Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | metallopeptidase family M24 containing protein | 0.0102 | 0.0179 | 0.0213 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0362 | 0.1996 | 0.2377 |
Echinococcus granulosus | thymidylate synthase | 0.0314 | 0.166 | 0.166 |
Plasmodium falciparum | MO15-related protein kinase | 0.0246 | 0.1183 | 0.1223 |
Plasmodium vivax | hypothetical protein, conserved | 0.0467 | 0.2735 | 0.3111 |
Schistosoma mansoni | chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.1276 | 0.8395 | 0.8395 |
Echinococcus granulosus | Proliferation associated protein 2G4 | 0.0102 | 0.0179 | 0.0179 |
Echinococcus multilocularis | xaa Pro dipeptidase | 0.0102 | 0.0179 | 0.0179 |
Chlamydia trachomatis | methionine aminopeptidase | 0.0809 | 0.5124 | 1 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.1276 | 0.8395 | 1 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.1276 | 0.8395 | 1 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0102 | 0.0179 | 0.0213 |
Echinococcus multilocularis | cyclin dependent kinase 7 | 0.0083 | 0.0042 | 0.0042 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0809 | 0.5124 | 0.5124 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.1276 | 0.8395 | 0.8395 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0149 | 0.0509 | 1 |
Echinococcus multilocularis | xaa pro aminopeptidase | 0.0102 | 0.0179 | 0.0179 |
Toxoplasma gondii | methionine aminopeptidase | 0.0809 | 0.5124 | 0.6018 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1505 | 1 | 1 |
Echinococcus granulosus | xaa Pro dipeptidase | 0.0102 | 0.0179 | 0.0179 |
Schistosoma mansoni | peptidase | 0.0102 | 0.0179 | 0.0179 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0314 | 0.166 | 0.1802 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0314 | 0.166 | 0.166 |
Toxoplasma gondii | cell-cycle-associated protein kinase, putative | 0.023 | 0.107 | 0.1085 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0467 | 0.2735 | 0.3111 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0314 | 0.166 | 0.1802 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0314 | 0.166 | 0.1802 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0083 | 0.0042 | 0.0042 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0362 | 0.1996 | 0.2212 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.1276 | 0.8395 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.0717 | 0.0717 |
Echinococcus multilocularis | methionyl aminopeptidase 2 | 0.0102 | 0.0179 | 0.0179 |
Echinococcus multilocularis | thymidylate synthase | 0.0314 | 0.166 | 0.166 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.0809 | 0.5124 | 1 |
Plasmodium falciparum | methionine aminopeptidase 1a, putative | 0.0809 | 0.5124 | 0.6018 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.1276 | 0.8395 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0467 | 0.2735 | 0.3111 |
Loa Loa (eye worm) | metallopeptidase family M24 containing protein | 0.0102 | 0.0179 | 0.0213 |
Onchocerca volvulus | 0.0314 | 0.166 | 1 | |
Schistosoma mansoni | Xaa-Pro dipeptidase (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0362 | 0.1996 | 0.2212 |
Loa Loa (eye worm) | DNA-binding protein | 0.0102 | 0.0179 | 0.0213 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0083 | 0.0042 | 0.0042 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0246 | 0.1183 | 0.1223 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.0809 | 0.5124 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.1996 | 0.2377 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.1276 | 0.8395 | 1 |
Echinococcus multilocularis | geminin | 0.0179 | 0.0717 | 0.0717 |
Loa Loa (eye worm) | thymidylate synthase | 0.0314 | 0.166 | 0.1977 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0144 | 0.0472 | 0.0563 |
Echinococcus granulosus | xaa Pro dipeptidase | 0.0102 | 0.0179 | 0.0179 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0149 | 0.0509 | 0.0667 |
Loa Loa (eye worm) | CMGC/CDK/CDK7 protein kinase | 0.0083 | 0.0042 | 0.005 |
Treponema pallidum | methionine aminopeptidase (map) | 0.0809 | 0.5124 | 1 |
Echinococcus multilocularis | Xaa Pro aminopeptidase 3 | 0.0102 | 0.0179 | 0.0179 |
Brugia malayi | thymidylate synthase | 0.0314 | 0.166 | 0.1977 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.0809 | 0.5124 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0809 | 0.5124 | 0.5124 |
