Detailed information for compound 1152012

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 324.417 | Formula: C20H24N2O2
  • H donors: 0 H acceptors: 1 LogP: 2.5 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c3c1CCCc3cn(c2=O)[C@@H]1CN2CCC1CC2
  • InChi: 1S/C20H24N2O2/c1-24-18-6-5-16-19-14(3-2-4-15(18)19)11-22(20(16)23)17-12-21-9-7-13(17)8-10-21/h5-6,11,13,17H,2-4,7-10,12H2,1H3/t17-/m1/s1
  • InChiKey: OJWRKJHAFNNPEK-QGZVFWFLSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0115 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0011 0.0068 0.006
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0068 0.0057
Echinococcus multilocularis geminin 0.019 0.1778 0.1769
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0068 0.0068
Echinococcus multilocularis transient receptor potential gamma protein 0.01 0.0915 0.0906
Trypanosoma cruzi aminopeptidase, putative 0.0056 0.0493 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0379 0.7579
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1051 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0068 0.0132
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0009
Echinococcus granulosus transient receptor potential gamma protein 0.01 0.0915 0.0906
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0068 0.0057
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0115 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0068 0.0132
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0047 0.0036
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0115 0.0105
Brugia malayi Peptidase family M1 containing protein 0.0056 0.0493 0.1062
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0056 0.0493 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0068 0.006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0115 0.0104
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1051 1 1
Schistosoma mansoni cpg binding protein 0.0031 0.0258 0.0258
Schistosoma mansoni coup transcription factor 0.0011 0.0068 0.0068
Brugia malayi TATA binding protein associated factor 0.0056 0.0493 0.1062
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0056 0.0493 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0009
Echinococcus granulosus geminin 0.019 0.1778 0.1769
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.1387 0.3019
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0115 0.0105
Loa Loa (eye worm) TATA binding protein associated factor 0.0056 0.0493 0.0486
Brugia malayi nuclear hormone receptor family member odr-7 0.0005 0.0011 0.0006
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0056 0.0493 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0379 0.7692
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0068 0.0132
Brugia malayi hypothetical protein 0.0483 0.4576 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0068 0.0132
Loa Loa (eye worm) hypothetical protein 0.0011 0.0068 0.006
Loa Loa (eye worm) hypothetical protein 0.0037 0.0315 0.0307
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0047 0.0039
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0011 0.0006
Trypanosoma brucei Aminopeptidase M1, putative 0.0056 0.0493 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0011 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0011 0.000005575
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0047 0.0036
Brugia malayi nuclear hormone receptor family member nhr-6 0.0005 0.0011 0.0006
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0056 0.0493 0.0483
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0068 0.006
Brugia malayi hypothetical protein 0.0006 0.0017 0.002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0011 0.0003
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0068 0.0068
Brugia malayi MH1 domain containing protein 0.0009 0.0047 0.0085
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0592 0.0582
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0068 0.0132
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0056 0.0493 1
Brugia malayi MH2 domain containing protein 0.0009 0.0047 0.0085
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0011 0.0011
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0005 0.0011 0.0003
Schistosoma mansoni nuclear receptor 0.0005 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0016 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0011 0.0068 0.006
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0056 0.0493 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0047 0.0036
Brugia malayi Bromodomain containing protein 0.0005 0.0011 0.0006
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0344 0.6067
Loa Loa (eye worm) hypothetical protein 0.0035 0.0295 0.0288
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0315 0.0305
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0068 0.0057
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0068 0.0068
Schistosoma mansoni cpg binding protein 0.003 0.0242 0.0242
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0068 0.0068
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.003 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0068 0.0132
Schistosoma mansoni hypothetical protein 0.019 0.1778 0.1778
Brugia malayi PHD-finger family protein 0.0005 0.0011 0.0006
