Detailed information for compound 1147265

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 502.155 | Formula: C21H14Br2N2O3
  • H donors: 2 H acceptors: 3 LogP: 4.78 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccccc1c1cc(cc(c1O)Br)C=C1C(=O)Nc2c1cc(Br)cn2
  • InChi: 1S/C21H14Br2N2O3/c1-28-18-5-3-2-4-13(18)14-6-11(8-17(23)19(14)26)7-16-15-9-12(22)10-24-20(15)25-21(16)27/h2-10,26H,1H3,(H,24,25,27)
  • InChiKey: RIJBDOXTEPVDPJ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens YES proto-oncogene 1, Src family tyrosine kinase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi pyruvate kinase 2, putative 0.0067 0.0362 0.6995
Leishmania major pyruvate kinase 0.0067 0.0362 0.6995
Brugia malayi Bromodomain containing protein 0.0073 0.0396 0.2587
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.009 0.1732
Brugia malayi Protein kinase domain containing protein 0.0052 0.0268 0.1748
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.009 0.1791
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0052 0.0268 0.4985
Echinococcus multilocularis cyclin dependent kinase 0.0052 0.0268 0.0268
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0518 0.0518
Schistosoma mansoni zinc finger protein 0.0019 0.0062 0.0142
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.0033 0.0055
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.0007
Entamoeba histolytica hypothetical protein 0.0037 0.0172 0.3416
Echinococcus granulosus cyclin dependent kinase 5 0.0052 0.0268 0.0618
Echinococcus granulosus cyclins 0.0038 0.0177 0.0408
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0518 0.1195
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0052 0.0268 0.1711
Trichomonas vaginalis cyclin B, putative 0.009 0.0504 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.0033 0.0055
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0576
Echinococcus granulosus pyruvate kinase 0.0067 0.0362 0.0836
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.0033 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0049
Schistosoma mansoni pyruvate kinase 0.0067 0.0362 0.0836
Onchocerca volvulus 0.001 0.0008 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0049
Echinococcus multilocularis microtubule associated protein 2 0.0705 0.4333 0.4333
Giardia lamblia Kinase, CMGC CDK 0.0052 0.0268 0.3169
Brugia malayi protein-tyrosine kinase 0.0044 0.0215 0.1401
Trypanosoma cruzi ISWI complex protein 0.0015 0.0036 0.0051
Echinococcus granulosus tyrosine protein kinase Blk 0.0044 0.0215 0.0495
Schistosoma mansoni hypothetical protein 0.0014 0.0033 0.0077
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0362 0.2315
Loa Loa (eye worm) hypothetical protein 0.004 0.0189 0.121
Echinococcus multilocularis cyclins 0.0038 0.0177 0.0177
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0191 0.0191
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0008 0.0017
Brugia malayi Cytochrome P450 family protein 0.0023 0.0089 0.0581
Entamoeba histolytica protein kinase, putative 0.0039 0.0187 0.37
Loa Loa (eye worm) pyruvate kinase-PB 0.0047 0.0236 0.1505
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0046 0.0107
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0004 0.0008
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0178 0.3081
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0046 0.0107
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.1448 0.334
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0178 0.0293
Trichomonas vaginalis cyclin B, putative 0.009 0.0504 1
Echinococcus granulosus cyclins 0.0038 0.0177 0.0408
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0242 0.0559
Echinococcus multilocularis tumor protein p63 0.0328 0.1985 0.1984
Echinococcus multilocularis cyclins 0.0038 0.0177 0.0177
Trichomonas vaginalis pyruvate kinase, putative 0.0067 0.0362 0.5675
Echinococcus granulosus FTZ F1 alpha 0.001 0.0008 0.0017
Schistosoma mansoni nuclear hormone receptor 0.001 0.0008 0.0017
Onchocerca volvulus Huntingtin homolog 0.0125 0.0723 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0048 0.0242 0.0559
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0178 0.3081
Loa Loa (eye worm) raf kinase 0.026 0.1565 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0008 0.0049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0518 0.1195
Brugia malayi Pyruvate kinase, M2 isozyme 0.0067 0.0362 0.2365
Brugia malayi Cyclin, N-terminal domain containing protein 0.0038 0.0177 0.1154
Schistosoma mansoni tyrosine kinase 0.0048 0.0242 0.0559
Mycobacterium ulcerans hypothetical protein 0.0024 0.009 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0048
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0048 0.0242 0.0559
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0242 0.0558
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.005 0.0319
Trypanosoma brucei cdc2-related kinase 3 0.0052 0.0268 0.4985
Mycobacterium ulcerans pyruvate kinase 0.0067 0.0362 0.0595
