Detailed information for compound 1148186

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 354.446 | Formula: C20H26N4O2
  • H donors: 1 H acceptors: 3 LogP: 0.84 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C[C@@H]1CCCN1C(=O)[C@H](C(CC(=O)N1Cc2c(C1)cccc2)(C)C)N
  • InChi: 1S/C20H26N4O2/c1-20(2,18(22)19(26)24-9-5-8-16(24)11-21)10-17(25)23-12-14-6-3-4-7-15(14)13-23/h3-4,6-7,16,18H,5,8-10,12-13,22H2,1-2H3/t16-,18+/m0/s1
  • InChiKey: DBDNUYSKDGIQAV-FUHWJXTLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0025 0.0142 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0141 0.245 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0044 0.0094
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0039 0.0061
Loa Loa (eye worm) hypothetical protein 0.0053 0.0701 0.1083
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0252 0.466 0.466
Loa Loa (eye worm) hypothetical protein 0.0029 0.0223 0.0345
Loa Loa (eye worm) hypothetical protein 0.0077 0.1178 0.1821
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0223 0.0479
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0208 0.3786 0.8124
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0019 0.0039 0.0084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.148 0.148
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0223 0.5939
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.1178 0.1821
Trypanosoma cruzi oligopeptidase b 0.0033 0.0314 0.0674
Mycobacterium tuberculosis Possible penicillin-binding protein 0.049 0.9383 1
Echinococcus multilocularis prolyl endopeptidase 0.0033 0.0314 0.0314
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0044 0.0094
Mycobacterium ulcerans hypothetical protein 0.0077 0.1178 0.2527
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0019 0.0039 0.0084
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1178 0.2527
Brugia malayi Pre-SET motif family protein 0.0236 0.4347 0.6721
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0314 0.1748
Brugia malayi prolyl oligopeptidase family protein 0.0208 0.3786 0.5853
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0032 0.0283 0.0302
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.062 0.133
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0032 0.0273
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0033 0.0314 0.0568
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0032 0.0283 0.0302
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0509 0.0509
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0044 0.0067
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.1178 0.1255
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1178 0.2308
Echinococcus multilocularis protein dispatched 1 0.0049 0.0629 0.0629
Mycobacterium ulcerans beta-lactamase 0.0077 0.1178 0.2527
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0337 0.0359
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.148 0.148
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0376 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0376 0.0401
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0025 0.0142 0.0305
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0032 0.0283 0.0608
Loa Loa (eye worm) hypothetical protein 0.0077 0.1178 0.1821
Loa Loa (eye worm) prolyl oligopeptidase 0.028 0.521 0.8054
Brugia malayi Pre-SET motif family protein 0.0034 0.0328 0.0507
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.062 0.133
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.062 0.133
Schistosoma mansoni ap endonuclease 0.0019 0.0032 0.0032
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0032 0.0032
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0033 0.0314 0.0314
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1178 0.1178
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0033 0.0314 0.1748
Loa Loa (eye worm) hypothetical protein 0.0036 0.0376 0.0581
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0252 0.466 0.9324
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0456 0.8724 0.8724
Giardia lamblia Serine peptidase, putative 0.0025 0.0142 0.391
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.1644 0.2542
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.2498 0.2498
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.062 0.133
Schistosoma mansoni hypothetical protein 0.0041 0.0478 0.0478
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0025 0.0142 0.0142
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0044 0.0023
Toxoplasma gondii prolyl endopeptidase 0.0033 0.0314 0.1281
Echinococcus multilocularis protein patched 0.0043 0.0509 0.0509
Brugia malayi beta-lactamase family protein 0.0077 0.1178 0.1821
Trypanosoma brucei unspecified product 0.002 0.0044 0.0094
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0032 0.0283 0.0438
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0328 0.0328
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.1178 0.2527
Loa Loa (eye worm) hypothetical protein 0.0343 0.6469 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.1644 1
Plasmodium falciparum peptidase, putative 0.0033 0.0314 0.835
Leishmania major NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0252 0.466 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0142 0.022
Entamoeba histolytica acyl-CoA synthetase, putative 0.0019 0.0039 0.0045
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0044 0.0094
Loa Loa (eye worm) hypothetical protein 0.0036 0.0376 0.0581
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0223 0.0911
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0044 0.0094
Loa Loa (eye worm) hypothetical protein 0.0077 0.1178 0.1821
Brugia malayi N-terminal motif family protein 0.0195 0.3538 0.547
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0033 0.0314 0.0674
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0314 0.0485
Brugia malayi hypothetical protein 0.0108 0.1791 0.2769
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0032 0.0855
