Detailed information for compound 1149487

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 484.469 | Formula: C20H24N10O5
  • H donors: 4 H acceptors: 6 LogP: -1.62 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)CCNC(=O)c1cc(cn1C)NC(=O)c1cc(cn1C)NC(=O)Cn1ccnc1[N+](=O)[O-]
  • InChi: 1S/C20H24N10O5/c1-27-10-13(8-14(27)18(32)23-4-3-16(21)22)26-19(33)15-7-12(9-28(15)2)25-17(31)11-29-6-5-24-20(29)30(34)35/h5-10H,3-4,11H2,1-2H3,(H3,21,22)(H,23,32)(H,25,31)(H,26,33)
  • InChiKey: RJUGMUXPGLFUEH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0008 0.0001 0.0002
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0304 0.0983
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0326 0.0879
Trichomonas vaginalis glutaminase, putative 0.0271 0.3091 0.9334
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0028 0.0237 0.0637
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.014 0.0375
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0108 0.029
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0008 0.0001 0.0001
Onchocerca volvulus 0.0072 0.0748 0.5299
Entamoeba histolytica alcohol dehydrogenase, putative 0.0028 0.0237 0.0714
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.015 0.0404
Trypanosoma brucei prostaglandin f synthase 0.0028 0.0237 0.0637
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0028 0.0237 0.0638
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0108 0.029
Brugia malayi intermediate filament protein 0.0027 0.0217 0.0584
Mycobacterium ulcerans glutaminase 0.0271 0.3091 0.8329
Echinococcus granulosus aldo keto reductase 0.0028 0.0237 0.0298
Brugia malayi hypothetical protein 0.0087 0.093 0.2506
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0126 0.1389 0.4194
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0066 0.0176
Echinococcus granulosus GPCR family 2 0.0017 0.0098 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0237 0.0714
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.014 0.042
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0028 0.0237 0.0637
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0098 0.0265
Mycobacterium ulcerans beta-lactamase 0.0036 0.0323 0.0869
Loa Loa (eye worm) hypothetical protein 0.0036 0.0323 0.1045
Loa Loa (eye worm) hypothetical protein 0.0072 0.0748 0.2419
Onchocerca volvulus 0.0021 0.015 0.1062
Mycobacterium ulcerans oxidoreductase 0.0028 0.0237 0.0637
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.014 0.042
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0304 0.2151
Echinococcus granulosus cation transporting ATPase 13A1 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0128 0.1411 0.4564
Leishmania major dihydroorotate dehydrogenase 0.0324 0.3711 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0002
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0324 0.3711 1
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0304 0.0817
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0028 0.0237 0.0298
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.015 0.0486
Leishmania major DNA polymerase eta, putative 0.002 0.014 0.0375
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0323 0.0869
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0008 0.0001 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.015 0.0404
Schistosoma mansoni hypothetical protein 0.0179 0.2012 0.253
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.0329 0.0886
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0324 0.3711 0.5
Schistosoma mansoni hypothetical protein 0.0017 0.0098 0.0124
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.015 0.0404
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0748 0.2014
Entamoeba histolytica aldose reductase, putative 0.0028 0.0237 0.0714
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0323 0.087
Brugia malayi Zinc finger, C2H2 type family protein 0.0126 0.1389 0.3744
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0028 0.0237 0.0298
Echinococcus multilocularis cpg binding protein 0.003 0.0256 0.0256
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0028 0.0237 0.0298
Schistosoma mansoni pol-related 0.0028 0.0237 0.0298
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0028 0.0237 0.0237
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0981 0.3173
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.015 0.0404
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0028 0.0237 0.0237
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0008 0.0001 0.0002
Trichomonas vaginalis aldo-keto reductase, putative 0.0028 0.0237 0.0714
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0217 0.0701
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0054 0.0174
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.1727
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0748 0.2014
Brugia malayi E1-E2 ATPase family protein 0.0008 0.0001 0.0002
Echinococcus multilocularis pyruvate kinase 0.0034 0.0304 0.0304
Echinococcus multilocularis cation transporting atpase worm 0.0008 0.0001 0.0001
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0304 0.0817
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0748 0.2014
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.015 0.0404
Loa Loa (eye worm) oxidoreductase 0.0028 0.0237 0.0766
