Detailed information for compound 1147510

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 377.436 | Formula: C22H23N3O3
  • H donors: 1 H acceptors: 3 LogP: 2.98 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)N[C@H]1CC[C@H](C1)C(=O)N(c1ccc(cc1)c1nc2c(o1)cccc2)C
  • InChi: 1S/C22H23N3O3/c1-14(26)23-17-10-7-16(13-17)22(27)25(2)18-11-8-15(9-12-18)21-24-19-5-3-4-6-20(19)28-21/h3-6,8-9,11-12,16-17H,7,10,13H2,1-2H3,(H,23,26)/t16-,17+/m1/s1
  • InChiKey: JMWPOZKRNXCSCZ-SJORKVTESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fatty acid synthase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum KR domain domain-containing protein, putative Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks12 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Soraphen polyketide synthase A, related Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks15 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks2 Get druggable targets OG5_126633 All targets in OG5_126633
Onchocerca volvulus Fatty acid synthase homolog Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Onchocerca volvulus Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) acyl carrier protein Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks7 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks8 Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks5 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii AMP-binding enzyme domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.107 0.104
Loa Loa (eye worm) fatty acid synthase 0.003 0.1669 0.1641
Brugia malayi hypothetical protein 0.0012 0.0144 0.0111
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.107 0.104
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.107 0.104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0144 0.0111
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.107 0.104
Mycobacterium ulcerans polyketide synthase 0.0032 0.1865 0.481
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0126 1 1
Onchocerca volvulus 0.0023 0.107 0.104
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.107 0.104
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.107 0.104
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.107 0.104
Schistosoma mansoni thyroid hormone receptor 0.0023 0.107 0.104
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.107 0.104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0144 0.0111
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.1703 0.4065
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.107 0.104
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.1703 0.4065
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.107 0.104
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0032 0.1865 0.481
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0126 1 1
Echinococcus granulosus inhibitor of apoptosis protein 0.0126 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.107 0.104
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.107 0.104
Brugia malayi AMP-binding enzyme family protein 0.0028 0.1533 0.1504
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.107 0.104
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.107 0.104
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.107 0.104
Brugia malayi nuclear hormone receptor 0.0023 0.107 0.104
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.1196 0.172
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.107 0.104
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.107 0.104
Onchocerca volvulus Fatty acid synthase homolog 0.0054 0.3787 0.3766
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0024 0.1196 0.172
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.107 0.104
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.107 0.104
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.107 0.104
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.107 0.104
Loa Loa (eye worm) hypothetical protein 0.0017 0.0562 0.053
Loa Loa (eye worm) hypothetical protein 0.0023 0.107 0.104
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.1703 0.4065
Echinococcus granulosus FTZ F1 alpha 0.0023 0.107 0.104
Toxoplasma gondii type I fatty acid synthase, putative 0.0021 0.0955 0.3708
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.107 0.104
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.003 0.1703 0.1675
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0017 0.0583 0.1953
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0032 0.1865 0.6242
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.107 0.104
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0144 0.0111
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.1533 0.1504
Loa Loa (eye worm) hypothetical protein 0.0012 0.0144 0.0111
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0022 0.0972 0.3255
Loa Loa (eye worm) hypothetical protein 0.0126 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.107 0.104
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.107 0.104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.107 0.104
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.1703 0.5702
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.107 0.104
Brugia malayi nuclear receptor NHR-88 0.0023 0.107 0.104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0144 0.0111
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0032 0.1865 0.481
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.107 0.104
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.003 0.1703 0.4065
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0144 0.0111
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0144 0.0111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.107 0.104
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.107 0.104
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.107 0.104
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0126 1 1
Mycobacterium ulcerans polyketide synthase Pks13 0.0045 0.2987 1
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0032 0.1865 0.6242
Loa Loa (eye worm) hypothetical protein 0.0023 0.107 0.104
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.107 0.104
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.107 0.104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.107 0.104
Brugia malayi steroid hormone receptor 0.0023 0.107 0.104
Loa Loa (eye worm) hypothetical protein 0.0023 0.107 0.104
Brugia malayi hypothetical protein 0.0012 0.0144 0.0111
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0029 0.1624 0.5436
Loa Loa (eye worm) hypothetical protein 0.0023 0.107 0.104
Onchocerca volvulus 0.0028 0.1533 0.1504
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.002 0.0792 0.2574
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.107 0.104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.107 0.104
Echinococcus multilocularis inhibitor of apoptosis protein 0.0126 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.107 0.104
Mycobacterium ulcerans polyketide synthase 0.003 0.1703 0.4065
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0144 0.0111
Schistosoma mansoni hypothetical protein 0.0126 1 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.1703 0.4065
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.107 0.104
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.1865 0.481
Mycobacterium ulcerans thioesterase 0.0025 0.1271 0.2064
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.107 0.104
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0045 0.2987 1
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0029 0.1624 0.5436
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.107 0.104
Loa Loa (eye worm) hypothetical protein 0.0023 0.107 0.104
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0025 0.1271 0.2064
Loa Loa (eye worm) acyl carrier protein 0.0014 0.0301 0.0269
Brugia malayi nuclear receptor RXR 0.0012 0.0144 0.0111
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.003 0.1703 0.5702
Loa Loa (eye worm) hypothetical protein 0.0012 0.0144 0.0111
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0032 0.1865 0.481
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0144 0.0111
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.107 0.104
Onchocerca volvulus 0.0126 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.107 0.104
Onchocerca volvulus Deterin homolog 0.0126 1 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0024 0.1196 0.172
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.003 0.1703 0.4065
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0144 0.0111
Loa Loa (eye worm) hypothetical protein 0.0023 0.107 0.104
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.107 0.104
Mycobacterium ulcerans thioesterase TesA 0.0025 0.1271 0.2064
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0057 0.4027 0.4007
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.107 0.104
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.107 0.104
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.107 0.104
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.107 0.104
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.1533 0.5131
Loa Loa (eye worm) hypothetical protein 0.0051 0.3468 0.3446
Mycobacterium tuberculosis Probable thioesterase TesA 0.0025 0.1271 0.4254
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.003 0.1703 0.5702
Schistosoma mansoni nuclear hormone receptor 0.0023 0.107 0.104
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0025 0.123 0.4119
Schistosoma mansoni coup transcription factor 0.0023 0.107 0.104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.107 0.104
Schistosoma mansoni thyroid hormone receptor 0.0023 0.107 0.104
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0126 1 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.1865 0.6242
Toxoplasma gondii type I fatty acid synthase, putative 0.0032 0.1865 1
Loa Loa (eye worm) hypothetical protein 0.0126 1 1
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0045 0.2987 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.107 0.104
Onchocerca volvulus 0.0052 0.3625 0.3604
Schistosoma mansoni inhibitor of apoptosis protein 0.0126 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.107 0.104
Loa Loa (eye worm) hypothetical protein 0.0023 0.107 0.104
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.107 0.104
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.107 0.104
Brugia malayi ecdysteroid receptor 0.0023 0.107 0.104
Mycobacterium leprae Probable polyketide synthase Pks1 0.0032 0.1865 0.481
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.107 0.104
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0012 0.0157 0.0527
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0144 0.0111
Mycobacterium leprae Polyketide synthase Pks13 0.0045 0.2987 1
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.107 0.104

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.2 uM Inhibition of human FAS assessed as synthesis of long chain fatty acids from malonyl CoA after 60 mins by fluorescence assay ChEMBL. 21873051

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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