Detailed information for compound 1152441

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 466.523 | Formula: C26H28F2N4O2
  • H donors: 1 H acceptors: 2 LogP: 4.11 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)n1c2CN(CCCCCCN3C(=O)CNC3=O)CCc2c2c1ccc(c2)F
  • InChi: 1S/C26H28F2N4O2/c27-18-5-8-20(9-6-18)32-23-10-7-19(28)15-22(23)21-11-14-30(17-24(21)32)12-3-1-2-4-13-31-25(33)16-29-26(31)34/h5-10,15H,1-4,11-14,16-17H2,(H,29,34)
  • InChiKey: VUMQDBPJZSMXDV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0118 0.1091 0.1528
Toxoplasma gondii ABC1 family protein 0.0118 0.1091 0.3409
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0444 0.0556
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0418 0.0427
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.1091 0.1822
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0366 0.0354
Trypanosoma brucei NADH dehydrogenase 0.0027 0.0103 0.0301
Mycobacterium ulcerans hypothetical protein 0.0118 0.1091 0.1822
Leishmania major hypothetical protein, conserved 0.0118 0.1091 0.3608
Loa Loa (eye worm) hypothetical protein 0.0026 0.0092 0.0129
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0027 0.0103 0.0116
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0092 0.0135
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0315 0.101
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.13 0.182
Brugia malayi hypothetical protein 0.0272 0.2763 0.4646
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0102 0.0916 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0182 0.0179
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.157 0.1641
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0182 0.0568
Mycobacterium ulcerans ferredoxin reductase 0.0027 0.0103 0.0152
Echinococcus granulosus geminin 0.0731 0.7764 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.0063 0.0496 0.0694
Giardia lamblia Glutamate synthase 0.0027 0.0103 0.0998
Trypanosoma cruzi NADH dehydrogenase, putative 0.0027 0.0103 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0314 0.0509
Entamoeba histolytica Ran family GTPase 0.0046 0.0315 0.3103
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0075 0.0622 0.1029
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0012 0.0004
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.02 0.1923
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0092 0.0267
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0027 0.0103 0.0152
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0418 0.0523
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0027 0.0103 0.0152
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0027 0.0103 0.0152
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0092 0.0135
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0315 0.0731
Loa Loa (eye worm) hypothetical protein 0.0118 0.1091 0.1528
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.067 0.7094 0.8864
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0092 0.0135
Brugia malayi Importin beta-1 subunit 0.0063 0.0496 0.0816
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.157 0.1641
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0027 0.0103 0.0301
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0315 0.039
Mycobacterium ulcerans hypothetical protein 0.0026 0.0092 0.0135
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0027 0.0103 0.0301
Echinococcus multilocularis GPCR, family 2 0.0034 0.0182 0.0178
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0092 0.0819
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0027 0.0103 0.0152
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0103 0.0301
Mycobacterium ulcerans hypothetical protein 0.0027 0.0103 0.0152
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0753 0.8002 1
Schistosoma mansoni glutamate synthase 0.0027 0.0103 0.009
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0496 0.1617
Echinococcus granulosus beta LACTamase domain containing family member 0.0118 0.1091 0.1392
Brugia malayi RNA, U transporter 1 0.018 0.1763 0.2956
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0182 0.0543
Toxoplasma gondii thioredoxin reductase 0.0294 0.3002 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0182 0.0218
Schistosoma mansoni hypothetical protein 0.0674 0.7144 0.714
Onchocerca volvulus 0.0118 0.1091 0.3037
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0198 0.0195
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0418 0.0523
Brugia malayi Thioredoxin reductase 0.0294 0.3002 0.505
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.087 0.0859
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.027 0.0862
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0027 0.0103 0.0301
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0027 0.0103 0.0116
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0012 0.0017
Onchocerca volvulus 0.0118 0.1091 0.3037
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0222 0.0266
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0182 0.0255
Schistosoma mansoni hypothetical protein 0.0045 0.0296 0.0284
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0027 0.0103 0.0275
