TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 288.408 | Formula: C16H20N2OS
H donors: 1 H acceptors: 1 LogP: 2.68 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cc1cccc2c1ccs2)NCCN1CCCC1
InChi: 1S/C16H20N2OS/c19-16(17-7-10-18-8-1-2-9-18)12-13-4-3-5-15-14(13)6-11-20-15/h3-6,11H,1-2,7-10,12H2,(H,17,19)
InChiKey: OUXJBVNPPBKBJV-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	proteasome subunit beta type 1	0.0062	0.055	0.0587
Echinococcus granulosus	proteasome prosome macropain	0.0081	0.0851	0.0839
Echinococcus multilocularis	ferritin	0.0027	0.0013	0.0013
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0109	0.1146
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0075	0.0761	0.106
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0035	0.0138	0.0138
Brugia malayi	MH1 domain containing protein	0.0035	0.0138	0.0039
Brugia malayi	MH2 domain containing protein	0.0035	0.0138	0.0039
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0482	0.7068	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0175	0.0088
Toxoplasma gondii	proteasome subunit beta type, putative	0.0081	0.0851	1
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0035	0.0138	0.0138
Echinococcus multilocularis	Smad4	0.0035	0.0138	0.0138
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0047	0.0315	0.2774
Mycobacterium tuberculosis	Probable lipase LipD	0.0075	0.0761	0.106
Brugia malayi	Bromodomain containing protein	0.0169	0.2214	0.2802
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0109	0.0109
Giardia lamblia	Proteasome subunit beta type 1	0.0062	0.055	0.5946
Echinococcus multilocularis	GPCR, family 2	0.0148	0.1883	0.1883
Leishmania major	hypothetical protein, conserved	0.0075	0.0761	0.1428
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0761	0.106
Mycobacterium ulcerans	proteasome PrcB	0.0081	0.0851	0.3713
Plasmodium vivax	hypothetical protein, conserved	0.0075	0.0761	0.8789
Mycobacterium tuberculosis	Probable hydrolase	0.0075	0.0761	0.106
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0155	0.1998	0.4135
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0761	0.8928
Echinococcus multilocularis	tumor protein p63	0.0329	0.4688	0.4688
Schistosoma mansoni	tar DNA-binding protein	0.0315	0.4475	0.4468
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0062	0.055	0.0538
Echinococcus granulosus	beta LACTamase domain containing family member	0.0075	0.0761	0.0749
Loa Loa (eye worm)	PHD-finger family protein	0.0046	0.0298	0.0251
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0081	0.0851	1
Brugia malayi	PHD-finger family protein	0.0058	0.0498	0.0518
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0761	0.106
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.005	0.0363	0.0351
Schistosoma mansoni	hypothetical protein	0.0148	0.1883	0.1873
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0027	0.0013	0.5
Leishmania major	proteasome beta 5 subunit, putative	0.0081	0.0851	0.1624
Trichomonas vaginalis	esterase, putative	0.0075	0.0761	0.8928
Leishmania major	mitochondrial DNA polymerase beta	0.0328	0.4677	1
Schistosoma mansoni	pyruvate kinase	0.0033	0.0109	0.0096
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0135	0.169	0.169
Onchocerca volvulus		0.0075	0.0761	1
Loa Loa (eye worm)	RNA binding protein	0.0315	0.4475	0.5812
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0148	0.1883	0.2362
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0081	0.0851	0.1188
Loa Loa (eye worm)	hypothetical protein	0.0156	0.2014	0.2536
Loa Loa (eye worm)	hypothetical protein	0.0467	0.6836	0.8955
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0075	0.0761	0.0868
Mycobacterium ulcerans	pyruvate kinase	0.0033	0.0109	0.0425
Loa Loa (eye worm)	TAR-binding protein	0.0315	0.4475	0.5812
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0134	0.1671	0.166
Schistosoma mansoni	smad1 5 8 and	0.0035	0.0138	0.0125
Trichomonas vaginalis	penicillin-binding protein, putative	0.0075	0.0761	0.8928
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0062	0.055	0.055
Brugia malayi	RNA binding protein	0.0315	0.4475	0.5812
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0134	0.1671	0.166
Echinococcus granulosus	tar DNA binding protein	0.0315	0.4475	0.4468
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0056	0.0463	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0319	0.4544	0.5903
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0075	0.0761	0.0868
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0173	0.227	0.3199
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0134	0.1671	0.2078
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0047	0.0315	0.3602
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0047	0.0315	0.3602
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0467	0.6836	0.8955
Echinococcus multilocularis	zinc finger protein	0.0047	0.0315	0.0315
Brugia malayi	hypothetical protein	0.0071	0.0693	0.0777
Leishmania major	hypothetical protein, conserved	0.0034	0.0115	0.0013
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0306	0.0431
Schistosoma mansoni	transcription factor LCR-F1	0.0071	0.0693	0.068
Loa Loa (eye worm)	transcription factor SMAD2	0.0518	0.7622	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0134	0.1671	0.166
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1106	0.1327
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0062	0.055	0.0587
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0038	0.0175	0.0175
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0062	0.055	0.5516
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0134	0.1671	0.2078
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1883	0.2362
