Detailed information for compound 1150701

Basic information

Technical information
  • TDR Targets ID: 1150701
  • Name: 6,7-dimethoxy-N-(4-methoxyphenyl)quinazolin-4 -amine
  • MW: 311.335 | Formula: C17H17N3O3
  • H donors: 1 H acceptors: 2 LogP: 3.33 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Nc1ncnc2c1cc(OC)c(c2)OC
  • InChi: 1S/C17H17N3O3/c1-21-12-6-4-11(5-7-12)20-17-13-8-15(22-2)16(23-3)9-14(13)18-10-19-17/h4-10H,1-3H3,(H,18,19,20)
  • InChiKey: AHZHKZBDSLBFFP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6,7-dimethoxy-N-(4-methoxyphenyl)-4-quinazolinamine
  • (6,7-dimethoxyquinazolin-4-yl)-(4-methoxyphenyl)amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References
Homo sapiens CDC-like kinase 1 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0074 0.1226 0.2148
Echinococcus granulosus tyrosine protein kinase Src42A 0.0019 0.0128 0.0121
Loa Loa (eye worm) hypothetical protein 0.0067 0.1085 0.1832
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0173
Echinococcus granulosus tyrosine protein kinase Fyn 0.0019 0.0128 0.0121
Loa Loa (eye worm) TK/Met protein kinase 0.0013 0.0006 0.0011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0465 0.0776
Echinococcus multilocularis tyrosine kinase 0.0022 0.0181 0.0296
Brugia malayi Carboxylesterase family protein 0.0266 0.5056 0.8892
Brugia malayi hypothetical protein 0.0016 0.0067 0.0107
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0006 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1081 0.1816
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0006 0.0011
Brugia malayi hypothetical protein 0.0019 0.0128 0.0213
Onchocerca volvulus 0.0019 0.0128 0.0357
Echinococcus granulosus tyrosine kinase 0.0019 0.0128 0.0121
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0019 0.0128 0.0121
Loa Loa (eye worm) hypothetical protein 0.025 0.4741 0.8007
Echinococcus multilocularis BC026374 protein (S09 family) 0.0045 0.0642 0.1075
Loa Loa (eye worm) hypothetical protein 0.0045 0.0642 0.1084
Echinococcus multilocularis cpg binding protein 0.0031 0.0358 0.0594
Onchocerca volvulus 0.0034 0.0425 0.1234
Schistosoma mansoni tyrosine kinase 0.0019 0.0128 0.0205
Echinococcus granulosus c src tyrosine kinase 0.0019 0.0128 0.0121
Schistosoma mansoni hypothetical protein 0.0028 0.0313 0.0518
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.0808 0.4188
Onchocerca volvulus Poor gastrulation protein homolog 0.0015 0.0047 0.0118
Loa Loa (eye worm) TK protein kinase 0.0013 0.0006 0.0011
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.004 0.0174
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0106 0.186 0.3134
Giardia lamblia PHD finger protein 15 0.0028 0.0313 0.251
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0313 0.0518
Schistosoma mansoni hypothetical protein 0.0015 0.0047 0.0068
Echinococcus granulosus tyrosine protein kinase shark 0.0019 0.0128 0.0121
Loa Loa (eye worm) hypothetical protein 0.0045 0.0642 0.1084
Onchocerca volvulus 0.0045 0.0642 0.1876
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0808 0.1356
Schistosoma mansoni survival motor neuron protein 0.0047 0.0685 0.1148
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0126 0.0213
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0128 0.0215
Schistosoma mansoni tyrosine kinase 0.0022 0.0181 0.0296
Onchocerca volvulus 0.0047 0.0685 0.2003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1705 0.2991
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1081 0.1816
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1081 0.1816
Schistosoma mansoni hypothetical protein 0.0176 0.3255 0.5493
Echinococcus granulosus geminin 0.0176 0.3255 0.3251
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0465 0.0786
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1223 0.2056
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0245 0.1953
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1605 0.2702
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0224 0.2244
Echinococcus granulosus GPCR family 2 0.0031 0.0365 0.0359
Schistosoma mansoni hypothetical protein 0.0031 0.0365 0.0606
Brugia malayi Furin-like cysteine rich region family protein 0.0192 0.3586 0.6303
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0313 0.0306
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0224 0.2244
Loa Loa (eye worm) TAR-binding protein 0.0067 0.1081 0.1825
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.1081 0.1892
Echinococcus granulosus hypothetical protein 0.0072 0.1193 0.1187
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.1226 0.2062
Echinococcus multilocularis Immunoglobulin 0.0025 0.025 0.0412
