Detailed information for compound 1154355

Basic information

Technical information
  • TDR Targets ID: 1154355
  • Name: 5-(4-nitrophenyl)-2,3-di(phenyl)tetrazol-2-iu m
  • MW: 344.347 | Formula: C19H14N5O2+
  • H donors: 0 H acceptors: 4 LogP: 6.19 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc(cc1)c1nn([n+](n1)c1ccccc1)c1ccccc1
  • InChi: 1S/C19H14N5O2/c25-24(26)18-13-11-15(12-14-18)19-20-22(16-7-3-1-4-8-16)23(21-19)17-9-5-2-6-10-17/h1-14H/q+1
  • InChiKey: YJKWWDQXTDOFHP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(4-nitrophenyl)-2,3-di(phenyl)-1,2,3,4-tetrazol-2-ium

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0017 0.0212 0.0212
Loa Loa (eye worm) FAD binding domain-containing protein 0.0279 1 1
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0032 0.0758 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.1595 0.1595
Trichomonas vaginalis sulfite reductase, putative 0.0279 1 1
Brugia malayi Pre-SET motif family protein 0.0034 0.0836 0.0836
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0279 1 1
Echinococcus multilocularis tar DNA binding protein 0.0069 0.2143 0.2143
Entamoeba histolytica type A flavoprotein, putative 0.0107 0.3561 0.5
Loa Loa (eye worm) FAD binding domain-containing protein 0.0172 0.6011 0.6011
Loa Loa (eye worm) TAR-binding protein 0.0069 0.2143 0.2143
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0248 0.8815 0.8159
Onchocerca volvulus 0.0269 0.9603 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.4544 0.4544
Loa Loa (eye worm) diaphorase 0.0032 0.0758 0.0758
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.4417 0.4417
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0836 0.0836
Brugia malayi FAD binding domain containing protein 0.0279 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Loa Loa (eye worm) flavodoxin family protein 0.0107 0.3561 0.3561
Brugia malayi hypothetical protein 0.0133 0.4544 0.4544
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0212 0.0212
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1428 0.1428
Schistosoma mansoni tar DNA-binding protein 0.0069 0.2143 0.2143
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0279 1 1
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0279 1 1
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0279 1 1
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0107 0.3561 0.3033
Loa Loa (eye worm) hypothetical protein 0.0133 0.4544 0.4544
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1428 0.1428
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0279 1 1
Treponema pallidum flavodoxin 0.0107 0.3561 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.1428 0.1428
Echinococcus granulosus geminin 0.0184 0.6449 0.6449
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0032 0.0758 0.0758
Schistosoma mansoni hypothetical protein 0.0017 0.0212 0.0212
Brugia malayi FAD binding domain containing protein 0.0172 0.6011 0.6011
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.2143 0.2143
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.4417 0.4417
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0107 0.3561 0.3033
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.1595 0.1595
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0836 0.0836
Schistosoma mansoni hypothetical protein 0.0017 0.0212 0.0212
Onchocerca volvulus 0.0034 0.0836 0.0871
Echinococcus granulosus tar DNA binding protein 0.0069 0.2143 0.2143
Onchocerca volvulus 0.0032 0.0758 0.0789
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0836 0.0836
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0107 0.3561 0.3033
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.1428 0.1428
Schistosoma mansoni cytochrome B5 0.0032 0.0758 0.0758
Onchocerca volvulus Huntingtin homolog 0.0133 0.4544 0.4732
Schistosoma mansoni cytochrome P450 reductase 0.0279 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.1428 0.1428
Brugia malayi Pre-SET motif family protein 0.0236 0.8385 0.8385
Echinococcus granulosus cytochrome b5 reductase 4 0.0032 0.0758 0.0758
Schistosoma mansoni hypothetical protein 0.0037 0.0955 0.0955
Leishmania major hypothetical protein, conserved 0.0107 0.3561 0.3033
Toxoplasma gondii flavodoxin domain-containing protein 0.0139 0.4746 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.2143 0.2143
Loa Loa (eye worm) hypothetical protein 0.0054 0.1595 0.1595
Loa Loa (eye worm) hypothetical protein 0.0037 0.0955 0.0955
Toxoplasma gondii flavodoxin domain-containing protein 0.0139 0.4746 1
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0107 0.3561 0.3033
Schistosoma mansoni diflavin oxidoreductase 0.0139 0.4746 0.4746
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0279 1 1
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0279 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.1428 0.1428
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0279 1 1