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0981 0.2643
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0534 1
Trypanosoma brucei unspecified product 0.0014 0.0066 0.0176
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.015 0.0452
Brugia malayi MH2 domain containing protein 0.0122 0.134 0.3611
Trichomonas vaginalis aldo-keto reductase, putative 0.0028 0.0237 0.0714
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0098 0.0098
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0135 0.1485 0.4002
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0036 0.0329 0.0414
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0001 0.0001
Echinococcus multilocularis lamin 0.0027 0.0217 0.0217
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0126 0.1389 0.4194
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.015 0.0404
Brugia malayi AMP-binding enzyme family protein 0.0021 0.015 0.0405
Loa Loa (eye worm) calcium ATPase 0.0008 0.0001 0.0002
Schistosoma mansoni dihydroorotate dehydrogenase 0.0324 0.3711 0.4666
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.0329 0.0886
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.014 0.0375
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.015 0.0404
Trichomonas vaginalis aldo-keto reductase, putative 0.0028 0.0237 0.0714
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0028 0.0237 0.0714
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0323 0.0869
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0002
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0028 0.0237 0.0298
Trypanosoma brucei unspecified product 0.0014 0.0066 0.0176
Loa Loa (eye worm) E1-E2 ATPase 0.0008 0.0001 0.0002
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.015 0.0189
Loa Loa (eye worm) hypothetical protein 0.0034 0.0304 0.0983
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.015 0.0404
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0156
Echinococcus granulosus voltage gated potassium channel subunit 0.0028 0.0237 0.0298
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.1727
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3312 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0054 0.0068
Brugia malayi beta-lactamase family protein 0.0036 0.0323 0.087
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0126 0.1389 0.4194
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.015 0.0404
Trichomonas vaginalis aldo/keto reductase, putative 0.0028 0.0237 0.0714
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0156
Loa Loa (eye worm) hypothetical protein 0.0027 0.0217 0.0701
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.014 0.0375
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.015 0.0404
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.015 0.0404
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.015 0.0404
Echinococcus granulosus microtubule associated protein 2 0.0684 0.7953 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.014 0.0375
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0304 0.0817
Loa Loa (eye worm) hypothetical protein 0.0087 0.093 0.3009
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0126 0.1389 0.4194
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0182 0.0549
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.1568 0.4223
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0008 0.0001 0.0001
Onchocerca volvulus 0.0027 0.0217 0.1532
Plasmodium falciparum dihydroorotate dehydrogenase 0.0324 0.3711 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0981 0.1233
Plasmodium falciparum aldo-keto reductase, putative 0.0028 0.0237 0.0637
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0748 0.2015
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0613 0.077
Toxoplasma gondii propionate-CoA ligase 0.0021 0.015 0.0404
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.014 0.0375
Treponema pallidum fructose-bisphosphate aldolase 0.029 0.3312 1
Echinococcus multilocularis aldo keto reductase 0.0028 0.0237 0.0237
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0028 0.0237 0.0714
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0028 0.0237 0.0638
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0323 0.0869
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0028 0.0237 0.0298
Trichomonas vaginalis aldo-keto reductase, putative 0.0028 0.0237 0.0714
Loa Loa (eye worm) hypothetical protein 0.0036 0.0323 0.1045
Onchocerca volvulus 0.0028 0.0237 0.1676
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0028 0.0237 0.0714
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0323 0.0323
Schistosoma mansoni microtubule-associated protein tau 0.0684 0.7953 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0748 0.2014
Trichomonas vaginalis aldo-keto reductase, putative 0.0028 0.0237 0.0714
Schistosoma mansoni cation-transporting atpase worm 0.0008 0.0001 0.0001
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0028 0.0237 0.0637
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.015 0.0404
Schistosoma mansoni phosphoserine phosphatase 0.0008 0.0001 0.0001
Trypanosoma cruzi aldo/keto reductase, putative 0.0028 0.0237 0.0637
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0028 0.0237 0.0237
Onchocerca volvulus 0.0028 0.0237 0.1676
Schistosoma mansoni pyruvate kinase 0.0034 0.0304 0.0382