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0128 0.0215
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0365 0.0616
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0019 0.0128 0.0205
Loa Loa (eye worm) hypothetical protein 0.0034 0.0425 0.0717
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.0808 0.1365
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0019 0.0128 0.0205
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0465 0.3758
Schistosoma mansoni ap endonuclease 0.0019 0.0126 0.0202
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0045 0.0642 0.1075
Schistosoma mansoni tyrosine kinase 0.0192 0.3586 0.6051
Brugia malayi hypothetical protein 0.0025 0.025 0.0429
Loa Loa (eye worm) hypothetical protein 0.0025 0.025 0.0422
Onchocerca volvulus 0.0019 0.0128 0.0357
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0844 0.6865
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0535 0.0894
Loa Loa (eye worm) hypothetical protein 0.0045 0.0642 0.1084
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0808 0.1356
Loa Loa (eye worm) hypothetical protein 0.0148 0.2702 0.4562
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0465 0.0776
Loa Loa (eye worm) RGC/RGC protein kinase 0.0022 0.0181 0.0306
Schistosoma mansoni hypothetical protein 0.0176 0.3255 0.5493
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0126 0.0202
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0074 0.1226 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.004 0.0174
Loa Loa (eye worm) hypothetical protein 0.0025 0.025 0.0422
Schistosoma mansoni hypothetical protein 0.0034 0.0425 0.0707
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0126 0.0625
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0102 0.035
Loa Loa (eye worm) hypothetical protein 0.0049 0.0718 0.1213
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0808 0.1356
Plasmodium falciparum protein kinase, putative 0.0015 0.004 0.0274
Echinococcus granulosus tyrosine protein kinase Lyn 0.0021 0.0161 0.0155
Schistosoma mansoni tyrosine kinase 0.0019 0.0128 0.0205
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.0808 0.0802
Loa Loa (eye worm) hypothetical protein 0.0034 0.0415 0.07
Plasmodium falciparum protein kinase 5 0.0053 0.0808 0.6573
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0126 0.5
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0019 0.0128 0.0121
Echinococcus multilocularis epidermal growth factor receptor 0.0192 0.3586 0.6051
Schistosoma mansoni tyrosine kinase 0.0019 0.0128 0.0205
Schistosoma mansoni cpg binding protein 0.0031 0.0358 0.0594
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0109 0.1921 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0019 0.0128 0.0633
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0011
Leishmania major protein kinase, putative 0.0015 0.004 0.0174
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.5921 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0022 0.0181 0.0175
Loa Loa (eye worm) TK/FAK protein kinase 0.0013 0.0006 0.0011
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0465 0.2395
Brugia malayi Protein kinase domain containing protein 0.0019 0.0128 0.0213
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0016 0.0064 0.0057
Echinococcus granulosus epidermal growth factor receptor 0.0109 0.192 0.1915
Brugia malayi SRC-1 0.0019 0.0128 0.0213
Loa Loa (eye worm) hypothetical protein 0.0266 0.5056 0.8538
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0808 0.1365
Loa Loa (eye worm) TK protein kinase 0.0013 0.0006 0.0011
Loa Loa (eye worm) TK/DDR protein kinase 0.0013 0.0006 0.0011
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0024 0.0221 0.0374
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0365 0.0631
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0109 0.192 0.1915
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0224 0.2244
Mycobacterium ulcerans hypothetical protein 0.0024 0.0224 0.2244
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0808 0.4188
Schistosoma mansoni tyrosine kinase 0.0022 0.0181 0.0296
Echinococcus multilocularis roundabout 2 0.0036 0.0472 0.0787
Schistosoma mansoni neuroligin 3 (S09 family) 0.0045 0.0642 0.1075
Echinococcus granulosus cyclin dependent kinase 0.0053 0.0808 0.0802
Toxoplasma gondii exonuclease III APE 0.0019 0.0126 0.0982
Trypanosoma brucei protein kinase, putative 0.0015 0.004 0.0174
Loa Loa (eye worm) TK protein kinase 0.0013 0.0006 0.0011
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0128 0.0215
