 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0052 | 0.1481 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0052 | 0.1481 | 1 |
Trypanosoma brucei | ISWI complex protein | 0.0017 | 0.007 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.