Detailed information for compound 1153235

Basic information

Technical information
  • TDR Targets ID: 1153235
  • Name: 1-butyl-3-(2-methylpropyl)-9-(6-phenylhexyl)- 1,4,9-triazaspiro[5.5]undecane-2,5-dione
  • MW: 455.676 | Formula: C28H45N3O2
  • H donors: 1 H acceptors: 2 LogP: 5.98 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN1C(=O)C(CC(C)C)NC(=O)C21CCN(CC2)CCCCCCc1ccccc1
  • InChi: 1S/C28H45N3O2/c1-4-5-19-31-26(32)25(22-23(2)3)29-27(33)28(31)16-20-30(21-17-28)18-12-7-6-9-13-24-14-10-8-11-15-24/h8,10-11,14-15,23,25H,4-7,9,12-13,16-22H2,1-3H3,(H,29,33)
  • InChiKey: FDWPPSXZXOZKJQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-Butyl-3-isobutyl-9-(6-phenylhexyl)-1,4,9-triazaspiro[5.5]undecane-2,5-dione
  • 1-butyl-3-isobutyl-9-(6-phenylhexyl)-1,4,9-triazaspiro[5.5]undecane-2,5-quinone
  • AIDS-115886
  • AIDS115886
  • E910

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis smad 0.0034 0.0172 0.0172
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.047 0.1495
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.032 0.032
Loa Loa (eye worm) glutathione reductase 0.0113 0.1102 0.1102
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.047 0.047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0234 0.1145
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0039 0.0234 0.1145
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0075 0.0661 0.1225
Echinococcus granulosus smad 0.0034 0.0172 0.0172
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0207 0.0207
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0535 0.0535
Schistosoma mansoni hypothetical protein 0.0029 0.0116 0.0116
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.0061 0.0495 0.0495
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0039 0.0234 0.1145
Mycobacterium tuberculosis Probable dehydrogenase 0.0257 0.2803 0.8924
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.047 0.2295
Loa Loa (eye worm) hypothetical protein 0.0042 0.0273 0.0273
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0234 0.1145
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.1973 0.1973
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0396 0.0396
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0193 0.0193
Brugia malayi hypothetical protein 0.0026 0.0077 0.0077
Entamoeba histolytica hypothetical protein 0.0036 0.0193 0.2467
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0257 0.2803 0.8924
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0518 0.0518
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0086 0.0783 0.1451
Mycobacterium ulcerans hypothetical protein 0.0037 0.0207 0.1011
Brugia malayi Pre-SET motif family protein 0.0061 0.0495 0.0495
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0079 0.0079
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0221 0.0221
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0172 0.0172
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0086 0.0783 0.0783
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0207 0.0383
Echinococcus multilocularis high affinity choline transporter 1 0.0344 0.3825 0.3825
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0039 0.0234 0.1145
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0077 0.0376
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0207 0.0383
Schistosoma mansoni cpg binding protein 0.0057 0.0446 0.0446
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0193 0.2046 0.6512
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0086 0.0783 0.1451
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0419 0.4716 0.4716
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.0941 0.0941
Entamoeba histolytica hypothetical protein 0.0036 0.0193 0.2467
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0214 0.2292 0.2292
Echinococcus granulosus Smad4 0.0034 0.0172 0.0172
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0941 0.0941
Echinococcus granulosus jumonji domain containing protein 0.004 0.0249 0.0249
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0116 0.0565
Brugia malayi RNA binding protein 0.0063 0.0518 0.0518
Schistosoma mansoni smad1 5 8 and 0.0034 0.0172 0.0172
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0077 0.0376
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.032 0.032
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0193 0.2046 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0114 0.112 0.112
Schistosoma mansoni hypothetical protein 0.0065 0.0535 0.0535
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0086 0.0783 0.0783
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1749 0.324
Echinococcus granulosus peregrin 0.0029 0.0116 0.0116
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0207 0.1011
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0065 0.0065
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.1419 0.1419
Echinococcus granulosus geminin 0.0168 0.1749 0.1749
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0226 0.0226
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0495 0.2422
Onchocerca volvulus 0.0057 0.0443 0.0331
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0273 0.0273
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.032 0.032
Mycobacterium tuberculosis Probable reductase 0.0257 0.2803 0.8924
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1855 0.3437
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.0077
Toxoplasma gondii NADPH-glutathione reductase 0.0039 0.0234 0.1145
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0286 0.3142 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0234 0.1145
Mycobacterium ulcerans lipase LipD 0.0037 0.0207 0.1011
Trichomonas vaginalis set domain proteins, putative 0.0477 0.5397 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0207 0.1011
