TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 200.172 | Formula: C6H4N2O4S-
H donors: 0 H acceptors: 4 LogP: -0.73 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: [NH-]=[N+]=C1C=CC(=O)C(=C1)S(=O)(=O)[O-]
InChi: 1S/C6H4N2O4S/c7-8-4-1-2-5(9)6(3-4)13(10,11)12/h1-3H,(H,10,11,12)/p-1
InChiKey: AESOAPDOHQLZNT-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cysteine protease	0.0019	0.0103	0.0103
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0019	0.0103	0.0071
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0068	0.0652	0.0652
Echinococcus multilocularis	cysteine protease	0.0019	0.0103	0.0103
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0068	0.0652	0.0622
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0136	0.0136
Giardia lamblia	20S proteasome alpha subunit 7	0.0068	0.0652	0.0524
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.0662	0.0553
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0103	0.0103
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0068	0.0652	0.0652
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0192	0.0192
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0068	0.0652	0.0622
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0019	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.002	0.0116	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0192	0.0159
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0701	0.0701
Onchocerca volvulus		0.0019	0.0103	0.1136
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0068	0.0652	0.0652
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0103	0.0103
Loa Loa (eye worm)	ctsf protein	0.0019	0.0103	0.0071
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0068	0.0652	0.0622
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0068	0.0652	0.0652
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0068	0.0652	0.0622
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0701	0.0701
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0068	0.0652	0.0652
Echinococcus granulosus	proteasome subunit beta t family	0.0068	0.0652	0.0652
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0103	0.0103
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0019	0.0103	0.0103
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0103	0.0103
Loa Loa (eye worm)	cysteine protease	0.0019	0.0103	0.0071
Brugia malayi	proteasome subunit beta type 3	0.0068	0.0652	0.0652
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0068	0.0652	0.0652
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0068	0.0652	0.0652
Echinococcus granulosus	Proteasome subunit alpha beta	0.0068	0.0652	0.0652
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0103	0.0103
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0068	0.0652	0.0555
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0068	0.0652	0.0652
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0068	0.0652	0.0652
Leishmania major	proteasome beta-1 subunit, putative	0.0068	0.0652	0.0555
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0192	0.0077
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0068	0.0652	0.0652
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0103	0.0103
Schistosoma mansoni	DNA polymerase eta	0.0022	0.0136	0.0136
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0068	0.0652	0.0622
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0068	0.0652	0.0652
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0103	0.0103
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0068	0.0652	0.0652
Leishmania major	proteasome alpha 1 subunit, putative	0.0068	0.0652	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0192	0.0159
Schistosoma mansoni	aldehyde dehydrogenase	0.0069	0.0662	0.0662
Brugia malayi	proteasome subunit alpha type 4	0.0068	0.0652	0.0652
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0068	0.0652	0.0652
Leishmania major	proteasome alpha 3 subunit, putative	0.0068	0.0652	0.0555
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0068	0.0652	0.0652
Trypanosoma cruzi	cruzipain precursor, putative	0.0073	0.0701	0.0701
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.0136	0.0033
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0068	0.0652	0.0652
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0068	0.0652	0.0652
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0068	0.0652	0.0652
Echinococcus granulosus	proteasome subunit beta type 7	0.0068	0.0652	0.0652
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0192	0.0089
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0068	0.0652	0.0652
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0068	0.0652	0.0652
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0068	0.0652	0.0652
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0068	0.0652	0.0652
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0068	0.0652	0.0555
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0068	0.0652	0.0622
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0103	0.0103
Brugia malayi	Proteasome A-type and B-type family protein	0.0068	0.0652	0.0652
Trypanosoma brucei	unspecified product	0.0015	0.006	0.006
Trypanosoma cruzi	major cysteine proteinase, putative	0.0057	0.0528	0.0528
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0136	0.0136
Leishmania major	DNA polymerase kappa, putative	0.0022	0.0136	0.0033
Brugia malayi	proteasome subunit beta type 2	0.0068	0.0652	0.0652
Trypanosoma cruzi	20S proteasome subunit	0.0068	0.0652	0.0652
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0068	0.0652	0.0652
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0103	0.0103
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0068	0.0652	0.0652
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0068	0.0652	0.0652
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0068	0.0652	0.0652
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0068	0.0652	0.0652
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0103	0.0103
