Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.0352 | 0.041 |
Brugia malayi | hypothetical protein | 0.0593 | 0.4652 | 0.5432 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1264 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0171 | 0.1282 | 0.1497 |
Schistosoma mansoni | lamin | 0.0031 | 0.0168 | 0.0142 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1084 | 0.8564 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0154 | 0.1152 | 0.1344 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0018 | 0.0068 | 0.0022 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.1405 | 0.1595 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0048 | 0.0304 | 0.0258 |
Schistosoma mansoni | dihydrofolate reductase | 0.0403 | 0.3132 | 0.3623 |
Echinococcus granulosus | lamin | 0.0031 | 0.0168 | 0.0195 |
Brugia malayi | CXXC zinc finger family protein | 0.0032 | 0.0179 | 0.0209 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0018 | 0.0068 | 0.0025 |
Brugia malayi | hypothetical protein | 0.0031 | 0.0168 | 0.0196 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0135 | 0.0999 | 0.1118 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0168 | 0.0196 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0122 | 0.0891 | 0.0991 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0352 | 0.0358 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0054 | 0.0352 | 0.041 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0018 | 0.0068 | 0.0025 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0016 | 0.0047 | 0.0053 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0593 | 0.4652 | 0.5407 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0068 | 0.0022 |
Brugia malayi | Cytochrome P450 family protein | 0.0016 | 0.0047 | 0.0055 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0014 | 0.0029 | 0.0034 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0154 | 0.1152 | 0.1345 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0018 | 0.0068 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0851 | 0.0993 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0016 | 0.0047 | 0.0053 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0018 | 0.0068 | 0.0079 |
Schistosoma mansoni | hypothetical protein | 0.0117 | 0.0851 | 0.0945 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1264 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0053 | 0.0061 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0168 | 0.0196 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0048 | 0.0304 | 0.0237 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0053 | 0.0346 | 0.0301 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0135 | 0.0994 | 0.116 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0068 | 0.0022 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0048 | 0.0304 | 0.0258 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0352 | 0.0358 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0403 | 0.3132 | 0.3623 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1084 | 0.8564 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0018 | 0.0068 | 0.0022 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0403 | 0.3132 | 0.3623 |
Echinococcus granulosus | dihydrofolate reductase | 0.0403 | 0.3132 | 0.3657 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0054 | 0.0352 | 0.0411 |
Brugia malayi | thymidylate synthase | 0.1084 | 0.8564 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0069 | 0.0469 | 0.0495 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0022 | 0.0093 | 0.0107 |
Brugia malayi | hypothetical protein | 0.0141 | 0.1043 | 0.1218 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0135 | 0.0999 | 0.1118 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0018 | 0.0068 | 0.0022 |
Echinococcus granulosus | thymidylate synthase | 0.1084 | 0.8564 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0014 | 0.0029 | 0.0034 |
Treponema pallidum | NADH oxidase | 0.0018 | 0.0068 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0053 | 0.0346 | 0.0403 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0048 | 0.0304 | 0.0258 |
Plasmodium falciparum | glutathione reductase | 0.0053 | 0.0346 | 0.028 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.1405 | 0.1595 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0018 | 0.0068 | 0.0022 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0068 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0036 | 0.0041 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0461 | 0.3598 | 0.4201 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0032 | 0.0179 | 0.0208 |
Leishmania major | hypothetical protein, conserved | 0.0048 | 0.0304 | 0.0258 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0168 | 0.0195 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0403 | 0.3132 | 0.3623 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0068 | 0.0022 |
Echinococcus multilocularis | 0.0016 | 0.0047 | 0.0053 | |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.1282 | 0.1496 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0093 | 0.0054 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0048 | 0.0304 | 0.0258 |
Brugia malayi | hypothetical protein | 0.0048 | 0.0304 | 0.0355 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0154 | 0.1152 | 0.1297 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0015 | 0.004 | 0.0046 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0168 | 0.0195 |
Onchocerca volvulus | 0.0032 | 0.0179 | 0.0013 | |
Schistosoma mansoni | hypothetical protein | 0.0461 | 0.3598 | 0.417 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0171 | 0.1282 | 0.1496 |
Echinococcus granulosus | cpg binding protein | 0.0034 | 0.0194 | 0.0225 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1264 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0168 | 0.0142 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0053 | 0.0346 | 0.0403 |
Brugia malayi | Cytochrome P450 family protein | 0.0016 | 0.0047 | 0.0055 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0403 | 0.3132 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.004 | 0.0046 |
Brugia malayi | Cytochrome P450 family protein | 0.0101 | 0.0724 | 0.0845 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.0352 | 0.041 |
Echinococcus multilocularis | geminin | 0.0186 | 0.1405 | 0.164 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.0047 | 0.0053 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.0194 | 0.0173 |
Echinococcus multilocularis | cpg binding protein | 0.0034 | 0.0194 | 0.0225 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0018 | 0.0068 | 0.0025 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0068 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0048 | 0.0304 | 0.0237 |
