Detailed information for compound 115356

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 575.655 | Formula: C31H37N5O6
  • H donors: 3 H acceptors: 4 LogP: 3.54 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)N1C(=O)CC2N(C1=O)CCCC2NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)OC(C)(C)C
  • InChi: 1S/C31H37N5O6/c1-31(2,3)42-29(39)34-25(16-19-18-32-23-9-6-5-8-22(19)23)28(38)33-24-10-7-15-35-26(24)17-27(37)36(30(35)40)20-11-13-21(41-4)14-12-20/h5-6,8-9,11-14,18,24-26,32H,7,10,15-17H2,1-4H3,(H,33,38)(H,34,39)/t24?,25-,26?/m0/s1
  • InChiKey: OEPYGXGGFXLPRT-JNLGVIEDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Cholecystokinin B receptor Starlite/ChEMBL References
Trypanosoma cruzi cysteine peptidase, putative Curated by TDR Targets References
Rattus norvegicus Cholecystokinin A receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132882 All targets in OG5_132882
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_132882 All targets in OG5_132882
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi sulfakinin receptor protein Get druggable targets OG5_132882 All targets in OG5_132882
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis g protein coupled receptor Cholecystokinin A receptor   444 aa 396 aa 23.2 %
Schistosoma mansoni rhodopsin-like orphan GPCR Cholecystokinin A receptor   444 aa 380 aa 24.2 %
Echinococcus granulosus rhodopsin orphan GPCR Cholecystokinin A receptor   444 aa 363 aa 19.6 %
Echinococcus granulosus orexin receptor type 2 Cholecystokinin A receptor   444 aa 366 aa 23.5 %
Schistosoma japonicum FMRFamide receptor, putative Cholecystokinin A receptor   444 aa 363 aa 21.2 %
Echinococcus granulosus g protein coupled receptor Cholecystokinin A receptor   444 aa 399 aa 23.3 %
Onchocerca volvulus Cholecystokinin A receptor   444 aa 385 aa 28.6 %
Echinococcus granulosus g protein coupled receptor Cholecystokinin A receptor   444 aa 396 aa 23.5 %
Echinococcus multilocularis g protein coupled receptor Cholecystokinin A receptor   444 aa 403 aa 24.1 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Cholecystokinin A receptor   444 aa 395 aa 24.6 %
Echinococcus multilocularis neuropeptides capa receptor Cholecystokinin A receptor   444 aa 400 aa 21.0 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Cholecystokinin A receptor   444 aa 374 aa 24.6 %
Schistosoma mansoni biogenic amine (5HT) receptor Cholecystokinin A receptor   444 aa 362 aa 28.2 %
Echinococcus multilocularis orexin receptor type 2 Cholecystokinin A receptor   444 aa 362 aa 22.4 %
Schistosoma mansoni amine GPCR Cholecystokinin A receptor   444 aa 412 aa 26.2 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Cholecystokinin A receptor   444 aa 383 aa 21.7 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Cholecystokinin A receptor   444 aa 379 aa 24.8 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Cholecystokinin A receptor   444 aa 364 aa 28.6 %
Echinococcus multilocularis serotonin receptor Cholecystokinin A receptor   444 aa 468 aa 22.4 %
Loa Loa (eye worm) hypothetical protein Cholecystokinin B receptor   452 aa 389 aa 31.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0033 0.0157 0.0171
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0625 0.0786
Brugia malayi Cathepsin L-like precursor 0.002 0.0027 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0069 0.0541 0.0709
Brugia malayi photoreceptor-specific nuclear receptor 0.0069 0.0541 0.0709
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0931 0.9616 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0069 0.0541 0.0536
Plasmodium falciparum flap endonuclease 1 0.0028 0.0112 1
Entamoeba histolytica hypothetical protein 0.0039 0.0225 0.0261
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0157 0.0205
Loa Loa (eye worm) hypothetical protein 0.0049 0.0326 0.0393
Brugia malayi nuclear receptor RXR 0.0033 0.0157 0.0205
Brugia malayi hypothetical protein 0.0033 0.0157 0.0205
Schistosoma mansoni nuclear receptor 0.0033 0.0157 0.0131
Brugia malayi nuclear receptor NHR-88 0.0033 0.0157 0.0205
Entamoeba histolytica hypothetical protein 0.0039 0.0225 0.0261
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0625 0.0786
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0033 0.0157 0.0131
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0743 0.7637 0.7936
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0539 0.0513
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0337 0.0311
Echinococcus granulosus dna polymerase kappa 0.0021 0.0035 0.0008
Brugia malayi hypothetical protein 0.0261 0.2564 0.3357
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0743 0.7637 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0069 0.0541 0.0516
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0069 0.0541 0.0709
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0069 0.0541 0.0516
Loa Loa (eye worm) hypothetical protein 0.0033 0.0157 0.0171
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0539 0.0534
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0069 0.0541 0.0536
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0033 0.0157 0.0205
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0743 0.7637 1
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0539 0.0705
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0337 0.0324
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0102 0.8877