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.1347 0.1338
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0056 0.0493 0.0483
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0068 0.1188
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0051 0.045 0.0443
Brugia malayi MH2 domain containing protein 0.0134 0.124 0.2699
Brugia malayi hypothetical protein 0.0056 0.0493 0.1062
Loa Loa (eye worm) hypothetical protein 0.0016 0.0115 0.0107
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0068 0.0057
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0017 0.0006
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0115 0.0105
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0068 0.0132
Schistosoma mansoni hypothetical protein 0.0035 0.0295 0.0295
Echinococcus multilocularis transient receptor potential ion channel A 0.0097 0.0884 0.0874
Schistosoma mansoni cpg binding protein 0.0031 0.0258 0.0258
Mycobacterium ulcerans aminopeptidase N PepN 0.0056 0.0493 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0068 0.006
Schistosoma mansoni hypothetical protein 0.0016 0.0115 0.0115
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0056 0.0493 0.0483
Toxoplasma gondii aminopeptidase n, putative 0.0056 0.0493 0.9099
Echinococcus granulosus transient receptor potential ion channel A 0.0097 0.0884 0.0874
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.003 0.0019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.003 0.003
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0068 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0068 0.0132
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0056 0.0493 1
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0315 0.0673
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0344 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0011 0.000005575
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0115 0.0104
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0056 0.0493 0.0483
Schistosoma mansoni smad1 5 8 and 0.0009 0.0047 0.0047
Brugia malayi ecdysteroid receptor 0.0011 0.0068 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0068 0.0132
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0068 0.0068
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0068 0.0068
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0056 0.0493 1
Echinococcus granulosus nuclear receptor nhr 48 0.0005 0.0011 0.000005575
Brugia malayi CXXC zinc finger family protein 0.003 0.0242 0.0514
Onchocerca volvulus 0.0056 0.0493 1
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0056 0.0493 0.0493
Trypanosoma brucei Aminopeptidase M1, putative 0.0056 0.0493 1
Onchocerca volvulus 0.003 0.0242 0.4804
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0379 0.6362
Schistosoma mansoni transient receptor potential channel 0.01 0.0915 0.0915
Toxoplasma gondii aminopeptidase N protein 0.0056 0.0493 0.9099
Echinococcus multilocularis nuclear receptor nhr 48 0.0005 0.0011 0.000005575
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0005 0.0011 0.000005575
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0068 0.0057
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0115 0.0104
Brugia malayi hypothetical protein 0.0005 0.0011 0.0006
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0017 0.002
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0005 0.0011 0.0006
Brugia malayi MH1 domain containing protein 0.0009 0.0047 0.0085
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0068 0.006
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0056 0.0493 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0836 0.7946 0.7944
Brugia malayi Smad1 0.0009 0.0047 0.0085
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0068 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0068 0.006
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0068 0.1188
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0056 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0005 0.0011 0.0003
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0242 0.0235
Loa Loa (eye worm) hypothetical protein 0.0005 0.0011 0.0003
Schistosoma mansoni hypothetical protein 0.019 0.1778 0.1778
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0115 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0068 0.0132
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.053 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0115 0.0105
Loa Loa (eye worm) peptidase family M1 containing protein 0.0056 0.0493 0.0486
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0005 0.0011 0.0003
Echinococcus multilocularis GPCR, family 2 0.0016 0.0115 0.0104
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0056 0.0493 1
Brugia malayi conserved hypotetical protein 0.0005 0.0011 0.0006
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0056 0.0493 0.0483
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0068 0.0132
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0068 0.0057
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0047 0.0036
Mycobacterium ulcerans aminopeptidase N PepN 0.0056 0.0493 0.5
Brugia malayi nuclear hormone receptor 0.0011 0.0068 0.0132
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0068 0.0057