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0304 0.0304
Brugia malayi Cytochrome P450 family protein 0.0023 0.0089 0.0581
Brugia malayi protein kinase C3,putative 0.001 0.0004 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0049
Brugia malayi Inositol-1 0.0038 0.0178 0.1163
Echinococcus granulosus pyruvate kinase 0.0035 0.0158 0.0365
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.0033 0.0055
Leishmania major cytochrome p450-like protein 0.0023 0.0089 0.1185
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0008 0.0048
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0048
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0518 0.3309
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0268 0.2782
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0052 0.0268 0.0618
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.0268 0.4985
Giardia lamblia Cyclin A 0.0038 0.0177 0.0536
Echinococcus granulosus geminin 0.0173 0.1021 0.2357
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.008 0.0183
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0008 0.0017
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0008 0.0103
Brugia malayi Protein kinase domain containing protein 0.001 0.0004 0.0023
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0048
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0013 0.0023 0.0053
Schistosoma mansoni protein kinase C mu 0.001 0.0004 0.0008
Mycobacterium ulcerans haloalkane dehalogenase 0.0987 0.6093 1
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.0268 0.4985
Loa Loa (eye worm) inositol-1 0.0038 0.0178 0.1138
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0155 0.0988
Echinococcus granulosus pyruvate kinase 0.0035 0.0158 0.0365
Trypanosoma brucei ISWI complex protein 0.0015 0.0036 0.0051
Echinococcus multilocularis pyruvate kinase 0.0035 0.0158 0.0158
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0046 0.0107
Schistosoma mansoni hypothetical protein 0.0173 0.1021 0.2357
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0052 0.0268 0.739
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0089 0.0568
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0008 0.0007
Entamoeba histolytica cyclin, putative 0.0038 0.0177 0.351
Plasmodium falciparum protein kinase 5 0.0052 0.0268 0.6943
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0046 0.0107
Echinococcus multilocularis Protein kinase C, brain isozyme 0.001 0.0004 0.0003
Plasmodium vivax pyruvate kinase 2, putative 0.0035 0.0158 0.3403
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.008 0.0079
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.025 0.1632
Echinococcus multilocularis cyclin dependent kinase 5 0.0052 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.1283
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0518 0.0518
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.009 0.0148
Plasmodium falciparum cyclin 0.0038 0.0177 0.4002
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0046 0.0107
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0004 0.0008
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0038 0.0177 0.0177
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.009 0.1211
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0518 0.1195
Brugia malayi ecdysteroid receptor 0.001 0.0008 0.0049
Loa Loa (eye worm) TK protein kinase 0.0039 0.0187 0.1191
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0049
Loa Loa (eye worm) hypothetical protein 0.0052 0.027 0.1725
Trichomonas vaginalis pyruvate kinase, putative 0.0067 0.0362 0.5675
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0007
Chlamydia trachomatis pyruvate kinase 0.0067 0.0362 1
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0014 0.0029 0.0065
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.008 0.0183
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0154 0.3656
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0049
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0268 0.5316
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0053 0.0087
Echinococcus multilocularis tyrosine protein kinase Blk 0.0044 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0049
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0014 0.0029 0.0065
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.0504 0.3288
Schistosoma mansoni cyclin B3 0.0038 0.0177 0.0408
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0049
Entamoeba histolytica cyclin family protein 0.0038 0.0177 0.351
Loa Loa (eye worm) hypothetical protein 0.009 0.0504 0.3218
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.0268 0.4985
Echinococcus multilocularis 0.0014 0.0033 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.009 0.0148
Entamoeba histolytica pyruvate kinase, putative 0.0047 0.0236 0.4675
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.0033 0.0055
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.0033 0.0055
Onchocerca volvulus Huntingtin homolog 0.0125 0.0723 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.009 0.0094
