Detailed information for compound 1148499

Basic information

Technical information
  • TDR Targets ID: 1148499
  • Name: (1R)-1-methyl-1,2,3,4-tetrahydroisoquinoline- 6,7-diol
  • MW: 179.216 | Formula: C10H13NO2
  • H donors: 3 H acceptors: 2 LogP: 1.02 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]1NCCc2c1cc(O)c(c2)O
  • InChi: 1S/C10H13NO2/c1-6-8-5-10(13)9(12)4-7(8)2-3-11-6/h4-6,11-13H,2-3H2,1H3/t6-/m1/s1
  • InChiKey: IBRKLUSXDYATLG-ZCFIWIBFSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0023 0.0042
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0131 0.0131
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.0131 0.0131
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0131 0.0235
Onchocerca volvulus 0.0026 0.0131 0.04
Brugia malayi N-terminal motif family protein 0.021 0.2063 0.5902
Schistosoma mansoni hypothetical protein 0.0026 0.0131 0.0235
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Echinococcus granulosus g protein coupled receptor 0.0026 0.0131 0.0235
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0131 0.0131
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0044 0.0321 0.0321
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0131 0.0235
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0056 0.01
Brugia malayi Calcitonin receptor-like protein seb-1 0.0275 0.2755 0.7905
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0131 0.0311
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0585 0.0585
Schistosoma mansoni neuropeptide receptor 0.0026 0.0131 0.0235
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0131 0.0235
Onchocerca volvulus 0.0026 0.0131 0.04
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0087 0.0774 0.0774
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0131 0.0311
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0131 0.0235
Brugia malayi hypothetical protein 0.003 0.0177 0.0443
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0131 0.0235
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0131 0.0131
Schistosoma mansoni tar DNA-binding protein 0.0344 0.348 0.6245
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0131 0.0311
Brugia malayi MH2 domain containing protein 0.0121 0.1127 0.3192
Onchocerca volvulus 0.0026 0.0131 0.04
Schistosoma mansoni hypothetical protein 0.0026 0.0131 0.0235
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0177 0.5245
Brugia malayi jmjC domain containing protein 0.0071 0.0604 0.1679
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0131 0.0235
Leishmania major protein kinase, putative 0.002 0.0065 0.0838
Schistosoma mansoni hypothetical protein 0.0087 0.0774 0.1388
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0044 0.0321 1
Schistosoma mansoni neuropeptide receptor 0.0026 0.0131 0.0235
Schistosoma mansoni opsin-like receptor 0.0026 0.0131 0.0235
Brugia malayi putative neuropeptide receptor 0.0026 0.0131 0.0311
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0056 0.01
Brugia malayi GnHR receptor homolog 0.0026 0.0131 0.0311
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1127 0.3205
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0344 0.348 1
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0177 0.5142
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0304 0.3055 0.8773
Schistosoma mansoni tar DNA-binding protein 0.0344 0.348 0.6245
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Plasmodium vivax JmjC domain containing protein 0.0019 0.0056 0.1081
Plasmodium vivax SET domain protein, putative 0.0036 0.0236 0.7123
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0299 0.099
Echinococcus multilocularis chromobox protein 1 0.0075 0.0646 0.0646
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0222 0.0398
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0044 0.0321 0.5
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0131 0.0235
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0131 0.0131
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0131 0.0235
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0131 0.0235
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Brugia malayi Heterochromatin protein 1 0.0075 0.0646 0.1802
Onchocerca volvulus 0.0026 0.0131 0.04
Schistosoma mansoni hypothetical protein 0.0037 0.0245 0.0439
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0056 0.1081
Echinococcus granulosus hypothetical protein 0.0026 0.0131 0.0235
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0245 0.0439
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0023 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0131 0.0131
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0333 0.1108
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0131 0.0131
Schistosoma mansoni amine GPCR 0.0026 0.0131 0.0235
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0585 0.1051
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0604 0.1084
Schistosoma mansoni amine GPCR 0.0026 0.0131 0.0235
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0131 0.0235
Schistosoma mansoni neuropeptide receptor 0.0026 0.0131 0.0235
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0023 0.0023
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0131 0.0235
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0131 0.0235
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0131 0.0235
Brugia malayi Dopamine receptor protein 1 0.0026 0.0131 0.0311
Treponema pallidum exodeoxyribonuclease (exoA) 0.0044 0.0321 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0131 0.0131