Leishmania major hypothetical protein, conserved 0.0036 0.0323 0.0869
Trichomonas vaginalis aldo/keto reductase, putative 0.0028 0.0237 0.0714
Onchocerca volvulus 0.0021 0.015 0.1062
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.3312 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.014 0.0452
Echinococcus granulosus dna polymerase eta 0.002 0.014 0.0176
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0748 0.2014
Echinococcus granulosus cation transporting ATPase 13A3 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Conserved protein 0.0036 0.0323 0.0869
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.014 0.0375
Loa Loa (eye worm) glutaminase 0.0271 0.3091 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0748 0.2257
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.015 0.0404
Loa Loa (eye worm) hypothetical protein 0.0053 0.0523 0.1691
Echinococcus multilocularis pyruvate kinase 0.0027 0.0219 0.0219
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0126 0.1389 0.4194
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.015 0.0404
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0008 0.0001 0.0002
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.015 0.0404
Echinococcus multilocularis pyruvate kinase 0.0034 0.0304 0.0304
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0534 0.1437
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0981 0.1233
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0981 0.0981
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0028 0.0237 0.0237
Onchocerca volvulus Huntingtin homolog 0.0128 0.1411 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0006 0.0018
Trichomonas vaginalis aldo-keto reductase, putative 0.0028 0.0237 0.0714
Brugia malayi beta-lactamase 0.0036 0.0323 0.087
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.015 0.0404
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.015 0.0404
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0748 0.2015
Schistosoma mansoni hypothetical protein 0.0036 0.0326 0.041
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.014 0.0176
Schistosoma mansoni DNA polymerase eta 0.002 0.014 0.0176
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.0329 0.0886
Echinococcus multilocularis microtubule associated protein 2 0.0684 0.7953 0.7953
Schistosoma mansoni potassium channel beta 0.0028 0.0237 0.0298
Echinococcus granulosus pyruvate kinase 0.0018 0.0108 0.0136
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0323 0.0974
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3312 1
Echinococcus multilocularis pyruvate kinase 0.0018 0.0108 0.0108
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.014 0.042
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0126 0.1389 0.1389
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0323 0.0974
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0324 0.3711 1
Leishmania major DNA polymerase kappa, putative 0.002 0.014 0.0375
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0324 0.3711 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0323 0.0869
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.0329 0.0886
Schistosoma mansoni hypothetical protein 0.0406 0.4674 0.5877
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0126 0.1389 0.1747
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0135 0.1485 0.4483
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0748 0.2014
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.015 0.0452
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.014 0.0176
Onchocerca volvulus 0.0036 0.0323 0.2286
Echinococcus granulosus copper transporting ATPase 1 0.0008 0.0001 0.0001
Onchocerca volvulus 0.0021 0.015 0.1062
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.134 0.4336
Loa Loa (eye worm) oxidoreductase 0.0028 0.0237 0.0766
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0126 0.1389 0.4194
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0028 0.0237 0.0298
Loa Loa (eye worm) hypothetical protein 0.0017 0.0098 0.0318
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0748 0.2014
Echinococcus granulosus pyruvate kinase 0.0018 0.0108 0.0136
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0028 0.0237 0.0237
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.015 0.0404
Schistosoma mansoni pyruvate kinase 0.0034 0.0304 0.0382
Echinococcus multilocularis GPCR, family 2 0.0017 0.0098 0.0098
Mycobacterium tuberculosis Conserved protein 0.0036 0.0323 0.0869
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0981 0.1233
Toxoplasma gondii ABC1 family protein 0.0036 0.0323 0.0869
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0981 0.1233
Giardia lamblia Aldose reductase 0.0028 0.0237 0.0714
Onchocerca volvulus 0.0028 0.0237 0.1676
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0748 0.2014
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0126 0.1389 0.3743
Schistosoma mansoni hypothetical protein 0.0179 0.2012 0.253
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0182 0.059
Brugia malayi AMP-binding enzyme family protein 0.0021 0.015 0.0405
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.015 0.0404
Echinococcus granulosus pyruvate kinase 0.0034 0.0304 0.0382
Schistosoma mansoni eyes absent homolog 0.0087 0.093 0.1169
