Detailed information for compound 1148890

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2141.04 | Formula: C78H89N11O46S7
  • H donors: 18 H acceptors: 37 LogP: -0.17 Rotable bonds: 67
    Rule of 5 violations (Lipinski): 4
  • SMILES: COC(=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)Nc1ccccc1OCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)OS(=O)(=O)O)Cc1ccc(cc1)OS(=O)(=O)O)CC(=O)OS(=O)(=O)O)CC(C)C)CC(=O)OS(=O)(=O)O)Cc1ccc(cc1)OS(=O)(=O)O)COS(=O)(=O)O)Cc1ccc(cc1)OS(=O)(=O)O)Cc1ccccc1
  • InChi: 1S/C78H89N11O46S7/c1-42(2)32-53(67(93)84-59(39-66(92)135-142(124,125)126)73(99)82-56(36-46-19-27-50(28-20-46)132-139(115,116)117)71(97)87-60(77(103)104)37-47-21-29-51(30-22-47)133-140(118,119)120)81-72(98)58(38-65(91)134-141(121,122)123)85-70(96)55(35-45-17-25-49(26-18-45)131-138(112,113)114)83-74(100)61(40-129-136(106,107)108)88-68(94)54(34-44-15-23-48(24-16-44)130-137(109,110)111)79-64(90)41-128-63-14-8-7-12-52(63)80-69(95)57(33-43-10-5-4-6-11-43)86-75(101)62-13-9-31-89(62)76(102)78(105)127-3/h4-8,10-12,14-30,42,53-62H,9,13,31-41H2,1-3H3,(H,79,90)(H,80,95)(H,81,98)(H,82,99)(H,83,100)(H,84,93)(H,85,96)(H,86,101)(H,87,97)(H,88,94)(H,103,104)(H,106,107,108)(H,109,110,111)(H,112,113,114)(H,115,116,117)(H,118,119,120)(H,121,122,123)(H,124,125,126)/t53-,54-,55-,56-,57+,58-,59-,60-,61-,62-/m0/s1
  • InChiKey: OFICFXDYXDIPNR-VDJFKOLKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum heat shock protein 90 0.0036 0.0224 0.0513
Brugia malayi Pre-SET motif family protein 0.0035 0.0205 0.0268
Echinococcus granulosus heat shock protein 90 0.0036 0.0224 0.0236
Echinococcus granulosus zinc finger protein 0.002 0.0032 0.0034
Onchocerca volvulus 0.0082 0.0777 0.2414
Leishmania major hexokinase, putative 0.0082 0.0777 0.1022
Leishmania major heat shock protein 83-1 0.0036 0.0224 0.0142
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0196 0.2153 0.2271
Echinococcus multilocularis neuropeptide receptor A26 0.0483 0.561 0.561
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0174 0.1888 0.4986
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0034 0.0034
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0329 0.3753 0.5816
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0406 0.0621
Schistosoma mansoni glutathione synthetase 0.0174 0.1888 0.1991
Loa Loa (eye worm) hypothetical protein 0.0077 0.0708 0.1092
Schistosoma mansoni loxhd1 0.0021 0.0034 0.0035
Brugia malayi heat shock protein 90 0.0036 0.0224 0.0298
Schistosoma mansoni polycystin 1-related 0.0021 0.0034 0.0035
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0386 0.0407
Schistosoma mansoni rab6-interacting 0.0021 0.0034 0.0035
Loa Loa (eye worm) inositol-1 0.0043 0.0304 0.0462
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0329 0.3753 0.3753
Onchocerca volvulus 0.005 0.0386 0.1144
Leishmania major solanesyl-diphosphate synthase, putative 0.0174 0.1888 0.2789
Loa Loa (eye worm) hexokinase 0.0082 0.0777 0.12
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0174 0.1888 0.1888
Echinococcus granulosus heat shock protein 90 0.0029 0.0135 0.0142
Schistosoma mansoni trans-prenyltransferase 0.0174 0.1888 0.1991
Onchocerca volvulus 0.0276 0.3114 1
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0174 0.1888 0.1991
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0329 0.3753 1
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0174 0.1888 0.4845
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1256 0.1946
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0034 0.0034
Plasmodium vivax SET domain protein, putative 0.0035 0.0205 0.046
Trypanosoma cruzi heat shock protein 85, putative 0.0029 0.0135 0.0142
Echinococcus granulosus geminin 0.0177 0.192 0.2025
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0406 0.0583
Leishmania major heat shock protein 83-1 0.0036 0.0224 0.0142
Leishmania major heat shock protein 83-1 0.0036 0.0224 0.0142
Schistosoma mansoni lipoxygenase 0.0021 0.0034 0.0035
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0329 0.3753 1
Brugia malayi hexokinase 0.0082 0.0777 0.1164
Brugia malayi Bromodomain containing protein 0.004 0.0268 0.0366