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0015 0.0047 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.1921 0.3237
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0173
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0011
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0107 0.0178
Loa Loa (eye worm) hypothetical protein 0.0231 0.4356 0.7357
Onchocerca volvulus 0.0019 0.0128 0.0357
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0011
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0025 0.025 0.0412
Brugia malayi jmjC domain containing protein 0.0036 0.0465 0.0808
Echinococcus multilocularis dual specificity 0.0109 0.1921 0.3237
Brugia malayi protein-tyrosine kinase 0.0019 0.0128 0.0213
Loa Loa (eye worm) hypothetical protein 0.0072 0.1193 0.2015
Brugia malayi RNA binding protein 0.0067 0.1081 0.1892
Echinococcus granulosus roundabout 2 0.0036 0.0472 0.0466
Loa Loa (eye worm) hypothetical protein 0.0025 0.025 0.0422
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0808 0.4188
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0011
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0365 0.0606
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0025 0.025 0.0412
Loa Loa (eye worm) RGC/RGC protein kinase 0.0022 0.0181 0.0306
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0465 0.3758
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0224 0.1134
Echinococcus multilocularis tar DNA binding protein 0.0067 0.1081 0.1816
Echinococcus granulosus tyrosine protein kinase Srms 0.0019 0.0128 0.0121
Schistosoma mansoni hypothetical protein 0.0067 0.1085 0.1823
Brugia malayi Fibronectin type III domain containing protein 0.0025 0.025 0.0429
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0465 0.3758
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.1226 0.2062
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0325 0.0548
Loa Loa (eye worm) hypothetical protein 0.0025 0.025 0.0422
Loa Loa (eye worm) protein kinase domain-containing protein 0.0013 0.0006 0.0011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0365 0.0631
Echinococcus multilocularis GPCR, family 2 0.0031 0.0365 0.0606
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0011
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0224 0.1134
Entamoeba histolytica protein kinase domain containing protein 0.0109 0.1921 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0313 0.0518
Brugia malayi Protein kinase domain containing protein 0.0053 0.0808 0.1412
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0045 0.0642 0.1075
Loa Loa (eye worm) hypothetical protein 0.0115 0.2035 0.3437
Loa Loa (eye worm) TK/ALK protein kinase 0.0297 0.5683 0.9598
Schistosoma mansoni protein kinase 0.0015 0.004 0.0056
Loa Loa (eye worm) TK protein kinase 0.0013 0.0006 0.0011
Echinococcus granulosus neuroglian 0.0028 0.0307 0.0301
Onchocerca volvulus 0.0045 0.0642 0.1876
Echinococcus multilocularis tyrosine protein kinase shark 0.0019 0.0128 0.0205
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0109 0.1921 1
Echinococcus granulosus MAM 0.0034 0.0425 0.0418
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0074 0.0115
Loa Loa (eye worm) RNA binding protein 0.0067 0.1081 0.1825
Schistosoma mansoni tyrosine kinase 0.0024 0.0228 0.0375
Schistosoma mansoni tyrosine kinase 0.0019 0.0128 0.0205
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.0808 0.0802
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0389 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0045 0.0642 0.0636
Loa Loa (eye worm) hypothetical protein 0.0045 0.0642 0.1084
Onchocerca volvulus Tyrosine kinase homolog 0.0183 0.3395 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0019 0.0128 0.0205
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0213 0.4008 0.6768
Onchocerca volvulus 0.0045 0.0642 0.1876
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0074 0.1226 0.2071
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0006 0.0011
Brugia malayi Receptor family ligand binding region containing protein 0.0024 0.0221 0.0379
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.0808 0.4188
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0224 0.2244
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0109 0.1921 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0013 0.0006 0.0011
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0006 0.0011
Echinococcus granulosus para nitrobenzyl esterase 0.0045 0.0642 0.0636
Brugia malayi Protein kinase domain containing protein 0.0019 0.0128 0.0213
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0013 0.0006 0.0011
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0015 0.004 0.0056