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.02 0.0626
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0182 0.0568
Plasmodium vivax glutathione reductase, putative 0.0294 0.3002 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.02 0.0335
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0118 0.1091 0.1354
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0092 0.0135
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.157 0.2198
Trichomonas vaginalis glutamate synthase, putative 0.0027 0.0103 0.0152
Brugia malayi CHE-14 protein 0.0046 0.0314 0.0509
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0104 0.0003
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.02 0.0197
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0092 0.0104
Loa Loa (eye worm) hypothetical protein 0.007 0.0574 0.0804
Trichomonas vaginalis glutathione reductase, putative 0.0102 0.0916 0.1525
Trichomonas vaginalis penicillin-binding protein, putative 0.0118 0.1091 0.1822
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0182 0.0218
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0411 0.0674
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0027 0.0103 0.0116
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0455 0.0466
Schistosoma mansoni aldehyde dehydrogenase 0.0199 0.1971 0.1961
Schistosoma mansoni hypothetical protein 0.0021 0.0032 0.002
Echinococcus granulosus microtubule associated protein 2 0.0686 0.7276 0.937
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0053 0.004
Mycobacterium tuberculosis Putative ferredoxin reductase 0.067 0.7094 0.8864
Plasmodium falciparum importin beta, putative 0.0063 0.0496 0.1594
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0198 0.0239
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0027 0.0103 0.0926
Entamoeba histolytica disulphide oxidoreductase, putative 0.0027 0.0103 0.0926
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0102 0.0916 1
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0104 0.0304
Trypanosoma brucei trypanothione reductase 0.0294 0.3002 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0102 0.0916 0.3001
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0674 0.7144 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0103 0.0152
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0027 0.0103 0.0275
Onchocerca volvulus 0.0118 0.1091 0.3037
Schistosoma mansoni hypothetical protein 0.0055 0.0411 0.0399
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0102 0.0916 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.157 0.2631
Loa Loa (eye worm) inositol-1 0.0042 0.027 0.0378
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0418 0.0685
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.02 0.0316
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0315 0.0986
Loa Loa (eye worm) hypothetical protein 0.0053 0.0381 0.0534
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0027 0.0103 0.0117
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0118 0.1091 0.108
Onchocerca volvulus 0.0053 0.0381 0.0879
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0012 0.0004
Entamoeba histolytica hypothetical protein 0.0051 0.0366 0.3632
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.02 0.0241
Loa Loa (eye worm) hypothetical protein 0.0026 0.0092 0.0129
Schistosoma mansoni hypothetical protein 0.0034 0.0182 0.0169
Echinococcus granulosus zinc finger protein 0.0019 0.0021 0.0011
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.13 0.182
Brugia malayi mbt repeat family protein 0.0051 0.0366 0.0598
Mycobacterium ulcerans aldehyde dehydrogenase 0.0199 0.1971 0.3308
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.027 0.0578
Trichomonas vaginalis apoptosis inducing factor, putative 0.0027 0.0103 0.0152
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0315 0.044
Leishmania major hypothetical protein, conserved 0.0027 0.0103 0.0301
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0118 0.1091 0.1822
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0418 0.1087
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0027 0.0103 0.0095
Trypanosoma cruzi NADH dehydrogenase, putative 0.0027 0.0103 0.0301
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0102 0.0916 0.2803
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0118 0.1091 0.108
Echinococcus granulosus importin subunit beta 1 0.0063 0.0496 0.0624
Trypanosoma brucei hypothetical protein, conserved 0.0118 0.1091 0.3608
Schistosoma mansoni intermediate filament proteins 0.0053 0.0381 0.0369
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0366 0.0457
Mycobacterium tuberculosis Conserved protein 0.0118 0.1091 0.1354
Mycobacterium ulcerans aldehyde dehydrogenase 0.0199 0.1971 0.3308
Loa Loa (eye worm) thioredoxin reductase 0.0294 0.3002 0.4203
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0182 0.0275
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0027 0.0103 0.0152
Mycobacterium ulcerans NADH dehydrogenase 0.0027 0.0103 0.0152
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0444 0.0432
Mycobacterium ulcerans beta-lactamase 0.0118 0.1091 0.1822
Schistosoma mansoni hypothetical protein 0.0045 0.0296 0.0284