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0028 0.0237 0.0638
Schistosoma mansoni cpg binding protein 0.003 0.0256 0.0322
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0217 0.0701
Leishmania major aldo-keto reductase-like protein 0.0028 0.0237 0.0637
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0534 0.1437
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.015 0.0404
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0028 0.0237 0.0637
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0066 0.0176
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0008 0.0001 0.0001
Trichomonas vaginalis aldo-keto reductase, putative 0.0028 0.0237 0.0714
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.015 0.0452
Trypanosoma cruzi aldo/keto reductase, putative 0.0028 0.0237 0.0637
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3312 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0304 0.2151
Schistosoma mansoni type V p-type atpase isoform 0.0008 0.0001 0.0001
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.1568 0.4223
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0748 0.2014
Echinococcus multilocularis aldo keto reductase 0.0028 0.0237 0.0237
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.014 0.0375
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0304 0.0819
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0981 0.1233
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0028 0.0237 0.0637
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0323 0.0869
Echinococcus multilocularis cation transporting ATPase 13A3 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.015 0.0404
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0304 0.0817
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0008 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0036 0.0329 0.0886
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0126 0.1389 0.1389
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0004 0.0012
Echinococcus multilocularis voltage gated potassium channel subunit 0.0028 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.0486
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0324 0.3711 1
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0304 0.0983
Loa Loa (eye worm) hypothetical protein 0.0036 0.0323 0.1045
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0135 0.1485 0.1485
Onchocerca volvulus 0.0028 0.0237 0.1676
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.0329 0.0886
Mycobacterium ulcerans DNA polymerase IV 0.002 0.014 0.0375
Loa Loa (eye worm) hypothetical protein 0.0026 0.0211 0.0682
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.014 0.0375
Mycobacterium ulcerans hypothetical protein 0.0072 0.0748 0.2014
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0324 0.3711 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0499 0.1344
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0304 0.0819
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0028 0.0237 0.0237
Loa Loa (eye worm) oxidoreductase 0.0021 0.015 0.0486
Loa Loa (eye worm) hypothetical protein 0.0087 0.093 0.3009
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.015 0.0404
Schistosoma mansoni aldo-keto reductase 0.0028 0.0237 0.0298
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0323 0.0974
Schistosoma mansoni copper ABC transporter ATPase 0.0008 0.0001 0.0001
Echinococcus multilocularis copper transporting ATPase 1 0.0008 0.0001 0.0001
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0008 0.0001 0.0002
Mycobacterium tuberculosis Probable oxidoreductase 0.0028 0.0237 0.0637
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0304 0.0817
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0135 0.1485 0.1867
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.015 0.0404
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0748 0.2257
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.1727
Plasmodium falciparum pyruvate kinase 0.0034 0.0304 0.0817
Schistosoma mansoni aldo-keto reductase 0.0028 0.0237 0.0298
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0304 0.0817
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0748 0.2015
Trichomonas vaginalis aldo-keto reductase, putative 0.0028 0.0237 0.0714
Echinococcus granulosus aldo keto reductase 0.0028 0.0237 0.0298
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0008 0.0001 0.0001
Leishmania major prostaglandin f synthase, putative 0.0028 0.0237 0.0637
Chlamydia trachomatis pyruvate kinase 0.0034 0.0304 0.5686
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.015 0.0404
Echinococcus granulosus intermediate filament protein 0.0027 0.0217 0.0272
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.0486
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0523 0.1409
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0499 0.1344
Onchocerca volvulus 0.0036 0.0323 0.2286
Echinococcus multilocularis geminin 0.0179 0.2012 0.2012
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0323 0.0869
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.4674 0.4674
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0098 0.0318
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0008 0.0001 0.0001
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0028 0.0237 0.0298
