Detailed information for compound 1154423

Basic information

Technical information
  • TDR Targets ID: 1154423
  • Name: 1-hexyl-N-[6-[(1-hexylpyridin-1-ium-4-carbony l)amino]hexyl]pyridin-1-ium-4-carboxamide
  • MW: 496.728 | Formula: C30H48N4O2++
  • H donors: 2 H acceptors: 2 LogP: 6.26 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCC[n+]1ccc(cc1)C(=O)NCCCCCCNC(=O)c1cc[n+](cc1)CCCCCC
  • InChi: 1S/C30H46N4O2/c1-3-5-7-13-21-33-23-15-27(16-24-33)29(35)31-19-11-9-10-12-20-32-30(36)28-17-25-34(26-18-28)22-14-8-6-4-2/h15-18,23-26H,3-14,19-22H2,1-2H3/p+2
  • InChiKey: AVRKVIRZKLJRAZ-UHFFFAOYSA-P  


Substructure search Similarity search

Network

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Synonyms

  • 1-hexyl-N-[6-[[(1-hexyl-4-pyridin-1-iumyl)-oxomethyl]amino]hexyl]-4-pyridin-1-iumcarboxamide
  • 1-hexyl-N-[6-[(1-hexylpyridin-1-ium-4-yl)carbonylamino]hexyl]pyridin-1-ium-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0311 0.0403
Brugia malayi Calcitonin receptor-like protein seb-1 0.016 0.1432 0.4626
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.003 0.0168 0.1327
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.04 0.1192
Brugia malayi latrophilin 2 splice variant baaae 0.0109 0.094 0.2988
Echinococcus granulosus lamin dm0 0.0032 0.0186 0.024
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.003 0.0168 0.1327
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0645 0.0645
Onchocerca volvulus 0.0079 0.0645 0.3289
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0645 0.1707
Schistosoma mansoni ferritin 0.0017 0.0045 0.0045
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.003 0.0168 0.4098
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0113 0.0975 0.2846
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.003 0.0168 0.1327
Leishmania major hypothetical protein, conserved 0.0028 0.0151 0.0217
Trichomonas vaginalis disulfide oxidoreductase, putative 0.003 0.0168 0.1327
Leishmania major trypanothione reductase 0.0326 0.3046 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.003 0.0168 0.02
Loa Loa (eye worm) hypothetical protein 0.003 0.0168 0.049
Plasmodium vivax thioredoxin reductase, putative 0.0326 0.3046 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0369 0.0478
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0113 0.0975 0.3002
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0645 0.1887
Schistosoma mansoni hypothetical protein 0.0168 0.1512 0.1512
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0645 0.0766
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1011 0.3274
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0286 0.037
Toxoplasma gondii ABC1 family protein 0.0079 0.0645 0.1707
Loa Loa (eye worm) hypothetical protein 0.0022 0.0087 0.022
Mycobacterium ulcerans hypothetical protein 0.0079 0.0645 0.6455
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.003 0.0168 0.042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.04 0.0475
Brugia malayi beta-lactamase family protein 0.0079 0.0645 0.2008
Plasmodium falciparum glutathione reductase 0.0326 0.3046 1
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0645 0.0763
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0113 0.0975 0.2846
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.1311 0.1698
Echinococcus granulosus expressed protein 0.0017 0.0045 0.0058
Toxoplasma gondii selenide, water dikinase 0.003 0.0168 0.0059
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.04 0.0519
Trypanosoma cruzi trypanothione reductase, putative 0.0113 0.0975 0.3002
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0275 0.0426
Mycobacterium ulcerans beta-lactamase 0.0079 0.0645 0.6455
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0743 0.7106 0.8975
Entamoeba histolytica hypothetical protein 0.0042 0.0286 1
Brugia malayi RNA binding protein 0.0074 0.0597 0.1846
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.1619 1
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0151 0.0428
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0597 0.0597
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0113 0.0975 0.3002
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0087 0.0216
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.003 0.0168 0.0218
Schistosoma mansoni hypothetical protein 0.0168 0.1512 0.1512
Schistosoma mansoni glutamate synthase 0.003 0.0168 0.0168
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0645 0.2062
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0168 0.0275
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0825 0.7913 1
Schistosoma mansoni ferritin light chain 0.0017 0.0045 0.0045
Echinococcus granulosus tar DNA binding protein 0.0074 0.0597 0.0773
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0113 0.0975 0.3002
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0311 0.0551
Entamoeba histolytica hypothetical protein 0.0042 0.0286 1
Mycobacterium ulcerans glutamate synthase subunit beta 0.003 0.0168 0.1327