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0418 0.0685
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.027 0.0862
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0182 0.0254
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.1091 0.3608
Onchocerca volvulus 0.0027 0.0103 0.0031
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.027 0.0862
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0092 0.0104
Echinococcus multilocularis protein dispatched 1 0.0053 0.0385 0.0393
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0027 0.0103 0.0301
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.02 0.0316
Loa Loa (eye worm) glutaminase 0.0563 0.5933 0.8305
Loa Loa (eye worm) hypothetical protein 0.0057 0.0428 0.0598
Trypanosoma cruzi trypanothione reductase, putative 0.0294 0.3002 1
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.1091 0.1822
Schistosoma mansoni lamin 0.0053 0.0381 0.0369
Plasmodium falciparum ferrodoxin reductase-like protein 0.0027 0.0103 0.0275
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0455 0.0571
Mycobacterium tuberculosis Conserved protein 0.0118 0.1091 0.1354
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.02 0.0316
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0102 0.0916 0.3001
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0182 0.0217
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0444 0.0454
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.087 0.0859
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0017
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0092 0.0819
Schistosoma mansoni alpha-glucosidase 0.0139 0.1325 0.1314
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0366 0.0597
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0103 0.0152
Echinococcus multilocularis geminin 0.0731 0.7764 0.8168
Plasmodium vivax importin-beta 2, putative 0.0063 0.0496 0.1594
Trichomonas vaginalis mercuric reductase, putative 0.0102 0.0916 0.1525
Loa Loa (eye worm) glutathione reductase 0.0294 0.3002 0.4203
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0314 0.0318
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0102 0.0916 0.302
Echinococcus granulosus GPCR family 2 0.0034 0.0182 0.0218
Schistosoma mansoni glutamate synthase 0.0027 0.0103 0.009
Echinococcus multilocularis snurportin 1 0.0674 0.7144 0.7515
Mycobacterium leprae Probable lipase LipE 0.0118 0.1091 0.1278
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0104 0.0278
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0102 0.0916 0.0952
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0444 0.0556
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0366 0.0834
Echinococcus granulosus glutamate synthase 0.0027 0.0103 0.0116
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0027 0.0103 0.0117
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0118 0.1091 0.1822
Mycobacterium ulcerans lipase LipD 0.0118 0.1091 0.1822
Loa Loa (eye worm) hypothetical protein 0.0118 0.1091 0.1528
Schistosoma mansoni hypothetical protein 0.0027 0.0103 0.009
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0027 0.0103 0.0926
Onchocerca volvulus 0.0328 0.3382 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0315 0.101
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0418 0.1356
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.02 0.0316
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.087 0.0904
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.027 0.2649
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0315 0.051
Treponema pallidum NADH oxidase 0.0102 0.0916 1
Echinococcus granulosus lamin 0.0053 0.0381 0.0476
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0315 0.0986
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0891 0.9502 1
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.1091 0.3608
Echinococcus multilocularis importin subunit beta 1 0.0063 0.0496 0.0509
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.027 0.2063
Schistosoma mansoni survival motor neuron protein 0.0055 0.0411 0.0399
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0029
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0027 0.0103 0.0117
Schistosoma mansoni lamin 0.0053 0.0381 0.0369
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.027 0.0435
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0366 0.0597
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0418 0.1356
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.087 0.0859
Echinococcus multilocularis lamin dm0 0.0053 0.0381 0.0389
Mycobacterium ulcerans glutaminase 0.0563 0.5933 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0182 0.0178
Schistosoma mansoni sulfide quinone reductase 0.0027 0.0103 0.009
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0027 0.0103 0.0152
Trichomonas vaginalis penicillin-binding protein, putative 0.0118 0.1091 0.1822
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0032 0.0045
Trypanosoma cruzi trypanothione reductase, putative 0.0102 0.0916 0.302
Schistosoma mansoni hypothetical protein 0.0312 0.3199 0.319
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0027 0.0103 0.0013
