Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.2611 | 0.5321 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0009 | 0.0175 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0211 | 0.0323 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0175 | 0.0233 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.2607 | 0.5313 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.2282 | 0.4637 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2823 | 0.2718 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0144 | 0.0173 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.2282 | 0.4349 |
Brugia malayi | Bromodomain containing protein | 0.0079 | 0.6213 | 0.6157 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3347 | 0.3249 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0018 | 0.0934 | 0.183 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0211 | 0.0068 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.1775 | 0.1655 |
Echinococcus granulosus | smad | 0.0008 | 0.0144 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.099 | 0.0858 |
Trichomonas vaginalis | ferritin, putative | 0.0009 | 0.0175 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0067 | 0.5175 | 1 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0144 | 0.0184 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.1251 | 0.1124 |
Trypanosoma cruzi | ISWI complex protein | 0.0016 | 0.0779 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0016 | 0.0779 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.1303 | 0.2597 |
Trypanosoma cruzi | ISWI complex protein | 0.0016 | 0.0779 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0018 | 0.099 | 0.1946 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0009 | 0.0175 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.099 | 0.1825 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0144 | 0.0173 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0989 | 0.0857 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0009 | 0.0175 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.2817 | 0.2711 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.1566 | 0.3145 |
Onchocerca volvulus | 0.003 | 0.1968 | 0.5 | |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0934 | 0.1717 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2611 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.2611 | 0.5321 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0018 | 0.099 | 0.1946 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.1566 | 0.295 |
Trypanosoma brucei | ISWI complex protein | 0.0016 | 0.0779 | 0.5 |
Echinococcus granulosus | ferritin | 0.0009 | 0.0175 | 0.0248 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.1968 | 0.3735 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0011 | 0.037 | 0.0229 |
Schistosoma mansoni | apoferritin-2 | 0.0009 | 0.0175 | 0.0233 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.2282 | 0.4349 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0144 | 0.0184 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0934 | 0.1717 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0175 | 0.0233 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.2611 | 0.4992 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0211 | 0.0323 |
Echinococcus multilocularis | ferritin | 0.0009 | 0.0175 | 0.0248 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.1251 | 0.2336 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.2282 | 0.4637 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0144 | 0.0184 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0144 | 0.0173 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0144 | 0.0184 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.1968 | 0.185 |
Schistosoma mansoni | ferritin light chain | 0.0009 | 0.0175 | 0.0233 |
Echinococcus granulosus | expressed protein | 0.0009 | 0.0175 | 0.0248 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0175 | 0.0233 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0144 | 0.0184 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0779 | 0.1413 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0009 | 0.0175 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.099 | 0.1825 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3032 | 0.2931 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0009 | 0.0175 | 0.5 |
Schistosoma mansoni | smad | 0.0008 | 0.0144 | 0.0173 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2611 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.1303 | 0.2597 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0058 | 0.4453 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0063 | 0.4858 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0063 | 0.4858 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0063 | 0.482 | 0.9308 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.5689 | 0.5626 |
Schistosoma mansoni | zinc finger protein | 0.0016 | 0.0779 | 0.1413 |
Schistosoma mansoni | ferritin light chain | 0.0009 | 0.0175 | 0.0233 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2611 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.1968 | 0.185 |
Schistosoma mansoni | apoferritin-2 | 0.0009 | 0.0175 | 0.0233 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0144 | 0.0173 |
Echinococcus multilocularis | smad | 0.0008 | 0.0144 | 0.0184 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0144 | 0.0184 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.2607 | 0.5313 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2611 | 0.5 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0009 | 0.0175 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.2611 | 0.4992 |
Echinococcus multilocularis | expressed protein | 0.0009 | 0.0175 | 0.0248 |
Schistosoma mansoni | ferritin | 0.0009 | 0.0175 | 0.0233 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0009 | 0.0175 | 0.5 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0144 | 0.0173 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.1566 | 0.3145 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.1303 | 0.2437 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0018 | 0.0934 | 0.183 |
Brugia malayi | hypothetical protein | 0.0037 | 0.2611 | 0.2503 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.