Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Proteasome A-type and B-type family protein | 0.0148 | 0.8609 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0148 | 0.8609 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0066 | 0.3266 | 0.3793 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0148 | 0.8609 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0066 | 0.3266 | 0.3266 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0066 | 0.3266 | 0.3266 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0066 | 0.3266 | 0.3793 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.2019 | 0.2345 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.2019 | 0.2345 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.2019 | 0.2019 |
Echinococcus granulosus | proteasome prosome macropain | 0.0148 | 0.8609 | 0.8609 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.2019 | 0.2345 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0066 | 0.3266 | 0.1892 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0066 | 0.3266 | 0.3793 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0148 | 0.8609 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0148 | 0.8609 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0066 | 0.3266 | 0.3793 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0148 | 0.8609 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0148 | 0.8609 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0 | 0.5 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0148 | 0.8609 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0148 | 0.8609 | 0.8609 |
Echinococcus multilocularis | geminin | 0.0169 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 1 | 0.0066 | 0.3266 | 0.3793 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0066 | 0.3266 | 0.3793 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.2019 | 0.2345 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.012 | 0.6763 | 0.7855 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.2019 | 0.2345 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0108 | 0.5976 | 0.6942 |
Mycobacterium tuberculosis | Probable reductase | 0.0108 | 0.5976 | 0.6942 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0016 | 0 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0148 | 0.8609 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0 | 0.5 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0066 | 0.3266 | 0.3793 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.012 | 0.6763 | 0.7855 |
Leishmania major | trypanothione reductase | 0.0047 | 0.2019 | 0.2345 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0066 | 0.3266 | 0.3266 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0148 | 0.8609 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0108 | 0.5976 | 0.6942 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0108 | 0.5976 | 0.6942 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0148 | 0.8609 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.2019 | 0.2019 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0066 | 0.3266 | 0.3793 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0148 | 0.8609 | 0.8609 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.2019 | 0.2345 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0148 | 0.8609 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.2019 | 0.2345 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0108 | 0.5976 | 0.6942 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0148 | 0.8609 | 1 |
Brugia malayi | glutathione reductase | 0.0047 | 0.2019 | 0.2345 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0066 | 0.3266 | 0.3793 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.012 | 0.6763 | 0.7855 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0148 | 0.8609 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.2019 | 0.2345 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0148 | 0.8609 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.2019 | 0.2345 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0108 | 0.5976 | 0.6942 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.012 | 0.6763 | 0.2987 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0066 | 0.3266 | 0.3793 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.