Giardia lamblia Hypothetical protein 0.0038 0.0177 0.0536
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.0017
Trichomonas vaginalis cyclins, putative 0.009 0.0504 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0008 0.0017
Echinococcus granulosus raf serine:threonine protein kinase 0.0264 0.1589 0.3666
Brugia malayi Pyruvate kinase, muscle isozyme 0.0067 0.0362 0.2365
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0178 0.3081
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.016 0.016
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0014 0.0029 0.0028
Mycobacterium leprae Probable pyruvate kinase PykA 0.0067 0.0362 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0048 0.0242 0.0559
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.001 0.0004 0.0008
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0178 0.3537
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.0033 0.0055
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0089 0.1185
Brugia malayi SRC-1 0.0048 0.0242 0.1581
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0048 0.0242 0.0242
Schistosoma mansoni cyclin B 0.009 0.0504 0.1162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0048
Trichomonas vaginalis cyclin B, putative 0.009 0.0504 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0576
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0008 0.0103
Echinococcus granulosus tumor protein p63 0.0328 0.1985 0.458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0048
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0151 0.0883 0.5643
Loa Loa (eye worm) cyclin domain-containing protein 0.0038 0.0177 0.113
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0044 0.0215 0.0495
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0008 0.0007
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.009 0.1791
Brugia malayi C1-like domain containing protein 0.001 0.0004 0.0023
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0362 0.2315
Echinococcus granulosus Protein kinase C brain isozyme 0.001 0.0004 0.0008
Echinococcus multilocularis tyrosine protein kinase Abl 0.0013 0.0023 0.0023
Echinococcus granulosus pyruvate kinase 0.0035 0.0158 0.0365
Echinococcus granulosus c src tyrosine kinase 0.0013 0.0023 0.0053
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0048 0.0242 0.0242
Onchocerca volvulus 0.0049 0.025 0.346
Echinococcus multilocularis tyrosine protein kinase HCK 0.0039 0.0187 0.0186
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0007
Echinococcus multilocularis pyruvate kinase 0.0053 0.0274 0.0274
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.1448 0.1447
Toxoplasma gondii hypothetical protein 0.0028 0.0121 0.3324
Loa Loa (eye worm) hypothetical protein 0.0047 0.0236 0.1505
Schistosoma mansoni atypical protein kinase C 0.001 0.0004 0.0008
Brugia malayi PHD-finger family protein 0.0024 0.0094 0.0611
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.001 0.0004 0.0023
Loa Loa (eye worm) TK protein kinase 0.0044 0.0215 0.1372
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0008 0.0049
Echinococcus multilocularis protein kinase c epsilon type 0.001 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0069 0.0371 0.2367
Leishmania major hypothetical protein, conserved 0.0015 0.0036 0.0051
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0191 0.044
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0362 0.5014
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0008 0.0017
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0242 0.0559
Trypanosoma brucei pyruvate kinase 1 0.0067 0.0362 0.6995
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0268 0.0618
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.0033 0.0055
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0048 0.0242 0.0242
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0008 0.0007
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0154 0.0198
Echinococcus multilocularis cyclins 0.0038 0.0177 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0049
Brugia malayi Variant SH3 domain containing protein 0.0014 0.0029 0.0185
Trichomonas vaginalis cyclin A, putative 0.009 0.0504 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0048 0.0242 0.0242
Toxoplasma gondii pyruvate kinase PyKII 0.0035 0.0158 0.4369
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0178 0.0411
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0017
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0518 0.338
Trichomonas vaginalis cyclins, putative 0.0062 0.0327 0.4577
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0068 0.0433
Echinococcus multilocularis protein kinase c iota type 0.001 0.0004 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0004 0.0008
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0013 0.0023 0.0023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.0023
Trypanosoma cruzi pyruvate kinase 2, putative 0.0067 0.0362 0.6995
