Detailed information for compound 1151219

Basic information

Technical information
  • TDR Targets ID: 1151219
  • Name: 1-(2-fluorophenyl)-N,N-dimethyl-1,4-dihydrois oquinolin-3-amine
  • MW: 268.329 | Formula: C17H17FN2
  • H donors: 0 H acceptors: 0 LogP: 2.76 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C1=NC(c2c(C1)cccc2)c1ccccc1F)C
  • InChi: 1S/C17H17FN2/c1-20(2)16-11-12-7-3-4-8-13(12)17(19-16)14-9-5-6-10-15(14)18/h3-10,17H,11H2,1-2H3
  • InChiKey: CRXJXQDPESGACJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-(2-fluorophenyl)-1,4-dihydroisoquinolin-3-yl]-dimethyl-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans ATPase 0.0018 0.0499 0.5
Schistosoma mansoni cell division control protein 48 aaa family protein 0.003 0.1347 0.1252
Giardia lamblia AAA family ATPase 0.0018 0.0499 0.5
Toxoplasma gondii fructose-bisphospatase I 0.0057 0.3239 0.2883
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0152 1 1
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0057 0.3239 0.2283
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0152 1 1
Entamoeba histolytica cdc48-like protein, putative 0.0028 0.1238 0.5
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0152 1 1
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0028 0.1238 1
Toxoplasma gondii fructose-bisphospatase II 0.0152 1 1
Toxoplasma gondii cell division protein CDC48AP 0.0018 0.0499 0.00000087414
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0152 1 1
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0057 0.3239 0.2283
Leishmania major 0.0152 1 1
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.003 0.1347 0.1252
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0152 1 1
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0028 0.1238 0.5
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.003 0.1347 0.5
Mycobacterium tuberculosis Putative conserved ATPase 0.0018 0.0499 0.5
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0057 0.3239 0.2883
Loa Loa (eye worm) hypothetical protein 0.0017 0.0474 0.0369
Brugia malayi valosin containing protein 0.0017 0.0474 0.0369
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0057 0.3239 0.2283
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0028 0.1238 0.5
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0028 0.1238 0.1142
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0152 1 1
Loa Loa (eye worm) vesicle-fusing ATPase 0.0017 0.0474 0.0369
Brugia malayi vesicle-fusing ATPase 0.0017 0.0474 0.0369
Trichomonas vaginalis spermatogenesis associated factor, putative 0.003 0.1347 0.5
Toxoplasma gondii cell division protein CDC48CY 0.003 0.1347 0.0892
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0152 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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