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0033	0.0109	0.1146
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0148	0.1883	0.1873
Entamoeba histolytica	hypothetical protein	0.0071	0.0693	0.7636
Schistosoma mansoni	Smad4	0.0035	0.0138	0.0125
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0135	0.169	0.1679
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0148	0.1883	0.1883
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0761	0.0868
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0075	0.0761	0.0749
Trypanosoma brucei	proteasome beta 6 subunit	0.0062	0.055	0.0966
Echinococcus multilocularis	tar DNA binding protein	0.0315	0.4475	0.4475
Entamoeba histolytica	hypothetical protein	0.0071	0.0693	0.7636
Schistosoma mansoni	hypothetical protein	0.0349	0.4997	0.4991
Schistosoma mansoni	hypothetical protein	0.0046	0.0298	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0337	0.0303
Schistosoma mansoni	hypothetical protein	0.0148	0.1883	0.1873
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0761	0.0868
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0137	0.1716	0.1705
Mycobacterium tuberculosis	Probable esterase LipL	0.0075	0.0761	0.106
Schistosoma mansoni	tar DNA-binding protein	0.0315	0.4475	0.4468
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0047	0.0315	0.0302
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0081	0.0851	0.1624
Mycobacterium ulcerans	lipase LipD	0.0075	0.0761	0.3315
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0761	0.8928
Brugia malayi	TAR-binding protein	0.0315	0.4475	0.5812
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0071	0.0693	0.0693
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0081	0.0851	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0134	0.1671	0.1671
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0081	0.0851	0.0839
Schistosoma mansoni	smad1 5 8 and	0.0035	0.0138	0.0125
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0155	0.1998	0.4135
Brugia malayi	Latrophilin receptor protein 2	0.0148	0.1883	0.2362
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0761	0.0868
Brugia malayi	beta-lactamase family protein	0.0075	0.0761	0.0868
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0109	0.0109
Echinococcus multilocularis	geminin	0.0349	0.4997	0.4997
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0038	0.0175	0.0175
Mycobacterium tuberculosis	Probable lipase LipE	0.0075	0.0761	0.106
Brugia malayi	MH1 domain containing protein	0.0035	0.0138	0.0039
Trichomonas vaginalis	penicillin-binding protein, putative	0.0075	0.0761	0.8928
Echinococcus granulosus	GPCR family 2	0.0148	0.1883	0.1873
Mycobacterium leprae	conserved hypothetical protein	0.0075	0.0761	0.8928
Brugia malayi	Proteasome A-type and B-type family protein	0.0081	0.0851	0.0988
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.018	0.0959
Mycobacterium ulcerans	beta-lactamase	0.0075	0.0761	0.3315
Brugia malayi	MH2 domain containing protein	0.0518	0.7622	1
Schistosoma mansoni	hypothetical protein	0.0148	0.1883	0.1873
Trypanosoma brucei	hypothetical protein, conserved	0.0075	0.0761	0.1428
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0075	0.0761	0.106
Loa Loa (eye worm)	Smad1	0.0035	0.0138	0.0039
Toxoplasma gondii	hypothetical protein	0.0053	0.0411	0.4072
Schistosoma mansoni	microtubule-associated protein tau	0.0671	1	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0761	0.0868
Schistosoma mansoni	zinc finger protein	0.0034	0.0115	0.0102
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0079	0.0822	0.0822
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0328	0.4677	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0075	0.0761	0.3315
Loa Loa (eye worm)	acetyltransferase	0.0146	0.1858	0.2328
Schistosoma mansoni	pyruvate kinase	0.0033	0.0109	0.0096
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0761	0.106
Brugia malayi	beta-lactamase family protein	0.0075	0.0761	0.0868
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0038	0.0175	0.0162
Echinococcus granulosus	histone lysine methyltransferase setb	0.0038	0.0175	0.0162
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0062	0.055	0.0966
Schistosoma mansoni	bromodomain containing protein	0.0143	0.1813	0.1802
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0081	0.0851	0.1624
Loa Loa (eye worm)	MH1 domain-containing protein	0.0035	0.0138	0.0039
Toxoplasma gondii	ABC1 family protein	0.0075	0.0761	0.8789
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0306	0.0431
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0467	0.6836	0.8955
Echinococcus granulosus	tumor protein p63	0.0329	0.4688	0.4681
Plasmodium falciparum	proteasome subunit beta type-5	0.0081	0.0851	1
Mycobacterium ulcerans	hypothetical protein	0.0173	0.227	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0315	0.4475	0.5812
Brugia malayi	RNA recognition motif domain containing protein	0.0315	0.4475	0.5812
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0038	0.0175	0.0162
Echinococcus granulosus	geminin	0.0349	0.4997	0.4991
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0038	0.0175	0.0162
Onchocerca volvulus		0.0075	0.0761	1
Entamoeba histolytica	hypothetical protein	0.0071	0.0693	0.7636
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0155	0.1998	0.4135
Schistosoma mansoni	zinc finger protein	0.0047	0.0315	0.0303
Echinococcus granulosus	smad	0.0035	0.0138	0.0125
Schistosoma mansoni	smad	0.0035	0.0138	0.0125
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0038	0.0175	0.0162
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0148	0.1883	0.1883
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0062	0.055	0.641
Echinococcus granulosus	Smad4	0.0035	0.0138	0.0125
