Detailed information for compound 1150860

Basic information

Technical information
  • TDR Targets ID: 1150860
  • Name: methyl 5-(diaminomethylideneamino)-2-[6-[[3-( 3,8-diamino-5-methylphenanthridin-5-ium-6-yl) benzoyl]amino]hexanoylamino]pentanoate
  • MW: 627.756 | Formula: C34H43N8O4+
  • H donors: 6 H acceptors: 3 LogP: 2.59 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 3
  • SMILES: COC(=O)C(NC(=O)CCCCCNC(=O)c1cccc(c1)c1c2cc(N)ccc2c2c([n+]1C)cc(cc2)N)CCCN=C(N)N
  • InChi: 1S/C34H42N8O4/c1-42-29-20-24(36)13-15-26(29)25-14-12-23(35)19-27(25)31(42)21-8-6-9-22(18-21)32(44)39-16-5-3-4-11-30(43)41-28(33(45)46-2)10-7-17-40-34(37)38/h6,8-9,12-15,18-20,28,36H,3-5,7,10-11,16-17,35H2,1-2H3,(H6,37,38,39,40,41,43,44)/p+1
  • InChiKey: FIFQSXLYJGNOFU-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

  • methyl 2-[6-[[3-(3,8-diamino-5-methyl-phenanthridin-5-ium-6-yl)benzoyl]amino]hexanoylamino]-5-guanidino-pentanoate
  • 2-[[6-[[[3-(3,8-diamino-5-methyl-6-phenanthridin-5-iumyl)phenyl]-oxomethyl]amino]-1-oxohexyl]amino]-5-guanidinopentanoic acid methyl ester
  • 2-[6-[[3-(3,8-diamino-5-methyl-phenanthridin-5-ium-6-yl)benzoyl]amino]hexanoylamino]-5-guanidino-valeric acid methyl ester
  • methyl 5-(diaminomethylideneamino)-2-[6-[[3-(3,8-diamino-5-methyl-phenanthridin-5-ium-6-yl)phenyl]carbonylamino]hexanoylamino]pentanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.1509 0.2995
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0076 0.0491 0.0749
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0117 0.0238
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0061 0.0371 0.0562
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0098 0.0092
Loa Loa (eye worm) hypothetical protein 0.0061 0.0371 0.0756
Schistosoma mansoni 6-phosphofructokinase 0.0247 0.1865 0.1865
Trichomonas vaginalis DNA helicase recq, putative 0.0038 0.0187 0.0275
Onchocerca volvulus 0.0207 0.1538 0.5125
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0337
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0169 0.0247
Trichomonas vaginalis phosphofructokinase, putative 0.0067 0.0415 0.0745
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0627 0.4914 1
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.1509 0.2995
Echinococcus multilocularis lysine specific demethylase 6a 0.003 0.0117 0.0168
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.1075 0.2173
Brugia malayi Associated with TFs and helicases family protein 0.0061 0.0371 0.0739
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0092
Mycobacterium tuberculosis Conserved hypothetical protein 0.024 0.1804 0.3659
Onchocerca volvulus 0.0018 0.0021 0.0033
Leishmania major hypothetical protein, conserved 0.0081 0.0525 0.1052
Trypanosoma brucei DNA polymerase IV, putative 0.0268 0.2028 0.4116
Schistosoma mansoni hypothetical protein 0.0332 0.2545 0.2545
Trypanosoma brucei DNA polymerase kappa, putative 0.0268 0.2028 0.4116
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0247 0.1865 0.3795
Trichomonas vaginalis ran, putative 0.0023 0.0062 0.0019
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0049 0.0269 0.0529
Loa Loa (eye worm) Smad1 0.0017 0.0014 0.0029
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.023 0.0469
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0207 0.1538 0.1538
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0062 0.0127
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0023
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0034 0.0155 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.021 0.1566 0.3113
Entamoeba histolytica phosphoglycerate kinase, putative 0.0627 0.4914 1
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0201 0.0391
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0012 0.0023
Loa Loa (eye worm) mbt repeat family protein 0.0207 0.1538 0.3129
Mycobacterium ulcerans DNA polymerase IV 0.0268 0.2028 0.4062
Trypanosoma brucei phosphoglycerate kinase 0.0627 0.4914 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.023 0.0451
Schistosoma mansoni dishevelled 0.0019 0.0032 0.0032
Echinococcus granulosus Smad4 0.0017 0.0014 0.0008
Treponema pallidum phosphoglycerate kinase 0.0627 0.4914 1
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.1509 0.2995
Trypanosoma cruzi DNA polymerase kappa, putative 0.0268 0.2028 0.4127
Leishmania major phosphoglycerate kinase B, cytosolic 0.0627 0.4914 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0175 0.1287 0.2605
Echinococcus multilocularis chromobox protein 1 0.0375 0.2889 0.447
Trichomonas vaginalis DNA helicase recq1, putative 0.0072 0.0455 0.0827
Brugia malayi SEA domain containing protein 0.0016 0.0011 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.1509 0.2995
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0491 0.0983
Schistosoma mansoni smad1 5 8 and 0.0017 0.0014 0.0014
Echinococcus granulosus histone acetyltransferase MYST2 0.0235 0.1767 0.2729
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0476 0.0969
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0014 0.0008
Echinococcus granulosus ubiquitin 0.01 0.068 0.1042
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.003 0.0117 0.0167
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0686 0.1301
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0067 0.0415 0.0845
Loa Loa (eye worm) SMO-1 protein 0.0162 0.1177 0.2395
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0247 0.186 0.3772
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0819 0.6452 1
Brugia malayi hypothetical protein 0.0061 0.0371 0.0739
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0027 0.0098 0.0138
Onchocerca volvulus 0.01 0.068 0.2247
Schistosoma mansoni cpg binding protein 0.0069 0.0436 0.0436
Leishmania major ATP-dependent phosphofructokinase 0.0247 0.1865 0.3783
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0062 0.0083
Entamoeba histolytica phosphofructokinase, putative 0.0247 0.1865 0.3795
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0592 0.4628 0.9062
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0205 0.0303
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0237 0.0237
Leishmania major DNA polymerase kappa, putative 0.0074 0.0476 0.0952