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0011 0.000005575
Loa Loa (eye worm) hypothetical protein 0.0011 0.0068 0.006
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0056 0.0493 0.0493
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0115 0.2325
Loa Loa (eye worm) hypothetical protein 0.0005 0.0011 0.0003
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0379 0.6362
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0068 0.0057
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0592 0.0582
Brugia malayi nuclear hormone receptor 0.0005 0.0011 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0068 0.0057
Echinococcus granulosus aminopeptidase N 0.0056 0.0493 0.0483
Schistosoma mansoni smad 0.0009 0.0047 0.0047
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0011 0.0011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0115 0.0234
Brugia malayi Peptidase family M1 containing protein 0.0056 0.0493 0.1062
Loa Loa (eye worm) hypothetical protein 0.01 0.0915 0.0908
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0379 0.0369
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0005 0.0011 0.000005575
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0068 0.0132
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0047 0.0036
Onchocerca volvulus 0.0011 0.0068 0.1188
Brugia malayi hypothetical protein 0.0006 0.0017 0.002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0011 0.0003
Echinococcus granulosus smad 0.0009 0.0047 0.0036
Loa Loa (eye worm) hypothetical protein 0.0034 0.0283 0.0276
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1051 1 1
Brugia malayi tailless protein 0.0005 0.0011 0.0006
Echinococcus multilocularis Smad4 0.0009 0.0047 0.0036
Brugia malayi nuclear receptor NHR-88 0.0005 0.0011 0.0006
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0115 0.0107
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0056 0.0493 0.0483
Loa Loa (eye worm) hypothetical protein 0.0005 0.0011 0.0003
Echinococcus multilocularis aminopeptidase N 0.0056 0.0493 0.0483
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0011 0.0006
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0011 0.0011
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0068 0.0057
Loa Loa (eye worm) Smad1 0.0009 0.0047 0.0039
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0056 0.0493 1
Brugia malayi steroid hormone receptor 0.0011 0.0068 0.0132
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0068 0.0068
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0068 0.0057
Brugia malayi isocitrate dehydrogenase 0.0016 0.0115 0.0235
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0011 0.000005575
Schistosoma mansoni smad1 5 8 and 0.0009 0.0047 0.0047
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0115 0.0105
Loa Loa (eye worm) hypothetical protein 0.0005 0.0011 0.0003
Loa Loa (eye worm) hypothetical protein 0.0005 0.0011 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.124 0.1234
Loa Loa (eye worm) nuclear receptor NHR-67 0.0005 0.0011 0.0003
Schistosoma mansoni smad1 5 8 and 0.0009 0.0047 0.0047
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0017 0.0006
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0047 0.0036
Toxoplasma gondii aminopeptidase N, putative 0.0056 0.0493 0.9099
Loa Loa (eye worm) acetyltransferase 0.0149 0.1387 0.138
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0295 0.0629
Echinococcus multilocularis cpg binding protein 0.0031 0.0258 0.0248
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0005 0.0011 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0068 0.006
Brugia malayi Peptidase family M1 containing protein 0.0056 0.0493 0.1062
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0115 0.0234
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0056 0.0493 0.0483
Schistosoma mansoni zinc finger protein 0.0005 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0063 0.056 0.0553
Schistosoma mansoni bromodomain containing protein 0.0005 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0011 0.0068 0.006
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0047 0.0039
Brugia malayi ecdysone receptor 0.0005 0.0011 0.0006
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0115 0.0105
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.124 0.1234
Brugia malayi nuclear receptor NHR-88 0.0011 0.0068 0.0132
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0056 0.0493 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0068 0.0057
Schistosoma mansoni bromodomain containing protein 0.0005 0.0011 0.0011
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0056 0.0493 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0009
Trypanosoma brucei aminopeptidase, putative 0.0056 0.0493 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0493 0.0486
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0056 0.0493 1
Schistosoma mansoni transient receptor potential channel 0.0066 0.0592 0.0592
Onchocerca volvulus 0.0056 0.0493 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0056 0.0493 0.0483
Brugia malayi nuclear receptor NHR-67 0.0005 0.0011 0.0006
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0017 0.0009
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0047 0.0039
Loa Loa (eye worm) hypothetical protein 0.0005 0.0011 0.0003
