Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | fli-1 protein | 0.0216 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0757 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0697 | 0.0697 |
Onchocerca volvulus | 0.0027 | 0.0697 | 0.5 | |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.2325 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0697 | 0.061 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0697 | 0.0808 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0757 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.8545 | 0.8544 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0093 | 0.0093 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0757 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.2325 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0757 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.0697 | 0.5 | |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0071 | 0.2889 | 0.2889 |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.8545 | 0.8544 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.2816 | 0.2816 |
Brugia malayi | Ets-domain containing protein | 0.0071 | 0.2889 | 0.2822 |
Schistosoma mansoni | gabp alpha | 0.0071 | 0.2889 | 0.2884 |
Brugia malayi | TAR-binding protein | 0.007 | 0.2816 | 0.2749 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0024 | 0.002 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2816 | 0.2812 |
Brugia malayi | RNA binding protein | 0.007 | 0.2816 | 0.2749 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0757 | 0.067 |
Schistosoma mansoni | lamin | 0.0027 | 0.0697 | 0.0691 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0673 | 0.0673 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0071 | 0.2889 | 0.3375 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0697 | 0.0697 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.2816 | 0.2749 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.2382 | 0.2382 |
Schistosoma mansoni | lamin | 0.0027 | 0.0697 | 0.0691 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.2325 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0697 | 0.0808 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2816 | 0.2812 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0697 | 0.0808 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.2816 | 0.3291 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0697 | 0.0808 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.2325 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.2325 | 0.2715 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0071 | 0.2889 | 0.3375 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0757 | 0.5 |
Echinococcus granulosus | lamin | 0.0027 | 0.0697 | 0.0808 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0697 | 0.0808 |
Echinococcus granulosus | geminin | 0.0187 | 0.8545 | 1 |
Echinococcus multilocularis | geminin | 0.0187 | 0.8545 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.5154 | 0.5154 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.5154 | 0.5109 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.5154 | 0.5154 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.2325 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.2816 | 0.2816 |
Brugia malayi | Ets-domain containing protein | 0.0071 | 0.2889 | 0.2822 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0757 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0697 | 0.0691 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0697 | 0.0697 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.2325 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0757 | 0.0757 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2816 | 0.2812 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.2325 | 0.232 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.2325 | 0.232 |
Schistosoma mansoni | ets-related | 0.0216 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0024 | 0.0024 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0697 | 0.061 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2816 | 0.2812 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0275 | 0.0184 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.2816 | 0.3291 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.2816 | 0.2816 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.2325 | 0.2715 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.2816 | 0.2812 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0024 | 0.002 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.