Brugia malayi hypothetical protein 0.0037 0.0172 0.1123
Schistosoma mansoni microtubule-associated protein tau 0.0705 0.4333 1
Echinococcus granulosus cyclins 0.0038 0.0177 0.0408
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0362 0.5014
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.009 0.0148
Schistosoma mansoni pyruvate kinase 0.0067 0.0362 0.0836
Schistosoma mansoni tyrosine kinase 0.0013 0.0023 0.0053
Trichomonas vaginalis cyclins, putative 0.009 0.0504 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.009 0.0148
Schistosoma mansoni bromodomain containing protein 0.0061 0.0326 0.0751
Brugia malayi AMP-binding enzyme family protein 0.0024 0.009 0.0589
Brugia malayi nuclear receptor NHR-88 0.001 0.0008 0.0049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0518 0.1195
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0017
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0268 0.1711
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0014 0.0029 0.0065
Schistosoma mansoni hypothetical protein 0.0015 0.0036 0.0082
Trichomonas vaginalis cyclins, putative 0.009 0.0504 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.0023
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0008 0.0007
Schistosoma mansoni coup transcription factor 0.001 0.0008 0.0017
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0089 0.0568
Leishmania major cyclin 0.009 0.0504 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.009 0.0094
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0242 0.0242
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0268 0.1711
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0049
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0178 0.0041
Schistosoma mansoni tyrosine kinase 0.0048 0.0242 0.0559
Trichomonas vaginalis cyclin B, putative 0.009 0.0504 1
Brugia malayi Raf kinase 0.0255 0.1532 1
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0178 0.0178
Schistosoma mansoni hypothetical protein 0.0173 0.1021 0.2357
Echinococcus granulosus microtubule associated protein 2 0.0705 0.4333 1
Schistosoma mansoni inositol monophosphatase 0.0038 0.0178 0.0411
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0049
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0008 0.0017
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.0033 0.0055
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0339
Trichomonas vaginalis cyclins, putative 0.009 0.0504 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0017
Echinococcus granulosus N chimaerin 0.0014 0.0029 0.0065
Echinococcus granulosus cyclin dependent kinase 0.0052 0.0268 0.0618
Toxoplasma gondii pyruvate kinase PyK1 0.0067 0.0362 1
Schistosoma mansoni hypothetical protein 0.002 0.0068 0.0157
Plasmodium falciparum pyruvate kinase 2 0.0035 0.0158 0.3403
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0048 0.0242 0.0559
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.0504 0.3288
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0008 0.0017
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.009 0.1211
Echinococcus granulosus tyrosine kinase 0.0044 0.0215 0.0495
Brugia malayi hypothetical protein 0.0242 0.1448 0.9449
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.009 0.0148
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0339
Brugia malayi Cytochrome P450 family protein 0.0014 0.0033 0.0217
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0242 0.0242
Trypanosoma cruzi cyclin, putative 0.009 0.0504 1
Schistosoma mansoni cyclins 0.0038 0.0177 0.0408
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0362 0.5014
Echinococcus multilocularis pyruvate kinase 0.0035 0.0158 0.0158
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0004 0.0008
Brugia malayi pyruvate kinase 0.0014 0.0032 0.0205
Brugia malayi steroid hormone receptor 0.001 0.0008 0.0049
Echinococcus multilocularis cyclins 0.0038 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0125 0.0723 0.4617
Brugia malayi cytochrome P450 0.0014 0.0033 0.0217
Trypanosoma cruzi ISWI complex protein 0.0015 0.0036 0.0051
Schistosoma mansoni hypothetical protein 0.0037 0.0172 0.0397
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0268 0.5316
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0178 0.3081
Echinococcus multilocularis cyclins 0.0038 0.0177 0.0177
Loa Loa (eye worm) pyruvate kinase 0.0014 0.0032 0.0201
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0518 0.1195
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.0033 0.0055
Brugia malayi Cytochrome P450 family protein 0.0034 0.0155 0.1009
Onchocerca volvulus 0.0024 0.009 0.1248
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.009 0.0148
Brugia malayi protein kinase C II. 0.001 0.0004 0.0023
Echinococcus multilocularis tyrosine protein kinase Srms 0.0044 0.0215 0.0215
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.009 0.1211
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.0023
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0048