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0068	0.0652	0.0652
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0068	0.0652	0.0622
Echinococcus multilocularis	dna polymerase eta	0.0022	0.0136	0.0136
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0068	0.0652	0.0652
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0033	0.0033
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0136	0.0136
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0068	0.0652	0.0652
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0068	0.0652	0.0652
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0068	0.0652	0.0652
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0068	0.0652	0.0652
Brugia malayi	Proteasome subunit alpha type 7-1	0.0068	0.0652	0.0652
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0103	0.0103
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0069	0.0662	0.0565
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0068	0.0652	0.0652
Echinococcus granulosus	proteasome prosome macropain	0.0906	1	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0136	0.0136
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0701	0.0701
Brugia malayi	Proteasome A-type and B-type family protein	0.0068	0.0652	0.0652
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0068	0.0652	0.0555
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0136	0.0136
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.0192	0.0077
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0068	0.0652	0.0622
Mycobacterium leprae	probable proteasome (alpha subunit) PrcA	0.0068	0.0652	0.047
Loa Loa (eye worm)	hypothetical protein	0.002	0.0116	0.0083
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0136	0.0136
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0068	0.0652	0.0652
Trypanosoma brucei	DNA polymerase eta, putative	0.0022	0.0136	0.0136
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0103	0.0103
Echinococcus granulosus	proteasome subunit alpha type 6	0.0068	0.0652	0.0652
Plasmodium falciparum	acyl-CoA synthetase	0.002	0.0116	0.0116
Echinococcus granulosus	cathepsin l1	0.0019	0.0103	0.0103
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0068	0.0652	0.0652
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0103	0.0103
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0906	1	1
Leishmania major	proteasome beta 5 subunit, putative	0.0906	1	1
Giardia lamblia	20S proteasome alpha subunit 3	0.0068	0.0652	0.0524
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0019	0.0103	0.0103
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0068	0.0652	0.0652
Trypanosoma brucei	proteasome beta 6 subunit	0.0068	0.0652	0.0652
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0068	0.0652	0.0652
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0068	0.0652	0.0652
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0068	0.0652	0.0652
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.006	0.006
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0068	0.0652	0.0652
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.0136	0.0033
Giardia lamblia	Proteasome subunit beta type 2	0.0068	0.0652	0.0524
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0068	0.0652	0.0652
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0019	0.0103	0.0071
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0068	0.0652	0.0652
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0103	0.1136
Leishmania major	proteasome alpha 2 subunit, putative	0.0068	0.0652	0.0555
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0103	0.0103
Giardia lamblia	20S proteasome alpha subunit 1	0.0068	0.0652	0.0524
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0103	0.0103
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0068	0.0652	0.0555
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0068	0.0652	0.0652
Mycobacterium ulcerans	proteasome PrcA	0.0068	0.0652	0.0543
Leishmania major	proteasome beta 3 subunit, putative	0.0068	0.0652	0.0555
Echinococcus granulosus	cathepsin l1	0.0013	0.0033	0.0033
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.0662	0.0553
Schistosoma mansoni	aldehyde dehydrogenase	0.0069	0.0662	0.0662
Leishmania major	proteasome alpha 7 subunit, putative	0.0068	0.0652	0.0555
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0068	0.0652	0.0652
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0068	0.0652	0.0652
Onchocerca volvulus		0.0019	0.0103	0.1136
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.0192	0.0077
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0136	0.0136
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0068	0.0652	0.0652
Giardia lamblia	Proteasome subunit beta type 3	0.0068	0.0652	0.0524
Toxoplasma gondii	aldehyde dehydrogenase	0.0069	0.0662	0.0565
Brugia malayi	proteasome subunit alpha type 6	0.0068	0.0652	0.0652
Echinococcus multilocularis	proteasome subunit beta type 6	0.0068	0.0652	0.0652
Toxoplasma gondii	proteasome beta subunit	0.0068	0.0652	0.0555
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.0662	0.0553
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0068	0.0652	0.0652
Giardia lamblia	Proteasome subunit beta type 9 precursor	0.0068	0.0652	0.0524
Plasmodium vivax	acyl-CoA synthetase, putative	0.002	0.0116	0.0116
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0136	0.0136
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0068	0.0652	0.0652
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.006	0.006
Plasmodium vivax	vivapain-2	0.0019	0.0103	0.0103
Giardia lamblia	Proteasome subunit beta type 7 precursor	0.0068	0.0652	0.0524
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0068	0.0652	0.0555
Onchocerca volvulus		0.0027	0.0192	0.2565
Brugia malayi	20S proteasome alpha5 subunit	0.0068	0.0652	0.0652
Echinococcus granulosus	dna polymerase eta	0.0022	0.0136	0.0136
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.002	0.0116	0.5
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0068	0.0652	0.0652
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0068	0.0652	0.0652
