Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 reverse transcriptase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0212 | 1 | 1 |
Brugia malayi | Flap endonuclease-1 | 0.0064 | 0.2031 | 0.2031 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0212 | 1 | 1 |
Entamoeba histolytica | DNA-repair protein, putative | 0.0074 | 0.2554 | 0.0656 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0212 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0212 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.2554 | 0.0656 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0212 | 1 | 1 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0027 | 0 | 0.5 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0212 | 1 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0029 | 0.0122 | 0.0122 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0029 | 0.0122 | 0.0122 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0064 | 0.2031 | 0.2031 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0212 | 1 | 1 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0074 | 0.2554 | 0.2554 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0064 | 0.2031 | 0.2031 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0029 | 0.0122 | 0.0122 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0212 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0212 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0212 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0212 | 1 | 1 |
Brugia malayi | XPG N-terminal domain containing protein | 0.0063 | 0.1936 | 0.1936 |
Mycobacterium ulcerans | proteasome PrcB | 0.0212 | 1 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0212 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0027 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0029 | 0.0122 | 0.0122 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0064 | 0.2031 | 0.2031 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0064 | 0.2031 | 0.2031 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0212 | 1 | 1 |
Echinococcus granulosus | flap endonuclease 1 | 0.0064 | 0.2031 | 0.2031 |
Plasmodium falciparum | DNA repair protein RAD2, putative | 0.0074 | 0.2554 | 0.0656 |
Plasmodium vivax | DNA repair protein RAD2, putative | 0.0074 | 0.2554 | 0.0656 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0064 | 0.2031 | 0.2031 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0064 | 0.2031 | 0.2031 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0.3947 | 0.3947 |
Echinococcus granulosus | DNA repair protein complementing XP G cells | 0.0074 | 0.2554 | 0.2554 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.3947 | 0.3947 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0212 | 1 | 1 |
Echinococcus multilocularis | DNA repair protein complementing XP G cells | 0.0074 | 0.2554 | 0.2554 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0212 | 1 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0212 | 1 | 0.5 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | xp-G/rad2 DNA repair endonuclease family | 0.0074 | 0.2554 | 0.2554 |
Schistosoma mansoni | flap endonuclease-1 | 0.0054 | 0.1478 | 0.1478 |
Toxoplasma gondii | XPG N-terminal domain-containing protein | 0.0074 | 0.2554 | 0.2554 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0029 | 0.0122 | 0.0122 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0064 | 0.2031 | 0.2031 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1 uM | In vitro inhibitory activity against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) | ChEMBL. | 1712395 |
IC50 (binding) | > 1 uM | In vitro inhibitory activity against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) | ChEMBL. | 1712395 |
Inhibition (binding) | = 47 % | In vitro inhibitory activity against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) at a concentration of 10 ug/mL. | ChEMBL. | 1712395 |
Inhibition (binding) | = 47 % | In vitro inhibitory activity against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) at a concentration of 10 ug/mL. | ChEMBL. | 1712395 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.