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0036 0.0198 0.0225
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0035 0.0008
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0157 0.0136
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0157 0.0131
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0035 0.0934
Leishmania major cathepsin L-like protease 0.0077 0.0625 0.0786
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0069 0.0541 0.0709
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0036 0.0198 0.0172
Onchocerca volvulus 0.0033 0.0157 0.2531
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0069 0.0541 0.0709
Brugia malayi orphan nuclear receptor NR2E1 0.0033 0.0157 0.0205
Loa Loa (eye worm) hypothetical protein 0.0033 0.0157 0.0171
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0743 0.7637 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0539 0.0513
Brugia malayi Cathepsin L-like precursor 0.002 0.0027 0.0035
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0112 0.0112
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0112 1
Schistosoma mansoni coup transcription factor 0.0069 0.0541 0.0516
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0036 0.0198 0.0179
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0337 0.0408
Echinococcus multilocularis nuclear receptor nhr 48 0.0033 0.0157 0.0136
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0069 0.0541 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0069 0.0541 0.0516
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0033 0.0157 0.2531
Brugia malayi tailless protein 0.0033 0.0157 0.0205
Loa Loa (eye worm) hypothetical protein 0.0261 0.2564 0.3334
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0743 0.7637 0.7631
Echinococcus granulosus nuclear receptor nhr 48 0.0033 0.0157 0.0131
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0035 0.001
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0157 0.0131
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0102 0.0099
Brugia malayi hypothetical protein 0.0036 0.0198 0.0259
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0069 0.0541 0.0676
Loa Loa (eye worm) hypothetical protein 0.0036 0.0198 0.0225
Brugia malayi steroid hormone receptor 0.0069 0.0541 0.0709
Echinococcus multilocularis ecdysone induced protein 78C 0.0069 0.0541 0.0536
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0554 0.0694
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0337 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0069 0.0541 0.0709
Leishmania major cathepsin L-like protease 0.0077 0.0625 0.0786
Loa Loa (eye worm) nuclear hormone receptor 0.0033 0.0157 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0069 0.0541 0.0676
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0069 0.0541 0.0536
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0625 0.0776
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0035 0.0934
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0035 0.5
Schistosoma mansoni DNA polymerase eta 0.0049 0.0326 0.03
Loa Loa (eye worm) hypothetical protein 0.0069 0.0541 0.0676
Brugia malayi RNA binding protein 0.0069 0.0539 0.0705
Echinococcus granulosus geminin 0.0184 0.1753 0.1731
Loa Loa (eye worm) hypothetical protein 0.0069 0.0541 0.0676
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0035 0.001
Brugia malayi hypothetical protein 0.0039 0.0225 0.0295
Brugia malayi hypothetical protein 0.0036 0.0198 0.0259
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0033 0.0157 0.2531
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0337 0.0311
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0069 0.0541 0.0536
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0069 0.0541 0.0536
Echinococcus multilocularis FTZ F1 alpha 0.0069 0.0541 0.0536
Echinococcus granulosus thyroid hormone receptor alpha 0.0033 0.0157 0.0131
Brugia malayi nuclear receptor NHR-67 0.0033 0.0157 0.0205
Loa Loa (eye worm) hypothetical protein 0.0033 0.0157 0.0171
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0069 0.0541 0.0516
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0174 0.0193
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0102 0.0099
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0157 0.0131
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0157 0.0131
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0069 0.0541 0.0516
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0033 0.0157 0.0131
Echinococcus multilocularis dna polymerase eta 0.0049 0.0326 0.0312
Brugia malayi Cathepsin L-like precursor 0.002 0.0027 0.0035
Loa Loa (eye worm) hypothetical protein 0.0027 0.0102 0.0099
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0035 0.0008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0337 0.0442
Brugia malayi nuclear receptor NHR-88 0.0069 0.0541 0.0709
Loa Loa (eye worm) hypothetical protein 0.0069 0.0541 0.0676
Schistosoma mansoni RAR-like nuclear receptor 0.0069 0.0541 0.0516
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0451 0.0558
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0069 0.0541 0.0516
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0069 0.0541 0.0709
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0625 0.0786
Entamoeba histolytica hypothetical protein 0.0039 0.0225 0.0261
Loa Loa (eye worm) hypothetical protein 0.0069 0.0541 0.0676