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0068	0.0652	0.0622
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0068	0.0652	0.0622
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0068	0.0652	0.0652
Leishmania major	proteasome beta 2 subunit, putative	0.0068	0.0652	0.0555
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0906	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0192	0.0077
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0192	0.0192
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0068	0.0652	0.0652
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0068	0.0652	0.0652
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0136	0.0033
Plasmodium vivax	vivapain-2	0.0019	0.0103	0.0103
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0068	0.0652	0.0652
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0103	0.0103
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0019	0.0103	0.0103
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.0192	0.0089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0103	0.0103
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0068	0.0652	0.0555
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0068	0.0652	0.0652
Brugia malayi	proteasome subunit alpha type 2	0.0068	0.0652	0.0652
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0068	0.0652	0.0652
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0068	0.0652	0.0652
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0022	0.0136	0.0136
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0068	0.0652	0.0555
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0103	0.0103
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0068	0.0652	0.0652
Echinococcus granulosus	dna polymerase kappa	0.0022	0.0136	0.0136
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0906	1	1
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0068	0.0652	0.0652
Brugia malayi	Proteasome A-type and B-type family protein	0.0068	0.0652	0.0652
Leishmania major	cathepsin L-like protease	0.0073	0.0701	0.0604
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0192	0.0089
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0013	0.0033	0.0033
Leishmania major	proteasome beta 2 subunit, putative	0.0068	0.0652	0.0555
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0068	0.0652	0.0555
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.0103	0.0103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0701	0.0701
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0068	0.0652	0.0652
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.0192	0.0089
Onchocerca volvulus		0.0019	0.0103	0.1136
Trypanosoma brucei	proteasome alpha 7 subunit	0.0068	0.0652	0.0652
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0068	0.0652	0.0652
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0103	0.0103
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0136	0.0136
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0068	0.0652	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0103	0.0103
Giardia lamblia	20S proteasome alpha subunit 4	0.0068	0.0652	0.0524
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0068	0.0652	0.0652
Leishmania major	proteasome beta 7 subunit, putative	0.0068	0.0652	0.0555
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0068	0.0652	0.0652
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0069	0.0662	0.0662
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0136	0.002
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0068	0.0652	0.0652
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0068	0.0652	0.0652
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0068	0.0652	0.0652
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0103	0.1136
Trypanosoma brucei	unspecified product	0.0022	0.0136	0.0136
Leishmania major	proteasome alpha 7 subunit, putative	0.0068	0.0652	0.0555
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0068	0.0652	0.0555
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.0103	0.0103
Giardia lamblia	Proteasome subunit beta type 4 precursor	0.0068	0.0652	0.0524
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0906	1	1
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0068	0.0652	0.0652
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0068	0.0652	0.0652
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0192	0.0077
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0068	0.0652	0.0652
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0068	0.0652	0.0652
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0068	0.0652	0.0652
Mycobacterium ulcerans	proteasome PrcB	0.0906	1	1
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0103	0.0103
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0192	0.0192
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0906	1	1
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0068	0.0652	0.0652
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0068	0.0652	0.0622
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0068	0.0652	0.0652
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0136	0.0136
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0068	0.0652	0.0555
Loa Loa (eye worm)	PAS-3 protein	0.0068	0.0652	0.0622
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0192	0.0159
Leishmania major	cathepsin L-like protease	0.0073	0.0701	0.0604
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0069	0.0662	0.0662
Echinococcus granulosus	proteasome subunit alpha type 2	0.0068	0.0652	0.0652
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.0103	0.0103
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0103	0.0103
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0022	0.0136	0.0136
Onchocerca volvulus		0.0019	0.0103	0.1136
Trypanosoma brucei	unspecified product	0.0015	0.006	0.006
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0103	0.0103
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0068	0.0652	0.0652