Loa Loa (eye worm) TK/ABL protein kinase 0.0019 0.0128 0.0215
Echinococcus multilocularis tyrosine protein kinase Blk 0.0019 0.0128 0.0205
Entamoeba histolytica protein kinase, putative 0.0109 0.1921 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0022 0.0181 0.0296
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0917 0.1549
Echinococcus granulosus dual specificity protein kinase clk2 0.0074 0.1226 0.1221
Echinococcus multilocularis Immunoglobulin 0.0025 0.025 0.0412
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0019 0.0128 0.0205
Loa Loa (eye worm) hypothetical protein 0.0036 0.0472 0.0797
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0224 0.1134
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0224 0.0382
Loa Loa (eye worm) hypothetical protein 0.0266 0.5056 0.8538
Loa Loa (eye worm) TK/EPH protein kinase 0.0013 0.0006 0.0011
Giardia lamblia Kinase, CMGC CLK 0.0074 0.1226 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0245 0.0413
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0808 0.6573
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0808 0.4188
Echinococcus multilocularis activin receptor type 0.0015 0.004 0.0056
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0128 0.0215
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0245 0.1953
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0019 0.0128 0.0205
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0313 0.251
Schistosoma mansoni gliotactin 0.0045 0.0642 0.1075
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0808 0.1356
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1597 0.2689
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0074 0.1226 0.6372
Onchocerca volvulus 0.0024 0.0224 0.0641
Loa Loa (eye worm) glutamate receptor 0.0037 0.0476 0.0805
Schistosoma mansoni tyrosine kinase 0.0109 0.192 0.3235
Schistosoma mansoni inositol monophosphatase 0.0036 0.0465 0.0775
Brugia malayi Inositol-1 0.0036 0.0465 0.0807
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0389 0.5482
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0365 0.0606
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0109 0.1921 1
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0313 0.0528
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0215
Echinococcus granulosus tyrosine kinase 0.0019 0.0128 0.0121
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0074 0.1226 0.6372
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.1081 0.1825
Brugia malayi SH2 domain containing protein 0.0019 0.0128 0.0213
Echinococcus multilocularis acetylcholinesterase 0.0266 0.5056 0.8537
Loa Loa (eye worm) hypothetical protein 0.0148 0.2702 0.4562
Loa Loa (eye worm) TK protein kinase 0.0019 0.0128 0.0215
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0245 0.1245
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0313 0.251
Brugia malayi Receptor family ligand binding region containing protein 0.0022 0.0181 0.0308
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0224 0.2244
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0465 0.2395
Echinococcus multilocularis GPCR, family 3, C terminal 0.0015 0.0047 0.0068
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.4356 0.4353
Schistosoma mansoni vesicular amine transporter 0.0025 0.025 0.0412
Schistosoma mansoni hypothetical protein 0.0034 0.0425 0.0707
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0808 0.6573
Echinococcus granulosus cpg binding protein 0.0031 0.0358 0.0352
Trichomonas vaginalis spcc417.12 protein, putative 0.0045 0.0642 0.521
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0019 0.0128 0.0205
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0102 0.0787
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0808 0.4188
Loa Loa (eye worm) hypothetical protein 0.0045 0.0642 0.1084
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0011
Onchocerca volvulus 0.0045 0.0642 0.1876
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0465 0.0459
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0528
Schistosoma mansoni tyrosine kinase 0.0019 0.0128 0.0205
Loa Loa (eye worm) RGC/RGC protein kinase 0.0022 0.0181 0.0306
Schistosoma mansoni BC026374 protein (S09 family) 0.0045 0.0642 0.1075
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0109 0.1921 0.3244
Schistosoma mansoni metabotropic glutamate receptor 0.0045 0.0651 0.109
Leishmania major hypothetical protein, conserved 0.0025 0.0245 0.1245
Schistosoma mansoni cpg binding protein 0.0029 0.0325 0.0538
Echinococcus multilocularis 0.0056 0.0859 0.1441
Schistosoma mansoni inositol monophosphatase 0.0036 0.0465 0.0775
