Detailed information for compound 1154419

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 263.251 | Formula: C15H9N3O2
  • H donors: 1 H acceptors: 2 LogP: 2.1 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)N1C(=O)N=C2C1=Nc1c2cccc1
  • InChi: 1S/C15H9N3O2/c19-10-7-5-9(6-8-10)18-14-13(17-15(18)20)11-3-1-2-4-12(11)16-14/h1-8,19H
  • InChiKey: HTEBNZVRKLJTAL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0437 0.6421
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.012 0.0085
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0425 0.505
Leishmania major heat shock protein 83-1 0.0031 0.0806 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0727 0.0694
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.012 0.0117
Plasmodium vivax SET domain protein, putative 0.0029 0.0727 0.8981
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0661 0.8119
Echinococcus granulosus lamin dm0 0.0026 0.063 0.0596
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0234 0.0199
Entamoeba histolytica hypothetical protein 0.0035 0.0916 1
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0596 0.0769
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0425 0.6427
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0425 0.622
Leishmania major heat shock protein 83-1 0.0031 0.0806 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.3886 0.3864
Brugia malayi Pre-SET motif family protein 0.0029 0.0727 0.0956
Leishmania major heat shock protein 83-1 0.0031 0.0806 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0661 0.0864
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0481 0.0447
Loa Loa (eye worm) hypothetical protein 0.0026 0.0615 0.0581
Schistosoma mansoni heat shock protein 0.0013 0.0198 0.0163
Mycobacterium ulcerans hypothetical protein 0.0027 0.0661 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0734 0.0966
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0596 0.8962
Schistosoma mansoni heat shock protein 0.0031 0.0806 0.0772
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0734 0.9069
Schistosoma mansoni survival motor neuron protein 0.0047 0.1304 0.1272
Brugia malayi heat shock protein 90 0.0031 0.0806 0.1065
Entamoeba histolytica hypothetical protein 0.0035 0.0916 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0661 0.8119
Trypanosoma cruzi heat shock protein, putative 0.0013 0.0198 0.2106
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0198 0.2106
Schistosoma mansoni hypothetical protein 0.0047 0.1304 0.1272
Plasmodium falciparum heat shock protein 90 0.0031 0.0806 1
Onchocerca volvulus 0.0026 0.063 0.0816
Onchocerca volvulus 0.0231 0.7322 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0553 0.0709
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0425 0.4418
Echinococcus multilocularis lamin 0.0026 0.063 0.0596
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0596 0.4497
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.012 0.0085
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1296 0.1742
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.012 0.0117
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0661 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1296 0.1264
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0661 1
Brugia malayi Pre-SET motif family protein 0.0203 0.6406 0.8811
Trichomonas vaginalis ran, putative 0.0022 0.0481 0.0611
Loa Loa (eye worm) hypothetical protein 0.0027 0.0661 0.0627
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.012 0.0085
Toxoplasma gondii heat shock protein 90, putative 0.0031 0.0806 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0036 0.0546
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0661 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.012 0.0117
Loa Loa (eye worm) heat shock protein 90 0.0031 0.0806 0.0772
Leishmania major GTP-binding protein, putative 0.0022 0.0481 0.5784
Plasmodium vivax heat shock protein 86, putative 0.0031 0.0806 1
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.012 0.0085
Echinococcus multilocularis lamin dm0 0.0026 0.063 0.0596
Loa Loa (eye worm) hypothetical protein 0.0011 0.012 0.0085
Trypanosoma brucei heat shock protein, putative 0.0031 0.0806 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0031 0.0806 1
Schistosoma mansoni hypothetical protein 0.0035 0.0916 0.0883
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0734 0.0701
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0692 0.0659
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0727 0.0694
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3886 0.3864
Toxoplasma gondii heat shock protein HSP90 0.0031 0.0806 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.012 0.0117
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.012 0.0085
Schistosoma mansoni ran 0.0022 0.0481 0.0447
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0661 0.0864
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.012 0.0085
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0189 0.0153
Loa Loa (eye worm) hypothetical protein 0.0013 0.0189 0.0153
Loa Loa (eye worm) hypothetical protein 0.0011 0.012 0.0085
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0036 0.0546
Leishmania major heat shock protein 83-1 0.0031 0.0806 1
Echinococcus granulosus heat shock protein 90 0.0025 0.0596 0.0562
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0661 0.7103
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0727 0.0694
Echinococcus multilocularis snurportin 1 0.0313 1 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0481 0.5784