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0068	0.0652	0.0555
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0192	0.0192
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0068	0.0652	0.0652
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0022	0.0136	0.0136
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0068	0.0652	0.0652
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0068	0.0652	0.0652
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0068	0.0652	0.0652
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0068	0.0652	0.0652
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0103	0.0103
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0068	0.0652	0.0652
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0192	0.0089
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0068	0.0652	0.0652
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0068	0.0652	0.0652
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0068	0.0652	0.0555
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0068	0.0652	0.0652
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0103	0.0103
Toxoplasma gondii	proteasome subunit beta type, putative	0.0906	1	1
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0068	0.0652	0.0555
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0103	0.0103
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0068	0.0652	0.0652
Onchocerca volvulus		0.0019	0.0103	0.1136
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0068	0.0652	0.0652
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0136	0.0136
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0701	0.0701
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0022	0.0136	0.0136
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0068	0.0652	0.0652
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0701	0.0701
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0068	0.0652	0.0652
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0103	0.0103
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0103	0.0103
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0068	0.0652	0.0555
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0068	0.0652	0.0652
Trichomonas vaginalis	DNA polymerase eta, putative	0.0022	0.0136	0.0136
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0068	0.0652	0.0652
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.006	0.006
Plasmodium falciparum	proteasome subunit beta type-5	0.0906	1	1
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0068	0.0652	0.0652
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0103	0.0103
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0068	0.0652	0.0652
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0136	0.0136
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0019	0.0103	0.0103
Entamoeba histolytica	cysteine proteinase, putative	0.0013	0.0033	0.0033
Toxoplasma gondii	heat shock protein hslv, putative	0.0068	0.0652	0.0555
Brugia malayi	Cathepsin L-like precursor	0.0013	0.0033	0.0033
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0068	0.0652	0.0652
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0068	0.0652	0.0652
Echinococcus multilocularis	dna polymerase kappa	0.0022	0.0136	0.0136
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0068	0.0652	0.0652
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0136	0.0103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0701	0.0701
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0068	0.0652	0.0652
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0068	0.0652	0.0652
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0906	1	1
Brugia malayi	proteasome subunit alpha type 1	0.0068	0.0652	0.0652
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0068	0.0652	0.0652
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0103	0.0071
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.0103	0.0103
Giardia lamblia	20S proteasome alpha subunit 2	0.0068	0.0652	0.0524
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0033	0.0033
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0136	0.002
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0068	0.0652	0.0652
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0068	0.0652	0.0652
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0103	0.0103
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0068	0.0652	0.0622
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0068	0.0652	0.0652
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0906	1	1
Leishmania major	DNA polymerase eta, putative	0.0022	0.0136	0.0033
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0068	0.0652	0.0652
Giardia lamblia	Proteasome subunit beta type 1	0.0068	0.0652	0.0524
Brugia malayi	Proteasome subunit alpha type 1	0.0068	0.0652	0.0652
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.0136	0.0103
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0103	0.0103
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0068	0.0652	0.0652
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0068	0.0652	0.0652
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0192	0.0077
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0068	0.0652	0.0652
Giardia lamblia	20S proteasome alpha subunit 6	0.0068	0.0652	0.0524
Schistosoma mansoni	cathepsin F (C01 family)	0.0013	0.0033	0.0033
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0906	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0019	0.0103	0.1136
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0068	0.0652	0.0652
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0103	0.0103
Echinococcus multilocularis	proteasome subunit beta type 7	0.0068	0.0652	0.0652
Loa Loa (eye worm)	hypothetical protein	0.002	0.0116	0.0083
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.0068	0.0652	0.0555
Toxoplasma gondii	peptidase, T1 family protein	0.0068	0.0652	0.0555
Brugia malayi	Cathepsin L-like precursor	0.0013	0.0033	0.0033
Giardia lamblia	20S proteasome alpha subunit 5	0.0068	0.0652	0.0524