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0597 0.0597
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.003 0.0168 0.1327
Echinococcus multilocularis ferritin 0.0017 0.0045 0.0053
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0087 0.0113
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.003 0.0168 0.0059
Trichomonas vaginalis disulfide oxidoreductase, putative 0.003 0.0168 0.1327
Schistosoma mansoni apoferritin-2 0.0017 0.0045 0.0045
Trypanosoma brucei NADH dehydrogenase 0.003 0.0168 0.0485
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.003 0.0168 0.0275
Mycobacterium tuberculosis Conserved protein 0.0079 0.0645 0.0763
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0275 0.9435
Trypanosoma brucei unspecified product 0.0022 0.0087 0.0216
Trypanosoma brucei trypanothione reductase 0.0326 0.3046 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0113 0.0975 1
Entamoeba histolytica thioredoxin reductase, putative 0.003 0.0168 0.4098
Mycobacterium tuberculosis Conserved protein 0.0079 0.0645 0.0763
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0113 0.0975 0.1263
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.1352 0.1604
Loa Loa (eye worm) hypothetical protein 0.016 0.1432 0.4665
Schistosoma mansoni glutamate synthase 0.003 0.0168 0.0168
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0645 0.0763
Loa Loa (eye worm) hypothetical protein 0.0079 0.0645 0.2066
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0113 0.0975 0.1157
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.003 0.0168 0.0275
Loa Loa (eye worm) hypothetical protein 0.0028 0.0151 0.0433
Loa Loa (eye worm) hypothetical protein 0.0079 0.0645 0.2066
Brugia malayi hypothetical protein 0.0028 0.0151 0.0363
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.003 0.0168 0.1327
Mycobacterium tuberculosis Probable dehydrogenase 0.0743 0.7106 0.8975
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0743 0.7106 0.8975
Plasmodium falciparum thioredoxin reductase 0.0113 0.0975 0.2846
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0087 0.0216
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0113 0.0975 0.2846
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0645 0.6455
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0026 0.0031
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0645 0.0763
Loa Loa (eye worm) hypothetical protein 0.0109 0.094 0.3039
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0275 0.2112
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0825 0.7913 1
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0645 0.6455
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0083 0.0684 0.2135
Echinococcus granulosus GPCR family 2 0.0051 0.0369 0.0478
Schistosoma mansoni apoferritin-2 0.0017 0.0045 0.0045
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.003 0.0168 0.1327
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0645 0.0763
Echinococcus multilocularis lamin 0.0032 0.0186 0.022
Mycobacterium tuberculosis Conserved protein 0.0079 0.0645 0.0763
Onchocerca volvulus 0.0032 0.0186 0.0118
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0645 0.6455
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0087 0.0216
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0645 0.0645
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0113 0.0975 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0825 0.7913 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0369 0.1152
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.003 0.0168 0.0059
Loa Loa (eye worm) glutathione reductase 0.0326 0.3046 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0186 0.0546
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0743 0.7106 0.8975
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0087 0.0451
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0326 0.3046 0.3814
Brugia malayi hypothetical protein 0.0018 0.0054 0.0039
Brugia malayi TAR-binding protein 0.0074 0.0597 0.1846
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0186 0.0546
Echinococcus granulosus lamin 0.0032 0.0186 0.024
Echinococcus multilocularis musashi 0.0032 0.0186 0.022
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0087 0.0451
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.003 0.0168 0.0218
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0743 0.7106 0.8975
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.003 0.0168 0.1327
Schistosoma mansoni hypothetical protein 0.003 0.0168 0.0168
Schistosoma mansoni lamin 0.0032 0.0186 0.0186
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0311 0.2856
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0113 0.0975 0.3002
Loa Loa (eye worm) hypothetical protein 0.0032 0.0186 0.0546
Echinococcus multilocularis thioredoxin glutathione reductase 0.0327 0.3062 0.3633
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0087 0.0216
Loa Loa (eye worm) hypothetical protein 0.0079 0.0645 0.2066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.04 0.04