Leishmania major heat shock protein 83-1 0.0031 0.0806 1
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0806 1
Loa Loa (eye worm) hypothetical protein 0.0229 0.7265 0.7255
Loa Loa (eye worm) TAR-binding protein 0.0126 0.3886 0.3864
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.0198 0.2106
Loa Loa (eye worm) hypothetical protein 0.0011 0.012 0.0085
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0661 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.012 0.0117
Schistosoma mansoni endoplasmin 0.0031 0.0806 0.0772
Trypanosoma brucei heat shock protein, putative 0.0031 0.0806 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.012 0.0085
Plasmodium vivax importin-beta 2, putative 0.0029 0.0734 0.9069
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.012 0.0085
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0661 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0425 0.0533
Schistosoma mansoni ran 0.0022 0.0481 0.0447
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0437 0.5
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0481 0.5784
Brugia malayi TAR-binding protein 0.0126 0.3886 0.5326
Brugia malayi RNA, U transporter 1 0.0083 0.25 0.3408
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 1 1
Trypanosoma brucei Heat shock protein 83, putative 0.0031 0.0806 1
Plasmodium falciparum importin beta, putative 0.0029 0.0734 0.9069
Brugia malayi RNA binding protein 0.0126 0.3886 0.5326
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.012 0.0085
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0596 0.0769
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0425 0.0533
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0661 1
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0437 0.5213
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0661 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0437 0.0403
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0806 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.012 0.0085
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.012 0.0085
Onchocerca volvulus 0.0026 0.063 0.0816
Trypanosoma brucei heat shock protein, putative 0.0031 0.0806 1
Echinococcus multilocularis musashi 0.0026 0.063 0.0596
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0384 0.452
Brugia malayi steroid hormone receptor 0.0011 0.012 0.0117
Loa Loa (eye worm) hypothetical protein 0.0029 0.0727 0.0694
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0727 0.0694
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0727 0.0694
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0661 0.7103
Leishmania major importin beta-1 subunit, putative 0.0024 0.0553 0.6716
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.063 0.0596
Toxoplasma gondii exonuclease III APE 0.002 0.0425 0.505
Brugia malayi Hsp90 protein 0.0013 0.0198 0.0224
Loa Loa (eye worm) hypothetical protein 0.002 0.0437 0.0403
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.6406 0.6393
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.012 0.0085
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0036 0.0546
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.3886 0.5326
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0425 0.0538
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0553 0.0709
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0806 1
Trichomonas vaginalis set domain proteins, putative 0.0231 0.7322 1
Echinococcus granulosus endoplasmin 0.0025 0.0596 0.0562
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0481 0.0616
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0727 0.0694
Giardia lamblia Grp94/Hsp90 0.0025 0.0596 0.4497
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0806 1
Schistosoma mansoni ap endonuclease 0.002 0.0425 0.039
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.012 0.0085
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.012 0.0117
Brugia malayi nuclear receptor NHR-88 0.0011 0.012 0.0117
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0425 0.039
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.012 0.0117
Entamoeba histolytica hypothetical protein 0.0035 0.0916 1
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.0198 0.0163
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0596 0.7276
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.063 0.0822
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.012 0.0085
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0036 0.0546
Plasmodium falciparum endoplasmin, putative 0.0019 0.0408 0.483
Leishmania major heat shock protein 83-1 0.0031 0.0806 1
Brugia malayi intermediate filament protein 0.0026 0.063 0.0822
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1296 0.1264
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0198 0.0163
Entamoeba histolytica Ran family GTPase 0.0022 0.0481 0.506
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.012 0.0117
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.7265 0.7255
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0198 0.2106
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0425 0.505
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0661 0.0864
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0036 0.0546
Plasmodium vivax heat shock protein 90, putative 0.0013 0.0198 0.2106
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0234 0.0274
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.0198 0.0163
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.012 0.0085