Echinococcus multilocularis neuroglian 0.0028 0.0307 0.0508
Brugia malayi Carboxylesterase family protein 0.0045 0.0642 0.1119
Echinococcus multilocularis insulin receptor 0.007 0.1136 0.191
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.5921 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.025 0.0422
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0465 0.2395
Loa Loa (eye worm) TK/CSK protein kinase 0.0013 0.0006 0.0011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0126 0.0625
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.025 0.0429
Loa Loa (eye worm) inositol-1 0.0036 0.0465 0.0785
Plasmodium falciparum protein serine/threonine kinase-1 0.0074 0.1226 1
Schistosoma mansoni tyrosine kinase 0.007 0.1136 0.191
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0019 0.0128 0.0121
Echinococcus granulosus tyrosine protein kinase ABL1 0.0019 0.0128 0.0121
Echinococcus granulosus epidermal growth factor receptor 0.0192 0.3586 0.3582
Onchocerca volvulus Alhambra homolog 0.0028 0.0313 0.0903
Loa Loa (eye worm) hypothetical protein 0.0036 0.0472 0.0797
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0224 0.2244
Echinococcus multilocularis 0.0072 0.1193 0.2006
Echinococcus granulosus tyrosine protein kinase Src64B 0.0019 0.0128 0.0121
Echinococcus granulosus tar DNA binding protein 0.0067 0.1081 0.1075
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0022 0.0181 0.0516
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1597 0.1591
Onchocerca volvulus 0.0019 0.0128 0.0357
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0034 0.0415 0.0408
Echinococcus granulosus jumonji domain containing protein 0.004 0.0535 0.0529
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0685 0.1195
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0126 0.0625
Brugia malayi hypothetical protein 0.0034 0.0425 0.0736
Loa Loa (eye worm) TK/EGFR protein kinase 0.0192 0.3586 0.6055
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0102 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0019 0.0128 0.0121
Brugia malayi Protein kinase domain containing protein 0.007 0.1136 0.199
Loa Loa (eye worm) TK protein kinase 0.0013 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0052 0.0775 0.1308
Echinococcus multilocularis geminin 0.0176 0.3255 0.5493
Loa Loa (eye worm) SRC-1 0.0019 0.0128 0.0215
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0013 0.0006 0.0011
Onchocerca volvulus 0.0029 0.0325 0.0939
Schistosoma mansoni hypothetical protein 0.0047 0.0685 0.1148
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0128 0.0215
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0126 0.044
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.1226 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0173
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.0808 0.4188
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0102 0.0787
Loa Loa (eye worm) hypothetical protein 0.0309 0.5921 1
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.0808 0.6573
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0245 0.1953
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0173
Loa Loa (eye worm) TK protein kinase 0.0013 0.0006 0.0011
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0019 0.0128 0.0205
Brugia malayi Carboxylesterase family protein 0.0045 0.0642 0.1119
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1081 0.1816
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.1597 0.2801
Schistosoma mansoni cpg binding protein 0.0031 0.0358 0.0594
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1597 0.2689
Loa Loa (eye worm) hypothetical protein 0.0107 0.1888 0.3188
Leishmania major protein kinase, putative 0.0074 0.1226 0.6372
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0019 0.0128 0.0205
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0128 0.0215
Brugia malayi cell division control protein 2 homolog 0.0053 0.0808 0.1412
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0064 0.0101
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.4356 0.7354
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0808 0.6573
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0126 0.0982
Loa Loa (eye worm) glutamate receptor 0.0093 0.1605 0.2711
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0808 0.6573
Loa Loa (eye worm) acetylcholinesterase 1 0.0266 0.5056 0.8538
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0128 0.0215
Loa Loa (eye worm) carboxylesterase 0.0266 0.5056 0.8538
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0045 0.0642 1