Trichomonas vaginalis glutathione reductase, putative 0.0039 0.0234 0.0434
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0086 0.0783 0.0783
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0039 0.0234 0.0234
Brugia malayi beta-lactamase family protein 0.0037 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0207
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0117 0.0117
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.2784 0.5158
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.2784 0.5158
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0221 0.0221
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0286 0.3142 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0518 0.0518
Schistosoma mansoni hypothetical protein 0.0168 0.1749 0.1749
Mycobacterium tuberculosis Conserved protein 0.0037 0.0207 0.0658
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.2181 0.2181
Brugia malayi hypothetical protein 0.0042 0.0273 0.0273
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0226 0.0226
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.047 0.2295
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0075 0.0661 0.1225
Plasmodium vivax glutathione reductase, putative 0.0113 0.1102 0.5387
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0446 0.0446
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0008 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.2784 0.5158
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0077 0.0376
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.0941 0.0941
Trichomonas vaginalis chaperonin, putative 0.0025 0.0065 0.012
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0249 0.0249
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0221 0.0221
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0039 0.0234 0.0234
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0077 0.0376
Echinococcus multilocularis RUN 0.0042 0.0273 0.0273
Plasmodium vivax multidomain scavenger receptor, putative 0.0042 0.0273 0.1333
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0221 0.0221
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.117 0.117
Plasmodium falciparum phd finger protein, putative 0.0029 0.0116 0.0565
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0663 0.0663
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0025 0.0065 0.0317
Schistosoma mansoni hypothetical protein 0.0065 0.0535 0.0535
Plasmodium vivax SET domain protein, putative 0.0061 0.0495 0.2422
Loa Loa (eye worm) hypothetical protein 0.0046 0.032 0.032
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0207 0.0207
Schistosoma mansoni survival motor neuron protein 0.0057 0.0443 0.0443
Plasmodium falciparum glutathione reductase 0.0039 0.0234 0.1145
Schistosoma mansoni sodium/solute symporter 0.0038 0.0221 0.0221
Onchocerca volvulus 0.0061 0.0495 0.0384
Echinococcus multilocularis GPCR, family 2 0.0065 0.0535 0.0535
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0257 0.2803 0.8924
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0039 0.0234 0.0234
Trypanosoma cruzi trypanothione reductase, putative 0.0113 0.1102 0.5387
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0234 0.1145
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0039 0.0234 0.1145
Echinococcus granulosus survival motor neuron protein 1 0.0278 0.3052 0.3052
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0495 0.0495
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.0065 0.0065
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0207 0.0383
Schistosoma mansoni smad1 5 8 and 0.0034 0.0172 0.0172
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0039 0.0234 0.1145
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0207 0.0383
Echinococcus granulosus sodium bile acid cotransporter 0.0868 1 1
Schistosoma mansoni hypothetical protein 0.0036 0.0193 0.0193
Loa Loa (eye worm) RNA binding protein 0.0063 0.0518 0.0518
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0172 0.0172
Echinococcus multilocularis sodium bile acid cotransporter 0.0868 1 1
Trypanosoma brucei trypanothione reductase 0.0113 0.1102 0.5387
Onchocerca volvulus 0.0042 0.0273 0.0159
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.2784 0.5158
Leishmania major hypothetical protein, conserved 0.0026 0.0077 0.0376
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0193 0.2046 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0535 0.0535
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0273 0.0273
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0495 0.0495
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0221 0.0221
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0535 0.0535
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0455 0.0455
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0116 0.0116
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0193 0.0193
Schistosoma mansoni cpg binding protein 0.006 0.0484 0.0484
Schistosoma mansoni smad 0.0034 0.0172 0.0172
Leishmania major trypanothione reductase 0.0113 0.1102 0.5387
Leishmania major dihydroorotate dehydrogenase 0.0193 0.2046 1
Onchocerca volvulus 0.0046 0.032 0.0207
Brugia malayi MH2 domain containing protein 0.0034 0.0172 0.0172
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0257 0.2803 0.8924
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0278 0.3052 0.3052
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0075 0.0661 0.1225
Echinococcus multilocularis cpg binding protein 0.006 0.0484 0.0484
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0039 0.0234 0.1145
Schistosoma mansoni inositol transporter 0.0038 0.0221 0.0221
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0172 0.0172