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0337 0.0311
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0225 0.0199
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0743 0.7637 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0157 0.0171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0625 0.0776
Loa Loa (eye worm) steroid hormone receptor 0.0069 0.0541 0.0676
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0198 0.0259
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0033 0.0157 0.0131
Loa Loa (eye worm) hypothetical protein 0.0069 0.0541 0.0676
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0157 0.0136
Loa Loa (eye worm) hypothetical protein 0.0036 0.0198 0.0225
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0033 0.0157 0.0136
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0112 0.5784
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0743 0.7637 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0198 0.0225
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0539 0.0673
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0337 0.0324
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0625 0.0776
Brugia malayi Cathepsin L-like precursor 0.002 0.0027 0.0035
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0225 0.0199
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0539 0.0513
Schistosoma mansoni flap endonuclease-1 0.0026 0.0083 0.0057
Brugia malayi nuclear hormone receptor family member nhr-6 0.0033 0.0157 0.0205
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0069 0.0541 0.0676
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0102 0.5134
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0036 0.0198 0.0172
Onchocerca volvulus 0.0033 0.0157 0.2531
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0069 0.0541 0.0709
Schistosoma mansoni hypothetical protein 0.0184 0.1753 0.1731
Schistosoma mansoni zinc finger protein 0.0033 0.0157 0.0131
Loa Loa (eye worm) hypothetical protein 0.0069 0.0541 0.0676
Loa Loa (eye worm) hypothetical protein 0.0033 0.0157 0.0171
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0112 0.0112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0625 0.0776
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0069 0.0541 0.0536
Schistosoma mansoni nuclear receptor 0.0033 0.0157 0.0131
Loa Loa (eye worm) hypothetical protein 0.0033 0.0157 0.0171
Loa Loa (eye worm) hypothetical protein 0.0036 0.0198 0.0225
Schistosoma mansoni steroid hormone receptor ad4bp 0.0069 0.0541 0.0516
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0069 0.0541 0.0516
Loa Loa (eye worm) hypothetical protein 0.0036 0.0198 0.0225
Loa Loa (eye worm) hypothetical protein 0.0033 0.0157 0.0171
Brugia malayi Flap endonuclease-1 0.0028 0.0112 0.0146
Leishmania major cathepsin L-like protease 0.0077 0.0625 0.0786
Schistosoma mansoni hypothetical protein 0.0184 0.1753 0.1731
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0102 0.0089
Entamoeba histolytica hypothetical protein 0.0039 0.0225 0.0261
Schistosoma mansoni nuclear receptor nhr-48 0.0033 0.0157 0.0131
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0337 0.0311
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0157 0.0205
Schistosoma mansoni retinoic acid receptor RXR 0.0968 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0027 0.0035
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0112 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0069 0.0541 0.0709
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0035 0.001
Brugia malayi TAR-binding protein 0.0069 0.0539 0.0705
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0326 0.0393
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0112 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0539 0.0513
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0625 0.0776
Loa Loa (eye worm) hypothetical protein 0.0069 0.0541 0.0676
Leishmania major DNA polymerase eta, putative 0.0034 0.0174 0.0193
Leishmania major DNA polymerase eta, putative 0.0049 0.0326 0.0393
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0112 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0157 0.0136
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0112 0.0112
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0035 0.001
Brugia malayi hypothetical protein 0.0027 0.0102 0.0134
Onchocerca volvulus Bile acid receptor homolog 0.0069 0.0541 1
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0112 0.0089
Onchocerca volvulus 0.0069 0.0541 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0069 0.0541 0.0709
Echinococcus multilocularis transcription factor Dp 1 0.043 0.4342 0.45
Schistosoma mansoni nuclear hormone receptor 0.0069 0.0541 0.0516
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0069 0.0541 0.0516
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0625 0.0776
Echinococcus granulosus tar DNA binding protein 0.0069 0.0539 0.0513
Echinococcus multilocularis thyroid hormone receptor alpha 0.0069 0.0541 0.0536
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0035 0.001
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0027 0.0035
Brugia malayi nuclear hormone receptor 0.0033 0.0157 0.0205
Echinococcus multilocularis geminin 0.0184 0.1753 0.18
Loa Loa (eye worm) hypothetical protein 0.0033 0.0157 0.0171
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0069 0.0541 0.0516