Loa Loa (eye worm) hypothetical protein 0.0012 0.0173 0.0137
Echinococcus granulosus lamin 0.0026 0.063 0.0596
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0036 0.0546
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0916 0.0883
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.012 0.0085
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0661 1
Leishmania major heat shock protein 83-1 0.0031 0.0806 1
Onchocerca volvulus 0.0029 0.0727 0.0949
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0916 0.0883
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.012 0.0085
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0481 0.5784
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0401 0.6071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.012 0.0117
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0806 0.8749
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0596 0.9019
Trypanosoma brucei heat shock protein 84, putative 0.0013 0.0198 0.2106
Echinococcus granulosus FTZ F1 alpha 0.0011 0.012 0.0085
Onchocerca volvulus 0.0011 0.012 0.0116
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0596 0.0562
Leishmania major heat shock protein 83-1 0.0031 0.0806 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.012 0.0085
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1296 0.1264
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3886 0.3864
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0437 0.6617
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1296 0.1264
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.012 0.0117
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0401 0.6071
Echinococcus multilocularis heat shock protein 0.0031 0.0806 0.0772
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.7265 0.7255
Schistosoma mansoni endoplasmin 0.0031 0.0806 0.0772
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0727 0.8981
Leishmania major heat shock protein 83-1 0.0031 0.0806 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.063 0.0596
Entamoeba histolytica hypothetical protein 0.0024 0.0553 0.5876
Brugia malayi nuclear hormone receptor 0.0011 0.012 0.0117
Brugia malayi hypothetical protein 0.0229 0.7265 1
Schistosoma mansoni heat shock protein 0.0031 0.0806 0.0772
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0553 0.6716
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.012 0.0117
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0036 0.0546
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3886 0.3864
Echinococcus granulosus heat shock protein 90 0.0031 0.0806 0.0772
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0596 0.7276
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1296 0.1264
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.012 0.0116
Brugia malayi Endoplasmin precursor 0.0031 0.0806 0.1065
Schistosoma mansoni lamin 0.0026 0.063 0.0596
Loa Loa (eye worm) hypothetical protein 0.002 0.0437 0.0403
Trypanosoma brucei heat shock protein, putative 0.0031 0.0806 1
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.012 0.0116
Entamoeba histolytica hypothetical protein 0.0035 0.0916 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0401 0.6071
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.012 0.0085
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0661 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0425 0.039
Onchocerca volvulus 0.0047 0.1304 0.174
Leishmania major heat shock protein 83-1 0.0031 0.0806 1
Trichomonas vaginalis heat shock protein, putative 0.0013 0.0198 0.0222
Echinococcus granulosus intermediate filament protein 0.0026 0.063 0.0596
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0806 0.1056
Echinococcus granulosus heat shock protein 0.0031 0.0806 0.0772
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.012 0.0085
Echinococcus multilocularis heat shock protein 90 0.0025 0.0596 0.0562
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.012 0.0085
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0806 1
Plasmodium vivax heat shock protein, putative 0.0013 0.0198 0.2106
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0806 0.8749
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0596 0.7276
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0806 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0661 0.0627
Loa Loa (eye worm) hypothetical protein 0.0029 0.0734 0.0701
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.0198 0.2106
Loa Loa (eye worm) endoplasmin 0.0031 0.0806 0.0772
Loa Loa (eye worm) hypothetical protein 0.0012 0.0173 0.0137
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0425 0.505
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.012 0.0085
Loa Loa (eye worm) RNA binding protein 0.0126 0.3886 0.3864
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.012 0.0085
Leishmania major heat shock protein, putative 0.0013 0.0198 0.2106
Echinococcus granulosus importin subunit beta 1 0.0029 0.0734 0.0701
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0425 0.505
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.012 0.0116
Schistosoma mansoni hypothetical protein 0.0313 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0437 0.0403
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0661 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.012 0.0085
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.012 0.0085
Trypanosoma brucei heat shock protein, putative 0.0031 0.0806 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.012 0.0085