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0008 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1749 0.324
Loa Loa (eye worm) Smad1 0.0034 0.0172 0.0172
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.0112 0.0112
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0116 0.0116
Treponema pallidum NADH oxidase 0.0039 0.0234 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.032 0.0207
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0255 0.2784 0.2784
Schistosoma mansoni loxhd1 0.0042 0.0273 0.0273
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0207 0.0658
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0518 0.0518
Echinococcus multilocularis thioredoxin glutathione reductase 0.0114 0.112 0.112
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1749 0.324
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0077 0.0376
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0039 0.0234 0.1145
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0193 0.2046 0.2046
Loa Loa (eye worm) hypothetical protein 0.0868 1 1
Schistosoma mansoni inositol transporter 0.0038 0.0221 0.0221
Mycobacterium tuberculosis Probable oxidoreductase 0.0286 0.3142 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0039 0.0234 0.1145
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0479 0.0479
Echinococcus granulosus solute carrier family 5 0.0038 0.0221 0.0221
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0025 0.0065 0.0317
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0221 0.0221
Schistosoma mansoni lipoxygenase 0.0042 0.0273 0.0273
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0116 0.0565
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0065 0.0065
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0518 0.0518
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.032 0.032
Loa Loa (eye worm) doublecortin family protein 0.0042 0.0273 0.0273
Onchocerca volvulus 0.0038 0.0221 0.0106
Brugia malayi jmjC domain containing protein 0.0038 0.0226 0.0226
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0941 0.0941
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0207 0.0383
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0518 0.0518
Echinococcus granulosus GPCR family 2 0.0065 0.0535 0.0535
Brugia malayi jmjC domain containing protein 0.0095 0.0893 0.0893
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0086 0.0783 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.047 0.047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0234 0.1145
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0039 0.0234 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0496 0.5617 0.5617
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.1073 0.5247
Schistosoma mansoni sodium-bile acid cotransporter 0.0516 0.5853 0.5853
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0039 0.0234 0.0745
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0075 0.0661 0.1225
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1749 0.324
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0193 0.2046 1
Echinococcus granulosus Polycystic kidney disease protein 0.0042 0.0273 0.0273
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.032 0.032
Schistosoma mansoni sodium-bile acid cotransporter related 0.0868 1 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0172 0.0172
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0039 0.0234 0.1145
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.2539 0.8083
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0489 0.5536 0.5536
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0893 0.0893
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0207
Schistosoma mansoni cpg binding protein 0.006 0.0484 0.0484
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0893 0.0893
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0234 0.1145
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.443 0.443
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0257 0.2803 0.8848
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0193 0.2046 1
Brugia malayi MH1 domain containing protein 0.0034 0.0172 0.0172
Brugia malayi Bromodomain containing protein 0.0029 0.0116 0.0116
Trichomonas vaginalis esterase, putative 0.0037 0.0207 0.0383
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0396 0.0396
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1749 0.324
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0353 0.3938 0.3938
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0039 0.0234 0.0234
Onchocerca volvulus 0.0042 0.0273 0.0159
Echinococcus multilocularis Polycystic kidney disease protein 0.0042 0.0273 0.0273
Toxoplasma gondii ABC1 family protein 0.0037 0.0207 0.1011
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0207 0.1011
Echinococcus multilocularis peregrin 0.0029 0.0116 0.0116
Brugia malayi Doublecortin family protein 0.0042 0.0273 0.0273
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0172 0.0172
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0518 0.0518
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.2181 0.2181
Echinococcus granulosus cpg binding protein 0.006 0.0484 0.0484
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.047 0.2295
Brugia malayi hypothetical protein 0.0278 0.3052 0.3052
Echinococcus granulosus RUN 0.0042 0.0273 0.0273
Mycobacterium tuberculosis Conserved protein 0.0037 0.0207 0.0658
Brugia malayi beta-lactamase family protein 0.0037 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0207
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0273 0.0273
Plasmodium falciparum dihydroorotate dehydrogenase 0.0193 0.2046 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0207
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0495 0.0495
Schistosoma mansoni polycystin 1-related 0.0042 0.0273 0.0273