Schistosoma mansoni hypothetical protein 0.0087 0.0774 0.1388
Schistosoma mansoni ap endonuclease 0.0044 0.0321 0.0577
Schistosoma mansoni biogenic amine receptor 0.0026 0.0131 0.0235
Schistosoma mansoni amine GPCR 0.0026 0.0131 0.0235
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0131 0.0131
Schistosoma mansoni hypothetical protein 0.0188 0.1838 0.3299
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0314 0.0314
Schistosoma mansoni adenoreceptor 0.0026 0.0131 0.0235
Echinococcus granulosus g protein coupled receptor 0.0026 0.0131 0.0235
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0131 0.0131
Brugia malayi hypoxia-induced factor 1 0.0182 0.177 0.5054
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0177 0.5245
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0131 0.0131
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0131 0.0235
Brugia malayi Melatonin receptor type 1A 0.0026 0.0131 0.0311
Schistosoma mansoni chromobox protein 0.0075 0.0646 0.116
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0087 0.0774 0.1388
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0131 0.0235
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0236 0.7123
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0131 0.0329
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0131 0.0235
Schistosoma mansoni gabp alpha 0.007 0.0593 0.1064
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0131 0.0235
Onchocerca volvulus 0.0026 0.0131 0.04
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Schistosoma mansoni tar DNA-binding protein 0.0344 0.348 0.6245
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0056 0.1081
Brugia malayi jmjC domain containing protein 0.0019 0.0056 0.0093
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0023 0.0023
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0023 0.0023
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0131 0.0235
Brugia malayi hypothetical protein 0.0026 0.0131 0.0311
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0131 0.0329
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0585 1
Brugia malayi G-protein coupled receptor 0.0026 0.0131 0.0311
Echinococcus granulosus geminin 0.0543 0.5572 1
Echinococcus granulosus chromobox protein 1 0.0075 0.0646 0.116
Echinococcus granulosus neuropeptide receptor 0.0026 0.0131 0.0235
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0245 0.0439
Loa Loa (eye worm) TAR-binding protein 0.0344 0.348 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0131 0.0131
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0044 0.0321 0.0577
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0056 0.1269
Loa Loa (eye worm) hypothetical protein 0.0275 0.2755 0.7909
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0044 0.0321 0.5356
Schistosoma mansoni histamine h1 receptor 0.0026 0.0131 0.0235
Echinococcus granulosus orexin receptor type 2 0.0026 0.0131 0.0235
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0131 0.0235
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0023 0.0023
Brugia malayi latrophilin 2 splice variant baaae 0.0188 0.1838 0.5251
Echinococcus granulosus neuropeptide s receptor 0.0026 0.0131 0.0235
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0604 0.1084
Echinococcus multilocularis sex peptide receptor 0.0026 0.0131 0.0131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0131 0.0235
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0275 0.2755 0.7905
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0131 0.0311
Schistosoma mansoni biogenic amine receptor 0.0026 0.0131 0.0235
Brugia malayi hypothetical protein 0.0026 0.0131 0.0311
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0131 0.0235
Schistosoma mansoni neuropeptide receptor 0.0026 0.0131 0.0235
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0131 0.0131
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0131 0.0131
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0131 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.003 0.017 0.0536
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0131 0.0235
Brugia malayi Dopamine receptor 0.0026 0.0131 0.0311
Brugia malayi sulfakinin receptor protein 0.0026 0.0131 0.0311
Mycobacterium leprae Possible regulatory protein 0.0015 0.0017 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0056 0.0112
Echinococcus granulosus serotonin receptor 0.0026 0.0131 0.0235
Schistosoma mansoni tar DNA-binding protein 0.0344 0.348 0.6245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0131 0.0235
Loa Loa (eye worm) hypothetical protein 0.006 0.0486 0.1354
Echinococcus granulosus fmrfamide receptor 0.0026 0.0131 0.0235
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0177 0.5142
Leishmania major hypothetical protein, conserved 0.003 0.0177 0.2809
Echinococcus multilocularis neuropeptide s receptor 0.0026 0.0131 0.0131
Brugia malayi hypothetical protein 0.0026 0.0131 0.0311
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0236 0.0423
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0056 0.1081
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0131 0.0235
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0131 0.0235
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0131 0.0329
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0131 0.0131
Onchocerca volvulus 0.0026 0.0131 0.04
Brugia malayi G protein-coupled receptor 0.0026 0.0131 0.0311
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0131 0.0131