Brugia malayi hypothetical protein 0.0042 0.0286 0.0811
Brugia malayi beta-lactamase 0.0079 0.0645 0.2008
Loa Loa (eye worm) beta-lactamase 0.0079 0.0645 0.2066
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0087 0.0149
Trichomonas vaginalis esterase, putative 0.0079 0.0645 0.6455
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.04 0.1256
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0113 0.0975 0.3002
Loa Loa (eye worm) RNA binding protein 0.0074 0.0597 0.1906
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.003 0.0168 0.0218
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.003 0.0168 0.0485
Schistosoma mansoni sulfide quinone reductase 0.003 0.0168 0.0168
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0026 0.0034
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.003 0.0168 0.02
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0597 0.1846
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0083 0.0684 0.2135
Brugia malayi Thioredoxin reductase 0.0326 0.3046 1
Schistosoma mansoni ferritin 0.0017 0.0045 0.0045
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.003 0.0168 0.0157
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0186 0.0477
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.003 0.0168 0.1327
Treponema pallidum oxidoreductase 0.003 0.0168 0.1327
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0597 0.0708
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.003 0.0168 0.0157
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0369 0.1087
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0087 0.0216
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0019
Mycobacterium ulcerans dehydrogenase 0.003 0.0168 0.1327
Schistosoma mansoni glutamate synthase 0.003 0.0168 0.0168
Entamoeba histolytica glutamate synthase beta subunit, putative 0.003 0.0168 0.4098
Loa Loa (eye worm) programmed cell death 8 0.003 0.0168 0.049
Plasmodium falciparum ferrodoxin reductase-like protein 0.003 0.0168 0.0059
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.003 0.0168 0.4098
Treponema pallidum NADH oxidase 0.0113 0.0975 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.1352 0.1352
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.003 0.0168 0.0059
Schistosoma mansoni hypothetical protein 0.0051 0.0369 0.0369
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0825 0.7913 1
Schistosoma mansoni hypothetical protein 0.0051 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0079 0.0645 0.2066
Onchocerca volvulus 0.0032 0.0186 0.0118
Loa Loa (eye worm) hypothetical protein 0.0079 0.0645 0.2066
Echinococcus granulosus geminin 0.0168 0.1512 0.1959
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.003 0.0168 0.0218
Schistosoma mansoni lamin 0.0032 0.0186 0.0186
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0645 0.0763
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0113 0.0975 0.3002
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.003 0.0168 0.0157
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.016 0.1432 0.4626
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.003 0.0168 0.0157
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.003 0.0168 0.0157
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.003 0.0168 0.1327
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.003 0.0168 0.1327
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0087 0.0216
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0597 0.1906
Schistosoma mansoni microtubule-associated protein tau 0.0806 0.772 0.772
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.003 0.0168 0.042
Echinococcus granulosus intermediate filament protein 0.0032 0.0186 0.024
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.003 0.0168 0.0157
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0087 0.0216
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0645 0.0763
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0645 0.6455
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0113 0.0975 1
Entamoeba histolytica disulphide oxidoreductase, putative 0.003 0.0168 0.4098
Plasmodium vivax glutathione reductase, putative 0.0326 0.3046 1
Brugia malayi intermediate filament protein 0.0032 0.0186 0.0477
Echinococcus granulosus microtubule associated protein 2 0.0806 0.772 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0113 0.0975 0.3002
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.003 0.0168 0.02
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0504 0.4787 0.6027
Loa Loa (eye worm) hypothetical protein 0.0179 0.1619 0.5283
Mycobacterium ulcerans NADH dehydrogenase 0.003 0.0168 0.1327
Giardia lamblia Thioredoxin reductase 0.003 0.0168 0.0918
Schistosoma mansoni hypothetical protein 0.0051 0.0369 0.0369
Schistosoma mansoni ferritin 0.0017 0.0045 0.0045
Trichomonas vaginalis mercuric reductase, putative 0.0113 0.0975 1
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.003 0.0168 0.0485
Leishmania major NADH dehydrogenase, putative 0.003 0.0168 0.0275