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0495 0.0495
Schistosoma mansoni high-affinity choline transporter 0.0344 0.3825 0.3825
Echinococcus multilocularis solute carrier family 5 0.0038 0.0221 0.0221
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0207 0.0658
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0039 0.0234 0.1145
Loa Loa (eye worm) hypothetical protein 0.0353 0.3938 0.3938
Schistosoma mansoni dihydroorotate dehydrogenase 0.0193 0.2046 0.2046
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0116 0.0116
Brugia malayi PHD-finger family protein 0.0029 0.0116 0.0116
Schistosoma mansoni lipoxygenase 0.0119 0.117 0.117
Brugia malayi glutathione reductase 0.0113 0.1102 0.1102
Plasmodium falciparum T-complex protein 1 subunit beta 0.0025 0.0065 0.0317
Loa Loa (eye worm) hypothetical protein 0.0053 0.0396 0.0396
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0226 0.0226
Onchocerca volvulus 0.0477 0.5397 0.5343
Loa Loa (eye worm) MBCTL1 0.0053 0.0396 0.0396
Brugia malayi MH1 domain containing protein 0.0034 0.0172 0.0172
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0207 0.0658
Loa Loa (eye worm) hypothetical protein 0.005 0.036 0.036
Leishmania major T-complex protein 1, beta subunit, putative 0.0025 0.0065 0.0317
Schistosoma mansoni smad1 5 8 and 0.0034 0.0172 0.0172
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0193 0.2046 0.2046
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0025 0.0065 0.012
Schistosoma mansoni hypothetical protein 0.0065 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0042 0.0273 0.0273
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.032 0.032
Mycobacterium tuberculosis Conserved protein 0.0037 0.0207 0.0658
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0039 0.0234 0.1145
Brugia malayi Pre-SET motif family protein 0.0419 0.4716 0.4716
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0207 0.0207
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0075 0.0661 0.3231
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0207 0.1011
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0207 0.0207
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0065 0.0065
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0221 0.0221
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.047 0.2295
Brugia malayi Smad1 0.0034 0.0172 0.0172
Brugia malayi mbt repeat family protein 0.0046 0.032 0.032
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.1226 0.1226
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0226 0.0226
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.032 0.032
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0113 0.1102 0.3508
Loa Loa (eye worm) hypothetical protein 0.0029 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.0065 0.0535 0.0535
Plasmodium falciparum glutathione reductase 0.0113 0.1102 0.5387
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0039 0.0234 0.1145
Toxoplasma gondii thioredoxin reductase 0.0113 0.1102 0.5387
Loa Loa (eye worm) hypothetical protein 0.014 0.1419 0.1419
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0941 0.0941
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0396 0.0396
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.0112 0.0112
Brugia malayi MH2 domain containing protein 0.0496 0.5617 0.5617
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0941 0.0941
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.047 0.047
Schistosoma mansoni Smad4 0.0034 0.0172 0.0172
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.032 0.032
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0495 0.0495
Brugia malayi hypothetical protein 0.0036 0.0193 0.0193
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0518 0.0518
Loa Loa (eye worm) T-complex protein 1 0.0025 0.0065 0.0065
Echinococcus multilocularis geminin 0.0168 0.1749 0.1749
Echinococcus granulosus dnaJ subfamily B 0.0395 0.443 0.443
Schistosoma mansoni rab6-interacting 0.0042 0.0273 0.0273
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0214 0.2292 0.2292
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0286 0.3142 1
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1855 0.3437
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0207 0.1011
Loa Loa (eye worm) MH2 domain-containing protein 0.0496 0.5617 0.5617
Plasmodium falciparum thioredoxin reductase 0.0039 0.0234 0.1145
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0187 0.0187
Brugia malayi mbt repeat family protein 0.0046 0.032 0.032
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0039 0.0234 0.1145
Echinococcus multilocularis sodium bile acid cotransporter 0.0868 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0535 0.0535
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0396 0.0396
Onchocerca volvulus 0.0037 0.0207 0.0092
Schistosoma mansoni hypothetical protein 0.0286 0.3142 0.3142
Leishmania major hypothetical protein, conserved 0.0037 0.0207 0.1011
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0207 0.0658
Echinococcus multilocularis survival motor neuron protein 1 0.0278 0.3052 0.3052
Loa Loa (eye worm) hypothetical protein 0.0038 0.0221 0.0221
Giardia lamblia TCP-1 chaperonin subunit beta 0.0025 0.0065 0.2773
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0221 0.1079
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0207
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0077 0.0376
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0207 0.0207
Schistosoma mansoni rab6-interacting 0.0042 0.0273 0.0273
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0207 0.0658
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0234 0.1145
Echinococcus granulosus sodium bile acid cotransporter 0.0868 1 1
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.0065 0.0065