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0304 0.0675
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0469 0.0469
Trypanosoma cruzi vacuolar-type proton translocating pyrophosphatase 1 0.0325 0.3708 0.5745
Loa Loa (eye worm) hexokinase 0.0025 0.0092 0.0132
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0537 0.0567
Brugia malayi hypothetical protein 0.0169 0.1826 0.2807
Schistosoma mansoni endoplasmin 0.0036 0.0224 0.0236
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0304 0.0321
Loa Loa (eye worm) polyprenyl synthetase 0.0174 0.1888 0.2932
Brugia malayi Hexokinase family protein 0.0052 0.0407 0.0585
Giardia lamblia Heat shock protein HSP 90-alpha 0.0036 0.0224 0.0247
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0386 0.0386
Toxoplasma gondii melibiase subfamily protein 0.0115 0.1169 0.2717
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0329 0.3753 0.3958
Schistosoma mansoni microtubule-associated protein tau 0.0804 0.9482 1
Brugia malayi hexokinase type II 0.0026 0.0101 0.0105
Plasmodium vivax heat shock protein 86, putative 0.0036 0.0224 0.0513
Trypanosoma brucei hexokinase 0.0082 0.0777 0.1567
Onchocerca volvulus 0.0035 0.0205 0.0556
Schistosoma mansoni hypothetical protein 0.0177 0.192 0.2025
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0034 0.0034
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0077 0.0708 0.0746
Leishmania major heat shock protein 83-1 0.0036 0.0224 0.0142
Loa Loa (eye worm) hypothetical protein 0.0169 0.1826 0.2836
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0419 0.0442
Echinococcus multilocularis heat shock protein 0.0036 0.0224 0.0224
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0304 0.0966
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0045 0.0058
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0034 0.0035
Toxoplasma gondii V-type H(+)-translocating pyrophosphatase VP1 0.0325 0.3708 0.9872
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0329 0.3753 1
Schistosoma mansoni heat shock protein 0.0036 0.0224 0.0236
Schistosoma mansoni rab6-interacting 0.0021 0.0034 0.0035
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0537 0.0537
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.025 0.0318
Plasmodium vivax hexokinase, putative 0.0082 0.0777 0.1999
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0304 0.0675
Echinococcus granulosus muscleblind protein 0.0156 0.1667 0.1758
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0034 0.004
Loa Loa (eye worm) MBCTL1 0.0057 0.0469 0.072
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0174 0.1888 0.4845
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0174 0.1888 1
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0135 0.0217
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0329 0.3753 0.3958
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0224 0.0282
Toxoplasma gondii hexokinase 0.0082 0.0777 0.1613
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0115 0.1169 0.1233
Brugia malayi mbt repeat family protein 0.005 0.0386 0.0552
Brugia malayi Polyprenyl synthetase family protein 0.0174 0.1888 0.2903
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0115 0.1169 0.1169
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0135 0.0217
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0069 0.0073
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0304 0.0675
Trypanosoma cruzi heat shock protein 90, putative 0.0036 0.0224 0.0282
Echinococcus multilocularis endoplasmin 0.0029 0.0135 0.0135
Brugia malayi Pre-SET motif family protein 0.0243 0.271 0.419
Echinococcus granulosus hexokinase 0.0082 0.0777 0.0819
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0029 0.0135 0.0142
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0481 0.0507
Echinococcus granulosus neuropeptide receptor A26 0.0483 0.561 0.5917
Trypanosoma cruzi polyprenyl synthase, putative 0.055 0.6421 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0304 0.0281
Loa Loa (eye worm) hypothetical protein 0.0057 0.0469 0.072
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0174 0.1888 0.4845
Brugia malayi mbt repeat family protein 0.005 0.0386 0.0552