Mycobacterium tuberculosis | Probable reductase | 0.0122 | 0.0891 | 0.0991 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0122 | 0.0891 | 0.0991 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0101 | 0.0724 | 0.0844 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0168 | 0.0195 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0168 | 0.0195 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0168 | 0.0195 |
Brugia malayi | Dihydrofolate reductase | 0.0403 | 0.3132 | 0.3657 |
Brugia malayi | dihydrofolate reductase family protein | 0.0403 | 0.3132 | 0.3657 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.0068 | 0.008 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0154 | 0.1152 | 0.1344 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.0194 | 0.0173 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0068 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.1043 | 0.1217 |
Loa Loa (eye worm) | thymidylate synthase | 0.1084 | 0.8564 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0168 | 0.0195 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0068 | 0.0022 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0403 | 0.3132 | 0.3657 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0054 | 0.0352 | 0.0411 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0179 | 0.0156 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0048 | 0.0304 | 0.0237 |
Loa Loa (eye worm) | cytochrome P450 | 0.0016 | 0.0047 | 0.0053 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0061 | 0.041 | 0.0365 |
Onchocerca volvulus | 0.1084 | 0.8564 | 1 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0171 | 0.1282 | 0.1497 |
Brugia malayi | MH2 domain containing protein | 0.0135 | 0.0994 | 0.1161 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0117 | 0.0851 | 0.0994 |
Echinococcus granulosus | dnaJ subfamily B | 0.0461 | 0.3598 | 0.4201 |
Mycobacterium ulcerans | thymidylate synthase | 0.1084 | 0.8564 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0135 | 0.0999 | 0.1118 |
Plasmodium vivax | glutathione reductase, putative | 0.0053 | 0.0346 | 0.028 |
Onchocerca volvulus | Huntingtin homolog | 0.0141 | 0.1043 | 0.1042 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0018 | 0.0068 | 0.0025 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0018 | 0.0068 | 0.0025 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1264 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0135 | 0.0994 | 0.116 |
Toxoplasma gondii | thioredoxin reductase | 0.0053 | 0.0346 | 0.0301 |
Brugia malayi | cytochrome P450 | 0.0016 | 0.0047 | 0.0055 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0593 | 0.4652 | 0.4627 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0164 | 0.019 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0154 | 0.1152 | 0.1344 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0018 | 0.0068 | 0.0079 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0122 | 0.0891 | 0.0991 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0015 | 0.004 | 0.0046 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0018 | 0.0068 | 0.0022 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0053 | 0.0346 | 0.0352 |
Echinococcus granulosus | GPCR family 2 | 0.0054 | 0.0352 | 0.041 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0018 | 0.0068 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0593 | 0.4652 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0068 | 0.0022 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0022 | 0.0093 | 0.0107 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0352 | 0.0358 |
Loa Loa (eye worm) | glutathione reductase | 0.0053 | 0.0346 | 0.0403 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0168 | 0.0195 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0016 | 0.0047 | 0.0053 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0053 | 0.0346 | 0.028 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0122 | 0.0891 | 0.0991 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.0352 | 0.041 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0018 | 0.0068 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0304 | 0.0354 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0018 | 0.0068 | 0.0022 |
Leishmania major | trypanothione reductase | 0.0053 | 0.0346 | 0.0301 |
Echinococcus granulosus | geminin | 0.0186 | 0.1405 | 0.164 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0068 | 0.0022 |
Schistosoma mansoni | lamin | 0.0031 | 0.0168 | 0.0142 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0154 | 0.1152 | 0.1344 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.0352 | 0.041 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.1043 | 0.1217 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0135 | 0.0999 | 0.1118 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0053 | 0.0062 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0068 | 0.0022 |
Trypanosoma brucei | trypanothione reductase | 0.0053 | 0.0346 | 0.0301 |
Echinococcus multilocularis | GPCR, family 2 | 0.0054 | 0.0352 | 0.041 |
Plasmodium falciparum | thioredoxin reductase | 0.0053 | 0.0346 | 0.028 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0154 | 0.1152 | 0.1344 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0122 | 0.0891 | 0.0991 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0053 | 0.0346 | 0.0403 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0352 | 0.0358 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0352 | 0.041 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0122 | 0.0891 | 0.0991 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0154 | 0.1152 | 0.1297 |
Echinococcus multilocularis | thymidylate synthase | 0.1084 | 0.8564 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1264 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0154 | 0.1152 | 0.1297 |
Brugia malayi | Thioredoxin reductase | 0.0053 | 0.0346 | 0.0404 |
Onchocerca volvulus | Huntingtin homolog | 0.0141 | 0.1043 | 0.1042 |
Brugia malayi | glutathione reductase | 0.0053 | 0.0346 | 0.0404 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1084 | 0.8564 | 1 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0018 | 0.0068 | 0.0022 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0168 | 0.0195 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0068 | 0.0022 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0403 | 0.3132 | 0.3657 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0068 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0036 | 0.0041 |
Brugia malayi | Cytochrome P450 family protein | 0.0016 | 0.0047 | 0.0055 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.