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0077 0.0376
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0193 0.2046 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0193 0.0193
Onchocerca volvulus 0.0037 0.0207 0.0092
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0535 0.0535
Toxoplasma gondii t-complex protein beta subunit 0.0025 0.0065 0.0317
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1749 0.324
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0086 0.0783 0.0783
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0116 0.0116
Brugia malayi follicle stimulating hormone receptor 0.0489 0.5536 0.5536
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0207 0.0207
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.047 0.047
Plasmodium falciparum thioredoxin reductase 0.0113 0.1102 0.5387
Echinococcus granulosus tar DNA binding protein 0.0063 0.0518 0.0518
Loa Loa (eye worm) thioredoxin reductase 0.0113 0.1102 0.1102
Trichomonas vaginalis mercuric reductase, putative 0.0039 0.0234 0.0434
Echinococcus multilocularis Smad4 0.0034 0.0172 0.0172
Mycobacterium ulcerans beta-lactamase 0.0037 0.0207 0.1011
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0039 0.0234 0.1145
Brugia malayi Thioredoxin reductase 0.0113 0.1102 0.1102
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0495 0.0495
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0535 0.0535
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0039 0.0234 0.1145
Loa Loa (eye worm) beta-lactamase 0.0037 0.0207 0.0207
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0025 0.0065 0.0829
Onchocerca volvulus 0.0868 1 1
Schistosoma mansoni hypothetical protein 0.014 0.1419 0.1419
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0116 0.0565
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0207 0.1011
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1749 0.324
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0193 0.2046 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.1973 0.1973
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0039 0.0234 0.1145
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0039 0.0234 0.1145
Onchocerca volvulus 0.0037 0.0207 0.0092
Brugia malayi GH02984p 0.0344 0.3825 0.3825
Loa Loa (eye worm) histone methyltransferase 0.002 0.0008 0.0008
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0065 0.0065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0941 0.0941
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0207 0.0658
Loa Loa (eye worm) hypothetical protein 0.0344 0.3825 0.3825
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0257 0.2803 0.8924
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0039 0.0234 0.1145
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.0443 0.0443
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0172 0.0172
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0172 0.0172
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.1749 0.1652
Brugia malayi hypothetical protein 0.0042 0.0273 0.0273
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0025 0.0065 0.0317
Echinococcus multilocularis sodium bile acid cotransporter 0.0868 1 1
Brugia malayi CXXC zinc finger family protein 0.0057 0.0446 0.0446
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0273 0.1333
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0039 0.0234 0.1145
Onchocerca volvulus 0.0057 0.0446 0.0334
Brugia malayi Zinc finger, C2H2 type family protein 0.0075 0.0661 0.0661
Schistosoma mansoni hypothetical protein 0.0057 0.0443 0.0443
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0941 0.0941
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.2784 0.5158
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0193 0.2046 1
Entamoeba histolytica hypothetical protein 0.0036 0.0193 0.2467
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0207 0.0658
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0255 0.2784 0.2784
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0518 0.0518
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0396 0.0396
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0193 0.2046 0.6266
Brugia malayi MH2 domain containing protein 0.0034 0.0172 0.0172
Schistosoma mansoni hypothetical protein 0.0395 0.443 0.443
Plasmodium vivax thioredoxin reductase, putative 0.0113 0.1102 0.5387
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0396 0.0396
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0495 0.0495
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0273 0.0273
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0221 0.0221
Echinococcus granulosus high affinity choline transporter 1 0.0344 0.3825 0.3825
Echinococcus granulosus sodium bile acid cotransporter 0.0868 1 1
Brugia malayi TAR-binding protein 0.0063 0.0518 0.0518
Giardia lamblia NADH oxidase lateral transfer candidate 0.0039 0.0234 1
Schistosoma mansoni hypothetical protein 0.0042 0.0273 0.0273
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.047 0.2295
Schistosoma mansoni hypothetical protein 0.0168 0.1749 0.1749
Schistosoma mansoni sodium-bile acid cotransporter related 0.0352 0.3921 0.3921
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.117 0.117
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0039 0.0234 0.1145
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0193 0.2046 1
Brugia malayi beta-lactamase 0.0037 0.0207 0.0207
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.2784 0.5158
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0207
Entamoeba histolytica hypothetical protein 0.0036 0.0193 0.2467
Giardia lamblia PHD finger protein 15 0.0029 0.0116 0.4936

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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