Leishmania major pyruvate kinase 0.0034 0.0304 0.0817
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.015 0.0404
Mycobacterium ulcerans hypothetical protein 0.0028 0.0237 0.0637
Onchocerca volvulus Huntingtin homolog 0.0128 0.1411 1
Echinococcus granulosus pyruvate kinase 0.0018 0.0108 0.0136
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.1727
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0002
Loa Loa (eye worm) oxidoreductase 0.0028 0.0237 0.0766
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0008 0.0001 0.0001
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0237 0.0766
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0008 0.0001 0.0001
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.1485 0.4001
Schistosoma mansoni intermediate filament proteins 0.0027 0.0217 0.0272
Trichomonas vaginalis aldo-keto reductase, putative 0.0028 0.0237 0.0714
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.015 0.0486
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3312 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0323 0.1045
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0748 0.2014
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0008 0.0001 0.0001
Toxoplasma gondii aldose reductase, putative 0.0028 0.0237 0.0637
Loa Loa (eye worm) hypothetical protein 0.0036 0.0323 0.1045
Echinococcus multilocularis lamin dm0 0.0027 0.0217 0.0217
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0135 0.1485 0.4001
Brugia malayi hypothetical protein 0.0008 0.0001 0.0002
Brugia malayi Na,K-ATPase alpha subunit 0.0008 0.0001 0.0002
Echinococcus granulosus pyruvate kinase 0.0034 0.0304 0.0382
Entamoeba histolytica aldose reductase, putative 0.0028 0.0237 0.0714
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0323 0.0406
Giardia lamblia DINP protein human, muc B family 0.002 0.014 0.042
Echinococcus multilocularis aldo keto reductase 0.0028 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0036 0.0326 0.1056
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.0329 0.0886
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3312 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.015 0.0405
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0499 0.1344
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0748 0.2014
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0028 0.0237 0.0637
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.015 0.0404
Onchocerca volvulus 0.0028 0.0237 0.1676
Schistosoma mansoni lamin 0.0027 0.0217 0.0272
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.015 0.0404
Echinococcus granulosus cation transporting atpase worm 0.0008 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.014 0.0375
Schistosoma mansoni hypothetical protein 0.0017 0.0098 0.0124
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.015 0.0404
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.1485 0.4001
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.134 0.4336
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0748 0.2014
Schistosoma mansoni lamin 0.0027 0.0217 0.0272
Echinococcus granulosus geminin 0.0179 0.2012 0.253
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0304 0.0916
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0028 0.0237 0.0714
Giardia lamblia Pyruvate kinase 0.0034 0.0304 0.0916
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0237 0.0767
Loa Loa (eye worm) oxidoreductase 0.0028 0.0237 0.0766
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.1568 0.4223
Entamoeba histolytica aldose reductase, putative 0.0028 0.0237 0.0714
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0008 0.0001 0.0002
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0324 0.3711 1
Echinococcus multilocularis transcription factor Dp 1 0.0078 0.0818 0.0818
Entamoeba histolytica alcohol dehydrogenase, putative 0.0028 0.0237 0.0714
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0323 0.0869
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0323 0.0974
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0098 0.0124
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.014 0.0375
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0028 0.0237 0.0638
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.015 0.0404
Mycobacterium ulcerans lipase LipD 0.0036 0.0323 0.0869
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0028 0.0237 0.0638
Loa Loa (eye worm) beta-lactamase 0.0036 0.0323 0.1045
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.015 0.0405
Mycobacterium leprae Possible oxidoreductase 0.0028 0.0237 0.0637
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0304 0.0817
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0108 0.029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3312 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0237 0.0639
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0323 0.0869
Trichomonas vaginalis aldo-keto reductase, putative 0.0028 0.0237 0.0714
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0028 0.0237 0.0237
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0304 0.0983
Trichomonas vaginalis aldo/keto reductase, putative 0.0028 0.0237 0.0714
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.014 0.0375
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.014 0.0375