Brugia malayi	MH2 domain containing protein	0.0035	0.0138	0.0039
Schistosoma mansoni	hypothetical protein	0.0071	0.0693	0.068
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0062	0.055	0.0966
Echinococcus granulosus	pyruvate kinase	0.0033	0.0109	0.0096
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0079	0.0822	0.081
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0337	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0761	0.0868
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0075	0.0761	0.106
Brugia malayi	Smad1	0.0035	0.0138	0.0039
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0035	0.0138	0.0125
Brugia malayi	latrophilin 2 splice variant baaae	0.0319	0.4544	0.5903
Mycobacterium leprae	Probable lipase LipE	0.0075	0.0761	0.8928
Echinococcus granulosus	mothers against decapentaplegic 5	0.0035	0.0138	0.0125
Schistosoma mansoni	hypothetical protein	0.0319	0.4544	0.4537
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.005	0.0363	0.0363
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0081	0.0851	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0075	0.0761	0.0749
Chlamydia trachomatis	pyruvate kinase	0.0033	0.0109	0.5
Echinococcus multilocularis	microtubule associated protein 2	0.0671	1	1
Brugia malayi	acetyltransferase, GNAT family protein	0.0146	0.1858	0.2328
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0046	0.0306	0.0431
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0081	0.0851	0.0988
Onchocerca volvulus		0.0075	0.0761	1
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0081	0.0851	0.0851
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0075	0.0761	0.0761
Brugia malayi	Bromodomain containing protein	0.0088	0.0957	0.1128
Loa Loa (eye worm)	beta-lactamase	0.0075	0.0761	0.0868
Echinococcus granulosus	pyruvate kinase	0.0033	0.0109	0.0096
Loa Loa (eye worm)	bromodomain containing protein	0.0042	0.025	0.0187
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0146	0.1858	0.1848
Loa Loa (eye worm)	hypothetical protein	0.0093	0.104	0.1239
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0047	0.0315	0.2774
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0062	0.055	0.5946
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0328	0.4677	1
Entamoeba histolytica	hypothetical protein	0.0071	0.0693	0.7636
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.0761	0.1428
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0134	0.1671	0.1671
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0035	0.0138	0.0125
Echinococcus granulosus	zinc finger protein	0.0047	0.0315	0.0303
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0328	0.4677	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0467	0.6836	0.8955
Echinococcus multilocularis	smad	0.0035	0.0138	0.0138
Echinococcus multilocularis	expressed protein	0.0027	0.0013	0.0013
Loa Loa (eye worm)	MH2 domain-containing protein	0.0035	0.0138	0.0039
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0134	0.1671	0.166
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0148	0.1883	0.1873
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.0761	0.1428
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0046	0.0306	0.0431
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0062	0.055	0.5946
Schistosoma mansoni	tar DNA-binding protein	0.0315	0.4475	0.4468
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0081	0.0851	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0075	0.0761	0.3315
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0134	0.1671	0.166
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0761	0.8928
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0148	0.1883	0.2362
Schistosoma mansoni	smad1 5 8 and	0.0035	0.0138	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0761	0.0868
Trypanosoma brucei	ISWI complex protein	0.0034	0.0115	0.0013
Schistosoma mansoni	hypothetical protein	0.0349	0.4997	0.4991
Schistosoma mansoni	hypothetical protein	0.0148	0.1883	0.1873
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0081	0.0851	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0115	0.0102
Mycobacterium ulcerans	hypothetical protein	0.0075	0.0761	0.3315
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0062	0.055	0.0966
Trypanosoma cruzi	ISWI complex protein	0.0034	0.0115	0.0013
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.018	0.0959
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0109	0.1146
Loa Loa (eye worm)	MH2 domain-containing protein	0.0518	0.7622	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.005	0.0363	0.0351
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0038	0.0175	0.0162
Trypanosoma cruzi	ISWI complex protein	0.0034	0.0115	0.0013
Treponema pallidum	bacterioferrin (TpF1)	0.0027	0.0013	0.5
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0081	0.0851	0.1624
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0062	0.055	0.0538
Schistosoma mansoni	tar DNA-binding protein	0.0315	0.4475	0.4468
Onchocerca volvulus		0.0048	0.0337	0.3493
Schistosoma mansoni	tar DNA-binding protein	0.0315	0.4475	0.4468
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0033	0.0109	0.0136
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0146	0.1858	0.1858
Brugia malayi	beta-lactamase	0.0075	0.0761	0.0868
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0062	0.055	0.5946
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0906	0.106
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0071	0.0693	0.068
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0047	0.0315	0.2774

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1195280

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1148082