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0062 0.0109
Schistosoma mansoni ran 0.0023 0.0062 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.07 0.1409
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0067 0.0415 0.0845
Mycobacterium ulcerans 6-phosphofructokinase 0.0247 0.1865 0.3727
Echinococcus multilocularis caspase 8 0.0027 0.0098 0.0138
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0233 0.0348
Loa Loa (eye worm) hypothetical protein 0.0235 0.1767 0.3597
Toxoplasma gondii exonuclease III APE 0.0022 0.0053 0.0108
Echinococcus granulosus Chromobox protein 3 0.0061 0.0371 0.0562
Trichomonas vaginalis hypothetical protein 0.0061 0.0371 0.0655
Trichomonas vaginalis DNA polymerase eta, putative 0.0268 0.2028 0.4062
Loa Loa (eye worm) acetyltransferase 0.0149 0.1075 0.2188
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.0525 0.1052
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.1509 0.1509
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0201 0.0304
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0205 0.0398
Brugia malayi PHD-finger family protein 0.0092 0.0618 0.1242
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0627 0.4914 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0371 0.0756
Schistosoma mansoni jumonji domain containing protein 0.003 0.0117 0.0117
Schistosoma mansoni ap endonuclease 0.0022 0.0053 0.0053
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0247 0.1865 0.3783
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0021
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0592 0.4628 0.9417
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0205 0.0416
Trypanosoma brucei polo-like protein kinase 0.0203 0.1509 0.3058
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0062 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0268 0.2028 0.4116
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0067 0.0415 0.0845
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0117 0.0239
Onchocerca volvulus Heterochromatin protein 1 homolog 0.021 0.1566 0.522
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0027 0.0098 0.0098
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0061 0.0371 0.0655
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0162 0.1177 0.1177
Trypanosoma cruzi polo-like protein kinase, putative 0.0203 0.1509 0.3071
Echinococcus multilocularis jumonji domain containing 1A 0.003 0.0117 0.0168
Mycobacterium ulcerans DNA polymerase IV 0.0268 0.2028 0.4062
Loa Loa (eye worm) hypothetical protein 0.003 0.0117 0.0238
Toxoplasma gondii 6-phosphofructokinase 0.0067 0.0415 0.0845
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0019 0.0032 0.0032
Leishmania major phosphoglycerate kinase C, glycosomal 0.0627 0.4914 1
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0032 0.0046
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0053 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.1074 0.2099
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0027 0.0098 0.0181
Onchocerca volvulus Alhambra homolog 0.0092 0.0618 0.204
Loa Loa (eye worm) heterochromatin protein 1 0.0375 0.2889 0.588
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0247 0.186 0.3772
Entamoeba histolytica ubiquitin like protein 0.0162 0.1177 0.2395
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0205 0.0311
Entamoeba histolytica recQ family helicase, putative 0.0038 0.0187 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0371 0.0655
Chlamydia trachomatis phosphoglycerate kinase 0.0627 0.4914 1
Giardia lamblia DINP protein human, muc B family 0.0247 0.186 0.3716
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0205 0.0416
Entamoeba histolytica hypothetical protein 0.0025 0.0081 0.0165
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0062 0.0109
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0235 0.1767 0.2729
Toxoplasma gondii small ubiquitin family modifier, putative 0.0162 0.1177 0.2395
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0371 0.0739
Loa Loa (eye worm) transcription factor SMAD2 0.0248 0.1871 0.3807
Loa Loa (eye worm) hypothetical protein 0.0081 0.0525 0.1068
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0237 0.0353
Brugia malayi hypothetical protein 0.0081 0.0525 0.1052
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0081 0.0057
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0081 0.0165
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0237 0.0353
Trypanosoma brucei phosphoglycerate kinase 0.0627 0.4914 1
Echinococcus granulosus Small ubiquitin modifier 2 0.0162 0.1177 0.1812
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0053 0.009
Echinococcus multilocularis chromobox protein 1 0.0375 0.2889 0.447
Trypanosoma cruzi phosphoglycerate kinase, putative 0.023 0.1727 0.3515
Echinococcus granulosus polycomb protein SCMH1 0.0207 0.1538 0.2373
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0076 0.0491 0.0749
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0098 0.0199
Entamoeba histolytica phosphofructokinase, putative 0.0247 0.1865 0.3795
Leishmania major DNA damage repair protein, putative 0.0074 0.0476 0.0952
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0034 0.0155 0.0226
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0128 0.0243
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.1075 0.1075
Echinococcus granulosus Chromo domain 0.0061 0.0371 0.0562
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0009 0.0009
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0226 0.1694 0.565
Trypanosoma brucei DNA polymerase kappa, putative 0.0268 0.2028 0.4116
Onchocerca volvulus 0.0165 0.1202 0.3997
Loa Loa (eye worm) hypothetical protein 0.0061 0.0371 0.0756
Schistosoma mansoni phosphatidylserine receptor 0.003 0.0117 0.0117
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0032 0.0035
Echinococcus granulosus dna polymerase kappa 0.0268 0.2028 0.3133
Onchocerca volvulus 0.008 0.052 0.1709
Schistosoma mansoni cpg binding protein 0.0069 0.0436 0.0436
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0332 0.2545 0.5179
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0128 0.0185
