Detailed information for compound 1152201

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 637.725 | Formula: C36H39N5O6
  • H donors: 4 H acceptors: 3 LogP: 5.27 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)[C@@H]1C/C=C\COc2ccc3c(c2c2c(OCC(=O)N[C@@H](C(=O)N1)CCCCNC(=N)N)ccc1c2cccc1)cccc3
  • InChi: 1S/C36H39N5O6/c1-45-35(44)28-15-7-9-21-46-29-18-16-23-10-2-4-12-25(23)32(29)33-26-13-5-3-11-24(26)17-19-30(33)47-22-31(42)40-27(34(43)41-28)14-6-8-20-39-36(37)38/h2-5,7,9-13,16-19,27-28H,6,8,14-15,20-22H2,1H3,(H,40,42)(H,41,43)(H4,37,38,39)/b9-7-/t27-,28+/m1/s1
  • InChiKey: YCRZWLODWYQUBW-HCZZCBLYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0074 0.0199
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0061 0.0166
Loa Loa (eye worm) hypothetical protein 0.0051 0.0197 0.0532
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0085 0.0595 0.1882
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0214 0.0214
Giardia lamblia DINP protein human, muc B family 0.0063 0.034 1
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0037 0.0044 0.2055
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0074 0.0999
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.1397 0.1359
Brugia malayi Carboxylesterase family protein 0.0309 0.3162 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0074 0.0074
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0429 0.4531 0.4531
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.034 0.034
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0074 0.0199
Schistosoma mansoni hypothetical protein 0.0182 0.1709 0.4616
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.034 0.0297
Loa Loa (eye worm) RNA binding protein 0.007 0.042 0.1135
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0074 0.0999
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0074 0.0199
Loa Loa (eye worm) hypothetical protein 0.0052 0.0216 0.0585
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0074 0.0999
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0429 0.4531 0.4507
Brugia malayi Carboxylesterase family protein 0.0052 0.0216 0.0684
Loa Loa (eye worm) beta-lactamase 0.004 0.0074 0.0199
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0061 0.0166
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0037 0.0044 0.2055
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0074 0.1006
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0037 0.0044 0.0139
Brugia malayi RNA, U transporter 1 0.0095 0.0705 0.2231
Trichomonas vaginalis DNA polymerase eta, putative 0.0063 0.034 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0052 0.0216 0.0285
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0116 0.0116
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0127 0.1077 0.1038
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0277 0.0749
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0214 0.0171
Plasmodium vivax hypothetical protein, conserved 0.004 0.0074 0.3436
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.034 0.034
Schistosoma mansoni tar DNA-binding protein 0.007 0.042 0.1135
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.1902 0.5137
Echinococcus granulosus CTD small phosphatase protein like 0.0037 0.0044 0.0119
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0063 0.034 0.0297
Loa Loa (eye worm) hypothetical protein 0.0052 0.0216 0.0585
Brugia malayi beta-lactamase family protein 0.004 0.0074 0.0233
Schistosoma mansoni tar DNA-binding protein 0.007 0.042 0.1135
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0063 0.034 0.0532
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0197 0.0532
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0037 0.0044 0.0119
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0197 0.0532
Echinococcus granulosus dna polymerase kappa 0.0063 0.034 0.0919
Loa Loa (eye worm) hypothetical protein 0.004 0.0074 0.0199
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0061 0.0166
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0074 0.1006
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0214 1
Leishmania major DNA polymerase eta, putative 0.0091 0.0661 0.062
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0303 0.082
Toxoplasma gondii ABC1 family protein 0.004 0.0074 0.0569
Loa Loa (eye worm) hypothetical protein 0.0309 0.3162 0.8543
Schistosoma mansoni gliotactin 0.0052 0.0216 0.0585
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0429 0.4531 0.4507
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0197 0.0532
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0065 0.0363 0.0981
Echinococcus granulosus acetylcholinesterase 0.0309 0.3162 0.8543
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0052 0.0216 0.0585
Echinococcus granulosus geminin 0.0182 0.1709 0.4616
Echinococcus multilocularis tar DNA binding protein 0.007 0.042 0.1135
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0197 0.0532