Echinococcus granulosus neuroligin 0.0045 0.0642 0.0636
Brugia malayi Protein kinase domain containing protein 0.0297 0.5685 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1597 0.2689
Echinococcus granulosus dual specificity 0.0109 0.1921 0.1916
Echinococcus multilocularis peregrin 0.0028 0.0313 0.0518
Loa Loa (eye worm) TK/ROR protein kinase 0.0016 0.0064 0.0108
Echinococcus multilocularis dual specificity protein kinase clk2 0.0074 0.1226 0.2062
Brugia malayi Protein kinase domain containing protein 0.0019 0.0128 0.0213
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0045 0.0642 0.1075
Echinococcus granulosus GPCR family 3 C terminal 0.0015 0.0047 0.004
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.0808 0.4188
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1597 0.2689
Mycobacterium ulcerans carboxylesterase, LipT 0.0045 0.0642 1
Schistosoma mansoni protein kinase 0.0022 0.0181 0.0296
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0006 0.0011
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.1597 0.2697
Loa Loa (eye worm) hypothetical protein 0.0031 0.0365 0.0616
Loa Loa (eye worm) hypothetical protein 0.0107 0.1888 0.3188
Loa Loa (eye worm) hypothetical protein 0.0025 0.025 0.0422
Schistosoma mansoni protein kinase 0.0015 0.004 0.0056
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0224 0.2515
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0245 0.1245
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1081 0.1816
Brugia malayi Tyrosine-protein kinase abl-1 0.0019 0.0128 0.0213
Echinococcus granulosus defective proboscis extension response 0.0025 0.025 0.0244
Echinococcus granulosus activin receptor type 0.0015 0.004 0.0033
Loa Loa (eye worm) hypothetical protein 0.0034 0.0425 0.0717
Echinococcus granulosus tyrosine protein kinase Fyn 0.0019 0.0128 0.0121
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1597 0.1591
Schistosoma mansoni cell adhesion molecule 0.0034 0.0415 0.069
Onchocerca volvulus 0.0034 0.0425 0.1234
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0074 0.1226 0.6372
Loa Loa (eye worm) hypothetical protein 0.0098 0.1705 0.2879
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0115 0.2035 0.343
Loa Loa (eye worm) hypothetical protein 0.0022 0.0181 0.0306
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0126 0.0211
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0019 0.0128 0.0205
Brugia malayi hypothetical protein 0.0045 0.0642 0.1119
Echinococcus granulosus peregrin 0.0028 0.0313 0.0306
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0078 0.1303 0.2192
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0465 0.0775
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1605 0.16
Echinococcus granulosus Immunoglobulin 0.0025 0.025 0.0244
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.0808 0.1356
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0006 0.0011
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0126 0.0982
Echinococcus multilocularis neuroligin 0.0045 0.0642 0.1075
Loa Loa (eye worm) TK protein kinase 0.0013 0.0006 0.0011
Echinococcus multilocularis para nitrobenzyl esterase 0.0045 0.0642 0.1075
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0011
Brugia malayi jmjC domain containing protein 0.0093 0.1605 0.2815
Loa Loa (eye worm) hypothetical protein 0.0024 0.0224 0.0377
Brugia malayi Immunoglobulin I-set domain containing protein 0.0213 0.4008 0.7046
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0045 0.0642 0.1075
Schistosoma mansoni tyrosine kinase 0.007 0.1136 0.191
Brugia malayi Protein kinase domain containing protein 0.0109 0.1921 0.3371
Loa Loa (eye worm) hypothetical protein 0.0034 0.0425 0.0717
Schistosoma mansoni tyrosine kinase 0.0019 0.0128 0.0205
Brugia malayi Carboxylesterase family protein 0.0045 0.0642 0.1119
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0173
Onchocerca volvulus 0.0022 0.0181 0.0516
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0074 0.1226 0.6372
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0266 0.5056 0.8537
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0128 0.0215
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0975 0.1638
Schistosoma mansoni acetylcholinesterase 0.0045 0.0642 0.1075
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0365 0.0359
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0126 0.0982
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0074 0.1226 0.6372
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0019 0.0128 0.0205
Schistosoma mansoni hypothetical protein 0.0031 0.0365 0.0606
Echinococcus multilocularis tyrosine kinase 0.0019 0.0128 0.0205