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0329 0.3753 1
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0174 0.1888 0.2891
Leishmania major farnesyl pyrophosphate synthase 0.0329 0.3753 0.5756
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0304 0.0304
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0174 0.1888 0.2891
Leishmania major heat shock protein 83-1 0.0036 0.0224 0.0142
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0174 0.1888 0.4986
Loa Loa (eye worm) hexokinase 0.0052 0.0407 0.0623
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0115 0.1169 0.1233
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0034 0.0035
Toxoplasma gondii heat shock protein HSP90 0.0036 0.0224 0.0055
Plasmodium falciparum V-type H(+)-translocating pyrophosphatase, putative 0.0325 0.3708 0.9878
Schistosoma mansoni hypothetical protein 0.0022 0.0045 0.0048
Loa Loa (eye worm) hypothetical protein 0.005 0.0386 0.059
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0174 0.1888 0.2891
Plasmodium falciparum endoplasmin, putative 0.0022 0.0054 0.0056
Schistosoma mansoni zinc finger protein 0.002 0.0032 0.0034
Toxoplasma gondii heat shock protein 90, putative 0.0036 0.0224 0.0055
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0386 0.0407
Schistosoma mansoni hypothetical protein 0.0177 0.192 0.2025
Brugia malayi Hexokinase family protein 0.0025 0.0092 0.0092
Loa Loa (eye worm) endoplasmin 0.0036 0.0224 0.0338
Echinococcus granulosus neuropeptide s receptor 0.0483 0.561 0.5917
Giardia lamblia Farnesyl diphosphate synthase 0.0329 0.3753 1
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.055 0.6421 0.6421
Echinococcus multilocularis muscleblind protein 1 0.0156 0.1667 0.1667
Plasmodium vivax endoplasmin, putative 0.0036 0.0224 0.0513
Brugia malayi Polyprenyl synthetase family protein 0.0329 0.3753 0.5823
Brugia malayi Endoplasmin precursor 0.0036 0.0224 0.0298
Echinococcus multilocularis hexokinase 0.0082 0.0777 0.0777
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0174 0.1888 0.1991
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0189 0.02
Loa Loa (eye worm) hypothetical protein 0.0035 0.021 0.0315
Loa Loa (eye worm) hypothetical protein 0.0074 0.0676 0.1042
Leishmania major heat shock protein 83-1 0.0036 0.0224 0.0142
Treponema pallidum octaprenyl-diphosphate synthase 0.055 0.6421 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0419 0.0442
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0034 0.0035
Echinococcus granulosus endoplasmin 0.0029 0.0135 0.0142
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0205 0.0216
Schistosoma mansoni endoplasmin 0.0036 0.0224 0.0236
Loa Loa (eye worm) hypothetical protein 0.0156 0.1667 0.2587
Brugia malayi Melibiase family protein 0.0077 0.0708 0.1056
Leishmania major vacuolar-type proton translocating pyrophosphatase 1, putative 0.0325 0.3708 0.5683
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.004
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0238 0.0251
Onchocerca volvulus 0.0082 0.0777 0.2414
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 0.0325 0.3708 0.9871
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0386 0.0407
Echinococcus granulosus hexokinase type 2 0.0082 0.0777 0.0819
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.025 0.0656
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0386 0.0407
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.055 0.6421 1
Schistosoma mansoni hypothetical protein 0.0303 0.3438 0.3626
Loa Loa (eye worm) hypothetical protein 0.0026 0.0101 0.0145
Leishmania major heat shock protein 83-1 0.0036 0.0224 0.0142
Leishmania major heat shock protein 83-1 0.0036 0.0224 0.0142
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0174 0.1888 1
Trichomonas vaginalis heat shock protein, putative 0.0036 0.0224 0.0459
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0469 0.0682
Trypanosoma cruzi heat shock protein 90, putative 0.0029 0.0135 0.0142
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0386 0.1144
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.004
