Detailed information for compound 1150060

Basic information

Technical information
  • TDR Targets ID: 1150060
  • Name: (3-amino-2,3-dihydro-1H-inden-5-yl) N-cyclohe xyl-N-methylcarbamate
  • MW: 288.385 | Formula: C17H24N2O2
  • H donors: 1 H acceptors: 1 LogP: 2.78 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N(C1CCCCC1)C)Oc1ccc2c(c1)C(N)CC2
  • InChi: 1S/C17H24N2O2/c1-19(13-5-3-2-4-6-13)17(20)21-14-9-7-12-8-10-16(18)15(12)11-14/h7,9,11,13,16H,2-6,8,10,18H2,1H3
  • InChiKey: RVNORUCXEIIROU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3-aminoindan-5-yl) N-cyclohexyl-N-methyl-carbamate
  • N-cyclohexyl-N-methylcarbamic acid (3-amino-5-indanyl) ester
  • N-cyclohexyl-N-methyl-carbamic acid (3-aminoindan-5-yl) ester
  • (3-amino-2,3-dihydro-1H-inden-5-yl) N-cyclohexyl-N-methyl-carbamate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tar DNA binding protein 0.013 0.4074 0.7342
Entamoeba histolytica hypothetical protein 0.0037 0.0753 0.0654
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.283 0.283
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.112 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.3316 0.7238
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.283 0.283
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0106 0.019
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0106 0.019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.283 0.283
Loa Loa (eye worm) hypothetical protein 0.0151 0.4821 1
Echinococcus granulosus muscleblind protein 0.0151 0.4821 0.8689
Echinococcus granulosus dna polymerase eta 0.0019 0.0106 0.019
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1607 0.2896
Trypanosoma brucei polo-like protein kinase 0.0095 0.283 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0106 0.0373
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0106 0.0373
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1607 0.3508
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0753 0.1357
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0254 0.2265
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1607 0.3508
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0106 0.0373
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.283 0.5101
Schistosoma mansoni tar DNA-binding protein 0.013 0.4074 0.7342
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1607 0.2896
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0106 0.023
Leishmania major DNA polymerase kappa, putative 0.0019 0.0106 0.0373
Loa Loa (eye worm) RNA binding protein 0.013 0.4074 0.8416
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.112 0.3958
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 1 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0254 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1607 0.5679
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.283 0.283
Schistosoma mansoni hypothetical protein 0.0171 0.5548 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0254 0.0896
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0254 0.0554
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.3316 0.7238
Echinococcus multilocularis geminin 0.0171 0.5548 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0295 1 1
Brugia malayi MH2 domain containing protein 0.0124 0.3875 0.8039
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.112 0.2019
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.112 0.2019
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.283 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0106 0.0373
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0106 0.019
Trypanosoma brucei unspecified product 0.0019 0.0106 0.0373
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.283 0.5778
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0106 0.0373
Echinococcus multilocularis muscleblind protein 1 0.0151 0.4821 0.8689
Entamoeba histolytica hypothetical protein 0.0037 0.0753 0.0654
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0254 0.0554
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.112 0.2445
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 1 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0106 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0106 0.0373
Leishmania major trypanothione reductase 0.0048 0.112 0.3958
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.283 0.5101
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 1 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0254 0.0554
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0753 0.1357
Brugia malayi glutathione reductase 0.0048 0.112 0.2323
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.283 1
Treponema pallidum fructose-bisphosphate aldolase 0.0295 1 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.4581 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1607 0.3508
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0106 0.023
Schistosoma mansoni DNA polymerase eta 0.0019 0.0106 0.019
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.1101 0.1101
Brugia malayi Muscleblind-like protein 0.0151 0.4821 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0106 0.0373
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0106 0.0373
Trypanosoma brucei trypanothione reductase 0.0048 0.112 0.3958
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.283 0.2753
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0106 0.0219
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0753 0.1357
Echinococcus granulosus geminin 0.0171 0.5548 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0106 0.0373
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.3752 0.8084
Brugia malayi RNA recognition motif domain containing protein 0.013 0.4074 0.845
Schistosoma mansoni tar DNA-binding protein 0.013 0.4074 0.7342
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0106 0.0373
Giardia lamblia DINP protein human, muc B family 0.0019 0.0106 0.0106
Plasmodium vivax glutathione reductase, putative 0.0048 0.112 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0106 0.0219
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 1 1
Schistosoma mansoni tar DNA-binding protein 0.013 0.4074 0.7342
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0106 0.0373
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.283 0.283
Giardia lamblia Kinase, PLK 0.0095 0.283 0.283
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.3316 0.7238
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.283 0.5871
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0106 0.0373
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.3316 0.7238
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0106 0.0373
Loa Loa (eye worm) hypothetical protein 0.0084 0.242 0.4908
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.242 0.502
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0106 0.0373
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0106 0.0373
Schistosoma mansoni tar DNA-binding protein 0.013 0.4074 0.7342
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.242 0.4361
Schistosoma mansoni tar DNA-binding protein 0.013 0.4074 0.7342
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.242 0.4361
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0254 0.1579
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.4581 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.3316 0.7076
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0254 0.2265
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0106 0.0373
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0106 0.0373
Schistosoma mansoni hypothetical protein 0.0171 0.5548 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0254 0.0254
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1607 0.2896
Mycobacterium tuberculosis Probable reductase 0.0109 0.3316 0.7238
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.3752 0.819
Echinococcus multilocularis dna polymerase eta 0.0019 0.0106 0.019
Schistosoma mansoni kinase 0.0048 0.1146 0.2066
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1607 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.283 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0106 0.0373
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0254 0.1579
Brugia malayi hypothetical protein 0.0037 0.0753 0.1562
Echinococcus granulosus tar DNA binding protein 0.013 0.4074 0.7342
Plasmodium falciparum glutathione reductase 0.0048 0.112 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.4581 1
Plasmodium falciparum thioredoxin reductase 0.0048 0.112 1
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.283 0.283
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.283 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0106 0.019
Brugia malayi Thioredoxin reductase 0.0048 0.112 0.2323
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.3752 0.819
Entamoeba histolytica hypothetical protein 0.0037 0.0753 0.0654
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0106 0.0373
Entamoeba histolytica hypothetical protein 0.0037 0.0753 0.0654
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.3752 0.819
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0106 0.0106
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.3875 0.7995
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0254 1
Toxoplasma gondii thioredoxin reductase 0.0048 0.112 0.697
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 1 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0106 0.023
Leishmania major DNA polymerase eta, putative 0.0019 0.0106 0.0373
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.112 0.2151
Brugia malayi RNA binding protein 0.013 0.4074 0.845
Loa Loa (eye worm) TAR-binding protein 0.013 0.4074 0.8416
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.242 0.4361
Entamoeba histolytica hypothetical protein 0.0024 0.0254 0.015
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.3875 0.7995
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 1 1
Loa Loa (eye worm) glutathione reductase 0.0048 0.112 0.2151
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0106 0.0373
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.3316 0.7238
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.4074 0.8416
Schistosoma mansoni hypothetical protein 0.0037 0.0753 0.1357
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.283 0.283
Loa Loa (eye worm) hypothetical protein 0.0151 0.4821 1
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.1101 0.1101
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1607 0.2896
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0106 0.019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1607 0.3508
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.283 0.5101
Echinococcus multilocularis muscleblind protein 0.0151 0.4821 0.8689
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0254 0.0896
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0106 0.023
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0106 0.0106
Brugia malayi TAR-binding protein 0.013 0.4074 0.845

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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