Brugia malayi RNA binding protein 0.007 0.042 0.1328
Echinococcus multilocularis jumonji domain containing protein 0.004 0.008 0.0216
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0085 0.0595 0.104
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0037 0.0044 0.0341
Schistosoma mansoni neuroligin 3 (S09 family) 0.0052 0.0216 0.0585
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.034 0.1076
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0074 0.0074
Trypanosoma cruzi DNA polymerase eta, putative 0.0091 0.0661 0.062
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0105
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0074 0.0199
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0074 0.003
Brugia malayi Carboxylesterase family protein 0.0052 0.0216 0.0684
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0085 0.0595 0.104
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.1902 0.5137
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0032 0.01
Brugia malayi mbt repeat family protein 0.0051 0.0197 0.0623
Echinococcus granulosus para nitrobenzyl esterase 0.0052 0.0216 0.0585
Brugia malayi jmjC domain containing protein 0.0095 0.0706 0.2231
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.034 0.0297
Trypanosoma brucei unspecified product 0.0043 0.0116 0.0116
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0037 0.0044 0.0044
Echinococcus multilocularis neuroligin 0.0052 0.0216 0.0585
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.034 0.034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0131 0.0353
Loa Loa (eye worm) TAR-binding protein 0.007 0.042 0.1135
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0074 0.0199
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0197 0.0532
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0214 1
Mycobacterium leprae conserved hypothetical protein 0.004 0.0074 0.5
Echinococcus multilocularis carboxylesterase 5A 0.0309 0.3162 0.8543
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.034 0.034
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0905 1 1
Entamoeba histolytica hypothetical protein 0.0039 0.0061 0.0588
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0074 0.0999
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0074 0.003
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0277 0.0749
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0085 0.0595 0.104
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0074 0.0199
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.002 0.0053
Mycobacterium ulcerans carboxylesterase, LipT 0.0052 0.0216 0.0285
Leishmania major DNA polymerase eta, putative 0.0048 0.0163 0.0119
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0074 0.0199
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.034 0.034
Brugia malayi hypothetical protein 0.0052 0.0216 0.0684
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0127 0.1077 0.1038
Echinococcus multilocularis 0.0037 0.0044 0.0119
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0037 0.0044 0.0119
Loa Loa (eye worm) acetylcholinesterase 1 0.0309 0.3162 0.8543
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0052 0.0214 0.0578
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0131 0.0353
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.002 0.0053
Trichomonas vaginalis spcc417.12 protein, putative 0.0052 0.0216 0.5821
Loa Loa (eye worm) hypothetical protein 0.004 0.0074 0.0199
Mycobacterium leprae Probable lipase LipE 0.004 0.0074 0.5
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0074 0.0233
Brugia malayi hypothetical protein 0.0034 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.004 0.0074 0.0199
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0277 0.0749
Loa Loa (eye worm) MBCTL1 0.0058 0.0277 0.0749
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0074 0.003
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0085 0.0595 0.0554
Brugia malayi Carboxylesterase family protein 0.0309 0.3162 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0063 0.034 0.0919
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0052 0.0216 0.0285
Loa Loa (eye worm) hypothetical protein 0.0052 0.0216 0.0585
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0482 0.1302
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.002 0.0053
Toxoplasma gondii hypothetical protein 0.0146 0.1292 1
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.002 0.0053
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0074 0.0199
Loa Loa (eye worm) hypothetical protein 0.0036 0.0032 0.0085
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0197 0.0532
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0131 0.0353
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0037 0.0044 0.0119
Onchocerca volvulus 0.0052 0.0216 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0197 0.0532
Loa Loa (eye worm) carboxylesterase 0.0309 0.3162 0.8543