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0304 0.0269
Loa Loa (eye worm) heat shock protein 90 0.0036 0.0224 0.0338
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1256 0.1946
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0329 0.3753 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0462 0.0708
Echinococcus granulosus heat shock protein 0.0036 0.0224 0.0236
Loa Loa (eye worm) hypothetical protein 0.0053 0.0419 0.0642
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0174 0.1888 0.4715
Schistosoma mansoni hypothetical protein 0.0021 0.0034 0.0035
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0469 0.0469
Plasmodium falciparum hexokinase 0.0082 0.0777 0.1999
Echinococcus granulosus hexokinase 0.0082 0.0777 0.0819
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0419 0.0442
Loa Loa (eye worm) hypothetical protein 0.0043 0.0298 0.0453
Loa Loa (eye worm) hexokinase type II 0.0082 0.0777 0.12
Echinococcus multilocularis hexokinase 0.0082 0.0777 0.0777
Leishmania major heat shock protein 83-1 0.0036 0.0224 0.0142
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0174 0.1888 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0304 0.0227
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0329 0.3753 0.5816
Trypanosoma cruzi polyprenyl synthase, putative 0.055 0.6421 1
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0224 0.0282
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0205 0.0205
Leishmania major heat shock protein 83-1 0.0036 0.0224 0.0142
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.004 0.0269 0.0407
Leishmania major heat shock protein 83-1 0.0036 0.0224 0.0142
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0469 0.0495
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0329 0.3753 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0304 0.0481
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.055 0.6421 0.6772
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0386 0.059
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0329 0.3753 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0101 0.0145
Echinococcus multilocularis hexokinase 0.0082 0.0777 0.0777
Brugia malayi Muscleblind-like protein 0.0156 0.1667 0.2557
Echinococcus granulosus microtubule associated protein 2 0.0804 0.9482 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0115 0.1169 0.1233
Leishmania major heat shock protein 83-1 0.0036 0.0224 0.0142
Leishmania major heat shock protein 83-1 0.0036 0.0224 0.0142
Schistosoma mansoni bromodomain containing protein 0.0066 0.0582 0.0614
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0224 0.0282
Brugia malayi Bromodomain containing protein 0.0078 0.073 0.109
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0386 0.0407
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0115 0.1169 0.1233
Brugia malayi MH2 domain containing protein 0.0122 0.1256 0.1914
Schistosoma mansoni inositol monophosphatase 0.0043 0.0304 0.0321
Echinococcus granulosus hexokinase 0.0082 0.0777 0.0819
Echinococcus multilocularis microtubule associated protein 2 0.0804 0.9482 0.9482
Treponema pallidum hexokinase (hxk) 0.0082 0.0777 0.1022
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0174 0.1888 0.4845
Loa Loa (eye worm) hexokinase 0.0082 0.0777 0.12
Echinococcus multilocularis heat shock protein 90 0.0029 0.0135 0.0135
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.055 0.6421 1
Echinococcus multilocularis neuropeptide s receptor 0.0483 0.561 0.561
Loa Loa (eye worm) hypothetical protein 0.0156 0.1667 0.2587
Echinococcus multilocularis hexokinase type 2 0.0082 0.0777 0.0777
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0174 0.1888 0.5
Echinococcus multilocularis zinc finger protein 0.002 0.0032 0.0032
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0115 0.1169 0.1233
Entamoeba histolytica hexokinase 2 0.0082 0.0777 0.3323
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0174 0.1888 1
Trypanosoma brucei hexokinase, putative 0.0082 0.0777 0.1567
Trichomonas vaginalis set domain proteins, putative 0.0276 0.3114 0.8272
Plasmodium falciparum V-type K+-independent H+-translocating inorganic pyrophosphatase 0.0325 0.3708 0.9878