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0046 0.0083
Loa Loa (eye worm) hypothetical protein 0.0005 0.0011 0.0003
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0047 0.0047
Brugia malayi nuclear receptor RXR 0.0005 0.0011 0.0006
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0068 0.0132
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0056 0.0493 0.0483
Echinococcus granulosus thyroid hormone receptor alpha 0.0005 0.0011 0.000005575
Trypanosoma cruzi aminopeptidase, putative 0.0056 0.0493 1
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0068 0.006
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0011 0.000005575
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0559 0.0559
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.1387 0.1387
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0068 0.0057
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0005 0.0011 0.000005575
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0592 0.0582
Schistosoma mansoni Smad4 0.0009 0.0047 0.0047
Brugia malayi hypothetical protein 0.0056 0.0493 0.1062
Schistosoma mansoni hypothetical protein 0.0422 0.3988 0.3988
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0379 0.7579
Loa Loa (eye worm) hypothetical protein 0.0056 0.0493 0.0486
Echinococcus multilocularis dnaJ subfamily B 0.0422 0.3988 0.3982
Brugia malayi nuclear receptor RXR 0.0006 0.0017 0.002
Schistosoma mansoni hypothetical protein 0.0016 0.0115 0.0115
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0068 0.0068
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.003 0.0019
Brugia malayi MH2 domain containing protein 0.0009 0.0047 0.0085
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0017 0.0017
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0011 0.0011
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.003 0.0019
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0068 0.0132
Schistosoma mansoni zinc finger protein 0.0005 0.0011 0.0011
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0056 0.0493 0.0483
Trypanosoma cruzi Aminopeptidase M1, putative 0.0056 0.0493 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0115 0.0104
Echinococcus granulosus cpg binding protein 0.0031 0.0258 0.0248
Loa Loa (eye worm) nuclear hormone receptor 0.0005 0.0011 0.0003
Schistosoma mansoni aminopeptidase A (M01 family) 0.0056 0.0493 0.0493
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0068 0.0057
Echinococcus granulosus GPCR family 2 0.0016 0.0115 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0068 0.0132
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0068 0.1188
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0009
Loa Loa (eye worm) hypothetical protein 0.0056 0.0493 0.0486
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0056 0.0493 1
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0592 0.0582
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0011 0.0011
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0056 0.0493 1
Brugia malayi hypothetical protein 0.0005 0.0011 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0068 0.006
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0017 0.0017
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.045 0.0969
Loa Loa (eye worm) aminopeptidase N 0.0056 0.0493 0.0486
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.045 0.0969
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0068 0.0132
Schistosoma mansoni hypothetical protein 0.0016 0.0115 0.0115
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0056 0.0493 1
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0315 0.0305
Loa Loa (eye worm) hypothetical protein 0.0006 0.0017 0.0009
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0017 0.002
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0005 0.0011 0.0003
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.1387 0.1378
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0056 0.0493 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0115 0.0115
Echinococcus granulosus dnaJ subfamily B 0.0422 0.3988 0.3982
Loa Loa (eye worm) DR-78 0.0005 0.0011 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0068 0.006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0068 0.006
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0056 0.0493 0.0483
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0011 0.000005575
Schistosoma mansoni transient receptor potential channel 4 0.01 0.0915 0.0915
Schistosoma mansoni transient receptor potential channel 0.0066 0.0592 0.0592
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0068 0.006
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0056 0.0493 0.0483
Schistosoma mansoni nuclear receptor 0.0005 0.0011 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0068 0.0057
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.045 0.0443
Echinococcus multilocularis smad 0.0009 0.0047 0.0036
Entamoeba histolytica aminopeptidase, putative 0.0056 0.0493 1
Echinococcus granulosus Smad4 0.0009 0.0047 0.0036
Brugia malayi orphan nuclear receptor NR2E1 0.0005 0.0011 0.0006
Onchocerca volvulus 0.0056 0.0493 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0011 0.0003

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.