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0346 0.0936
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.034 0.0297
Leishmania major DNA polymerase kappa, putative 0.0063 0.034 0.0297
Schistosoma mansoni hypothetical protein 0.0039 0.0061 0.0166
Echinococcus multilocularis dna polymerase eta 0.0091 0.0661 0.1786
Brugia malayi TAR-binding protein 0.007 0.042 0.1328
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.042 0.1135
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0063 0.034 0.0919
Schistosoma mansoni hypothetical protein 0.0182 0.1709 0.4616
Brugia malayi jmjC domain containing protein 0.0035 0.002 0.0062
Onchocerca volvulus 0.004 0.0074 0.009
Entamoeba histolytica hypothetical protein 0.0039 0.0061 0.0588
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.034 0.0297
Loa Loa (eye worm) carboxylesterase 0.0052 0.0216 0.0585
Echinococcus multilocularis acetylcholinesterase 0.0309 0.3162 0.8543
Echinococcus multilocularis dna polymerase kappa 0.0063 0.034 0.0919
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0052 0.0216 0.5821
Loa Loa (eye worm) hypothetical protein 0.004 0.0074 0.0199
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0214 0.0171
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0277 0.0877
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0163 0.0119
Onchocerca volvulus 0.0052 0.0216 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0706 0.1906
Schistosoma mansoni DNA polymerase eta 0.0091 0.0661 0.1786
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0254 0.2532 0.4904
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0052 0.0216 0.0285
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0223 0.0706
Brugia malayi RNA recognition motif domain containing protein 0.007 0.042 0.1328
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0074 0.0199
Schistosoma mansoni hypothetical protein 0.0307 0.3141 0.8486
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0074 0.0999
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0074 0.003
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0074 0.0199
Mycobacterium tuberculosis Conserved hypothetical protein 0.0063 0.034 0.0532
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.034 0.034
Onchocerca volvulus 0.0052 0.0216 1
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.034 0.034
Brugia malayi beta-lactamase family protein 0.004 0.0074 0.0233
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0074 0.0199
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0063 0.034 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0661 0.1786
Loa Loa (eye worm) hypothetical protein 0.0052 0.0216 0.0585
Loa Loa (eye worm) hypothetical protein 0.004 0.0074 0.0199
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0197 0.0532
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.034 0.034
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0223 0.0706
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0706 0.1906
Echinococcus granulosus dna polymerase eta 0.0091 0.0661 0.1786
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0063 0.034 0.0919
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0223 0.0603
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0085 0.0595 0.1608
Echinococcus granulosus carboxylesterase 5A 0.0309 0.3162 0.8543
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0131 0.0353
Loa Loa (eye worm) hypothetical protein 0.0052 0.0216 0.0585
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0037 0.0044 0.2055
Schistosoma mansoni hypothetical protein 0.0036 0.0032 0.0085
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0074 0.1006
Brugia malayi hypothetical protein 0.0039 0.0061 0.0194
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0074 0.0199
Echinococcus granulosus jumonji domain containing protein 0.004 0.008 0.0216
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0048 0.0163 0.126
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0052 0.0216 0.0585
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0197 0.8662
Leishmania major hypothetical protein, conserved 0.0052 0.0214 0.0171
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0065 0.0363 0.0981
Mycobacterium ulcerans hypothetical protein 0.0477 0.5086 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0223 0.0603
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.002 0.0053
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0127 0.1077 0.1038
Schistosoma mansoni tar DNA-binding protein 0.007 0.042 0.1135
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0052 0.0216 0.0585
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0356 0.3701 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0131 0.0413
Loa Loa (eye worm) carboxylesterase 0.0052 0.0216 0.0585
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0127 0.1077 0.1077
Echinococcus granulosus BC026374 protein S09 family 0.0052 0.0216 0.0585
