Detailed information for compound 1151614

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 200.256 | Formula: C13H14NO+
  • H donors: 1 H acceptors: 1 LogP: 2.62 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[n+]1ccc(cc1)c1ccc(c(c1)C)O
  • InChi: 1S/C13H13NO/c1-10-9-12(3-4-13(10)15)11-5-7-14(2)8-6-11/h3-9H,1-2H3/p+1
  • InChiKey: SMJQUANITFUAKT-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0031 0.0079 0.0066
Loa Loa (eye worm) TAR-binding protein 0.0139 0.0662 0.0672
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0584 0.0591
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0202 0.0202
Brugia malayi Calcitonin receptor-like protein seb-1 0.0164 0.0797 0.0789
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0254 0.1281 0.2031
Loa Loa (eye worm) hypothetical protein 0.0147 0.0702 0.0713
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0254 0.1281 0.3324
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0173 0.0135
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0254 0.1281 0.3324
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0202 0.017
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0039
Brugia malayi hypothetical protein 0.0496 0.258 0.2645
Brugia malayi MH2 domain containing protein 0.0125 0.0584 0.0568
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0288 0.0284
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0066 0.0268 0.0268
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0254 0.1281 0.1247
Echinococcus granulosus neuropeptide s receptor 0.0483 0.2509 0.248
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0066 0.0268 0.023
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0715 0.3756 0.3756
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0254 0.1281 0.3324
Echinococcus granulosus chromobox protein 1 0.007 0.0288 0.0251
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0039 0.0039
Chlamydia trachomatis dihydrolipoamide acetyltransferase 0.0066 0.0268 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0124 0.3423
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1359 0.7213 1
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0066 0.0268 0.0153
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.014 0.1039
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0194 0.0161
Echinococcus multilocularis chromobox protein 1 0.007 0.0288 0.0251
Echinococcus multilocularis neuropeptide receptor A26 0.0483 0.2509 0.248
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0662 0.0625
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0066 0.0268 0.023
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0066 0.0268 0.0153
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0039 0.0025
Echinococcus multilocularis chromobox protein 1 0.007 0.0288 0.0251
Loa Loa (eye worm) hypothetical protein 0.0066 0.0268 0.0263
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0164 0.0797 0.0812
Chlamydia trachomatis acetyl-CoA carboxylase biotin carboxyl carrier protein 0.0066 0.0268 0.0747
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0066 0.0268 0.0351
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0066 0.0268 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0039
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0066 0.0268 0.0153
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0049 0.0105
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0186
Loa Loa (eye worm) hypothetical protein 0.0164 0.0797 0.0812
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0162 0.0783 0.1067
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0101 0.0458 0.0437
Loa Loa (eye worm) RNA binding protein 0.0139 0.0662 0.0672
Brugia malayi hypothetical protein 0.0147 0.0702 0.0691
Leishmania major DNA polymerase eta, putative 0.0038 0.0117 0.0078
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0162 0.0783 0.1476
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0173 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0039
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0715 0.3756 0.3732
Echinococcus granulosus microtubule associated protein 2 0.0826 0.435 0.4329
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0049 0.0105
Brugia malayi TAR-binding protein 0.0139 0.0662 0.0648
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0173 0.0135
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0066 0.0268 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0063 0.0974
Schistosoma mansoni hypothetical protein 0.038 0.1954 0.1923
Trichomonas vaginalis chromobox protein, putative 0.0042 0.014 0.406
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.024 0.0603
Schistosoma mansoni aspartate carbamoyltransferase 0.0162 0.0783 0.0747
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0066 0.0268 0.0375
Echinococcus multilocularis Biotin lipoyl attachment 0.0066 0.0268 0.023
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0254 0.1281 0.3385
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0066 0.0268 0.0676
Echinococcus multilocularis survival motor neuron protein 1 0.0496 0.258 0.2551
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0715 0.3756 0.3756
Trypanosoma brucei acetyl-CoA carboxylase 0.1878 1 1
Mycobacterium ulcerans hypothetical protein 0.0066 0.0268 0.0676
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.024 0.0203
Schistosoma mansoni survival motor neuron protein 0.0101 0.0458 0.0421
Brugia malayi RNA binding protein 0.0139 0.0662 0.0648
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0254 0.1281 0.1247
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.1878 1 1
Schistosoma mansoni pyruvate carboxylase 0.0715 0.3756 0.3732
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0039 0.0039
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0066 0.0268 0.069
Onchocerca volvulus 0.0031 0.0079 0.0342
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0049 0.001
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0662 0.0625
Schistosoma mansoni hypothetical protein 0.0101 0.0458 0.0421
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0162 0.0783 0.1216
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0039
Trichomonas vaginalis chromobox protein, putative 0.007 0.0288 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0124 0.0113
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0715 0.3756 1