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0067 0.0415 0.0745
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0061 0.0371 0.0562
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.024 0.1804 0.2786
Plasmodium vivax metacaspase 1, putative 0.0027 0.0098 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0098 0.0092
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0061 0.0371 0.0739
Onchocerca volvulus 0.0069 0.0436 0.1429
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0117 0.0168
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0237 0.0464
Trypanosoma cruzi metacaspase, putative 0.0027 0.0098 0.0199
Toxoplasma gondii PHD-finger domain-containing protein 0.0092 0.0618 0.1258
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0092 0.0618 0.0618
Trypanosoma brucei DNA polymerase kappa, putative 0.0268 0.2028 0.4116
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0009 0.0019
Toxoplasma gondii hypothetical protein 0.0019 0.0032 0.0065
Loa Loa (eye worm) 6-phosphofructokinase 0.0247 0.1865 0.3795
Schistosoma mansoni hypothetical protein 0.0092 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0061 0.0371 0.0756
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0388 0.2991 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0302 0.2302 0.3558
Brugia malayi M-phase phosphoprotein, mpp8 0.0061 0.0371 0.0739
Brugia malayi CHD4 protein 0.0061 0.0371 0.0739
Trypanosoma brucei small ubiquitin-related modifier 0.0162 0.1177 0.2381
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0098 0.0092
Schistosoma mansoni kinase 0.0103 0.0707 0.0707
Trypanosoma brucei unspecified product 0.0261 0.1972 0.4002
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0476 0.0952
Trypanosoma cruzi metacaspase, putative 0.0027 0.0098 0.0199
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0061 0.0371 0.0371
Brugia malayi ImpB/MucB/SamB family protein 0.0403 0.3115 0.6331
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0062 0.0127
Schistosoma mansoni phosphoglycerate kinase 0.0627 0.4914 0.4914
Loa Loa (eye worm) hypothetical protein 0.0207 0.1538 0.3129
Echinococcus multilocularis GPCR, family 2 0.0017 0.0012 0.0004
Plasmodium vivax importin-beta 2, putative 0.0031 0.0128 0.0243
Schistosoma mansoni ap endonuclease 0.0022 0.0053 0.0053
Trichomonas vaginalis phosphofructokinase, putative 0.0247 0.1865 0.3727
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0061 0.0371 0.0756
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0092
Brugia malayi chromobox protein homolog 3 0.021 0.1566 0.3175
Entamoeba histolytica hypothetical protein 0.01 0.068 0.1384
Schistosoma mansoni caspase-3 (C14 family) 0.0027 0.0098 0.0098
Trypanosoma cruzi DNA polymerase kappa, putative 0.0268 0.2028 0.4127
Schistosoma mansoni DNA helicase recq5 0.003 0.0117 0.0117
Plasmodium vivax phosphoglycerate kinase, putative 0.0627 0.4914 1
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0627 0.4914 1
Plasmodium falciparum small ubiquitin-related modifier 0.0162 0.1177 0.2381
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0371 0.0655
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0237 0.0237
Schistosoma mansoni smad1 5 8 and 0.0017 0.0014 0.0014
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0233 0.0348
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0062 0.0083
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.023 0.1727 0.3502
Plasmodium falciparum phd finger protein, putative 0.0092 0.0618 0.1242
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0042
Toxoplasma gondii PHD-finger domain-containing protein 0.0092 0.0618 0.1258
Schistosoma mansoni phd/f-box containing protein 0.003 0.0117 0.0117
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.003 0.0117 0.0167
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0061 0.0371 0.0655
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0117 0.0239
Brugia malayi polk-prov protein 0.0102 0.07 0.1409
Trichomonas vaginalis phosphofructokinase, putative 0.0067 0.0415 0.0745
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0032 0.0035
Onchocerca volvulus 0.0018 0.0021 0.0033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0061 0.0371 0.0655
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0012
Mycobacterium ulcerans hypothetical protein 0.0074 0.0476 0.087
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0012 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0268 0.2028 0.4116
Trichomonas vaginalis conserved hypothetical protein 0.01 0.068 0.129
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0053 0.0108
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0061 0.0371 0.0756
Leishmania major GTP-binding protein, putative 0.0023 0.0062 0.0109
Loa Loa (eye worm) ATP-dependent DNA helicase 0.003 0.0117 0.0238
Brugia malayi MH2 domain containing protein 0.0017 0.0014 0.0011
Entamoeba histolytica phosphofructokinase, putative 0.0247 0.1865 0.3795
Plasmodium vivax 6-phosphofructokinase, putative 0.0067 0.0415 0.0828
Loa Loa (eye worm) hypothetical protein 0.0061 0.0371 0.0756
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0476 0.0952
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0371 0.0655
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0128 0.0261
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0061 0.0371 0.0655
Schistosoma mansoni DNA polymerase eta 0.0403 0.3115 0.3115
Echinococcus multilocularis lysine specific demethylase 5A 0.0112 0.0774 0.1187
Onchocerca volvulus Cell death protein 3 homolog 0.0027 0.0098 0.0293
Echinococcus granulosus dna polymerase eta 0.0403 0.3115 0.482
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.1509 0.2995
Loa Loa (eye worm) CXXC zinc finger family protein 0.0069 0.0436 0.0888
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0199
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0041 0.0207 0.0422
Schistosoma mansoni SET domain protein 0.0034 0.0155 0.0155
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.003 0.0117 0.0219
Trypanosoma brucei DNA polymerase kappa, putative 0.0172 0.1262 0.2554
Echinococcus granulosus 6 phosphofructokinase 0.0247 0.1865 0.288
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0009 0.0019
