Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.1306 | 0.181 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0017 | 0.0571 | 0.0571 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.02 | 0.02 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.02 | 0.02 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.02 | 0.02 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5336 | 0.5336 |
Brugia malayi | ecdysteroid receptor | 0.0032 | 0.5336 | 0.5336 |
Brugia malayi | nuclear receptor NHR-88 | 0.0032 | 0.5336 | 0.5336 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0032 | 0.5336 | 0.5336 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0032 | 0.5336 | 0.5336 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0032 | 0.5336 | 0.5336 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.1306 | 0.5 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0571 | 0.0571 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0032 | 0.5336 | 0.5336 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0017 | 0.0571 | 0.0571 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.02 | 0.02 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.1306 | 0.181 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0032 | 0.5336 | 0.5336 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.1306 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0571 | 0.0571 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0017 | 0.0571 | 0.0571 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5336 | 0.5336 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0035 | 0.6308 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.02 | 0.02 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0032 | 0.5336 | 0.5336 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0032 | 0.5336 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0571 | 0.0571 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.1306 | 0.1306 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.6308 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.1306 | 0.181 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0032 | 0.5336 | 0.5336 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.1306 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0032 | 0.5336 | 0.5336 |
Onchocerca volvulus | 0.0032 | 0.5336 | 1 | |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0032 | 0.5336 | 0.5336 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0032 | 0.5336 | 0.5336 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0035 | 0.6308 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.1306 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0032 | 0.5336 | 0.5336 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0035 | 0.6308 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0032 | 0.5336 | 0.5336 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5336 | 0.5336 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0032 | 0.5336 | 0.5336 |
Schistosoma mansoni | nuclear hormone receptor | 0.0032 | 0.5336 | 0.5336 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0032 | 0.5336 | 0.5336 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0035 | 0.6308 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.1306 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.1306 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0032 | 0.5336 | 0.5336 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0032 | 0.5336 | 0.5336 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 1 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.02 | 0.02 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0032 | 0.5336 | 0.5336 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.1306 | 0.181 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0035 | 0.6308 | 0.6308 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0032 | 0.5336 | 0.5336 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0035 | 0.6308 | 0.6308 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0032 | 0.5336 | 0.5336 |
Schistosoma mansoni | coup transcription factor | 0.0032 | 0.5336 | 0.5336 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0017 | 0.0571 | 0.0571 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0032 | 0.5336 | 0.5336 |
Brugia malayi | nuclear hormone receptor | 0.0032 | 0.5336 | 0.5336 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0032 | 0.5336 | 0.5336 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0032 | 0.5336 | 0.5336 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0571 | 0.0571 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0032 | 0.5336 | 0.5336 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.02 | 0.02 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0017 | 0.0571 | 0.0571 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0017 | 0.0571 | 0.0571 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0032 | 0.5336 | 0.5336 |
Brugia malayi | nuclear receptor RXR | 0.0017 | 0.0571 | 0.0571 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0032 | 0.5336 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.1306 | 0.1306 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0032 | 0.5336 | 0.5336 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0032 | 0.5336 | 0.5336 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5336 | 0.5336 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.1306 | 0.181 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0032 | 0.5336 | 0.5336 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0032 | 0.5336 | 0.5336 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0032 | 0.5336 | 0.5336 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0032 | 0.5336 | 0.5336 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.1306 | 0.1306 |
Schistosoma mansoni | thyroid hormone receptor | 0.0032 | 0.5336 | 0.5336 |
Brugia malayi | Augmenter of liver regeneration | 0.0035 | 0.6308 | 0.6308 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0032 | 0.5336 | 0.5336 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0032 | 0.5336 | 0.5336 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0571 | 0.0571 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5336 | 0.5336 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0032 | 0.5336 | 0.5336 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.1306 | 0.1306 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.1306 | 0.181 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0032 | 0.5336 | 0.5336 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0032 | 0.5336 | 0.5336 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5336 | 0.5336 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.1306 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0571 | 0.0571 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0032 | 0.5336 | 0.5336 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.1306 | 0.5 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.02 | 0.02 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.1306 | 0.181 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0032 | 0.5336 | 0.5336 |
Schistosoma mansoni | thyroid hormone receptor | 0.0032 | 0.5336 | 0.5336 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0032 | 0.5336 | 0.5336 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0032 | 0.5336 | 0.5336 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.02 | 0.02 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0035 | 0.6308 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.1306 | 0.1306 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0035 | 0.6308 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0032 | 0.5336 | 0.5336 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0032 | 0.5336 | 0.5336 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5336 | 0.5336 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0035 | 0.6308 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0032 | 0.5336 | 0.5336 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0032 | 0.5336 | 0.5336 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0032 | 0.5336 | 0.5336 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.1306 | 0.1306 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0032 | 0.5336 | 0.5336 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0571 | 0.0571 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0032 | 0.5336 | 0.5336 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0035 | 0.6308 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.02 | 0.02 |
Brugia malayi | steroid hormone receptor | 0.0032 | 0.5336 | 0.5336 |
Echinococcus granulosus | FTZ F1 alpha | 0.0032 | 0.5336 | 0.5336 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0032 | 0.5336 | 0.5336 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0032 | 0.5336 | 0.5336 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0035 | 0.6308 | 0.6308 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0032 | 0.5336 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0032 | 0.5336 | 0.5336 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5336 | 0.5336 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0032 | 0.5336 | 0.5336 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0017 | 0.0571 | 0.0571 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
DRF (functional) | = 1 | Radioprotective effects in mice when administered i.p. at 50% LD50, 2 hr prior to whole body radiation. | ChEMBL. | 3023610 |
DRF (functional) | = 1 | Radioprotective effects in mice when administered i.p. at 12.5% LD50, 15 min prior to whole body radiation. | ChEMBL. | 3023610 |
DRF (functional) | = 1.4 | Radioprotective effects in mice when administered i.p. at 50% LD50, 15 min prior to whole body radiation. | ChEMBL. | 3023610 |
LD50 (ADMET) | = 1500 mg kg-1 | Lethal dose in mice (LD50) | ChEMBL. | 3023610 |
LD50 (ADMET) | = 1500 mg kg-1 | Lethal dose in mice (LD50) | ChEMBL. | 3023610 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.