Echinococcus granulosus tar DNA binding protein 0.007 0.042 0.1135
Schistosoma mansoni acetylcholinesterase 0.0052 0.0216 0.0585
Schistosoma mansoni hypothetical protein 0.0037 0.0039 0.0105
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0131 0.0353
Trypanosoma brucei DNA polymerase eta, putative 0.0091 0.0661 0.0661
Loa Loa (eye worm) matrixin family protein 0.0043 0.0113 0.0306
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0074 0.1006
Brugia malayi Matrixin family protein 0.0043 0.0113 0.0358
Echinococcus multilocularis BC026374 protein (S09 family) 0.0052 0.0216 0.0585
Echinococcus granulosus acetylcholinesterase 0.0309 0.3162 0.8543
Echinococcus granulosus snurportin 1 0.0356 0.3701 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0131 0.0353
Schistosoma mansoni BC026374 protein (S09 family) 0.0052 0.0216 0.0585
Entamoeba histolytica hypothetical protein 0.0039 0.0061 0.0588
Echinococcus multilocularis acetylcholinesterase 0.0309 0.3162 0.8543
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.034 0.034
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.034 0.034
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0905 1 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0063 0.034 0.0919
Echinococcus multilocularis para nitrobenzyl esterase 0.0052 0.0216 0.0585
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0042 0.0104 0.0282
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0074 0.1006
Loa Loa (eye worm) hypothetical protein 0.0052 0.0216 0.0585
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0074 0.003
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0052 0.0216 0.0585
Mycobacterium ulcerans DNA polymerase IV 0.0063 0.034 0.0532
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0905 1 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0277 0.0749
Entamoeba histolytica deoxycytidyl transferase, putative 0.0063 0.034 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0131 0.0353
Loa Loa (eye worm) hypothetical protein 0.0052 0.0216 0.0585
Onchocerca volvulus 0.0052 0.0216 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.042 0.1135
Trypanosoma brucei unspecified product 0.0063 0.034 0.034
Onchocerca volvulus 0.004 0.0074 0.009
Schistosoma mansoni hypothetical protein 0.0356 0.3701 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0309 0.3162 0.8543
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.034 0.034
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0085 0.0595 0.1608
Trypanosoma brucei unspecified product 0.0043 0.0116 0.0116
Brugia malayi Carboxylesterase family protein 0.0052 0.0216 0.0684
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0277 0.0749
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0214 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0477 0.5086 1
Entamoeba histolytica hypothetical protein 0.0039 0.0061 0.0588
Brugia malayi ImpB/MucB/SamB family protein 0.0091 0.0661 0.2091
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.034 0.034
Brugia malayi beta-lactamase 0.004 0.0074 0.0233
Leishmania major hypothetical protein, conserved 0.004 0.0074 0.003
Trichomonas vaginalis esterase, putative 0.004 0.0074 0.0999
Onchocerca volvulus 0.004 0.0074 0.009
Brugia malayi mbt repeat family protein 0.0051 0.0197 0.0623
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0052 0.0216 0.0585
Loa Loa (eye worm) matrixin family protein 0.004 0.0072 0.0195
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0037 0.0044 0.0119
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0131 0.0353
Echinococcus multilocularis geminin 0.0182 0.1709 0.4616
Mycobacterium ulcerans DNA polymerase IV 0.0063 0.034 0.0532
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0214 0.1657
Loa Loa (eye worm) hypothetical protein 0.004 0.0074 0.0199
Onchocerca volvulus 0.0052 0.0216 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0044 0.0119
Brugia malayi Carboxylesterase family protein 0.0052 0.0216 0.0684
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0085 0.0595 0.1608
Loa Loa (eye worm) hypothetical protein 0.0058 0.0277 0.0749
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.034 0.034
Brugia malayi hypothetical protein 0.0052 0.0214 0.0677
Loa Loa (eye worm) hypothetical protein 0.005 0.0187 0.0505
Echinococcus granulosus neuroligin 0.0052 0.0216 0.0585
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0063 0.034 0.0919
Loa Loa (eye worm) hypothetical protein 0.0309 0.3162 0.8543
Onchocerca volvulus 0.0051 0.0197 0.8662
Schistosoma mansoni tar DNA-binding protein 0.007 0.042 0.1135
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0116 0.0116
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0074 0.0233
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0074 0.0199
Loa Loa (eye worm) hypothetical protein 0.004 0.0074 0.0199
Echinococcus multilocularis snurportin 1 0.0356 0.3701 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.