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.023 0.1727 0.3515
Brugia malayi hypothetical protein 0.01 0.068 0.1368
Entamoeba histolytica hypothetical protein 0.0061 0.0371 0.0756
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0205 0.0303
Plasmodium vivax small ubiquitin-related modifier, putative 0.0162 0.1177 0.2381
Trypanosoma brucei metacaspase 5, putative 0.0027 0.0098 0.0181
Onchocerca volvulus 0.0019 0.0032 0.0071
Echinococcus granulosus snurportin 1 0.0332 0.2545 0.3936
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.003 0.0117 0.0221
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0067 0.0415 0.0745
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.012 0.0245
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0268 0.2028 0.4062
Trypanosoma brucei DNA polymerase kappa, putative 0.0268 0.2028 0.4116
Plasmodium falciparum importin beta, putative 0.0031 0.0128 0.0243
Schistosoma mansoni DNA polymerase IV / kappa 0.0074 0.0476 0.0476
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0371 0.0655
Brugia malayi Protein kinase domain containing protein 0.0018 0.0021 0.0023
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0205 0.0303
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0032 0.0065
Echinococcus multilocularis phosphoglycerate kinase 1 0.0627 0.4914 0.7613
Leishmania major DNA polymerase kappa, putative 0.0247 0.186 0.3772
Brugia malayi hypothetical protein 0.0019 0.0032 0.0046
Echinococcus granulosus ATP dependent DNA helicase Q1 0.003 0.0117 0.0167
Trypanosoma brucei unspecified product 0.0165 0.1206 0.2441
Trypanosoma cruzi DNA polymerase kappa, putative 0.0268 0.2028 0.4127
Trypanosoma cruzi DNA damage repair protein, putative 0.0074 0.0476 0.0969
Brugia malayi Protein cec-1. 0.0061 0.0371 0.0739
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0117 0.0239
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0012
Echinococcus multilocularis Chromobox protein 3 0.0061 0.0371 0.0562
Schistosoma mansoni Smad4 0.0017 0.0014 0.0014
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.003 0.0117 0.0117
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0061 0.0371 0.0655
Brugia malayi jmjC domain containing protein 0.003 0.0117 0.0221
Plasmodium falciparum heterochromatin protein 1 0.0061 0.0371 0.0739
Brugia malayi jmjC domain containing protein 0.0112 0.0774 0.1559
Brugia malayi MH2 domain containing protein 0.0017 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.003 0.0117 0.0239
Schistosoma mansoni hypothetical protein 0.0061 0.0371 0.0371
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0032 0.0035
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0092
Giardia lamblia DNA damage repair protein 0.0074 0.0476 0.087
Echinococcus granulosus chromobox protein 1 0.0375 0.2889 0.447
Loa Loa (eye worm) CHromoDomain protein family member 0.0061 0.0371 0.0756
Brugia malayi jmjC domain containing protein 0.0302 0.2302 0.4674
Trypanosoma brucei metacaspase MCA3 0.0027 0.0098 0.0181
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0053 0.009
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0627 0.4914 1
Onchocerca volvulus 0.0061 0.0371 0.1211
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0053 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0371 0.0655
Trypanosoma brucei DNA polymerase kappa, putative 0.0268 0.2028 0.4116
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0061 0.0371 0.0655
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0205 0.0311
Plasmodium vivax JmjC domain containing protein 0.003 0.0117 0.0221
Trichomonas vaginalis chromobox protein, putative 0.0061 0.0371 0.0655
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0098 0.0181
Loa Loa (eye worm) hypothetical protein 0.003 0.0117 0.0239
Schistosoma mansoni blooms syndrome DNA helicase 0.0057 0.0334 0.0334
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0014 0.0029
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0299 0.059
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0819 0.6452 1
Trypanosoma brucei DNA polymerase IV, putative 0.0261 0.1972 0.4002
Brugia malayi Ubiquitin-like protein SMT3 0.0162 0.1177 0.2381
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0205 0.0303
Schistosoma mansoni jumonji domain containing protein 0.024 0.1804 0.1804
Echinococcus granulosus lysine specific demethylase 6a 0.003 0.0117 0.0168
Plasmodium falciparum JmjC domain-containing protein, putative 0.003 0.0117 0.0221
Trypanosoma cruzi DNA polymerase kappa, putative 0.0268 0.2028 0.4127
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0076 0.0491 0.0983
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0237 0.0353
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0053 0.0108
Brugia malayi Heterochromatin protein 1 0.0375 0.2889 0.5872
Trypanosoma cruzi polo-like protein kinase, putative 0.0203 0.1509 0.3071
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.024 0.1804 0.1804
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0098 0.0092
Trypanosoma cruzi small ubiquitin protein, putative 0.0162 0.1177 0.2395
Loa Loa (eye worm) 6-phosphofructokinase 0.0247 0.1865 0.3795
Brugia malayi jmjC domain containing protein 0.003 0.0117 0.0221
Echinococcus multilocularis caspase 0.0027 0.0098 0.0138
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.1075 0.1654
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0247 0.1865 0.3795
Loa Loa (eye worm) TK/ALK protein kinase 0.0018 0.0021 0.0042
Echinococcus multilocularis disco interacting protein 2 0.008 0.052 0.0793
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0299 0.059
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0032 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0268 0.2028 0.4116
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0014 0.0008
Entamoeba histolytica Ran family GTPase 0.0023 0.0062 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.1177 0.2312
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0041 0.0207 0.0422
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0032 0.0035
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0012
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0237 0.0482
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0491 0.1
