Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | O-6-methylguanine-DNA methyltransferase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Dose-modifying factor (ADMET) | 0 | The compound was tested for its ability to enhance the cytotoxicity of ACNU toward HeLa S3 cells at 10 microM dose; 'b' means toxicity appeared at this dose | ChEMBL. | 9484500 |
Dose-modifying factor (functional) | = 1.2 | The compound was tested for its ability to enhance the cytotoxicity of ACNU toward HeLa S3 cells at 0.01 microM dose | ChEMBL. | 9484500 |
Dose-modifying factor (functional) | = 4.3 | The compound was tested for its ability to enhance the cytotoxicity of ACNU toward HeLa S3 cells at 0.1 microM dose | ChEMBL. | 9484500 |
Dose-modifying factor (functional) | = 8.8 | The compound was tested for its ability to enhance the cytotoxicity of ACNU toward HeLa S3 cells at 1 microM dose | ChEMBL. | 9484500 |
ED50 (binding) | = 0.02 uM | AGT-inactivating activity was determined by 50% inactivation in HT-29 cells upon incubation for 4 h | ChEMBL. | 7830279 |
ED50 (binding) | = 0.02 uM | AGT-inactivating activity was determined by 50% inactivation in HT-29 cells upon incubation for 4 h | ChEMBL. | 7830279 |
ED50 (binding) | = 0.06 uM | AGT-inactivating activity was determined by 50% inactivation in HT-29 cell free extract upon incubation for 30 min | ChEMBL. | 7830279 |
ED50 (binding) | = 0.06 uM | AGT-inactivating activity was determined by 50% inactivation in HT-29 cell free extract upon incubation for 30 min | ChEMBL. | 7830279 |
IC50 (binding) | = 0.13 uM | In vitro inhibitory activity against human O6-alkylguanine-DNA alkyltransferase (AGAT) | ChEMBL. | 9484500 |
IC50 (binding) | = 0.13 uM | In vitro inhibitory activity against human O6-alkylguanine-DNA alkyltransferase (AGAT) | ChEMBL. | 9484500 |
IC50 (binding) | = 27 uM | Inhibition of Cyclin dependent kinase 1-cyclin B1 from starfish oocytes at 12.5 microM ATP | ChEMBL. | 12482427 |
IC50 (binding) | = 27 uM | Inhibition of human Cyclin-dependent kinase 2 cyclin A3 at 12.5 microM ATP | ChEMBL. | 12482427 |
IC50 (binding) | = 27 uM | Inhibition of Cyclin dependent kinase 1-cyclin B1 from starfish oocytes at 12.5 microM ATP | ChEMBL. | 12482427 |
IC50 (binding) | = 27 uM | Inhibition of human Cyclin-dependent kinase 2 cyclin A3 at 12.5 microM ATP | ChEMBL. | 12482427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.