Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0203 | 0.2404 | 0.5998 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.024 | 0.0552 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0365 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0148 | 0.4745 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.1016 | 0.2341 |
Brugia malayi | Pre-SET motif family protein | 0.0221 | 0.2634 | 0.6573 |
Trypanosoma brucei | unspecified product | 0.0028 | 0.0197 | 0.2935 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0365 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0203 | 0.2404 | 0.5998 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.1381 | 0.3445 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0041 | 0.0358 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.024 | 0.7673 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0358 | 0.5337 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.024 | 0.0552 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0041 | 0.0358 | 0.5 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.024 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0221 | 0.2634 | 0.6573 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0148 | 0.2213 |
Schistosoma mansoni | tar DNA-binding protein | 0.0329 | 0.4008 | 0.9229 |
Schistosoma mansoni | tar DNA-binding protein | 0.0329 | 0.4008 | 0.9229 |
Loa Loa (eye worm) | TAR-binding protein | 0.0329 | 0.4008 | 1 |
Echinococcus granulosus | geminin | 0.0356 | 0.4342 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0358 | 0.5337 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0358 | 0.5337 |
Trypanosoma brucei | unspecified product | 0.0041 | 0.0358 | 0.5337 |
Leishmania major | DNA polymerase kappa, putative | 0.0041 | 0.0358 | 0.5337 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0041 | 0.0358 | 0.0322 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.065 | 0.1498 |
Schistosoma mansoni | tar DNA-binding protein | 0.0329 | 0.4008 | 0.9229 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0358 | 0.5337 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0032 | 0.024 | 0.0552 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0064 | 0.065 | 0.1623 |
Onchocerca volvulus | 0.0251 | 0.3021 | 1 | |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.1381 | 0.3445 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0365 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0358 | 0.5337 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0066 | 0.0671 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0365 | 0.091 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0365 | 0.0128 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0138 | 0.1592 | 0.3973 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0093 | 0.1016 | 0.2536 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0358 | 0.5337 |
Schistosoma mansoni | DNA polymerase eta | 0.0066 | 0.0671 | 0.1544 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0148 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0041 | 0.0358 | 0.0893 |
Brugia malayi | TAR-binding protein | 0.0329 | 0.4008 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0064 | 0.065 | 0.1623 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0329 | 0.4008 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0671 | 0.1673 |
Echinococcus granulosus | GPCR family 2 | 0.0064 | 0.065 | 0.1033 |
Trypanosoma brucei | unspecified product | 0.0028 | 0.0197 | 0.2935 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0064 | 0.065 | 0.1033 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0093 | 0.1016 | 0.2536 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.065 | 0.1623 |
Schistosoma mansoni | tar DNA-binding protein | 0.0329 | 0.4008 | 0.9229 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0365 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0148 | 0.2213 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0028 | 0.0197 | 0.2935 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0148 | 0.6184 |
Echinococcus multilocularis | tar DNA binding protein | 0.0329 | 0.4008 | 0.3861 |
Loa Loa (eye worm) | RNA binding protein | 0.0329 | 0.4008 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0041 | 0.0358 | 0.0121 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.1592 | 0.3667 |
Schistosoma mansoni | hypothetical protein | 0.0356 | 0.4342 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0329 | 0.4008 | 0.9229 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.065 | 0.1498 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.1016 | 0.0796 |
Echinococcus multilocularis | dna polymerase kappa | 0.0041 | 0.0358 | 0.0121 |
Trichomonas vaginalis | set domain proteins, putative | 0.0251 | 0.3021 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0365 | 0.0339 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0329 | 0.4008 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0365 | 0.084 |
Schistosoma mansoni | hypothetical protein | 0.0356 | 0.4342 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0148 | 0.037 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0358 | 0.5337 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0358 | 0.5337 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.1016 | 0.1922 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0066 | 0.0671 | 0.1673 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0039 | 0.0097 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0041 | 0.0358 | 0.0824 |
Giardia lamblia | DINP protein human, muc B family | 0.0041 | 0.0358 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0041 | 0.0358 | 0.0893 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.024 | 0.0599 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0358 | 0.5337 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0041 | 0.0358 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0041 | 0.0358 | 0.0824 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.024 | 0.0036 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.1016 | 0.1922 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.024 | 0.0552 |
Echinococcus granulosus | tar DNA binding protein | 0.0329 | 0.4008 | 0.9187 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0148 | 0.2213 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0064 | 0.065 | 0.0421 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0358 | 0.5337 |
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.024 | 0.0599 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.1016 | 0.0796 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0037 | 0.0313 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0041 | 0.0358 | 0.0322 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0041 | 0.0358 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.065 | 0.1498 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0066 | 0.0671 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.1016 | 0.2341 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0064 | 0.065 | 0.0421 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0064 | 0.065 | 0.1033 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2404 | 0.5998 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0028 | 0.0197 | 0.2935 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0358 | 0.5337 |
Brugia malayi | RNA binding protein | 0.0329 | 0.4008 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0064 | 0.065 | 0.1623 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0148 | 0.037 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0358 | 0.5337 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0028 | 0.0197 | 0.2935 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.065 | 0.1498 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.1016 | 0.2341 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.1381 | 0.3445 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0148 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0203 | 0.2404 | 0.5998 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0365 | 0.084 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0358 | 0.5337 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0037 | 0.0313 | 0.4663 |
Leishmania major | DNA polymerase eta, putative | 0.0037 | 0.0313 | 0.4663 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0148 | 0.2213 |
Echinococcus granulosus | dna polymerase eta | 0.0066 | 0.0671 | 0.1082 |
Echinococcus multilocularis | GPCR, family 2 | 0.0064 | 0.065 | 0.0421 |
Echinococcus multilocularis | geminin | 0.0356 | 0.4342 | 0.4203 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0358 | 0.5337 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0041 | 0.0358 | 0.5337 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0358 | 0.5337 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1592 | 0.3973 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0358 | 0.5337 |
Leishmania major | DNA polymerase eta, putative | 0.0066 | 0.0671 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0358 | 0.5337 |
Echinococcus multilocularis | dna polymerase eta | 0.0066 | 0.0671 | 0.0441 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.