Loa Loa (eye worm) hypothetical protein 0.0118 0.1091 0.1528
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0027 0.0103 0.0116
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.0986 0.1644
Loa Loa (eye worm) hypothetical protein 0.0034 0.0182 0.0254
Echinococcus granulosus Niemann Pick C1 protein 0.0155 0.1491 0.1907
Schistosoma mansoni hypothetical protein 0.0034 0.0182 0.0169
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0021 0.0014
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0027 0.0103 0.0117
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0418 0.1356
Schistosoma mansoni niemann-pick C1 (NPC1) 0.011 0.1004 0.0993
Mycobacterium tuberculosis Conserved protein 0.0118 0.1091 0.1354
Loa Loa (eye worm) hypothetical protein 0.0051 0.0366 0.0513
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0118 0.1091 0.1354
Schistosoma mansoni aldehyde dehydrogenase 0.0199 0.1971 0.1961
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0092 0.0135
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0102 0.0916 0.302
Trichomonas vaginalis ran, putative 0.0046 0.0315 0.051
Leishmania major NADH dehydrogenase, putative 0.0027 0.0103 0.0301
Mycobacterium ulcerans glutamate synthase subunit beta 0.0027 0.0103 0.0152
Mycobacterium tuberculosis Probable esterase LipL 0.0118 0.1091 0.1354
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0102 0.0916 0.302
Leishmania major hypothetical protein, conserved 0.0027 0.0104 0.0304
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0027 0.0103 0.0013
Mycobacterium tuberculosis Probable oxidoreductase 0.0744 0.7907 0.9881
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0916 0.302
Brugia malayi Inositol-1 0.0042 0.027 0.0435
Loa Loa (eye worm) hypothetical protein 0.0027 0.0103 0.0144
Mycobacterium tuberculosis Probable dehydrogenase 0.067 0.7094 0.8864
Loa Loa (eye worm) hypothetical protein 0.0027 0.0104 0.0145
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0102 0.0916 0.302
Schistosoma mansoni sulfide quinone reductase 0.0027 0.0103 0.009
Schistosoma mansoni alpha-glucosidase 0.0139 0.1325 0.1314
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0102 0.0916 0.302
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0103 0.0152
Echinococcus multilocularis microtubule associated protein 2 0.0686 0.7276 0.7654
Echinococcus granulosus snurportin 1 0.0674 0.7144 0.92
Onchocerca volvulus 0.0094 0.0827 0.2235
Loa Loa (eye worm) hypothetical protein 0.0074 0.0615 0.086
Echinococcus multilocularis Niemann Pick C1 protein 0.0155 0.1491 0.1558
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0744 0.7907 0.9881
Echinococcus granulosus survival motor neuron protein 1 0.0272 0.2763 0.3548
Brugia malayi beta-lactamase family protein 0.0118 0.1091 0.1822
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0027 0.0103 0.0275
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0102 0.0916 0.1134
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0104 0.0304
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0182 0.0179
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0102 0.0916 0.1525
Mycobacterium tuberculosis Probable lipase LipD 0.0118 0.1091 0.1354
Loa Loa (eye worm) hypothetical protein 0.0042 0.027 0.0378
Mycobacterium ulcerans monoxygenase 0.0027 0.0103 0.0152
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0381 0.0623
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0182 0.017
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0027 0.0103 0.0117
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0085 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0092 0.0135
Schistosoma mansoni disulfide oxidoreductase 0.0027 0.0103 0.009
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0027 0.0103 0.0152
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0199 0.1971 0.2526
Brugia malayi MH2 domain containing protein 0.0137 0.13 0.2175
Mycobacterium leprae conserved hypothetical protein 0.0118 0.1091 0.1278
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0182 0.0179
Trypanosoma brucei protein kinase, putative 0.0056 0.0418 0.1356
Leishmania major trypanothione reductase 0.0294 0.3002 1
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0381 0.0534
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0418 0.1356
Leishmania major importin beta-1 subunit, putative 0.0051 0.0366 0.1182
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0366 0.0373
Plasmodium vivax thioredoxin reductase, putative 0.0294 0.3002 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0119
Schistosoma mansoni hypothetical protein 0.0731 0.7764 0.7761
Schistosoma mansoni alpha glucosidase 0.0036 0.02 0.0187
Brugia malayi beta-lactamase 0.0118 0.1091 0.1822
Loa Loa (eye worm) hypothetical protein 0.0041 0.025 0.0349
Plasmodium falciparum thioredoxin reductase 0.0102 0.0916 0.3001
Plasmodium falciparum glutathione reductase 0.0102 0.0916 0.3001
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0092 0.0267
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0027 0.0103 0.0152
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.027 0.0862
Mycobacterium ulcerans dehydrogenase 0.0027 0.0103 0.0152
