Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0394 | 0.0394 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0092 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0092 | 0.0092 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0003 | 0.0003 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0394 | 0.1468 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0071 | 0.2757 | 0.3563 |
Brugia malayi | hypothetical protein | 0.012 | 0.5152 | 0.5152 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0394 | 0.1468 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0394 | 0.5 |
Loa Loa (eye worm) | fli-1 protein | 0.0217 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.215 | 0.215 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1422 | 0.1422 |
Onchocerca volvulus | Huntingtin homolog | 0.012 | 0.5152 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.215 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0444 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.012 | 0.5152 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.5404 | 0.5404 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0394 | 0.1468 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.5404 | 0.5404 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0444 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0394 | 0.1665 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0394 | 0.1468 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.0394 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5404 | 0.5404 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1422 | 0.1422 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1422 | 0.1422 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0444 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0092 | 0.0092 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.215 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0394 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5404 | 0.5404 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.5404 | 0.5404 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.7738 | 0.7738 |
Echinococcus multilocularis | geminin | 0.0172 | 0.7738 | 1 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.5404 | 0.5404 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0929 | 0.0929 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0092 | 0.0092 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0394 | 0.1468 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5152 | 0.5152 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.215 | 0.2778 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1422 | 0.1838 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5152 | 0.5152 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0394 | 0.0394 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0092 | 0.0092 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1422 | 0.1838 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1729 | 0.1729 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.2241 | 0.2241 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.5404 | 0.6983 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.215 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.5404 | 0.6983 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0444 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0092 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0444 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.215 | 0.215 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0071 | 0.2757 | 0.3563 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0444 | 0.0444 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0071 | 0.2757 | 0.2757 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0394 | 0.0394 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.5404 | 0.5404 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.215 | 0.2778 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1422 | 0.1838 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0929 | 0.0929 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1422 | 0.1422 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0394 | 0.1468 |
Brugia malayi | Ets-domain containing protein | 0.0071 | 0.2757 | 0.2757 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0394 | 0.1468 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0394 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5404 | 0.5404 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0394 | 0.0394 |
Schistosoma mansoni | gabp alpha | 0.0071 | 0.2757 | 0.2757 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.7738 | 0.7738 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0394 | 0.0394 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1729 | 0.1729 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1729 | 0.1729 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0444 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.215 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0394 | 0.1468 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0394 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5404 | 0.5404 |
Brugia malayi | RNA binding protein | 0.0125 | 0.5404 | 0.5404 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0394 | 0.1665 |
Brugia malayi | Ets-domain containing protein | 0.0071 | 0.2757 | 0.2757 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5404 | 0.5404 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.215 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0929 | 0.0929 |
Schistosoma mansoni | ets-related | 0.0217 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1422 | 0.1422 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1729 | 0.1729 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0444 | 0.0444 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0444 | 0.0281 |
Echinococcus granulosus | geminin | 0.0172 | 0.7738 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0394 | 0.0394 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1422 | 0.1838 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.215 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.