Echinococcus multilocularis geminin 0.0177 0.192 0.192
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0329 0.3753 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0069 0.0073
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0077 0.0708 0.1766
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0304 0.0408
Echinococcus multilocularis RUN 0.0021 0.0034 0.0034
Leishmania major heat shock protein 83-1 0.0036 0.0224 0.0142
Brugia malayi PHD-finger family protein 0.0026 0.0099 0.0102
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0135 0.0217
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0386 0.0386
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0469 0.0495
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0304 0.0468
Trypanosoma cruzi Heat shock protein 83, putative 0.0036 0.0224 0.0282
Leishmania major polyprenyl synthase, putative 0.055 0.6421 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0419 0.0419
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0174 0.1888 1
Entamoeba histolytica hexokinase 1 0.0082 0.0777 0.3323
Echinococcus granulosus RUN 0.0021 0.0034 0.0035
Plasmodium vivax vacuolar-type H+ pumping pyrophosphatase, putative 0.0325 0.3708 0.9878
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0481 0.0481
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0174 0.1888 0.4845
Schistosoma mansoni hexokinase 0.0082 0.0777 0.0819
Brugia malayi Inositol-1 0.0043 0.0304 0.0424
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.055 0.6421 0.6772
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0469 0.0495
Plasmodium vivax V-type H(+)-translocating pyrophosphatase, putative 0.0325 0.3708 0.9878
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0069 0.0069
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0174 0.1888 0.4744
Onchocerca volvulus 0.0052 0.0407 0.1214
Schistosoma mansoni inositol monophosphatase 0.0043 0.0304 0.0321
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.271 0.4213
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0077 0.0708 0.0746
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0174 0.1888 0.1888
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0329 0.3753 1
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0115 0.1169 0.1169
Onchocerca volvulus 0.0082 0.0777 0.2414
Schistosoma mansoni lipoxygenase 0.0058 0.0481 0.0507
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.021 0.0276
Onchocerca volvulus Hexokinase homolog 0.0052 0.0407 0.1214
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0304 0.0408
Trypanosoma cruzi hexokinase, putative 0.0082 0.0777 0.1149
Trypanosoma cruzi Vacuolar proton pyrophosphatase 1, putative 0.0325 0.3708 0.5745
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0196 0.2153 0.2153
Loa Loa (eye worm) polyprenyl synthetase 0.0329 0.3753 0.584
Loa Loa (eye worm) hypothetical protein 0.0051 0.0406 0.0621
Trypanosoma cruzi hexokinase, putative 0.0082 0.0777 0.1149
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0174 0.1888 1
Schistosoma mansoni hypothetical protein 0.0035 0.021 0.0221
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0329 0.3753 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0205 0.0216
Echinococcus multilocularis heat shock protein 90 0.0036 0.0224 0.0224
Leishmania major heat shock protein 83-1 0.0036 0.0224 0.0142
Onchocerca volvulus 0.0169 0.1826 0.582
Brugia malayi Hexokinase family protein 0.0082 0.0777 0.1164
Leishmania major hexokinase, putative 0.0082 0.0777 0.1022
Trypanosoma brucei hexokinase 0.0082 0.0777 0.1567
Echinococcus multilocularis muscleblind protein 0.0156 0.1667 0.1667
Leishmania major heat shock protein 83-1 0.0036 0.0224 0.0142
Leishmania major heat shock protein 83-1 0.0036 0.0224 0.0142
Loa Loa (eye worm) hypothetical protein 0.0045 0.0322 0.0491
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 2, putative 0.0325 0.3708 0.9871
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0406 0.0583
Schistosoma mansoni heat shock protein 0.0036 0.0224 0.0236

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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