Echinococcus granulosus tyrosine protein kinase HCK 0.0039 0.0187 0.043
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.009 0.0504 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0048 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.0295
Echinococcus granulosus cyclin B3 1 0.0038 0.0177 0.0408
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0053 0.0033
Trypanosoma brucei cdc2-related kinase 1 0.0052 0.0268 0.4985
Echinococcus multilocularis cyclin B 0.009 0.0504 0.0504
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.0033 0.0055
Schistosoma mansoni cytochrome P450 0.0014 0.0033 0.0077
Entamoeba histolytica hypothetical protein 0.0037 0.0172 0.3416
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0268 0.0268
Brugia malayi Bromodomain containing protein 0.0037 0.0175 0.1139
Onchocerca volvulus 0.009 0.0504 0.697
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0052 0.0264 0.1689
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.0033 0.0055
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0008 0.0017
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.0033 0.0055
Echinococcus granulosus protein kinase c epsilon type 0.001 0.0004 0.0008
Echinococcus multilocularis N chimaerin 0.0014 0.0029 0.0028
Echinococcus multilocularis zinc finger protein 0.0019 0.0062 0.0061
Echinococcus granulosus pyruvate kinase 0.0067 0.0362 0.0836
Trypanosoma brucei pyruvate kinase 1, putative 0.0067 0.0362 0.6995
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0046 0.0046
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.0033 0.0055
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0089 0.1185
Entamoeba histolytica hypothetical protein 0.0037 0.0172 0.3416
Giardia lamblia Kinase, CMGC CDK 0.0052 0.0268 0.3169
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0008 0.0049
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0048
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0268 0.2782
Echinococcus multilocularis c src tyrosine kinase 0.0013 0.0023 0.0023
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.016 0.037
Schistosoma mansoni survival motor neuron protein 0.0049 0.025 0.0577
Loa Loa (eye worm) hypothetical protein 0.009 0.0504 0.3218
Echinococcus multilocularis cyclin B3 1 0.0038 0.0177 0.0177
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0172 0.0172
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0013 0.0023 0.0053
Schistosoma mansoni vav2 0.0014 0.0029 0.0065
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0046 0.0046
Loa Loa (eye worm) SRC-1 0.0048 0.0242 0.1548
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0268 0.0268
Echinococcus multilocularis cyclin b3 0.0038 0.0177 0.0177
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0008 0.0017
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0172 0.0397
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.0033 0.0055
Loa Loa (eye worm) hypothetical protein 0.0048 0.0242 0.1546
Brugia malayi AMP-binding enzyme family protein 0.0024 0.009 0.0589
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0008 0.0017
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.009 0.1732
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0339
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0178 0.4917
Echinococcus granulosus protein kinase c iota type 0.001 0.0004 0.0008
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.0033 0.0055
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0008 0.0017
Brugia malayi hypothetical protein 0.0125 0.0723 0.4717
Entamoeba histolytica hypothetical protein 0.0037 0.0172 0.3416
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.0033 0.0055
Schistosoma mansoni zinc finger protein 0.0015 0.0036 0.0082
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0362 0.2315
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0008 0.0048
Giardia lamblia G2/mitotic-specific cyclin B 0.009 0.0504 1
Echinococcus granulosus zinc finger protein 0.0019 0.0062 0.0142
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.002 0.007 0.0457
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0268 0.0618
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.0268 0.4985
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0089 0.0146
Loa Loa (eye worm) hypothetical protein 0.0125 0.0723 0.4617
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0049
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0008 0.0017
Schistosoma mansoni hypothetical protein 0.0049 0.025 0.0577
Loa Loa (eye worm) hypothetical protein 0.0242 0.1448 0.925
Echinococcus multilocularis cyclins 0.0038 0.0177 0.0177
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0987 0.6093 1
Trypanosoma cruzi cyclin 6, putative 0.009 0.0504 1
Echinococcus granulosus cyclin b3 0.0038 0.0177 0.0408
Entamoeba histolytica cyclin family protein 0.0038 0.0177 0.351
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0067 0.0362 0.0543
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0033 0.0077
