Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.5609 | 0.6367 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.9173 | 0.9173 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.5609 | 0.6367 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0049 | 0.9173 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.5413 | 0.6145 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0125 | 0.0125 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.5175 | 0.3653 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.004 | 0.6872 | 0.78 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0047 | 0.881 | 0.898 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.2712 | 0.3078 |
Echinococcus multilocularis | ferritin | 0.0026 | 0.2873 | 0.3261 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0026 | 0.2873 | 0.5 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0022 | 0.1823 | 0.207 |
Echinococcus granulosus | expressed protein | 0.0026 | 0.2873 | 0.3261 |
Echinococcus granulosus | ferritin | 0.0026 | 0.2873 | 0.3261 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.3475 | 0.3945 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0026 | 0.2873 | 0.5 |
Giardia lamblia | GTOR | 0.0047 | 0.881 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0125 | 0.0125 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0049 | 0.9173 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0125 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.5731 | 0.5731 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.2701 | 0.3066 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.2712 | 0.3078 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.3397 | 0.3855 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0047 | 0.881 | 1 |
Echinococcus multilocularis | expressed protein | 0.0026 | 0.2873 | 0.3261 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.3397 | 0.3855 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.6098 | 0.6922 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.6098 | 0.6922 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0036 | 0.5731 | 0.4535 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0047 | 0.881 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.6098 | 0.6922 |
Schistosoma mansoni | ferritin | 0.0026 | 0.2873 | 0.3261 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0125 | 0.0142 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0049 | 0.9173 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0049 | 0.9173 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.3475 | 0.3945 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0125 | 0.0142 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0036 | 0.5731 | 0.5 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0038 | 0.6109 | 0.6934 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0047 | 0.881 | 0.9604 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0047 | 0.881 | 0.898 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0125 | 0.0142 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0049 | 0.9173 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.5609 | 0.6367 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.5175 | 0.3653 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.2712 | 0.3078 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 1 | 1 |
Schistosoma mansoni | ferritin | 0.0026 | 0.2873 | 0.3261 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0125 | 0.0142 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.2701 | 0.3066 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0036 | 0.5731 | 0.5 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0047 | 0.881 | 1 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0035 | 0.5413 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.5429 | 0.5429 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0049 | 0.9173 | 1 |
Schistosoma mansoni | ferritin | 0.0026 | 0.2873 | 0.3261 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0047 | 0.881 | 1 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0047 | 0.881 | 1 |
Schistosoma mansoni | ferritin | 0.0026 | 0.2873 | 0.3261 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0049 | 0.9173 | 1 |
Schistosoma mansoni | apoferritin-2 | 0.0026 | 0.2873 | 0.3261 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.5731 | 0.5731 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0049 | 0.9173 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.881 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0125 | 0.0142 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0125 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.5731 | 0.5731 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0047 | 0.881 | 0.9604 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0049 | 0.9173 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.5175 | 0.3653 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.2701 | 0.3066 |
Schistosoma mansoni | ferritin light chain | 0.0026 | 0.2873 | 0.3261 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.5413 | 0.6145 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.2712 | 0.3078 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0049 | 0.9173 | 1 |
Trichomonas vaginalis | ferritin, putative | 0.0026 | 0.2873 | 0.3261 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0125 | 0.0125 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0049 | 0.9173 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.9173 | 0.9173 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.9173 | 0.9173 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.9173 | 0.9173 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.3475 | 0.3945 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.5413 | 0.6145 |
Schistosoma mansoni | ferritin light chain | 0.0026 | 0.2873 | 0.3261 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.5413 | 0.6145 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.5413 | 0.6145 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0049 | 0.9173 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.5609 | 0.5609 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0047 | 0.881 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0049 | 0.9173 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.5731 | 0.5731 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.002 | 0.106 | 0.1204 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.5413 | 0.6145 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.6098 | 0.6922 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.5429 | 0.5429 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.5413 | 0.6145 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.5175 | 0.3653 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0036 | 0.5731 | 0.4535 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0049 | 0.9173 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.881 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.5429 | 0.6163 |
Schistosoma mansoni | apoferritin-2 | 0.0026 | 0.2873 | 0.3261 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0047 | 0.881 | 0.881 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0049 | 0.9173 | 1 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0038 | 0.6109 | 0.6659 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.9173 | 0.9173 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.6098 | 0.6922 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0125 | 0.0142 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0047 | 0.881 | 0.881 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.881 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.5731 | 0.5731 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0038 | 0.6109 | 0.6934 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0036 | 0.5731 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0125 | 0.0142 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0049 | 0.9173 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0049 | 0.9173 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0125 | 0.0125 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0125 | 0.0142 |
Onchocerca volvulus | 0.0049 | 0.9173 | 0.5 | |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0049 | 0.9173 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0031 | 0.416 | 0.4722 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.9173 | 0.9173 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.4446 | 0.5047 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.5609 | 0.6367 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0047 | 0.881 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.