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0604 0.1695
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0048 0.0365 0.0655
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0131 0.0235
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0131 0.0235
Schistosoma mansoni chromobox protein 0.0075 0.0646 0.116
Echinococcus multilocularis neuropeptide receptor A26 0.0026 0.0131 0.0131
Schistosoma mansoni hypothetical protein 0.0087 0.0774 0.1388
Schistosoma mansoni hypothetical protein 0.0087 0.0774 0.1388
Brugia malayi TAR-binding protein 0.0344 0.348 1
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0131 0.0131
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0131 0.0235
Brugia malayi ORL1-like opioid receptor 0.0026 0.0131 0.0311
Echinococcus granulosus single minded 2 0.0043 0.0314 0.0563
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0056 0.1081
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0056 0.0056
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0131 0.0131
Brugia malayi Ets-domain containing protein 0.007 0.0593 0.1647
Loa Loa (eye worm) hypothetical protein 0.0087 0.0774 0.2185
Leishmania major hypothetical protein, conserved 0.0019 0.0056 0.068
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0131 0.0329
Echinococcus multilocularis GPCR, family 2 0.0087 0.0774 0.0774
Loa Loa (eye worm) hypothetical protein 0.0036 0.0236 0.0632
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0333 0.1108
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Echinococcus granulosus neuropeptide receptor 0.0026 0.0131 0.0235
Trichomonas vaginalis ap endonuclease, putative 0.0044 0.0321 0.1068
Brugia malayi hypothetical protein 0.0026 0.0131 0.0311
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0044 0.0321 0.0278
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Brugia malayi jmjC domain containing protein 0.0019 0.0056 0.0093
Echinococcus granulosus allatostatin A receptor 0.0026 0.0131 0.0235
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0131 0.0235
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0585 0.1051
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0044 0.0321 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0056 0.0112
Onchocerca volvulus 0.0026 0.0131 0.04
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0056 0.1269
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0056 0.01
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0131 0.0131
Echinococcus granulosus phd:f box containing protein 0.0019 0.0056 0.01
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0536 0.15
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0044 0.0321 1
Onchocerca volvulus 0.0048 0.0365 0.1221
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0131 0.0235
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0131 0.0131
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0177 0.5142
Loa Loa (eye worm) hypothetical protein 0.0033 0.0203 0.0539
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0056 0.01
Brugia malayi RE15519p 0.0026 0.0131 0.0311
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0604 0.0604
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0177 0.5142
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0056 0.0056
Brugia malayi RNA binding protein 0.0344 0.348 1
Schistosoma mansoni ets-related 0.0212 0.2092 0.3755
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0112
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0275 0.2755 0.7909
Loa Loa (eye worm) hypothetical protein 0.003 0.0177 0.0461
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0131 0.0131
Brugia malayi neuropeptide F receptor 0.0026 0.0131 0.0311
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0236 0.0423
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0131 0.0131
Echinococcus granulosus tar DNA binding protein 0.0344 0.348 0.6245
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0604 0.1084
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0131 0.0329
Brugia malayi Latrophilin receptor protein 2 0.0087 0.0774 0.2171
Loa Loa (eye worm) RNA binding protein 0.0344 0.348 1
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0131 0.0235
Brugia malayi larval opioid receptor 0.0026 0.0131 0.0311
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0131 0.0235
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0131 0.0311
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0131 0.0131
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0131 0.0329
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0131 0.0329
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0131 0.0311
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0131 0.0235
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0604 0.1084
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Echinococcus multilocularis geminin 0.0543 0.5572 0.5572
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0299 0.099
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0131 0.0235
Brugia malayi Dopamine receptor protein 2 0.0026 0.0131 0.0311
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0023 0.0211
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.0475 0.0852
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0056 0.01
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.0131 0.0235
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.0593 0.0593
Schistosoma mansoni myosin xvIII 0.0026 0.0131 0.0235
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.021 0.2063 0.591
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0314 0.0841
