Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0157 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0157 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0157 | 1 | 1 |
Plasmodium vivax | aldehyde reductase, putative | 0.0046 | 0.1514 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0157 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0157 | 1 | 1 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0046 | 0.1514 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0157 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0157 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0157 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0157 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0157 | 1 | 1 |
Onchocerca volvulus | 0.0157 | 1 | 1 | |
Brugia malayi | NADH-dependent xylose reductase | 0.0046 | 0.1514 | 0.1514 |
Onchocerca volvulus | 0.0157 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 1 | 1 |
Onchocerca volvulus | 0.0157 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0157 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0157 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0157 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0157 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0157 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0112 | 0.654 | 0.5922 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0157 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0157 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0157 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0157 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0157 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0157 | 1 | 1 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0046 | 0.1514 | 0.1514 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 1 | 1 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0046 | 0.1514 | 0.1514 |
Onchocerca volvulus | 0.0157 | 1 | 1 | |
Loa Loa (eye worm) | oxidoreductase | 0.0157 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0157 | 1 | 1 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0046 | 0.1514 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0157 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0157 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0157 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0157 | 1 | 1 |
Onchocerca volvulus | 0.0157 | 1 | 1 | |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0157 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0157 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0157 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0157 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0157 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0157 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0157 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0157 | 1 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0112 | 0.654 | 0.5922 |
Onchocerca volvulus | 0.0157 | 1 | 1 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0157 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0157 | 1 | 1 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0046 | 0.1514 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0157 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0157 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0157 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0112 | 0.654 | 0.5922 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0157 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0157 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0157 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0157 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0157 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0157 | 1 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0157 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0157 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0157 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0157 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0157 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0157 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0157 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0157 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0157 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0157 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0157 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0157 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0157 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0157 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0157 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0157 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0157 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0157 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 34 % | Percent inhibition of Histidine containing protein K in kinase assay with histidine containing protein at 10 microM | ChEMBL. | 15084125 |
Inhibition (binding) | = 95 % | Percent inhibition of Histidine containing protein K in kinase assay with histidine containing protein at 100 microM | ChEMBL. | 15084125 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.