Brugia malayi Smad1 0.0017 0.0014 0.0011
Echinococcus granulosus disco interacting protein 2 0.008 0.052 0.0793
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.1509 0.2995
Schistosoma mansoni hypothetical protein 0.003 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0269 0.2036 0.4142
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0371 0.0655
Loa Loa (eye worm) hypothetical protein 0.0061 0.0371 0.0756
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0371 0.0739
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0117 0.0239
Giardia lamblia Phosphoglycerate kinase 0.0627 0.4914 1
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.1509 0.2995
Brugia malayi mbt repeat family protein 0.0207 0.1538 0.3116
Giardia lamblia Kinase, PLK 0.0203 0.1509 0.2995
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0042
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0205 0.0398
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.023 0.0344
Brugia malayi serine/threonine-protein kinase plk-2 0.0203 0.1509 0.3058
Trypanosoma brucei DNA polymerase kappa, putative 0.0268 0.2028 0.4116
Schistosoma mansoni smad 0.0017 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0371 0.0655
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.024 0.1804 0.3671
Trypanosoma brucei DNA polymerase eta, putative 0.0403 0.3115 0.6331
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0592 0.4628 0.9417
Brugia malayi ImpB/MucB/SamB family protein 0.024 0.1804 0.3659
Loa Loa (eye worm) phosphofructokinase 0.0247 0.1865 0.3795
Trypanosoma brucei DNA polymerase kappa, putative 0.0102 0.07 0.1409
Trypanosoma brucei DNA polymerase kappa, putative 0.0268 0.2028 0.4116
Trichomonas vaginalis phosphofructokinase, putative 0.0067 0.0415 0.0745
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0525 0.1052
Echinococcus multilocularis chromobox protein 2 0.0061 0.0371 0.0562
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.008 0.052 0.052
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0063 0.0385 0.0767
Trypanosoma brucei DNA damage repair protein, putative 0.0074 0.0476 0.0952
Treponema pallidum hypothetical protein 0.0592 0.4628 0.9418
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0009 0.0019
Schistosoma mansoni terminal deoxycytidyl transferase 0.024 0.1804 0.1804
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0247 0.1865 0.3783
Trypanosoma brucei Metacaspase-4 0.0027 0.0098 0.0181
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0053 0.0068
Loa Loa (eye worm) MH2 domain-containing protein 0.0248 0.1871 0.3807
Trypanosoma brucei DNA polymerase kappa, putative 0.0247 0.186 0.3772
Schistosoma mansoni cpg binding protein 0.0069 0.0436 0.0436
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0205 0.0205
Echinococcus granulosus caspase 0.0027 0.0098 0.0138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0237 0.0237
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0076 0.0491 0.1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.023 0.1727 0.3515
Loa Loa (eye worm) hypothetical protein 0.0092 0.0618 0.1258
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0012 0.0004
Echinococcus multilocularis jumonji domain containing protein 0.0128 0.0908 0.1395
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0061 0.0371 0.0739
Loa Loa (eye worm) helicase 0.0061 0.0371 0.0756
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0012 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0172 0.1262 0.2554
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0627 0.4914 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0092
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0092
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0098 0.0199
Trichomonas vaginalis DNA helicase recq, putative 0.0072 0.0455 0.0827
Brugia malayi Bloom's syndrome protein homolog 0.0072 0.0455 0.091
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0061 0.0371 0.0655
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.1041 0.1602
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0235 0.1767 0.3585
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0165 0.1202 0.2445
Schistosoma mansoni 6-phosphofructokinase 0.0247 0.1865 0.1865
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0205 0.0205
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0238 0.1787 0.3636
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0187 0.0362
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0041 0.0207 0.0404
Echinococcus granulosus PHD finger protein rhinoceros 0.0092 0.0618 0.0946
Plasmodium vivax hypothetical protein, conserved 0.003 0.012 0.0227
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0061 0.0371 0.0655
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0065
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0627 0.4914 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0081 0.0057
Echinococcus multilocularis JmjC domain containing protein 4 0.003 0.0117 0.0168
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0036 0.0166 0.0166
Echinococcus granulosus MAM 0.0018 0.0021 0.0018
Leishmania major DNA polymerase eta, putative 0.0238 0.1787 0.3624
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.003 0.012 0.0227
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0205 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0371 0.0655
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0092
Schistosoma mansoni chromobox protein 0.0061 0.0371 0.0371
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.023 0.0365
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0019 0.0032 0.0035
Leishmania major importin beta-1 subunit, putative 0.0025 0.0081 0.0147
Toxoplasma gondii hypothetical protein 0.0175 0.1287 0.2619
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0627 0.4914 1
Giardia lamblia Sentrin 0.0162 0.1177 0.2312
Echinococcus multilocularis smad 0.0017 0.0014 0.0008
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0491 0.1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0012 0.0005
Echinococcus multilocularis PHD finger protein rhinoceros 0.0092 0.0618 0.0946
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.023 0.0365