Loa Loa (eye worm) hypothetical protein 0.0188 0.1838 0.526
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0131 0.0131
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0131 0.0235
Trichomonas vaginalis ap endonuclease, putative 0.0044 0.0321 0.1068
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0131 0.0311
Loa Loa (eye worm) fli-1 protein 0.0212 0.2092 0.5993
Schistosoma mansoni opsin-like receptor 0.0026 0.0131 0.0235
Schistosoma mansoni biogenic amine receptor 0.0026 0.0131 0.0235
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0044 0.0321 1
Brugia malayi chromobox protein homolog 3 0.0042 0.0299 0.0798
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0131 0.0131
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0299 0.099
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.0593 0.1663
Echinococcus granulosus chromobox protein 1 0.0075 0.0646 0.116
Brugia malayi G-protein coupled receptor 0.0026 0.0131 0.0311
Brugia malayi Ets-domain containing protein 0.007 0.0593 0.1647
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0112
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0056 0.0056
Schistosoma mansoni amine GPCR 0.0026 0.0131 0.0235
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0044 0.0321 1
Onchocerca volvulus 0.0026 0.0131 0.04
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0056 0.0056
Brugia malayi AKH receptor 0.0026 0.0131 0.0311
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0646 0.2208
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0131 0.0329
Brugia malayi jmjC domain containing protein 0.0071 0.0604 0.1679
Brugia malayi hypothetical protein 0.0026 0.0131 0.0311
Brugia malayi hypothetical protein 0.0037 0.0245 0.064
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0056 0.01
Echinococcus multilocularis serotonin receptor 0.0026 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Brugia malayi Pre-SET motif family protein 0.0251 0.2502 0.7171
Schistosoma mansoni amine GPCR 0.0026 0.0131 0.0235
Echinococcus multilocularis serotonin receptor 0.0026 0.0131 0.0131
Onchocerca volvulus 0.0026 0.0131 0.04
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0017 0.0031
Loa Loa (eye worm) hypothetical protein 0.0197 0.1931 0.5527
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0044 0.0321 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0236 0.0236
Onchocerca volvulus 0.0026 0.0131 0.04
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0056 0.01
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0131 0.0329
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0131 0.0235
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0044 0.0321 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0131 0.0131
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0245 0.0245
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0023 0.0042
Brugia malayi follicle stimulating hormone receptor 0.0304 0.3055 0.8771
Onchocerca volvulus 0.0026 0.0131 0.04
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0131 0.0235
Toxoplasma gondii exonuclease III APE 0.0044 0.0321 1
Schistosoma mansoni hypothetical protein 0.0543 0.5572 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0026 0.0131 0.04
Echinococcus granulosus sex peptide receptor 0.0026 0.0131 0.0235
Onchocerca volvulus Neuropeptide F receptor homolog 0.0026 0.0131 0.04
Brugia malayi Serotonin receptor 0.0026 0.0131 0.0311
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0131 0.0235
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0131 0.0235
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0015 0.0017 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0056 0.0056
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0131 0.0235
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Onchocerca volvulus 0.0286 0.2867 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0044 0.0321 0.5303
Schistosoma mansoni ap endonuclease 0.0044 0.0321 0.0577
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0017 0.0031
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0056 0.01
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.021 0.2063 0.718
Loa Loa (eye worm) hypothetical protein 0.0042 0.0299 0.0815
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0131 0.0235
Brugia malayi hypothetical protein 0.0026 0.0131 0.0311
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Onchocerca volvulus 0.0026 0.0131 0.04
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0023 0.0113
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0333 0.1108
Schistosoma mansoni tar DNA-binding protein 0.0344 0.348 0.6245
Brugia malayi Pre-SET motif family protein 0.0036 0.0236 0.0614
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0236 0.0423
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0131 0.0235
Echinococcus granulosus neuropeptide receptor A26 0.0026 0.0131 0.0235
Onchocerca volvulus 0.0026 0.0131 0.04
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0131 0.0131
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0056 0.0112
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0585 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Brugia malayi hypothetical protein 0.0026 0.0131 0.0311
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0056 0.01
Echinococcus multilocularis tar DNA binding protein 0.0344 0.348 0.348
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2867 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0131 0.0131