Schistosoma mansoni hypothetical protein 0.0045 0.0296 0.0284
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.087 0.1107
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0102 0.0916 0.1525
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0182 0.0568
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.02 0.0626
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0418 0.0685
Chlamydia trachomatis thioredoxin reductase 0.0027 0.0103 0.0916
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.067 0.7094 0.896
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0222 0.0166
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0366 0.0513
Echinococcus granulosus lamin dm0 0.0053 0.0381 0.0476
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0102 0.0916 0.0904
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0444 0.0454
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0315 0.3344
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0104 0.0278
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0103 0.0301
Brugia malayi beta-lactamase family protein 0.0118 0.1091 0.1822
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0027 0.0103 0.0095
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.0986 0.1256
Schistosoma mansoni microtubule-associated protein tau 0.0686 0.7276 0.7272
Plasmodium falciparum glutathione reductase 0.0294 0.3002 1
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0027 0.0103 0.0275
Schistosoma mansoni inositol monophosphatase 0.0042 0.027 0.0258
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0315 0.0318
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0027 0.0103 0.0013
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0182 0.0543
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0199 0.1971 0.2454
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0418 0.0585
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0027 0.0103 0.0152
Leishmania major hypothetical protein, conserved 0.0027 0.0103 0.0301
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0102 0.0916 0.1525
Schistosoma mansoni bromodomain containing protein 0.0063 0.0494 0.0482
Schistosoma mansoni zinc finger protein 0.0019 0.0021 0.0008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.087 0.1449
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0418 0.0427
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0314 0.0389
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.027 0.0435
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0916 0.302
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0366 0.1182
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0053 0.0052
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0418 0.1356
Echinococcus granulosus thioredoxin glutathione reductase 0.0294 0.3009 0.3865
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0103 0.0301
Trichomonas vaginalis esterase, putative 0.0118 0.1091 0.1822
Loa Loa (eye worm) hypothetical protein 0.0118 0.1091 0.1528
Brugia malayi MAP kinase sur-1 0.0056 0.0418 0.0685
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.027 0.0435
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0418 0.449
Mycobacterium tuberculosis Probable hydrolase 0.0118 0.1091 0.1354
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0315 0.101
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.02 0.0316
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.027 0.0333
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0182 0.0286
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0418 0.0406
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.02 0.0626
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0104 0.0304
Loa Loa (eye worm) hypothetical protein 0.0108 0.0988 0.1382
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0108 0.0986 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0916 0.302
Schistosoma mansoni importin beta-1 0.0063 0.0496 0.0484
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0294 0.3002 0.3745
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0744 0.7907 0.9881
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0103 0.0152
Echinococcus multilocularis zinc finger protein 0.0019 0.0021 0.0009
Schistosoma mansoni ran 0.0046 0.0315 0.0302
Loa Loa (eye worm) MBCTL1 0.0058 0.0444 0.0621
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0182 0.0179
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0366 0.0457
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0199 0.1971 0.6549
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0027 0.0103 0.0301
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0988 0.1647
Onchocerca volvulus 0.0051 0.0366 0.0834
Loa Loa (eye worm) hypothetical protein 0.0024 0.0075 0.0104
Brugia malayi mbt repeat family protein 0.0051 0.0366 0.0598
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0029
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0182 0.0568
Mycobacterium ulcerans aldehyde dehydrogenase 0.0199 0.1971 0.3308
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0314 0.0439
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0104 0.0278
Schistosoma mansoni glutaminase 0.0563 0.5933 0.5928