Schistosoma mansoni coup transcription factor 0.0011 0.012 0.0085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1296 0.1264
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.012 0.0085
Loa Loa (eye worm) hypothetical protein 0.0011 0.012 0.0085
Loa Loa (eye worm) hypothetical protein 0.002 0.0437 0.0403
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0481 0.1483
Schistosoma mansoni lamin 0.0026 0.063 0.0596
Leishmania major heat shock protein 83-1 0.0031 0.0806 1
Onchocerca volvulus 0.0027 0.0661 0.0858
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.012 0.0117
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0481 0.5784
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0481 0.0447
Trichomonas vaginalis heat shock protein, putative 0.0019 0.0408 0.051
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.012 0.0085
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0661 0.8119
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.012 0.0117
Echinococcus multilocularis tar DNA binding protein 0.0126 0.3886 0.3864
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0036 0.0546
Schistosoma mansoni ap endonuclease 0.002 0.0425 0.039
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0036 0.0546
Trypanosoma brucei heat shock protein, putative 0.0031 0.0806 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0425 0.505
Echinococcus multilocularis endoplasmin 0.0025 0.0596 0.0562
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.012 0.0117
Loa Loa (eye worm) hypothetical protein 0.0026 0.063 0.0596
Brugia malayi hypothetical protein 0.0035 0.0916 0.1217
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0553 0.0709
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0481 0.5784
Schistosoma mansoni thyroid hormone receptor 0.0011 0.012 0.0085
Schistosoma mansoni importin beta-1 0.0029 0.0734 0.0701
Loa Loa (eye worm) hypothetical protein 0.0011 0.012 0.0085
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.1304 0.1754
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.012 0.0085
Trypanosoma brucei heat shock protein, putative 0.0031 0.0806 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0481 0.0447
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0189 0.0153
Loa Loa (eye worm) hypothetical protein 0.0027 0.0661 0.0627
Leishmania major heat shock protein 83-1 0.0031 0.0806 1
Brugia malayi ecdysteroid receptor 0.0011 0.012 0.0117
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3886 0.3864
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.012 0.0117
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0734 0.9069
Treponema pallidum heat shock protein 90 0.0025 0.0596 1
Trichomonas vaginalis endoplasmin, putative 0.0019 0.0408 0.051
Schistosoma mansoni intermediate filament proteins 0.0026 0.063 0.0596
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.012 0.0085
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0661 0.7103
Leishmania major heat shock protein 83-1 0.0031 0.0806 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.0596 0.8962
Schistosoma mansoni tar DNA-binding protein 0.0126 0.3886 0.3864
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0481 0.5784
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.012 0.0085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.012 0.0085
Leishmania major heat shock protein 83-1 0.0031 0.0806 1
Leishmania major heat shock protein 83-1 0.0031 0.0806 1
Leishmania major heat shock protein 83-1 0.0031 0.0806 1
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0806 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1296 0.1264
Plasmodium vivax endoplasmin, putative 0.0031 0.0806 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0916 0.0883
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.012 0.0085
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.0198 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.012 0.0117
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.012 0.0085
Schistosoma mansoni thyroid hormone receptor 0.0011 0.012 0.0085
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0401 0.6071
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0036 0.0546
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0013 0.0198 0.1842
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0425 0.039
Echinococcus granulosus tar DNA binding protein 0.0126 0.3886 0.3864
Echinococcus multilocularis heat shock protein 90 0.0031 0.0806 0.0772
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0036 0.0546
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0727 0.0694
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0425 0.505
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0734 0.9069
Loa Loa (eye worm) hypothetical protein 0.0011 0.012 0.0085
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0661 1
Leishmania major heat shock protein 83-1 0.0031 0.0806 1
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0596 0.0769
Schistosoma mansoni nuclear hormone receptor 0.0011 0.012 0.0085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1296 0.1264
Trypanosoma brucei heat shock protein, putative 0.0031 0.0806 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0025 0.0596 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.012 0.0085
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0437 0.5213
Loa Loa (eye worm) hypothetical protein 0.0011 0.012 0.0085

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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