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0017 0.0017
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0087 0.0774 0.0774
Onchocerca volvulus 0.0033 0.0203 0.0654
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0087 0.0774 0.2171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0131 0.0131
Brugia malayi Cytochrome P450 family protein 0.0027 0.0144 0.0348
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0131 0.0235
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Brugia malayi hypothetical protein 0.0026 0.0131 0.0311
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0177 0.5142
Echinococcus granulosus GA binding protein alpha chain 0.007 0.0593 0.1064
Onchocerca volvulus 0.0026 0.0131 0.04
Schistosoma mansoni hypothetical protein 0.0026 0.0131 0.0235
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Brugia malayi RNA recognition motif domain containing protein 0.0344 0.348 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0604 0.0604
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0646 0.2208
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0131 0.0329
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0131 0.0235
Brugia malayi hypothetical protein 0.0026 0.0131 0.0311
Schistosoma mansoni opsin-like receptor 0.0026 0.0131 0.0235
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2502 0.7176
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0131 0.0311
Schistosoma mansoni hypothetical protein 0.0026 0.0131 0.0235
Brugia malayi hypothetical protein 0.0026 0.0131 0.0311
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0087 0.0774 0.1388
Brugia malayi exodeoxyribonuclease III family protein 0.0044 0.0321 0.0862
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0131 0.0131
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0131 0.0235
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Loa Loa (eye worm) latrophilin receptor protein 2 0.0087 0.0774 0.2185
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0131 0.0235
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0131 0.0131
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0131 0.0235
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0131 0.0235
Echinococcus granulosus GPCR family 2 0.0087 0.0774 0.1388
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0023 0.0211
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0131 0.0235
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0131 0.0235
Brugia malayi Fli-1 protein 0.0212 0.2092 0.5985
Onchocerca volvulus 0.0043 0.0314 0.1042
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0112
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0131 0.0131
Brugia malayi PAS domain containing protein 0.0059 0.0475 0.1306
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.0646 0.1818
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.0131 0.0235
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1127 0.3205
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0585 1
Echinococcus multilocularis somatostatin receptor 0.0026 0.0131 0.0131
Schistosoma mansoni hypothetical protein 0.0543 0.5572 1
Brugia malayi neuropeptide F receptor 0.0026 0.0131 0.0311
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0131 0.0235
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0131 0.0235
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0585 0.1626
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0131 0.0131
Brugia malayi hypothetical protein 0.002 0.0063 0.0115
Echinococcus granulosus somatostatin receptor 0.0026 0.0131 0.0235
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0131 0.0235
Schistosoma mansoni single-minded 0.0059 0.0475 0.0852
Brugia malayi Serotonin receptor 0.0026 0.0131 0.0311
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0131 0.0131
Brugia malayi hypothetical protein 0.0197 0.1931 0.5519
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.177 0.5063
Onchocerca volvulus 0.0026 0.0131 0.04
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0236 0.0423
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0131 0.0235
Onchocerca volvulus 0.0026 0.0131 0.04
Brugia malayi jmjC domain containing protein 0.0019 0.0056 0.0093
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0131 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.003 0.017 0.0536
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0585 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0044 0.0321 0.0879
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0131 0.0235
Echinococcus granulosus g protein coupled receptor 0.0026 0.0131 0.0235
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0236 0.0236
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0604 0.1084
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Echinococcus multilocularis chromobox protein 1 0.0075 0.0646 0.0646
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0131 0.0235
Loa Loa (eye worm) hypothetical protein 0.0026 0.0131 0.0329
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0017 0.0017
Brugia malayi jmjC domain containing protein 0.0019 0.0056 0.0093
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0131 0.0131
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0131 0.0235
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0144 0.0366
Onchocerca volvulus 0.0026 0.0131 0.04

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 31 uM Competitive inhibition of human MAO-A ChEMBL. 24559070

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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