Echinococcus granulosus carboxylesterase 5A 0.0266 0.5056 0.5053
Onchocerca volvulus 0.0045 0.0642 0.1876
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.0808 0.0802
Schistosoma mansoni tyrosine kinase 0.0109 0.192 0.3235
Schistosoma mansoni hypothetical protein 0.0031 0.0365 0.0606
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0808 0.1365
Loa Loa (eye worm) TK/ACK protein kinase 0.0013 0.0006 0.0011
Echinococcus granulosus insulin growth factor 1 receptor beta 0.007 0.1136 0.1131
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0245 0.1953
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0126 0.0774
Schistosoma mansoni nephrin 0.0028 0.0307 0.0508
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0224 0.1134
Loa Loa (eye worm) hypothetical protein 0.0024 0.0224 0.0377
Loa Loa (eye worm) TK protein kinase 0.0016 0.0064 0.0108
Onchocerca volvulus 0.0167 0.3076 0.9058
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0465 0.2395
Mycobacterium tuberculosis Carboxylesterase LipT 0.0045 0.0642 1
Brugia malayi hypothetical protein 0.0148 0.2702 0.4746
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0245 0.1245
Echinococcus granulosus tyrosine protein kinase Blk 0.0019 0.0128 0.0121
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0016 0.0064 0.0097
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0015 0.0047 0.0071
Loa Loa (eye worm) hypothetical protein 0.0045 0.0642 0.1084
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0808 0.4188
Echinococcus granulosus insulin receptor 0.007 0.1136 0.1131
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0465 1
Echinococcus granulosus tyrosine kinase 0.0022 0.0181 0.0175
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0128 0.0215
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0045 0.0642 0.521
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0011
Entamoeba histolytica hypothetical protein 0.0109 0.1921 1
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0025 0.025 0.0412
Echinococcus granulosus metabotropic glutamate receptor 2 0.0078 0.1303 0.1298
Schistosoma mansoni tyrosine kinase 0.0096 0.1658 0.2793
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.004 0.0174
Entamoeba histolytica protein kinase domain containing protein 0.0015 0.004 0.0174
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0313 0.251
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0126 0.0982
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0024 0.0221 0.0374
Echinococcus multilocularis tyrosine protein kinase Abl 0.0019 0.0128 0.0205
Echinococcus granulosus metabotropic glutamate receptor 5 0.0115 0.2035 0.203
Plasmodium vivax protein kinase Crk2 0.0053 0.0808 0.6573
Echinococcus multilocularis acetylcholinesterase 0.0266 0.5056 0.8537
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0079
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0126 0.0625
Plasmodium vivax serine/threonine kinase-1, putative 0.0074 0.1226 1
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0465 0.0459
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0808 0.6573
Schistosoma mansoni tyrosine kinase 0.0096 0.1658 0.2793
Echinococcus multilocularis carboxylesterase 5A 0.0266 0.5056 0.8537
Brugia malayi Carboxylesterase family protein 0.0266 0.5056 0.8892
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0011
Brugia malayi metabotropic glutamate receptor type 2 0.0045 0.0651 0.1136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0221 0.0374
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0126 0.012
Echinococcus granulosus tyrosine protein kinase Fyn 0.0019 0.0128 0.0121
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0808 0.4188
Echinococcus multilocularis MAM 0.0034 0.0425 0.0707
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0013 0.0006 0.0011
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0432 0.072
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0224 0.0382
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0013 0.0006 0.0011
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0013 0.0006 0.0011
Brugia malayi hypothetical protein 0.0025 0.0245 0.042
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0465 0.3758
Loa Loa (eye worm) hypothetical protein 0.0024 0.0224 0.0377
Plasmodium falciparum phd finger protein, putative 0.0028 0.0313 0.251
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0084 0.143 0.2507
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0465 0.2395
Echinococcus multilocularis tyrosine protein kinase Srms 0.0019 0.0128 0.0205
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0015 0.004 0.0033