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0496 0.1617
Loa Loa (eye worm) hypothetical protein 0.0118 0.1091 0.1528
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0029
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.02 0.0316
Toxoplasma gondii NADPH-glutathione reductase 0.0102 0.0916 0.2803
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.02 0.0316
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0202 0.2006 0.2572
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0021 0.0014
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0444 0.0728
Loa Loa (eye worm) hypothetical protein 0.0024 0.0075 0.0104
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.02 0.0316
Plasmodium vivax ferrodoxin reductase, putative 0.0027 0.0103 0.0275
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0916 0.302
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0366 0.0597
Brugia malayi Bromodomain containing protein 0.0075 0.062 0.1027
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0075 0.0622 0.1029
Brugia malayi hypothetical protein 0.0328 0.3382 0.569
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0102 0.0916 0.302
Giardia lamblia NADH oxidase lateral transfer candidate 0.0102 0.0916 1
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0027 0.0103 0.0152
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0102 0.0916 0.302
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0182 0.0568
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0103 0.0301
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0381 0.0534
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0916 0.302
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0027 0.0103 0.0013
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0103 0.0301
Plasmodium falciparum thioredoxin reductase 0.0294 0.3002 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0102 0.0916 0.1165
Onchocerca volvulus 0.0053 0.0381 0.0879
Brugia malayi isocitrate dehydrogenase 0.0034 0.0182 0.0287
Echinococcus multilocularis thioredoxin glutathione reductase 0.0294 0.3009 0.3157
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0027 0.0103 0.0301
Echinococcus multilocularis beta LACTamase domain containing family member 0.0118 0.1091 0.1137
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0027 0.0103 0.0152
Brugia malayi Bromodomain containing protein 0.0038 0.0223 0.0356
Echinococcus multilocularis lamin 0.0053 0.0381 0.0389
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0027 0.0103 0.0301
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0027 0.0103 0.0301
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0027 0.0103 0.0152
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0744 0.7907 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0182 0.0178
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0092 0.0819
Brugia malayi glutaminase DH11.1 0.0563 0.5933 1
Schistosoma mansoni hypothetical protein 0.0034 0.0182 0.0169
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0314 0.0389
Loa Loa (eye worm) hypothetical protein 0.0272 0.2763 0.3868
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0027 0.0103 0.0152
Loa Loa (eye worm) hypothetical protein 0.0026 0.0092 0.0129
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0102 0.0916 0.302
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0092 0.0135
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0092 0.0135
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.02 0.1923
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0366 0.0373
Echinococcus multilocularis survival motor neuron protein 1 0.0272 0.2763 0.2899
Schistosoma mansoni hypothetical protein 0.0034 0.0182 0.0169
Trypanosoma brucei glucosidase, putative 0.0036 0.02 0.0626
Echinococcus multilocularis musashi 0.0053 0.0381 0.0389
Echinococcus multilocularis glutamate synthase 0.0027 0.0103 0.0095
Loa Loa (eye worm) programmed cell death 8 0.0027 0.0103 0.0144
Toxoplasma gondii aldehyde dehydrogenase 0.0199 0.1971 0.6442
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0027 0.0103 0.0095
Schistosoma mansoni hypothetical protein 0.0731 0.7764 0.7761
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0103 0.0152
Brugia malayi glutamate synthase 0.0027 0.0103 0.0152
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0029
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0202 0.2006 0.2101
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0027 0.0103 0.0152
Schistosoma mansoni glutamate synthase 0.0027 0.0103 0.009
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.067 0.7094 0.8864
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0182 0.0179
Brugia malayi PHD-finger family protein 0.0025 0.0078 0.0111
Loa Loa (eye worm) hypothetical protein 0.0038 0.0224 0.0314
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0102 0.0916 0.3001
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0182 0.0219
Onchocerca volvulus 0.0055 0.0411 0.097
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.087 0.0904
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0102 0.0916 0.302
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0182 0.0287
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0092 0.0267