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.023 0.0469
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0117 0.0219
Echinococcus multilocularis SAM and MBT domain containing protein 0.0207 0.1538 0.2373
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0074 0.0476 0.0969
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0128 0.0243
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0042
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0117 0.0239
Trypanosoma brucei DNA damage repair protein, putative 0.0074 0.0476 0.0952
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0302 0.2302 0.3558
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0021
Echinococcus granulosus Pleckstrin G protein interacting region 0.0019 0.0032 0.0035
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.013 0.0246
Echinococcus granulosus bloom syndrome protein 0.0072 0.0455 0.0693
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0205 0.0303
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0203 0.1509 0.2328
Brugia malayi hypothetical protein 0.0018 0.0021 0.0023
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0012 0.0004
Loa Loa (eye worm) hypothetical protein 0.01 0.068 0.1384
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0061 0.0371 0.0739
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0166 0.0319
Echinococcus multilocularis snurportin 1 0.0332 0.2545 0.3936
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0061 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0065
Mycobacterium ulcerans phosphoglycerate kinase 0.0627 0.4914 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.003 0.012 0.0227
Schistosoma mansoni protein phosphatase 2C 0.003 0.0117 0.0117
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0207 0.1538 0.5125
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.0525 0.1068
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0061 0.0371 0.0562
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0019 0.0032 0.0071
Echinococcus granulosus chromobox protein 1 0.0375 0.2889 0.447
Schistosoma mansoni smad1 5 8 and 0.0017 0.0014 0.0014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0061 0.0371 0.0655
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0381 0.0381
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0098 0.0199
Schistosoma mansoni hypothetical protein 0.0018 0.0021 0.0021
Trypanosoma cruzi phosphoglycerate kinase, putative 0.023 0.1727 0.3515
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0686 0.1301
Trichomonas vaginalis Heterochromatin protein, putative 0.0061 0.0371 0.0655
Onchocerca volvulus Serine\/threonine kinase homolog 0.0203 0.1509 0.5029
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0098 0.0092
Loa Loa (eye worm) DOMON domain-containing protein 0.0016 0.0011 0.0021
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0032 0.0035
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0053 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0098 0.0092
Trypanosoma cruzi metacaspase, putative 0.0027 0.0098 0.0199
Echinococcus multilocularis Chromo domain 0.0061 0.0371 0.0562
Echinococcus multilocularis polycomb protein SCMH1 0.0207 0.1538 0.2373
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.003 0.012 0.0227
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.003 0.012 0.0245
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0187 0.0362
Trichomonas vaginalis chromobox protein, putative 0.0375 0.2889 0.5835
Brugia malayi PHD-finger family protein 0.003 0.012 0.0227
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0205 0.0416
Echinococcus granulosus importin subunit beta 1 0.0031 0.0128 0.0185
Schistosoma mansoni phosphoglycerate kinase 0.0627 0.4914 0.4914
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0201 0.0409
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0061 0.0371 0.0756
Echinococcus granulosus jumonji domain containing 1A 0.003 0.0117 0.0168
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0067 0.0415 0.0828
Echinococcus multilocularis dna polymerase eta 0.0403 0.3115 0.482
Schistosoma mansoni myelin transcription factor 1 myt1 0.0235 0.1767 0.1767
Trichomonas vaginalis ubiquitin, putative 0.01 0.068 0.129
Trichomonas vaginalis chromobox protein, putative 0.0061 0.0371 0.0655
Trypanosoma cruzi DNA polymerase eta, putative 0.0403 0.3115 0.6338
Schistosoma mansoni chromobox protein 0.0061 0.0371 0.0371
Trichomonas vaginalis phosphofructokinase, putative 0.0067 0.0415 0.0745
Brugia malayi Importin beta-1 subunit 0.0031 0.0128 0.0243
Trichomonas vaginalis phosphofructokinase, putative 0.0247 0.1865 0.3727
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0032 0.0035
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0299 0.0608
Plasmodium vivax hypothetical protein, conserved 0.0092 0.0618 0.1242
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0038 0.0187 0.038
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0203 0.1509 0.3071
Trypanosoma brucei phosphoglycerate kinase 0.023 0.1727 0.3502
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0014 0.0008
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0053 0.0108
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0031 0.013 0.013
Schistosoma mansoni dishevelled 0.0019 0.0032 0.0032
Schistosoma mansoni sex comb on midleg homolog 0.0207 0.1538 0.1538
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0041 0.0207 0.0404
Loa Loa (eye worm) hypothetical protein 0.0061 0.0371 0.0756
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0032 0.0035
Giardia lamblia PHD finger protein 15 0.0092 0.0618 0.1163
Brugia malayi MH1 domain containing protein 0.0017 0.0014 0.0011
Echinococcus granulosus DNA methyltransferase 2, putative 0.0041 0.0207 0.0308
Loa Loa (eye worm) hypothetical protein 0.0041 0.0205 0.0416
Echinococcus granulosus SAM and MBT domain containing protein 0.0207 0.1538 0.2373
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0061 0.0371 0.0756
Schistosoma mansoni hypothetical protein 0.0017 0.0012 0.0012
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0592 0.4628 0.9411
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0076 0.0491 0.1
