Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.8208 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0056 | 0.0034 | 0.0021 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0056 | 0.0034 | 0.2798 |
Brugia malayi | cytochrome P450 | 0.0039 | 0.0012 | 0.0007 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.3205 | 0.3883 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.8208 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0013 | 0.0004 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.8208 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0056 | 0.0034 | 0.2798 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.8208 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.8208 | 1 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.8208 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0012 | 0.0003 |
Schistosoma mansoni | cytochrome P450 | 0.0039 | 0.0012 | 0.0003 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0013 | 0.002 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.8208 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0127 | 0.012 | 0.0115 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.3205 | 0.3883 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.8208 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.3205 | 0.3883 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.8208 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.8208 | 1 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0127 | 0.012 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.8208 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0115 | 0.0106 | 0.8801 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0013 | 0.0004 |
Brugia malayi | Cytochrome P450 family protein | 0.0056 | 0.0034 | 0.0028 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.8208 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0013 | 0.002 |
Brugia malayi | Cytochrome P450 family protein | 0.0056 | 0.0034 | 0.0028 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0056 | 0.0034 | 0.0021 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3205 | 0.3883 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.3205 | 0.3883 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0013 | 0.0008 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0033 | 0.0005 | 0.0446 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3205 | 0.3883 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0127 | 0.012 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3205 | 0.3883 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.3205 | 0.3883 | 0.3876 |
Loa Loa (eye worm) | cytochrome P450 | 0.0039 | 0.0012 | 0.1009 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.8208 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.3205 | 0.3883 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.3205 | 0.3883 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0056 | 0.0034 | 0.2798 |
Trypanosoma brucei | cytochrome P450, putative | 0.0056 | 0.0034 | 0.0021 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0039 | 0.0012 | 0.0017 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0056 | 0.0034 | 0.0021 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3205 | 0.3883 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0056 | 0.0034 | 0.0021 |
Brugia malayi | Cytochrome P450 family protein | 0.0039 | 0.0012 | 0.0007 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.3205 | 0.3883 | 0.388 |
Brugia malayi | Cytochrome P450 family protein | 0.0115 | 0.0106 | 0.01 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.8208 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.012 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.012 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3205 | 0.3883 | 1 |
Echinococcus multilocularis | 0.0039 | 0.0012 | 0.0017 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.