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0085 0.0076
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0027 0.0103 0.0144
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0053 0.0042
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.0986 0.1026
Trichomonas vaginalis glutamate synthase, putative 0.0027 0.0103 0.0152
Brugia malayi hypothetical protein 0.0027 0.0104 0.0154
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0115 0.0162
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0027 0.0103 0.0095
Mycobacterium tuberculosis Probable reductase 0.067 0.7094 0.8864
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0615 0.1017
Loa Loa (eye worm) hypothetical protein 0.0058 0.0444 0.0621
Schistosoma mansoni ran 0.0046 0.0315 0.0302
Mycobacterium tuberculosis Probable lipase LipE 0.0118 0.1091 0.1354
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0988 0.1382
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0027 0.0103 0.0926
Leishmania major hypothetical protein, conserved 0.0027 0.0103 0.0301
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0027 0.0103 0.0998
Brugia malayi intermediate filament protein 0.0053 0.0381 0.0623
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0182 0.0286
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.067 0.7094 0.8864
Schistosoma mansoni hypothetical protein 0.0045 0.0296 0.0284
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0027 0.0103 0.0152
Giardia lamblia Thioredoxin reductase 0.0027 0.0103 0.0998
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.087 0.1218
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0027 0.0103 0.0116
Echinococcus granulosus intermediate filament protein 0.0053 0.0381 0.0476
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0027 0.0103 0.0926
Loa Loa (eye worm) hypothetical protein 0.0046 0.0314 0.0439
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0102 0.0916 0.302
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0092 0.0135
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0092 0.0135
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0103 0.0301
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0199 0.1971 0.2064
Schistosoma mansoni patched 1 0.0046 0.0314 0.0302
Loa Loa (eye worm) hypothetical protein 0.0328 0.3382 0.4734
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0118 0.1091 0.1528
Brugia malayi glutathione reductase 0.0294 0.3002 0.505
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0418 0.0685
Mycobacterium ulcerans esterase/lipase LipP 0.0118 0.1091 0.1822
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.02 0.0279
Plasmodium vivax hypothetical protein, conserved 0.0118 0.1091 0.359
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.02 0.0316
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0366 0.0354
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0366 0.0354
Echinococcus multilocularis protein patched 0.0046 0.0314 0.0318
Loa Loa (eye worm) glutaminase 2 0.0563 0.5933 0.8305
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.02 0.0316
Loa Loa (eye worm) beta-lactamase 0.0118 0.1091 0.1528
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0988 0.1647
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.087 0.1107
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0102 0.0916 0.302
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0102 0.0916 0.3001
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0027 0.0103 0.0926
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0027 0.0103 0.0116
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0182 0.0275
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0102 0.0916 0.1525
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.157 0.2009
Loa Loa (eye worm) hypothetical protein 0.0108 0.0986 0.138
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0027 0.0103 0.0095
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0418 0.1356
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0027 0.0103 0.0095
Schistosoma mansoni hypothetical protein 0.0074 0.0615 0.0603
Trichomonas vaginalis glutaminase, putative 0.0563 0.5933 1
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.027 0.0272
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0115 0.0174
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.027 0.0435
Echinococcus granulosus expressed conserved protein 0.0102 0.0914 0.1163
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0418 0.1356
Toxoplasma gondii HEAT repeat-containing protein 0.0063 0.0496 0.1356
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.1091 0.1822
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0118 0.1091 0.1354
Schistosoma mansoni inositol monophosphatase 0.0042 0.027 0.0258
Entamoeba histolytica thioredoxin reductase, putative 0.0027 0.0103 0.0926
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0027 0.0103 0.0117
Leishmania major GTP-binding protein, putative 0.0046 0.0315 0.101
Loa Loa (eye worm) hypothetical protein 0.0052 0.0371 0.0519
Echinococcus multilocularis expressed conserved protein 0.0102 0.0914 0.095

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.