Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0097 | 0.3402 | 0.869 |
Plasmodium falciparum | mannose-6-phosphate isomerase, putative | 0.01 | 0.3531 | 0.8914 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0358 | 0.0864 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.01 | 0.3531 | 0.4073 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0409 | 0.0987 |
Plasmodium vivax | mannose-6-phosphate isomerase, putative | 0.01 | 0.3531 | 0.8914 |
Brugia malayi | mannose-6-phosphate isomerase, class I family protein | 0.01 | 0.3531 | 0.4073 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0097 | 0.3402 | 0.9473 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.3402 | 0.2509 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0409 | 0.0471 |
Toxoplasma gondii | phosphomannose isomerase type I protein | 0.01 | 0.3531 | 0.8914 |
Schistosoma mansoni | lipoxygenase | 0.004 | 0.0853 | 0.2059 |
Trypanosoma cruzi | cytosolic leucyl aminopeptidase, putative | 0.0108 | 0.3915 | 1 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.003 | 0.0376 | 0.0909 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.3402 | 0.2509 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0376 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0539 | 0.0622 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.0376 | 0.0434 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.004 | 0.0853 | 0.2059 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.124 | 0.143 |
Entamoeba histolytica | phosphomannose isomerase, putative | 0.01 | 0.3531 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.003 | 0.0376 | 0.0434 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.1839 | 0.4133 |
Schistosoma mansoni | rab6-interacting | 0.004 | 0.0853 | 0.2059 |
Brugia malayi | hypothetical protein | 0.004 | 0.0853 | 0.0984 |
Giardia lamblia | Kinase, PLK | 0.0097 | 0.3402 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0097 | 0.3402 | 0.8215 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.124 | 0.143 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0063 | 0.1862 | 0.2149 |
Brugia malayi | Doublecortin family protein | 0.004 | 0.0853 | 0.0984 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0063 | 0.1862 | 0.4497 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0097 | 0.3402 | 0.869 |
Plasmodium falciparum | LCCL domain-containing protein | 0.004 | 0.0853 | 0.1346 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0409 | 0.0987 |
Schistosoma mansoni | rab6-interacting | 0.004 | 0.0853 | 0.2059 |
Brugia malayi | Pre-SET motif family protein | 0.0213 | 0.8668 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0853 | 0.2059 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 0.0107 | 0.0124 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.004 | 0.0853 | 0.1346 |
Brugia malayi | hypothetical protein | 0.004 | 0.0853 | 0.0984 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.004 | 0.0853 | 0.2059 |
Echinococcus multilocularis | RUN | 0.004 | 0.0853 | 0.2059 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.066 | 0.0762 |
Onchocerca volvulus | 0.004 | 0.0853 | 0.0495 | |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.066 | 0.1595 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0108 | 0.3915 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0063 | 0.1862 | 0.4497 |
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.0108 | 0.3915 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.1839 | 0.4697 |
Trichomonas vaginalis | set domain proteins, putative | 0.0243 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.124 | 0.143 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0409 | 0.0987 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.1839 | 0.444 |
Echinococcus granulosus | mannose 6 phosphate isomerase | 0.01 | 0.3531 | 0.8526 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.003 | 0.0376 | 0.0909 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.3402 | 0.2509 |
Leishmania major | phosphomannose isomerase | 0.01 | 0.3531 | 0.9018 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.066 | 0.1595 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.003 | 0.0376 | 0.0909 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0853 | 0.0984 |
Echinococcus multilocularis | peregrin | 0.003 | 0.0376 | 0.0909 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.004 | 0.0853 | 0.2059 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.004 | 0.0853 | 0.2059 |
Schistosoma mansoni | loxhd1 | 0.004 | 0.0853 | 0.2059 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0097 | 0.3402 | 0.8215 |
Brugia malayi | Cytochrome P450 family protein | 0.0024 | 0.0107 | 0.0124 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.3402 | 0.2509 |
Schistosoma mansoni | mannose-6-phosphate isomerase | 0.01 | 0.3531 | 0.8526 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0409 | 0.0471 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0108 | 0.3915 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0539 | 0.1302 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0097 | 0.3402 | 0.869 |