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0068	0.0652	0.0652
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0068	0.0652	0.0652
Leishmania major	cathepsin L-like protease	0.0073	0.0701	0.0604
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0068	0.0652	0.0652
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0906	1	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0136	0.0136
Brugia malayi	proteasome subunit alpha type 3	0.0068	0.0652	0.0652
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0701	0.0701
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0192	0.0192
Onchocerca volvulus	Notchless protein homolog	0.0068	0.0652	1
Plasmodium falciparum	proteasome subunit beta type-4	0.0068	0.0652	0.0652
Onchocerca volvulus		0.0019	0.0103	0.1136
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0906	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0116	0.0083
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0701	0.0701
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0068	0.0652	0.0652
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0068	0.0652	0.0652
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0136	0.0136
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0069	0.0662	0.0565
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0136	0.0136
Entamoeba histolytica	acyl-coA synthetase, putative	0.0027	0.0192	0.0192
Trypanosoma cruzi	DNA polymerase eta, putative	0.0022	0.0136	0.0136
Onchocerca volvulus		0.0019	0.0103	0.1136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.002	0.0116	0.0083
Toxoplasma gondii	proteasome subunit	0.0068	0.0652	0.0555
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0136	0.0136
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0103	0.0103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0701	0.0701
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0068	0.0652	0.0555
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0068	0.0652	0.0652
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0068	0.0652	0.0652
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0022	0.0136	0.0136
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0068	0.0652	0.0652
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0906	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0701	0.0701
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0068	0.0652	0.0652
Leishmania major	proteasome alpha 1 subunit, putative	0.0068	0.0652	0.0555
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0068	0.0652	0.0652
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0068	0.0652	0.0652
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.0192	0.0077
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0068	0.0652	0.0652
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0701	0.0701
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0066	0.0631	0.0631
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0136	0.0136
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0068	0.0652	0.0652
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0068	0.0652	0.0652
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0116	0.0012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0103	0.0103
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.0103	0.0103
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0136	0.0136
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0068	0.0652	0.0555
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0068	0.0652	0.0555
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0701	0.0701
Brugia malayi	cathepsin L-like precursor	0.0013	0.0033	0.0033
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0136	0.0136
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0068	0.0652	0.0652
Echinococcus granulosus	proteasome subunit beta type 6	0.0068	0.0652	0.0652
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0701	0.0701
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0068	0.0652	0.0652
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.0192	0.0077
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0103	0.0103
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0068	0.0652	0.0652
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0103	0.0103
Brugia malayi	proteasome subunit beta type 1	0.0068	0.0652	0.0652
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0906	1	1
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0068	0.0652	0.0555
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0068	0.0652	0.0652
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0068	0.0652	0.0652
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0068	0.0652	0.0652
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0068	0.0652	0.0652
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0068	0.0652	0.0652
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0068	0.0652	0.0652
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0068	0.0652	0.0652
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0068	0.0652	0.0652
Loa Loa (eye worm)	fibroinase	0.0019	0.0103	0.0071
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0068	0.0652	0.0652
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0068	0.0652	0.0652
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0068	0.0652	0.0652
Trypanosoma brucei	proteasome beta 7 subunit	0.0068	0.0652	0.0652
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0022	0.0136	0.0136

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 15 %	Inhibition of [3H]-GABA binding to Gamma-aminobutyric-acid (GABA-A) receptor isolated from rat brain homogenates at 5*10e-4 M	ChEMBL.	2824775
T1/2 (ADMET)	0	Half-life period was determined at 20 degree centigrade at UV lambdamax nm of 306 (24000); Stable	ChEMBL.	2824775
T1/2 (ADMET)	0	Half-life period was determined at 20 degree centigrade at UV lambdamax nm of 346 (44000); Stable	ChEMBL.	2824775

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 212523

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 114879