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.003 0.0168 0.1327
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0113 0.0975 0.3002
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.003 0.0168 0.0059
Echinococcus granulosus dna polymerase kappa 0.0022 0.0087 0.0113
Loa Loa (eye worm) hypothetical protein 0.0051 0.0369 0.1152
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0087 0.0149
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.003 0.0168 0.0059
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.003 0.0168 0.02
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.1352 0.436
Trypanosoma cruzi NADH dehydrogenase, putative 0.003 0.0168 0.0275
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.04 0.0519
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0645 0.6455
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.003 0.0168 0.0157
Trichomonas vaginalis disulfide oxidoreductase, putative 0.003 0.0168 0.1327
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0113 0.0975 0.3002
Echinococcus granulosus glutamate synthase 0.003 0.0168 0.0218
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0311 0.0551
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0113 0.0975 0.3152
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0087 0.0216
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0259 0.2397 0.7855
Echinococcus multilocularis GPCR, family 2 0.0051 0.0369 0.0438
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0113 0.0975 0.0975
Plasmodium falciparum thioredoxin reductase 0.0326 0.3046 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0087 0.0451
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0113 0.0975 0.3152
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0087 0.0103
Echinococcus multilocularis microtubule associated protein 2 0.0806 0.772 0.916
Giardia lamblia Glutamate synthase 0.003 0.0168 0.0918
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0286 0.0339
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0597 0.1906
Mycobacterium tuberculosis Probable reductase 0.0743 0.7106 0.8975
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0087 0.0216
Brugia malayi MH2 domain containing protein 0.0116 0.1011 0.3225
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.003 0.0168 0.1327
Echinococcus granulosus ferritin 0.0017 0.0045 0.0058
Loa Loa (eye worm) hypothetical protein 0.0079 0.0645 0.2066
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0597 0.0597
Treponema pallidum thioredoxin reductase (trxB) 0.003 0.0168 0.1327
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.003 0.0168 0.1327
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0168 0.0275
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0645 0.2008
Brugia malayi glutamate synthase 0.003 0.0168 0.042
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.003 0.0168 0.0275
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0311 0.0551
Mycobacterium leprae Probable lipase LipE 0.0079 0.0645 0.0763
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0369 0.0438
Toxoplasma gondii NADPH-glutathione reductase 0.0113 0.0975 0.2846
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0087 0.0087
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0087 0.0103
Trichomonas vaginalis apoptosis inducing factor, putative 0.003 0.0168 0.1327
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0645 0.1887
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0113 0.0975 0.3002
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.003 0.0168 0.0157
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0113 0.0975 0.1182
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.003 0.0168 0.0275
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0113 0.0975 0.3002
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0597 0.0597
Toxoplasma gondii thioredoxin reductase 0.0326 0.3046 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.003 0.0168 0.0275
Onchocerca volvulus 0.0079 0.0645 0.3289
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.003 0.0168 0.1327
Schistosoma mansoni intermediate filament proteins 0.0032 0.0186 0.0186
Schistosoma mansoni hypothetical protein 0.0042 0.0286 0.0286
Mycobacterium ulcerans lipase LipD 0.0079 0.0645 0.6455
Echinococcus granulosus sulfide:quinone oxidoreductase 0.003 0.0168 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0087 0.0216
Loa Loa (eye worm) thioredoxin reductase 0.0326 0.3046 1
Schistosoma mansoni sulfide quinone reductase 0.003 0.0168 0.0168
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.003 0.0168 0.0157
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.003 0.0168 0.0485
Echinococcus multilocularis geminin 0.0168 0.1512 0.1794
Plasmodium falciparum glutathione reductase 0.0113 0.0975 0.2846
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.04 0.04
Mycobacterium ulcerans ferredoxin reductase 0.003 0.0168 0.1327
Entamoeba histolytica hypothetical protein 0.0042 0.0286 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0087 0.0087