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0376 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Loa Loa (eye worm) beta-lactamase 0.0077 0.1178 0.1821
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0032 0.0283 0.0302
Loa Loa (eye worm) hypothetical protein 0.0025 0.0142 0.022
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0039 0.0161
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.148 0.148
Mycobacterium tuberculosis Conserved protein 0.0077 0.1178 0.1255
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.062 0.133
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0328 0.0328
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0328 0.0328
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0252 0.466 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0283 0.0608
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0044 0.0094
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0314 0.1748
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0223 0.5939
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.4347 0.6721
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0328 0.0328
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.1178 0.1821
Brugia malayi AMP-binding enzyme family protein 0.0049 0.062 0.0958
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Brugia malayi AMP-binding enzyme family protein 0.0032 0.0283 0.0438
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0044 0.0094
Loa Loa (eye worm) hypothetical protein 0.0077 0.1178 0.1821
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0328 0.0328
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.062 0.0661
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) 0.0252 0.466 0.4967
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0032 0.0283 0.0302
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0032 0.0283 0.0608
Leishmania major DNA polymerase eta, putative 0.002 0.0044 0.0094
Onchocerca volvulus 0.0077 0.1178 0.1821
Leishmania major oligopeptidase b 0.0033 0.0314 0.0674
Schistosoma mansoni hypothetical protein 0.0521 1 1
Onchocerca volvulus 0.0032 0.0283 0.0438
Echinococcus multilocularis AMP dependent ligase 0.0019 0.0039 0.0039
Brugia malayi Serine protease Z688.6 precursor 0.0025 0.0142 0.022
Giardia lamblia Alanyl dipeptidyl peptidase 0.0033 0.0314 1
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase I subunit F 0.0252 0.466 1
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.1178 0.1255
Trichomonas vaginalis esterase, putative 0.0077 0.1178 0.2308
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative 0.0252 0.466 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.062 0.0958
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0025 0.0142 0.0305
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0044 0.0023
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0314 0.1748
Giardia lamblia Alanyl dipeptidyl peptidase 0.0033 0.0314 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1178 0.2308
Brugia malayi beta-lactamase 0.0077 0.1178 0.1821
Mycobacterium tuberculosis Conserved protein 0.0077 0.1178 0.1255
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Brugia malayi AMP-binding enzyme family protein 0.0049 0.062 0.0958
Schistosoma mansoni hypothetical protein 0.0041 0.0478 0.0478
Brugia malayi hypothetical protein 0.0029 0.0223 0.0345
Schistosoma mansoni hypothetical protein 0.0041 0.0478 0.0478
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0314 0.0314
Plasmodium vivax hypothetical protein, conserved 0.0077 0.1178 1
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) flavoprotein 1 0.0252 0.466 0.466
Brugia malayi prolyl oligopeptidase family protein 0.028 0.521 0.8054
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0033 0.0314 0.0674
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 51 kDa subunit 0.0252 0.466 0.7204
Schistosoma mansoni patched 1 0.0043 0.0509 0.0509
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0314 0.0485
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0456 0.8724 0.8724
Onchocerca volvulus 0.0077 0.1178 0.1821
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.062 0.5265
Mycobacterium tuberculosis Probable peptidase 0.0033 0.0314 0.0335
Onchocerca volvulus NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog 0.0135 0.2338 0.3614
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0314 0.0314
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.028 0.521 0.8054
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0044 0.0094
Plasmodium vivax SET domain protein, putative 0.0034 0.0328 0.2786
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0044 0.0047
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0337 0.0359
Loa Loa (eye worm) hypothetical protein 0.0036 0.0376 0.0581
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0337 0.0359
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0328 0.0328
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.148 0.148
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0337 0.0359
Loa Loa (eye worm) hypothetical protein 0.0036 0.0376 0.0581
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0032 0.0069
Leishmania major DNA polymerase kappa, putative 0.002 0.0044 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.062 0.133
Schistosoma mansoni hypothetical protein 0.0521 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0376 0.0581
Brugia malayi beta-lactamase family protein 0.0077 0.1178 0.1821
Mycobacterium tuberculosis Conserved protein 0.0077 0.1178 0.1255
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0067
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0025 0.0142 0.0684
Echinococcus granulosus dna polymerase kappa 0.002 0.0044 0.0044
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0208 0.3786 0.8124
Mycobacterium ulcerans NADH dehydrogenase I subunit F 0.0252 0.466 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.062 0.133
Echinococcus multilocularis acylamino acid releasing enzyme 0.0033 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0077 0.1178 0.1821