Schistosoma mansoni acetyl-CoA carboxylase 0.1878 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0202 0.0268
Echinococcus granulosus chromobox protein 1 0.007 0.0288 0.0251
Trypanosoma cruzi acetyl-CoA carboxylase 0.1162 0.6158 1
Schistosoma mansoni hypothetical protein 0.0052 0.0194 0.0156
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0066 0.0268 0.0239
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0117 0.0128
Schistosoma mansoni hypothetical protein 0.0052 0.0194 0.0156
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0173 0.0135
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0066 0.0268 0.0268
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0254 0.1281 0.1281
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0066 0.0268 0.0591
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.024 0.0203
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0162 0.0783 0.0783
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0715 0.3756 1
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0162 0.0783 0.2053
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1359 0.7213 1
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0715 0.3756 0.6075
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0066 0.0268 0.0153
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0066 0.0268 0.069
Schistosoma mansoni chromobox protein 0.007 0.0288 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0063 0.0974
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0194 0.0156
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0194 0.0161
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0039 0.0064
Echinococcus multilocularis neuropeptide s receptor 0.0483 0.2509 0.248
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0039
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0066 0.0268 0.023
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0194 0.0156
Echinococcus multilocularis geminin 0.038 0.1954 0.1923
Trichomonas vaginalis chromobox protein, putative 0.007 0.0288 1
Echinococcus multilocularis dna polymerase eta 0.0054 0.0202 0.0164
Schistosoma mansoni hypothetical protein 0.0112 0.0518 0.0481
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0254 0.1281 0.3738
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.1878 1 1
Mycobacterium ulcerans hypothetical protein 0.0025 0.0049 0.0091
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0715 0.3756 0.3732
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0173 0.014
Schistosoma mansoni hypothetical protein 0.0052 0.0194 0.0156
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0066 0.0268 0.0375
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0049 0.0011
Loa Loa (eye worm) hypothetical protein 0.0496 0.258 0.2663
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0049 0.001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0173 0.0165
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0254 0.1281 0.3385
Echinococcus granulosus tar DNA binding protein 0.0139 0.0662 0.0625
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0715 0.3756 0.3732
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0164 0.0797 0.0789
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0254 0.1281 0.1247
Loa Loa (eye worm) hypothetical protein 0.0054 0.0202 0.0195
Schistosoma mansoni microtubule-associated protein tau 0.0826 0.435 0.4329
Brugia malayi N-terminal motif family protein 0.0189 0.0927 0.0925
Plasmodium falciparum carbamoyl phosphate synthetase 0.0162 0.0783 0.1067
Onchocerca volvulus 0.0101 0.0458 0.466
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0066 0.0268 0.023
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0039 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0124 0.3423
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0066 0.0268 0.0747
Schistosoma mansoni hypothetical protein 0.0052 0.0194 0.0156
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0066 0.0268 0.0375
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0049 0.0064
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.024 0.0603
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0066 0.0268 0.023
Schistosoma mansoni hypothetical protein 0.038 0.1954 0.1923
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.0035
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.024 0.0603
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0049 0.0091
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0015 0.0015
Onchocerca volvulus Huntingtin homolog 0.0147 0.0702 0.7436
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0254 0.1281 0.1247
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0162 0.0783 0.0747
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0194 0.0156
Leishmania major carboxylase, putative 0.0715 0.3756 0.3732
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0139 0.0662 0.0672
Echinococcus granulosus Biotin lipoyl attachment 0.0066 0.0268 0.023
Toxoplasma gondii pyruvate carboxylase 0.0715 0.3756 0.3682
Loa Loa (eye worm) hypothetical protein 0.0066 0.0268 0.0263
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0254 0.1281 0.3395
Schistosoma mansoni DNA polymerase eta 0.0054 0.0202 0.0164
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0715 0.3756 1
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0162 0.0783 0.0747
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0066 0.0268 0.023
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0124 0.0858
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0173 0.0135
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.024 0.0203
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.0035
Trichomonas vaginalis chromobox protein, putative 0.0042 0.014 0.406
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0066 0.0268 0.0375
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0049 0.0091
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0049 0.0091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0173 0.0135
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0715 0.3756 1
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.1812 0.9647 1
Leishmania major carbamoyl-phosphate synthase, putative 0.0162 0.0783 0.0747
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.024 0.0125
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0066 0.0268 0.0591