Echinococcus multilocularis methionine synthase reductase 0.0172 0.6011 0.6011
Entamoeba histolytica type A flavoprotein, putative 0.0107 0.3561 0.5
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0212 0.0212
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0279 1 1
Brugia malayi flavodoxin family protein 0.0107 0.3561 0.3561
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0107 0.3561 0.3033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0836 0.0836
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1428 0.1428
Schistosoma mansoni tar DNA-binding protein 0.0069 0.2143 0.2143
Echinococcus granulosus cytochrome b5 reductase 4 0.0032 0.0758 0.0758
Echinococcus multilocularis geminin 0.0184 0.6449 0.6449
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0279 1 1
Schistosoma mansoni NADPH flavin oxidoreductase 0.0141 0.4826 0.4826
Trypanosoma cruzi p450 reductase, putative 0.0279 1 1
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0172 0.6011 0.6011
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0279 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0836 0.0836
Leishmania major cytochrome P450 reductase, putative 0.0248 0.8815 0.8717
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0032 0.0758 0.0758
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0032 0.0758 0.0758
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0212 0.0212
Entamoeba histolytica type A flavoprotein, putative 0.0107 0.3561 0.5
Brugia malayi diaphorase 0.0032 0.0758 0.0758
Brugia malayi RNA binding protein 0.0069 0.2143 0.2143
Schistosoma mansoni tar DNA-binding protein 0.0069 0.2143 0.2143
Entamoeba histolytica type A flavoprotein, putative 0.0107 0.3561 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.1428 0.1428
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.079 0.079
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0955 0.0955
Schistosoma mansoni hypothetical protein 0.0184 0.6449 0.6449
Schistosoma mansoni tar DNA-binding protein 0.0069 0.2143 0.2143
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0836 0.0836
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0279 1 1
Giardia lamblia Nitric oxide synthase, inducible 0.0248 0.8815 1
Trichomonas vaginalis set domain proteins, putative 0.0269 0.9603 0.9384
Plasmodium vivax flavodoxin domain containing protein 0.0248 0.8815 0.8717
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0212 0.0212
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.2143 0.2143
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.1595 0.1595
Loa Loa (eye worm) hypothetical protein 0.0279 1 1
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0107 0.3561 0.3033
Brugia malayi MH2 domain containing protein 0.013 0.4417 0.4417
Leishmania major p450 reductase, putative 0.0279 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0212 0.0212
Mycobacterium tuberculosis Probable oxidoreductase 0.0032 0.0758 0.5
Onchocerca volvulus Huntingtin homolog 0.0133 0.4544 0.4732
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0836 0.0836
Mycobacterium tuberculosis Probable monooxygenase 0.0032 0.0758 0.5
Echinococcus granulosus GPCR family 2 0.0017 0.0212 0.0212
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0279 1 1
Chlamydia trachomatis sulfite reductase 0.0172 0.6011 1
Echinococcus multilocularis cytochrome b5 reductase 4 0.0032 0.0758 0.0758
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0279 1 1
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0032 0.0758 0.0758
Plasmodium falciparum nitric oxide synthase, putative 0.0279 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0836 0.0197
Mycobacterium tuberculosis Possible oxygenase 0.0032 0.0758 0.5
Echinococcus granulosus methionine synthase reductase 0.0172 0.6011 0.6011
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.8385 0.8385
Echinococcus multilocularis GPCR, family 2 0.0017 0.0212 0.0212
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0032 0.0758 0.0758
Plasmodium vivax SET domain protein, putative 0.0034 0.0836 0.0085
Plasmodium vivax hypothetical protein, conserved 0.0107 0.3561 0.3033
Loa Loa (eye worm) RNA binding protein 0.0069 0.2143 0.2143
Entamoeba histolytica type A flavoprotein, putative 0.0107 0.3561 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0212 0.0212
Schistosoma mansoni hypothetical protein 0.0017 0.0212 0.0212
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0034 0.0836 0.0836
Giardia lamblia Hypothetical protein 0.0248 0.8815 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.1428 0.1428
Brugia malayi TAR-binding protein 0.0069 0.2143 0.2143
Schistosoma mansoni hypothetical protein 0.0184 0.6449 0.6449
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0032 0.0758 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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