Loa Loa (eye worm) hypothetical protein 0.0072 0.0748 0.2419
Onchocerca volvulus 0.0021 0.015 0.1062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0499 0.1344
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0324 0.3711 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.014 0.0176
Brugia malayi glutaminase DH11.1 0.0271 0.3091 0.833
Schistosoma mansoni cpg binding protein 0.0028 0.0237 0.0298
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0028 0.0237 0.0237
Schistosoma mansoni ATPase 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.014 0.0375
Echinococcus granulosus lamin dm0 0.0027 0.0217 0.0272
Brugia malayi hypothetical protein 0.0128 0.1411 0.3801
Leishmania major pyruvate kinase 0.0034 0.0304 0.0817
Schistosoma mansoni ATPase 0.0008 0.0001 0.0001
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.015 0.0404
Loa Loa (eye worm) hypothetical protein 0.0036 0.0323 0.1045
Echinococcus multilocularis pyruvate kinase 0.0018 0.0108 0.0108
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0304 0.0916
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0323 0.0869
Schistosoma mansoni cation-transporting ATPase 0.0008 0.0001 0.0001
Echinococcus granulosus cpg binding protein 0.003 0.0256 0.0322
Trypanosoma brucei aldo/keto reductase, putative 0.0028 0.0237 0.0637
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0116 0.031
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0002
Brugia malayi E1-E2 ATPase family protein 0.0008 0.0001 0.0002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0523 0.1409
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.014 0.0375
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.015 0.0404
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.015 0.0404
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.014 0.0375
Mycobacterium ulcerans hypothetical protein 0.0036 0.0323 0.0869
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0324 0.3711 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0304 0.2151
Trichomonas vaginalis aldo-keto reductase, putative 0.0028 0.0237 0.0714
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0748 0.2014
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.014 0.0375
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0523 0.1691
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.014 0.0376
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.014 0.0375
Trichomonas vaginalis aldo-keto reductase, putative 0.0028 0.0237 0.0714
Echinococcus multilocularis cation transporting ATPase 13A1 0.0008 0.0001 0.0001
Echinococcus multilocularis musashi 0.0027 0.0217 0.0217
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0324 0.3711 1
Mycobacterium tuberculosis Conserved protein 0.0028 0.0237 0.0637
Schistosoma mansoni hypothetical protein 0.0017 0.0098 0.0124
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.014 0.0375
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0036 0.0329 0.0329
Trypanosoma brucei unspecified product 0.002 0.014 0.0375
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0028 0.0237 0.0237
Echinococcus multilocularis dna polymerase eta 0.002 0.014 0.014
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0028 0.0237 0.0298
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0071 0.019
Trichomonas vaginalis esterase, putative 0.0036 0.0323 0.0974
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0098 0.0124
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0126 0.1389 0.1747
Trichomonas vaginalis aldo-keto reductase, putative 0.0028 0.0237 0.0714
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0537 0.1445
Giardia lamblia Fructose-bisphosphate aldolase 0.029 0.3312 1
Loa Loa (eye worm) glutaminase 2 0.0271 0.3091 1
Schistosoma mansoni cpg binding protein 0.003 0.0256 0.0322
Loa Loa (eye worm) hypothetical protein 0.0072 0.0748 0.2419
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0981 0.0981
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0028 0.0237 0.0637
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0028 0.0237 0.0298
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0028 0.0237 0.0237
Loa Loa (eye worm) oxidoreductase 0.0028 0.0237 0.0766
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3312 1
Trypanosoma cruzi aldo-keto reductase 0.0028 0.0237 0.0637
Toxoplasma gondii aldo-keto reductase 0.0028 0.0237 0.0637
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0534 0.1437
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0534 0.1437
Brugia malayi beta-lactamase family protein 0.0036 0.0323 0.087
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0323 0.0406
Brugia malayi Augmenter of liver regeneration 0.0036 0.0329 0.0887
Echinococcus multilocularis dna polymerase kappa 0.002 0.014 0.014
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.015 0.0189
Echinococcus granulosus lamin 0.0027 0.0217 0.0272
Onchocerca volvulus 0.0036 0.0323 0.2286
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0126 0.1389 0.4194
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.1727
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.015 0.0404
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0304 0.0817
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.015 0.0404
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.0329 0.0886