Echinococcus granulosus dna polymerase eta 0.0049 0.0326 0.03
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0069 0.0541 0.0516
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0035 0.0008
Loa Loa (eye worm) hypothetical protein 0.0069 0.0541 0.0676
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0743 0.7637 1
Echinococcus granulosus FTZ F1 alpha 0.0069 0.0541 0.0516
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0102 0.8877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0625 0.0776
Brugia malayi nuclear hormone receptor family member odr-7 0.0033 0.0157 0.0205
Brugia malayi nuclear hormone receptor 0.0069 0.0541 0.0709
Loa Loa (eye worm) RNA binding protein 0.0069 0.0539 0.0673
Loa Loa (eye worm) hypothetical protein 0.0033 0.0157 0.0171
Schistosoma mansoni thyroid hormone receptor 0.0069 0.0541 0.0516
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0035 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0069 0.0541 0.0516
Loa Loa (eye worm) nuclear receptor NHR-67 0.0033 0.0157 0.0171
Brugia malayi Cathepsin L-like precursor 0.002 0.0027 0.0035
Echinococcus granulosus flap endonuclease 1 0.0028 0.0112 0.0085
Brugia malayi sulfakinin receptor protein 0.0261 0.2564 0.3357
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0625 0.0776
Brugia malayi ImpB/MucB/SamB family protein 0.0049 0.0326 0.0427
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0069 0.0541 0.0709
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0539 0.0513
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0157 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0625 0.0776
Brugia malayi ecdysteroid receptor 0.0069 0.0541 0.0709
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0035 0.0045
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0225 0.0207
Brugia malayi conserved hypotetical protein 0.0033 0.0157 0.0205
Leishmania major DNA polymerase kappa, putative 0.0021 0.0035 0.001
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0743 0.7637 1
Brugia malayi nuclear receptor RXR 0.0036 0.0198 0.0259
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0035 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0035 0.001
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0102 0.8877
Brugia malayi hypothetical protein 0.0033 0.0157 0.0205
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0035 0.0008
Brugia malayi Nuclear hormone receptor-like 1 0.0069 0.0541 0.0709
Onchocerca volvulus Protein ultraspiracle homolog 0.0069 0.0541 1
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0035 0.5
Schistosoma mansoni hypothetical protein 0.0039 0.0225 0.0199
Echinococcus granulosus transcription factor Dp 1 0.043 0.4342 0.4327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0069 0.0541 0.0676
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0035 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0069 0.0541 0.0676
Echinococcus granulosus ecdysone induced protein 78C 0.0069 0.0541 0.0516
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0198 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0625 0.0776
Brugia malayi ecdysone receptor 0.0033 0.0157 0.0205
Trypanosoma brucei DNA polymerase eta, putative 0.0049 0.0326 0.0383
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0069 0.0541 0.0709
Loa Loa (eye worm) DR-78 0.0033 0.0157 0.0171
Schistosoma mansoni thyroid hormone receptor 0.0069 0.0541 0.0516
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0069 0.0541 0.0709
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0035 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0157 0.0171
Brugia malayi Steroid receptor seven-up type 2 0.0069 0.0541 0.0709
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0112 0.0112
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0174 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0069 0.0541 0.0709
Leishmania major hypothetical protein, conserved 0.0027 0.0102 0.0099
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0069 0.0541 0.0516
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0743 0.7637 0.7631
Loa Loa (eye worm) hypothetical protein 0.0033 0.0157 0.0171
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0198 0.0259
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0539 0.0673
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0625 0.0776
Loa Loa (eye worm) hypothetical protein 0.0033 0.0157 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0069 0.0541 0.0676
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0625 0.0786
Loa Loa (eye worm) hypothetical protein 0.0033 0.0157 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0069 0.0541 0.0676

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 15.9 nM Inhibition of [3H]-pCCK-8 specific binding to cholecystokinin type A receptor in rat pancreas ChEMBL. 11405658
IC50 (binding) = 15.9 nM Inhibition of [3H]-pCCK-8 specific binding to cholecystokinin type A receptor in rat pancreas ChEMBL. 11405658
IC50 (functional) = 38.1 nM Inhibition of amylase release stimulated by CCK-8 (0.1 nM) in dispersed pancreatic acini ChEMBL. 11405658
IC50 (binding) > 10000 nM Inhibition of [3H]-pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes ChEMBL. 11405658
IC50 (binding) > 10000 nM Inhibition of [3H]-pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes ChEMBL. 11405658

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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