Plasmodium falciparum | HP12 protein homolog, putative | 0.0467 | 0.2735 | 0.3111 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0179 | 0.0213 |
Entamoeba histolytica | Xaa-Pro dipeptidase, putative | 0.0102 | 0.0179 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0314 | 0.166 | 0.2995 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0314 | 0.166 | 0.2995 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.1276 | 0.8395 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0314 | 0.166 | 0.2995 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0758 | 0.0903 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0314 | 0.166 | 0.1802 |
Schistosoma mansoni | aminopeptidase P1 (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0144 | 0.0472 | 0.0563 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0102 | 0.0179 | 0.0213 |
Echinococcus granulosus | FACT complex subunit SPT16 | 0.0102 | 0.0179 | 0.0179 |
Brugia malayi | initiation factor 2-associated protein. | 0.0102 | 0.0179 | 0.0213 |
Echinococcus multilocularis | xaa Pro dipeptidase | 0.0102 | 0.0179 | 0.0179 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0102 | 0.0179 | 0.5 |
Echinococcus multilocularis | FACT complex subunit SPT16 | 0.0102 | 0.0179 | 0.0179 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0467 | 0.2735 | 0.3111 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0179 | 0.0213 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0314 | 0.166 | 0.1802 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0099 | 0.0155 | 0.0185 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.1276 | 0.8395 | 1 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.1276 | 0.8395 | 1 |
Toxoplasma gondii | methionine aminopeptidase | 0.1276 | 0.8395 | 1 |
Brugia malayi | Methionine aminopeptidase protein type I | 0.1276 | 0.8395 | 1 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.1276 | 0.8395 | 1 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.0809 | 0.5124 | 1 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0102 | 0.0179 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0467 | 0.2735 | 0.3111 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0102 | 0.0179 | 0.0213 |
Giardia lamblia | Methionine aminopeptidase | 0.0102 | 0.0179 | 0.5 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0102 | 0.0179 | 0.5 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0102 | 0.0179 | 0.5 |
Entamoeba histolytica | peptidase, putative | 0.0102 | 0.0179 | 0.5 |
Echinococcus granulosus | methionine aminopeptidase type I | 0.0102 | 0.0179 | 0.0179 |
Echinococcus multilocularis | Proliferation associated protein 2G4 | 0.0102 | 0.0179 | 0.0179 |
Echinococcus granulosus | methionyl aminopeptidase 2 | 0.0102 | 0.0179 | 0.0179 |
Echinococcus granulosus | xaa pro aminopeptidase | 0.0102 | 0.0179 | 0.0179 |
Brugia malayi | DNA-binding protein, 42 kDa containing protein | 0.0102 | 0.0179 | 0.0213 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0102 | 0.0179 | 0.0179 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.0809 | 0.5124 | 1 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.0809 | 0.5124 | 1 |
Echinococcus granulosus | Xaa Pro aminopeptidase 3 | 0.0102 | 0.0179 | 0.0179 |
Brugia malayi | hypothetical protein | 0.0149 | 0.0509 | 0.0606 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0362 | 0.1996 | 0.2212 |
Toxoplasma gondii | methionine aminopeptidase, type i, putative | 0.0809 | 0.5124 | 0.6018 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0314 | 0.166 | 0.1802 |
Echinococcus granulosus | cyclin dependent kinase 7 | 0.0083 | 0.0042 | 0.0042 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0467 | 0.2735 | 0.3111 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0179 | 0.0213 |
Echinococcus multilocularis | methionine aminopeptidase, type I | 0.0102 | 0.0179 | 0.0179 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1505 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0149 | 0.0509 | 0.0401 |
Plasmodium vivax | methionine aminopeptidase 1a, putative | 0.0809 | 0.5124 | 0.6018 |
Entamoeba histolytica | aminopeptidase, putative | 0.0102 | 0.0179 | 0.5 |
Echinococcus granulosus | geminin | 0.0179 | 0.0717 | 0.0717 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.0717 | 0.0717 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0809 | 0.5124 | 0.5124 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.0809 | 0.5124 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.