Brugia malayi RNA recognition motif domain containing protein 0.0139 0.0662 0.0648
Chlamydia trachomatis biotin carboxylase 0.0649 0.3403 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0173 0.0135
Treponema pallidum pyruvate carboxylase subunit B 0.0066 0.0268 0.5
Echinococcus granulosus survival motor neuron protein 1 0.0496 0.258 0.2551
Loa Loa (eye worm) hypothetical protein 0.0189 0.0927 0.0947
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.1878 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0112 0.0518 0.0499
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0049 0.0091
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0066 0.0268 0.0153
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0039 0.0078
Brugia malayi Heterochromatin protein 1 0.007 0.0288 0.026
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0254 0.1281 0.3385
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0066 0.0268 0.0351
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0039
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0049 0.0091
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0066 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0066 0.0268 0.0263
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0194 0.0156
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0066 0.0268 0.023
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0049 0.0064
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0194 0.0186
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0066 0.0268 0.0375
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0049 0.0091
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0662 0.0625
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0254 0.1281 0.3385
Brugia malayi chromobox protein homolog 3 0.0039 0.0124 0.0089
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0254 0.1281 0.2031
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0049 0.001
Echinococcus granulosus dna polymerase eta 0.0054 0.0202 0.0164
Echinococcus multilocularis microtubule associated protein 2 0.0826 0.435 0.4329
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0066 0.0268 0.0351
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.024 0.0203
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0584 0.0591
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0039 0.0078
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0066 0.0268 0.023
Loa Loa (eye worm) hypothetical protein 0.0112 0.0518 0.0522
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0715 0.3756 0.3732
Echinococcus granulosus geminin 0.038 0.1954 0.1923
Echinococcus granulosus neuropeptide receptor A26 0.0483 0.2509 0.248
Entamoeba histolytica acetyl-coA carboxylase, putative 0.032 0.1634 1
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0254 0.1281 0.1247
Schistosoma mansoni chromobox protein 0.007 0.0288 0.0251
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.032 0.1634 1
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0715 0.3756 0.3732
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0066 0.0268 0.0375
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0039
Mycobacterium ulcerans pyruvate carboxylase 0.0715 0.3756 1
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0715 0.3756 0.6075
Brugia malayi Carboxyl transferase domain containing protein 0.1812 0.9647 1
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0254 0.1281 0.1178
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0039
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0189 0.0927 1
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0662 0.0625
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0066 0.0268 0.023
Onchocerca volvulus Huntingtin homolog 0.0147 0.0702 0.7436
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0039
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0715 0.3756 1
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0066 0.0268 0.0747
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0254 0.1281 0.2905
Echinococcus multilocularis tar DNA binding protein 0.0139 0.0662 0.0625
Trypanosoma brucei unspecified product 0.0023 0.0039 0.0039
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0066 0.0268 0.0375
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0066 0.0268 0.023
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.024 0.0617
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0066 0.0268 0.023
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0715 0.3756 1
Toxoplasma gondii carbamoylphosphate synthetase 0.0162 0.0783 0.0674
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0662 0.0625
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0049 0.0064
Loa Loa (eye worm) hypothetical protein 0.0147 0.0702 0.0713
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0254 0.1281 0.2031
Leishmania major DNA polymerase eta, putative 0.0054 0.0202 0.0164
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0254 0.1281 0.3385
Echinococcus granulosus GPCR family 2 0.0052 0.0194 0.0156
Echinococcus multilocularis GPCR, family 2 0.0052 0.0194 0.0156
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0066 0.0268 0.0268
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0049 0.0011
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0066 0.0268 0.023
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0039
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.024 0.0203
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0049 0.0011
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0254 0.1281 0.3385
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0049 0.0091
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0162 0.0783 0.1216
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0066 0.0268 0.0676
Leishmania major acetyl-CoA carboxylase, putative 0.1878 1 1
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0715 0.3756 1
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0254 0.1281 0.3395
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0066 0.0268 0.069
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0066 0.0268 0.0351
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0066 0.0268 0.0351
Trypanosoma brucei unspecified product 0.047 0.244 0.244

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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