Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.017 | 0.6867 | 0.8837 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0026 | 0.029 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0135 | 0.0526 |
Brugia malayi | Thioredoxin reductase | 0.0075 | 0.2512 | 0.9988 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0026 | 0.029 | 0.0211 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.029 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0189 | 0.7733 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.017 | 0.6867 | 0.8837 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.017 | 0.6867 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.017 | 0.6867 | 0.8837 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.017 | 0.6867 | 0.8837 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0189 | 0.7733 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0026 | 0.029 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0135 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.096 | 0.3702 |
Plasmodium falciparum | thioredoxin reductase | 0.0075 | 0.2512 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0076 | 0.2557 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0075 | 0.2512 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0075 | 0.2512 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.017 | 0.6867 | 0.8837 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0189 | 0.7733 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.1983 | 0.1983 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0026 | 0.029 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0076 | 0.2557 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0026 | 0.029 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0048 | 0.0048 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0849 | 0.2673 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0026 | 0.029 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.182 | 0.7119 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0135 | 0.0526 |
Plasmodium vivax | glutathione reductase, putative | 0.0075 | 0.2512 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0742 | 0.2902 |
Brugia malayi | glutathione reductase | 0.0075 | 0.2512 | 0.9988 |
Toxoplasma gondii | thioredoxin reductase | 0.0075 | 0.2512 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0026 | 0.029 | 0.5 |
Leishmania major | trypanothione reductase | 0.0075 | 0.2512 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0075 | 0.2512 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0075 | 0.2512 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0189 | 0.7733 | 1 |
Treponema pallidum | NADH oxidase | 0.0026 | 0.029 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0075 | 0.2512 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.029 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0742 | 0.2902 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0026 | 0.029 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.232 | 0.9224 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0026 | 0.029 | 0.1134 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0026 | 0.029 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.182 | 0.7119 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1047 | 0.4054 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0075 | 0.2512 | 0.2985 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0853 | 0.3266 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0075 | 0.2512 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0075 | 0.2515 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0026 | 0.029 | 0.029 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.