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1085 0.1899
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0019 0.0128 0.0205
Echinococcus granulosus twitchin 0.003 0.0341 0.0334
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1597 0.2689
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0015 0.004 0.0274
Entamoeba histolytica protein kinase, putative 0.0109 0.1921 1
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.0808 0.1356
Brugia malayi TAR-binding protein 0.0067 0.1081 0.1892
Leishmania major protein kinase, putative 0.0074 0.1226 0.6372
Loa Loa (eye worm) hypothetical protein 0.0045 0.0642 0.1084
Loa Loa (eye worm) carboxylesterase 0.0045 0.0642 0.1084
Loa Loa (eye worm) TK/INSR protein kinase 0.007 0.1136 0.1919
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0365 0.0359
Brugia malayi Protein kinase domain containing protein 0.0019 0.0128 0.0213
Schistosoma mansoni metabotropic glutamate receptor 0.0078 0.1303 0.2192
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0045 0.0642 1
Loa Loa (eye worm) TK/FER protein kinase 0.0019 0.0128 0.0215
Schistosoma mansoni ap endonuclease 0.0019 0.0126 0.0202
Brugia malayi CXXC zinc finger family protein 0.0029 0.0325 0.0561
Schistosoma mansoni hypothetical protein 0.0031 0.0365 0.0606
Loa Loa (eye worm) carboxylesterase 0.0045 0.0642 0.1084
Loa Loa (eye worm) serine/threonine protein kinase 0.0013 0.0006 0.0011
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0224 0.1134
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1705 0.2991
Onchocerca volvulus 0.0019 0.0128 0.0357
Brugia malayi SH2 domain containing protein 0.0019 0.0128 0.0213
Echinococcus granulosus acetylcholinesterase 0.0266 0.5056 0.5053
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0013 0.0006 0.0011
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.007 0.1136 0.191
Brugia malayi hypothetical protein 0.0231 0.4356 0.766
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0011
Echinococcus granulosus BC026374 protein S09 family 0.0045 0.0642 0.0636
Schistosoma mansoni tyrosine kinase 0.0096 0.1658 0.2793
Brugia malayi Protein kinase domain containing protein 0.0019 0.0128 0.0213
Brugia malayi Bromodomain containing protein 0.0028 0.0313 0.0539
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0224 0.2244
Schistosoma mansoni protein kinase 0.0015 0.004 0.0056
Loa Loa (eye worm) TK/RYK protein kinase 0.0013 0.0006 0.0011
Onchocerca volvulus 0.0019 0.0128 0.0357
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0465 0.6717
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0019 0.0128 0.0205
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0019 0.0128 0.0205
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0006 0.0011
Brugia malayi PHD-finger family protein 0.0028 0.0313 0.0539
Brugia malayi Guanylyl cyclase protein 23 0.0022 0.0181 0.0308
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1705 0.2879
Echinococcus multilocularis epidermal growth factor receptor 0.0109 0.192 0.3235
Echinococcus granulosus acetylcholinesterase 0.0266 0.5056 0.5053
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0224 0.1134
Brugia malayi Metabotropic glutamate receptor precursor. 0.0093 0.1605 0.2815
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0224 0.0382
Loa Loa (eye worm) TK protein kinase 0.0013 0.0006 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0224 0.2515
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0019 0.0128 0.0121
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0126 0.0982
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0013 0.0006 0.0011
Echinococcus multilocularis c src tyrosine kinase 0.0019 0.0128 0.0205
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0019 0.0128 0.0205
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.5921 0.5919
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0126 0.0625
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0074 0.1226 0.6372
Brugia malayi Carboxylesterase family protein 0.0045 0.0642 0.1119

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Inhibition of human recombinant GST-fused CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate ChEMBL. 24530227
IC50 (binding) > 10 uM Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate by scintillation counting in presence of [gamma-33P]ATP ChEMBL. 24530227
IC50 (binding) > 10 uM inhibition of human recombinant CDK5/p25 using histone H1 as substrate by scintillation counting in presence of [gamma-33P]ATP ChEMBL. 24530227

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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