Echinococcus granulosus GPCR family 2 0.0017 0.0012 0.0004
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0032 0.0046
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0041 0.0207 0.0404
Trichomonas vaginalis chromobox protein, putative 0.0375 0.2889 0.5835
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0032 0.0032
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0062 0.0109
Echinococcus granulosus ATP dependent DNA helicase Q5 0.003 0.0117 0.0167
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0117 0.0238
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0098 0.0098
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0027 0.0098 0.0138
Echinococcus multilocularis Smad4 0.0017 0.0014 0.0008
Echinococcus granulosus phosphoglycerate kinase 1 0.0627 0.4914 0.7613
Echinococcus granulosus phd:f box containing protein 0.003 0.0117 0.0168
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0061 0.0371 0.0655
Echinococcus multilocularis caspase 2 0.0027 0.0098 0.0138
Brugia malayi hypothetical protein 0.0019 0.0032 0.0046
Plasmodium falciparum metacaspase 1 0.0027 0.0098 0.0181
Loa Loa (eye worm) hypothetical protein 0.008 0.052 0.1058
Brugia malayi jmjC domain containing protein 0.003 0.0117 0.0221
Giardia lamblia Sgs1 DNA helicase, putative 0.003 0.0117 0.0131
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0098 0.0098
Brugia malayi Disco-interacting protein 2 homolog 0.008 0.052 0.1041
Echinococcus multilocularis MAM 0.0018 0.0021 0.0018
Echinococcus granulosus smad 0.0017 0.0014 0.0008
Onchocerca volvulus 0.0061 0.0371 0.1211
Schistosoma mansoni hypothetical protein 0.0348 0.2673 0.2673
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0476 0.0969
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0062 0.0127
Brugia malayi Muscle positioning protein 4 0.0016 0.0011 0.0003
Plasmodium falciparum phosphoglycerate kinase 0.0627 0.4914 1
Brugia malayi mbt repeat family protein 0.0207 0.1538 0.3116
Trypanosoma brucei unspecified product 0.0165 0.1206 0.2441
Leishmania major DNA polymerase eta, putative 0.0403 0.3115 0.6331
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0081 0.0057
Loa Loa (eye worm) hypothetical protein 0.0031 0.0128 0.0261
Trypanosoma brucei chrX additional, unordered contigs 0.0074 0.0476 0.0952
Leishmania major hypothetical protein, conserved 0.003 0.0117 0.0221
Entamoeba histolytica hypothetical protein 0.0061 0.0371 0.0756
Loa Loa (eye worm) hypothetical protein 0.0158 0.1147 0.2334
Echinococcus granulosus geminin 0.0348 0.2673 0.4135
Brugia malayi RNA, U transporter 1 0.0088 0.0589 0.1182
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0012 0.0004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0199
Schistosoma mansoni hypothetical protein 0.0036 0.0169 0.0169
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.024 0.1804 0.2786
Brugia malayi SET domain containing protein 0.0063 0.0381 0.0757
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0041 0.0207 0.0308
Schistosoma mansoni sex comb on midleg homolog 0.0207 0.1538 0.1538
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0525 0.1052
Loa Loa (eye worm) jmjC domain-containing protein 0.019 0.1406 0.2861
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0062 0.0019
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0203 0.1509 0.2328
Echinococcus granulosus caspase 8 0.0027 0.0098 0.0138
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0592 0.4628 0.9417
Trypanosoma brucei DNA polymerase kappa, putative 0.0172 0.1262 0.2554
Brugia malayi Phosphoglycerate kinase 0.0627 0.4914 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0048 0.0264 0.0537
Trichomonas vaginalis phosphofructokinase, putative 0.0247 0.1865 0.3727
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0061 0.0371 0.0655
Schistosoma mansoni DNA helicase recq1 0.003 0.0117 0.0117
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.023 0.1727 0.3515
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0053 0.0108
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0061 0.0371 0.0655
Loa Loa (eye worm) hypothetical protein 0.003 0.012 0.0245
Echinococcus granulosus JmjC domain containing protein 4 0.003 0.0117 0.0168
Trypanosoma cruzi small ubiquitin protein, putative 0.0162 0.1177 0.2395
Schistosoma mansoni chromobox protein 0.0375 0.2889 0.2889
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0032 0.0046
Schistosoma mansoni chromobox protein 0.0375 0.2889 0.2889
Schistosoma mansoni jumonji/arid domain-containing protein 0.0112 0.0774 0.0774
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0098 0.0199
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0061 0.0371 0.0756
Echinococcus multilocularis 6 phosphofructokinase 0.0247 0.1865 0.288
Entamoeba histolytica deoxycytidyl transferase, putative 0.024 0.1804 0.3671
Echinococcus granulosus lysine specific demethylase 5A 0.0112 0.0774 0.1187
Echinococcus granulosus cpg binding protein 0.0069 0.0436 0.0663
Trichomonas vaginalis conserved hypothetical protein 0.021 0.1566 0.3113
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0098 0.0199
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0014 0.0008
Schistosoma mansoni hypothetical protein 0.0018 0.0021 0.0021
Trypanosoma brucei metacaspase 0.0027 0.0098 0.0181
Brugia malayi MH1 domain containing protein 0.0017 0.0014 0.0011
Plasmodium falciparum metacaspase-like protein 0.0027 0.0098 0.0181
Echinococcus multilocularis phd:f box containing protein 0.003 0.0117 0.0168
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0525 0.1068
Echinococcus multilocularis cpg binding protein 0.0069 0.0436 0.0663
Trypanosoma brucei metacaspase MCA2 0.0027 0.0098 0.0181
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0061 0.0371 0.0655
Echinococcus multilocularis peregrin 0.0106 0.0728 0.1116
Plasmodium vivax heterochromatin protein 1, putative 0.0061 0.0371 0.0739
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0053 0.0068
Echinococcus multilocularis histone acetyltransferase MYST2 0.0235 0.1767 0.2729
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0237 0.0353
Trypanosoma cruzi DNA polymerase eta, putative 0.0238 0.1787 0.3636
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0092