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.3312 1
Echinococcus granulosus hypothetical protein 0.0028 0.0237 0.0298
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.015 0.0404
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0028 0.0237 0.0298
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.0329 0.0886
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0304 0.0817
Loa Loa (eye worm) hepatopoietin HPO2 0.0036 0.0329 0.1065
Echinococcus granulosus transcription factor Dp 1 0.0078 0.0818 0.1029
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0748 0.2257
Trypanosoma brucei aldo-keto reductase, putative 0.0028 0.0237 0.0637
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.014 0.0375
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.015 0.0404
Trichomonas vaginalis aldo-keto reductase, putative 0.0028 0.0237 0.0714
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0028 0.0237 0.0237
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0323 0.0406
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0323 0.0869
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0323 0.0869
Giardia lamblia Pyruvate kinase 0.0018 0.0108 0.0325
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0323 0.0974
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.014 0.0375
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.015 0.0404
Giardia lamblia Aldose reductase 0.0028 0.0237 0.0714
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0323 0.0869
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.014 0.014
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.014 0.0375
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.2592 0.6983
Trichomonas vaginalis aldo-keto reductase, putative 0.0028 0.0237 0.0714
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0323 0.1045
Onchocerca volvulus 0.0027 0.0217 0.1532
Schistosoma mansoni glutaminase 0.0271 0.3091 0.3887
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.015 0.0404
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0748 0.2014
Schistosoma mansoni pyruvate kinase 0.0018 0.0108 0.0136
Echinococcus granulosus aldo keto reductase 0.0028 0.0237 0.0298
Onchocerca volvulus 0.0028 0.0237 0.1677
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.015 0.0404
Loa Loa (eye worm) hypothetical protein 0.002 0.014 0.0452
Schistosoma mansoni hypothetical protein 0.0017 0.0098 0.0124
Echinococcus granulosus dnaJ subfamily B 0.0406 0.4674 0.5877
Brugia malayi AMP-binding enzyme family protein 0.0021 0.015 0.0405
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0024 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.3312 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.015 0.0404
Echinococcus multilocularis aldo keto reductase 0.0028 0.0237 0.0237
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0135 0.1485 0.4804
Echinococcus granulosus dna polymerase kappa 0.002 0.014 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0066 0.0176
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0323 0.0869
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0054 0.0054
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0071 0.0228
Plasmodium vivax aldehyde reductase, putative 0.0028 0.0237 0.0637
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0028 0.0237 0.0766
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.1485 0.4001
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0217 0.0584
Brugia malayi NADH-dependent xylose reductase 0.0028 0.0237 0.0638
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0001 0.0001
Onchocerca volvulus 0.0028 0.0237 0.1676
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.015 0.0404
Echinococcus multilocularis pyruvate kinase 0.0018 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0128 0.1411 0.4564
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.015 0.0404
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0324 0.3711 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0098 0.0265
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.014 0.0375
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0008 0.0001 0.0002
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.014 0.0376
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0135 0.1485 0.1867
Mycobacterium ulcerans DNA polymerase IV 0.002 0.014 0.0375
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0324 0.3711 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.015 0.0404
Schistosoma mansoni cation-transporting atpase worm 0.0008 0.0001 0.0001
Plasmodium falciparum aldehyde reductase, putative 0.0028 0.0237 0.0637
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0323 0.0869
Onchocerca volvulus 0.0028 0.0237 0.1676
Loa Loa (eye worm) hypothetical protein 0.0024 0.0182 0.059
Mycobacterium leprae Probable lipase LipE 0.0036 0.0323 0.0869
Schistosoma mansoni atpase class VI type 11c 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Conserved protein 0.0036 0.0323 0.0869
Brugia malayi AMP-binding enzyme family protein 0.0021 0.015 0.0405
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0098 0.0098
Echinococcus granulosus phospholipid transporting ATPase VA 0.0008 0.0001 0.0001

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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