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0033 0.0314 0.1748
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Brugia malayi NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor 0.0252 0.466 0.7204
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.062 0.0661
Mycobacterium ulcerans membrane protein ComEA 0.0056 0.0771 0.1654
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0025 0.0142 0.0684
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.062 0.133
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.1178 0.1178
Echinococcus granulosus expressed conserved protein 0.0094 0.1524 0.1524
Giardia lamblia Thymus-specific serine protease precursor 0.0025 0.0142 0.391
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1178 0.1178
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0314 0.2666
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.1178 0.2527
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0044 0.0071
Brugia malayi hypothetical protein 0.0343 0.6469 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0509 0.0786
Brugia malayi CHE-14 protein 0.0043 0.0509 0.0786
Echinococcus multilocularis dna polymerase eta 0.002 0.0044 0.0044
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.062 0.5265
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0025 0.0142 0.0142
Loa Loa (eye worm) prolyl oligopeptidase 0.0033 0.0314 0.0485
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0044 0.0094
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0328 0.1339
Onchocerca volvulus 0.0025 0.0142 0.022
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0032 0.0283 0.0608
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0033 0.0314 0.0674
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.1178 0.1178
Mycobacterium ulcerans lipase LipD 0.0077 0.1178 0.2527
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.148 0.148
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0033 0.0314 0.0674
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0208 0.3786 0.8124
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0032 0.005
Echinococcus granulosus AMP dependent ligase 0.0019 0.0039 0.0039
Onchocerca volvulus 0.0343 0.6469 1
Loa Loa (eye worm) hypothetical protein 0.0195 0.3538 0.547
Leishmania major hypothetical protein, conserved 0.0029 0.0223 0.0479
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0025 0.0142 0.0684
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.062 0.3647
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Toxoplasma gondii ABC1 family protein 0.0077 0.1178 0.4806
Loa Loa (eye worm) hypothetical protein 0.0108 0.1791 0.2769
Loa Loa (eye worm) hypothetical protein 0.01 0.165 0.255
Onchocerca volvulus 0.0034 0.0328 0.0507
Mycobacterium ulcerans hypothetical protein 0.0049 0.062 0.133
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0044 0.0047
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.1178 0.1255
Onchocerca volvulus Prolyl endopeptidase homolog 0.0033 0.0314 0.0485
Treponema pallidum nitrogen fixation protein (rnfC) 0.0056 0.0771 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0033 0.0314 0.0568
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0032 0.0069
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1178 0.2308
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0025 0.0142 0.0305
Mycobacterium leprae conserved hypothetical protein 0.0077 0.1178 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0061
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.1178 0.1255
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0032 0.0283 0.0302
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0195 0.3538 0.547
Schistosoma mansoni ap endonuclease 0.0019 0.0032 0.0032
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.148 0.2288
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0328 0.0328
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.062 0.133
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0033 0.0314 0.0674
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0025 0.0142 0.0222
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0044 0.0044
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.1178 0.2527
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0314 0.1748
Onchocerca volvulus 0.0269 0.4996 0.7723
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0032 0.0069
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0039 0.0334
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0032 0.0069
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0033 0.0314 0.1281
Mycobacterium leprae Probable lipase LipE 0.0077 0.1178 1
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.1644 0.1644
Echinococcus multilocularis geminin 0.0521 1 1
Toxoplasma gondii hypothetical protein 0.0033 0.0314 0.1281
Loa Loa (eye worm) hypothetical protein 0.0033 0.0314 0.0485
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.028 0.521 0.521
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.062 0.133
Echinococcus granulosus NADH dehydrogenase ubiquinone flavoprotein 1 0.0252 0.466 0.466
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0142 0.0222
Entamoeba histolytica acyl-CoA synthetase, putative 0.0066 0.0965 0.5787
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1178 0.2308
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0025 0.0142 0.0222
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0208 0.3786 0.3786
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.148 0.148
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Toxoplasma gondii exonuclease III APE 0.0019 0.0032 0.0131
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0303 0.0303
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0252 0.466 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0314 0.0568
Echinococcus multilocularis dna polymerase kappa 0.002 0.0044 0.0044
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0032 0.0283 0.0608
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0025 0.0142 0.0142