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0008 0.0103
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.001 0.0004 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0049
Brugia malayi pyruvate kinase, muscle isozyme 0.0014 0.0032 0.0205
Loa Loa (eye worm) CAMK/PKD protein kinase 0.001 0.0004 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0048
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0033 0.0917
Echinococcus multilocularis geminin 0.0173 0.1021 0.1021
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0172 0.0397
Leishmania major pyruvate kinase 0.0067 0.0362 0.6995
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.0033 0.0055
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0339
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0178 0.0041
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0242 0.0242
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0178 0.5
Plasmodium vivax pyruvate kinase, putative 0.0067 0.0362 1
Schistosoma mansoni tyrosine kinase 0.0013 0.0023 0.0053
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.0017
Echinococcus granulosus cyclin B 0.009 0.0504 0.1162
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.001 0.0004 0.0022
Schistosoma mansoni pyruvate kinase 0.0035 0.0158 0.0365
Brugia malayi cell division control protein 2 homolog 0.0052 0.0268 0.1748
Loa Loa (eye worm) cytochrome P450 0.0014 0.0033 0.0212
Plasmodium falciparum pyruvate kinase 0.0067 0.0362 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.009 0.0589
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0048
Echinococcus granulosus cyclin dependent kinase 1 0.0052 0.0268 0.0618
Brugia malayi Tyrosine-protein kinase abl-1 0.0013 0.0023 0.015
Echinococcus multilocularis cyclins 0.0038 0.0177 0.0177
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0052 0.0268 0.4985
Plasmodium vivax protein kinase Crk2 0.0052 0.0268 0.6943
Schistosoma mansoni inositol monophosphatase 0.0038 0.0178 0.0411
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.0023
Echinococcus granulosus tyrosine protein kinase Lyn 0.0049 0.0246 0.0567
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.001 0.0004 0.0003
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.0215 0.0215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0048
Trypanosoma cruzi CYC2-like cyclin, putative 0.009 0.0504 1
Trypanosoma cruzi cyclin, putative 0.009 0.0504 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0048
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0089 0.0568
Echinococcus multilocularis pyruvate kinase 0.0067 0.0362 0.0362
Brugia malayi nuclear hormone receptor 0.001 0.0008 0.0049
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0268 0.2782
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.009 0.1791
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.009 0.0148
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.0017
Trypanosoma brucei mitotic cyclin 6 0.009 0.0504 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0264 0.1589 0.1589
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0014 0.0029 0.0181
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.0033 0.0055
Loa Loa (eye worm) hypothetical protein 0.0067 0.0362 0.2315
Echinococcus granulosus cyclins 0.0038 0.0177 0.0408
Entamoeba histolytica cyclin, putative 0.009 0.0504 1
Giardia lamblia Pyruvate kinase 0.0067 0.0362 0.5907
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0304 0.0701
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0037 0.0175 0.1118
Echinococcus multilocularis pyruvate kinase 0.0035 0.0158 0.0158
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0089 0.1185
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0017
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0008 0.0049
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0038 0.0177 0.0408
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0339
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0576
Echinococcus granulosus cyclins 0.0038 0.0177 0.0408
Onchocerca volvulus 0.0048 0.0242 0.3349
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.0033 0.0055
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0242 0.0559
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0048 0.0242 0.0242
Brugia malayi RhoGAP domain containing protein 0.0014 0.0029 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.0264 0.1589 0.3666
Echinococcus multilocularis pyruvate kinase 0.0067 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0048
Brugia malayi Protein kinase c protein 2 0.001 0.0004 0.0023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0046 0.0107
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0178 0.0041

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7333 uM PubChem BioAssay. qHTS for small molecule inhibitors of Yes1 kinase: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.8722 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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