Trypanosoma brucei | polo-like protein kinase | 0.0097 | 0.3402 | 0.869 |
Loa Loa (eye worm) | doublecortin family protein | 0.004 | 0.0853 | 0.0984 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.1839 | 0.444 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0409 | 0.0987 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0108 | 0.3915 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0097 | 0.3402 | 0.3925 |
Echinococcus granulosus | leucine aminopeptidase protein | 0.0108 | 0.3915 | 0.9454 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.3402 | 0.2509 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1341 | 0.1547 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.066 | 0.1595 |
Mycobacterium ulcerans | mannose-6-phosphate isomerase ManA | 0.01 | 0.3531 | 0.8149 |
Echinococcus granulosus | jumonji domain containing protein | 0.0042 | 0.0905 | 0.2186 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.1839 | 0.1516 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.1839 | 0.444 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.3402 | 0.2509 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0063 | 0.1862 | 0.4497 |
Brugia malayi | jmjC domain containing protein | 0.0098 | 0.3449 | 0.398 |
Trichomonas vaginalis | mannose-6-phosphate isomerase, putative | 0.01 | 0.3531 | 0.2655 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.0108 | 0.3915 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0063 | 0.1862 | 0.0113 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0409 | 0.0987 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0108 | 0.3915 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0409 | 0.0091 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0539 | 0.0622 |
Echinococcus multilocularis | leucine aminopeptidase protein | 0.0108 | 0.3915 | 0.9454 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0213 | 0.8668 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.004 | 0.0853 | 0.2059 |
Brugia malayi | mannose-6-phosphate isomerase, class I family protein | 0.01 | 0.3531 | 0.4073 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.0108 | 0.3915 | 1 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.01 | 0.3531 | 0.4073 |
Schistosoma mansoni | jumonji domain containing protein | 0.0078 | 0.254 | 0.6134 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0042 | 0.0905 | 0.2186 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0113 | 0.4141 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0097 | 0.3402 | 0.8215 |
Onchocerca volvulus | 0.0031 | 0.0409 | 0.0034 | |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0097 | 0.3402 | 0.3925 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.3402 | 0.2509 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0098 | 0.3449 | 0.833 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0097 | 0.3402 | 0.3144 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0063 | 0.1862 | 0.4757 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.01 | 0.3531 | 0.9018 |
Brugia malayi | Bromodomain containing protein | 0.003 | 0.0376 | 0.0434 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.01 | 0.3531 | 0.9018 |
Schistosoma mansoni | kinase | 0.0049 | 0.125 | 0.3018 |
Echinococcus granulosus | RUN | 0.004 | 0.0853 | 0.2059 |
Echinococcus multilocularis | mannose 6 phosphate isomerase | 0.01 | 0.3531 | 0.8526 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0063 | 0.1862 | 0.1612 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.066 | 0.1595 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0376 | 0.0909 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0409 | 0.0091 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0409 | 0.0987 |
Trypanosoma brucei | phosphomannose isomerase | 0.01 | 0.3531 | 0.9018 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0098 | 0.3449 | 0.833 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0853 | 0.0984 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.124 | 0.143 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.1839 | 0.444 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0055 | 0.1504 | 0.1736 |
Schistosoma mansoni | polycystin 1-related | 0.004 | 0.0853 | 0.2059 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0063 | 0.1862 | 0.0113 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0108 | 0.3915 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.066 | 0.0762 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0062 | 0.1815 | 0.2093 |
Onchocerca volvulus | 0.004 | 0.0853 | 0.0495 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0409 | 0.0987 |
Echinococcus granulosus | peregrin | 0.003 | 0.0376 | 0.0909 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.004 | 0.0853 | 0.2059 |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.0108 | 0.3915 | 1 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0108 | 0.3915 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0113 | 0.4141 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0113 | 0.4141 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MF, Family M17, putative | 0.0108 | 0.3915 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.