Loa Loa (eye worm) RecQ helicase 0.0072 0.0455 0.0927
Brugia malayi phosphofructokinase 0.0247 0.1865 0.3783
Echinococcus granulosus peregrin 0.0106 0.0728 0.1116
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0076 0.0491 0.0983
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0014 0.0029
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0062 0.0127
Toxoplasma gondii phosphofructokinase PFKII 0.0067 0.0415 0.0845
Leishmania major modification methylase-like protein 0.0041 0.0207 0.0404
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0041 0.0207 0.0207
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0076 0.0491 0.0491
Trypanosoma cruzi metacaspase, putative 0.0027 0.0098 0.0199
Echinococcus granulosus caspase 2 0.0027 0.0098 0.0138
Trichomonas vaginalis phosphofructokinase, putative 0.0247 0.1865 0.3727
Loa Loa (eye worm) hypothetical protein 0.0627 0.4914 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0235 0.1767 0.2729
Brugia malayi Valyl-tRNA synthetase 0.0061 0.0371 0.0739
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0032 0.0035
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0205 0.0311
Loa Loa (eye worm) hypothetical protein 0.0403 0.3115 0.6338
Loa Loa (eye worm) DIX domain-containing protein 0.0019 0.0032 0.0065
Schistosoma mansoni dep domain containing protein 0.0019 0.0032 0.0032
Plasmodium vivax 6-phosphofructokinase, putative 0.0067 0.0415 0.0828
Schistosoma mansoni hypothetical protein 0.0016 0.0011 0.0011
Brugia malayi Cell death protein 3 precursor 0.0027 0.0098 0.0181
Trypanosoma cruzi DNA damage repair protein, putative 0.0074 0.0476 0.0969
Trichomonas vaginalis phosphofructokinase, putative 0.0067 0.0415 0.0745
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0061 0.0371 0.0756
Schistosoma mansoni jumonji/arid domain-containing protein 0.0112 0.0774 0.0774
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0627 0.4914 1
Schistosoma mansoni importin beta-1 0.0031 0.0128 0.0128
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0525 0.1068
Loa Loa (eye worm) PHD-finger family protein 0.0092 0.0618 0.1258
Trichomonas vaginalis chromobox protein, putative 0.0226 0.1694 0.3376
Trichomonas vaginalis phosphofructokinase, putative 0.0067 0.0415 0.0745
Echinococcus multilocularis Small ubiquitin modifier 2 0.0162 0.1177 0.1812
Echinococcus granulosus chromobox protein 2 0.0061 0.0371 0.0562
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0065
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0117 0.0168
Entamoeba histolytica serine/threonine protein kinase, putative 0.0203 0.1509 0.3071
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0169 0.0247
Brugia malayi Phosphoglycerate kinase 0.023 0.1727 0.3502
Leishmania major small ubiquitin protein, putative 0.0162 0.1177 0.2381
Loa Loa (eye worm) hypothetical protein 0.0102 0.07 0.1425
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0009 0.0019
Plasmodium vivax DNA repair protein REV1, putative 0.0074 0.0476 0.0952
Toxoplasma gondii DNA methyltransferase 2, putative 0.0041 0.0207 0.0422
Trichomonas vaginalis chromobox protein, putative 0.0061 0.0371 0.0655
Schistosoma mansoni hypothetical protein 0.0348 0.2673 0.2673
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.1074 0.2099
Leishmania major metacaspase, putative 0.0027 0.0098 0.0181
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0061 0.0371 0.0371
Brugia malayi DIX domain containing protein 0.0019 0.0032 0.0046
Toxoplasma gondii histone lysine demethylase JMJD6a 0.003 0.0117 0.0239
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.003 0.0117 0.0239
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0205 0.0398
Echinococcus multilocularis geminin 0.0348 0.2673 0.4135
Brugia malayi hypothetical protein 0.0052 0.0296 0.0585
Brugia malayi jmjC domain containing protein 0.003 0.0117 0.0221
Entamoeba histolytica hypothetical protein 0.0061 0.0371 0.0756
Schistosoma mansoni ran 0.0023 0.0062 0.0062
Loa Loa (eye worm) MBCTL1 0.0235 0.1767 0.3597
Brugia malayi CXXC zinc finger family protein 0.0069 0.0436 0.0871
Brugia malayi 6-phosphofructokinase 0.0247 0.1865 0.3783
Brugia malayi Bromodomain containing protein 0.0096 0.0648 0.1302
Loa Loa (eye worm) hypothetical protein 0.0052 0.0299 0.0608
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0061 0.0371 0.0562
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0098 0.0092
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0053 0.009
Brugia malayi MH2 domain containing protein 0.0248 0.1871 0.3795
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0117 0.0219
Onchocerca volvulus 0.0063 0.0381 0.1242
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0627 0.4914 1
Loa Loa (eye worm) hypothetical protein 0.021 0.1566 0.3187
Trichomonas vaginalis chromobox protein, putative 0.0226 0.1694 0.3376
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0067 0.0415 0.0828
Brugia malayi AF-10 protein 0.003 0.012 0.0227
Echinococcus multilocularis bloom syndrome protein 0.0072 0.0455 0.0693
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0205 0.0303
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0203 0.1509 0.3058
Plasmodium falciparum DNA repair protein REV1, putative 0.0074 0.0476 0.0952
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0061 0.0371 0.0371
Trypanosoma brucei phosphoglycerate kinase, putative 0.023 0.1727 0.3502
Brugia malayi 6-phosphofructokinase 0.0247 0.1865 0.3783
Echinococcus multilocularis dna polymerase kappa 0.0268 0.2028 0.3133
Loa Loa (eye worm) hypothetical protein 0.0388 0.2991 0.6086
Echinococcus granulosus jumonji domain containing protein 0.0128 0.0908 0.1395
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0371 0.0655
Echinococcus multilocularis ubiquitin 0.01 0.068 0.1042
Loa Loa (eye worm) jmjC domain-containing protein 0.0112 0.0774 0.1575
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0081 0.0532 0.1082
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.0525 0.1052
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0053 0.009
Brugia malayi N-terminal motif family protein 0.0388 0.2991 0.6079

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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