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0509 0.0786
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0044 0.0067
Echinococcus granulosus prolyl endopeptidase 0.0033 0.0314 0.0314
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0314 0.0674
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1178 0.2527
Brugia malayi AMP-binding enzyme family protein 0.0049 0.062 0.0958
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0044 0.0094
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0039 0.0042
Brugia malayi hypothetical protein 0.0018 0.0022 0.0034
Trypanosoma cruzi oligopeptidase b 0.0033 0.0314 0.0674
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0033 0.0314 0.2666
Echinococcus multilocularis expressed conserved protein 0.0094 0.1524 0.1524
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.062 0.3647
Loa Loa (eye worm) hypothetical protein 0.0049 0.062 0.0958
Onchocerca volvulus 0.0032 0.0283 0.0438
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0032 0.0032
Onchocerca volvulus 0.0077 0.1178 0.1821
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0314 0.0485
Loa Loa (eye worm) hypothetical protein 0.0025 0.0142 0.022
Schistosoma mansoni DNA polymerase eta 0.002 0.0044 0.0044
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0044 0.0094
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.148 0.148
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.1178 0.1255
Brugia malayi Serine protease Z688.6 precursor 0.0025 0.0142 0.022
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0044 0.0044
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0019 0.0039 0.0161
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0044 0.0094
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1178 0.2308
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.2498 0.2498
Echinococcus granulosus acylamino acid releasing enzyme 0.0033 0.0314 0.0314
Leishmania major hypothetical protein, conserved 0.0077 0.1178 0.2527
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0314 0.0674
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0044 0.0094
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0032 0.0069
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0208 0.3786 0.8124
Mycobacterium tuberculosis Conserved hypothetical protein 0.0056 0.0771 0.0821
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0044 0.0067
Trypanosoma brucei prolyl endopeptidase 0.0033 0.0314 0.0674
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0509 0.0509
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0208 0.3786 0.8124
Loa Loa (eye worm) hypothetical protein 0.0034 0.0328 0.0507
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Brugia malayi Serine carboxypeptidase S28 family protein 0.0025 0.0142 0.022
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0376 0.0807
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0223 0.0479
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0223 0.0479
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0032 0.0283 0.2406
Giardia lamblia DINP protein human, muc B family 0.002 0.0044 0.0408
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0252 0.466 0.9324
Loa Loa (eye worm) hypothetical protein 0.0033 0.0314 0.0485
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0032 0.0034
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0033 0.0314 0.0674
Loa Loa (eye worm) hypothetical protein 0.0077 0.1178 0.1821
Trypanosoma brucei prolyl oligopeptidase, putative 0.0033 0.0314 0.0674
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0044 0.0094
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0032 0.005
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0314 0.0314
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0.0252 0.466 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.1178 0.1255
Onchocerca volvulus 0.0032 0.0283 0.0438
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0032 0.0069
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0033 0.0314 0.0674
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.1675 0.1675
Echinococcus granulosus dna polymerase eta 0.002 0.0044 0.0044
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0509 0.0509
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0025 0.0142 0.0581
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.028 0.521 0.521
Loa Loa (eye worm) hypothetical protein 0.0025 0.0142 0.022
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0376 0.3193
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0208 0.3786 0.3786
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0509 0.096
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0032 0.0283 0.0438
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0142 0.0222
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.148 0.2288
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.1178 0.1255
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.1644 0.1644
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0032 0.0417
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0142 0.0222
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0044 0.0044
Trypanosoma brucei oligopeptidase b 0.0033 0.0314 0.0674
Trichomonas vaginalis set domain proteins, putative 0.0269 0.4996 1
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0456 0.8724 0.8724
Schistosoma mansoni hypothetical protein 0.0041 0.0478 0.0478
Echinococcus granulosus Dipeptidyl peptidase 9 0.0208 0.3786 0.3786
Trypanosoma cruzi prolyl endopeptidase 0.0033 0.0314 0.0674
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.028 0.521 0.521
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0033 0.0314 0.0335
Onchocerca volvulus 0.0049 0.062 0.0958
Loa Loa (eye worm) hypothetical protein 0.0049 0.062 0.0958
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0223 0.1896
Loa Loa (eye worm) hypothetical protein 0.01 0.1644 0.2542

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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