Leishmania major hypothetical protein, conserved 0.003 0.0168 0.0275
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0645 0.0763
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0151 0.0217
Trichomonas vaginalis glutamate synthase, putative 0.003 0.0168 0.1327
Schistosoma mansoni disulfide oxidoreductase 0.003 0.0168 0.0168
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0113 0.0975 0.2846
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0087 0.0053
Mycobacterium ulcerans monoxygenase 0.003 0.0168 0.1327
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0645 0.6455
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.003 0.0168 0.042
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.003 0.0168 0.0218
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0878 0.8427 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.003 0.0168 0.0059
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0645 0.0763
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.003 0.0168 0.0918
Brugia malayi glutathione reductase 0.0326 0.3046 1
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.003 0.0168 0.02
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.04 0.0475
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0369 0.0478
Trichomonas vaginalis glutamate synthase, putative 0.003 0.0168 0.1327
Entamoeba histolytica hypothetical protein 0.0042 0.0286 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0113 0.0975 1
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.003 0.0168 0.0059
Onchocerca volvulus 0.0079 0.0645 0.3289
Trichomonas vaginalis glutathione reductase, putative 0.0113 0.0975 1
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0645 0.6455
Trichomonas vaginalis disulfide oxidoreductase, putative 0.003 0.0168 0.1327
Echinococcus multilocularis lamin dm0 0.0032 0.0186 0.022
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0311 0.2856
Loa Loa (eye worm) pigment dispersing factor receptor c 0.016 0.1432 0.4665
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0597 0.0597
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.003 0.0168 0.0485
Trypanosoma cruzi trypanothione reductase, putative 0.0326 0.3046 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0151 0.0217
Schistosoma mansoni hypothetical protein 0.0051 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0031 0.018 0.0528
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0113 0.0975 0.3106
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0087 0.0053
Trichomonas vaginalis disulfide oxidoreductase, putative 0.003 0.0168 0.1327
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.003 0.0168 0.4098
Mycobacterium ulcerans hypothetical protein 0.003 0.0168 0.1327
Entamoeba histolytica glutamate synthase beta subunit, putative 0.003 0.0168 0.4098
Plasmodium vivax ferrodoxin reductase, putative 0.003 0.0168 0.0059
Leishmania major hypothetical protein, conserved 0.003 0.0168 0.0275
Schistosoma mansoni DNA polymerase eta 0.0022 0.0087 0.0087
Brugia malayi follicle stimulating hormone receptor 0.0259 0.2397 0.784
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0113 0.0975 0.2846
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0087 0.022
Schistosoma mansoni hypothetical protein 0.0109 0.094 0.094
Loa Loa (eye worm) acetyltransferase 0.0152 0.1352 0.4401
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0113 0.0975 0.3002
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.003 0.0168 0.0059
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0113 0.0975 0.3152
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0087 0.0451
Giardia lamblia NADH oxidase lateral transfer candidate 0.0113 0.0975 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0327 0.3062 0.3967
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0369 0.0438
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0113 0.0975 1
Leishmania major hypothetical protein, conserved 0.0079 0.0645 0.1887
Echinococcus multilocularis expressed protein 0.0017 0.0045 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0087 0.0216
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.003 0.0168 0.0059
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0286 0.0286
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0087 0.0216
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.003 0.0168 0.0275
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0369 0.1087
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0168 0.0485
Schistosoma mansoni ferritin light chain 0.0017 0.0045 0.0045
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.003 0.0168 0.02
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.003 0.0168 0.0275
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0113 0.0975 1
Brugia malayi N-terminal motif family protein 0.0179 0.1619 0.5249
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.003 0.0168 0.0275
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.04 0.04
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0113 0.0975 0.3152
Brugia malayi beta-lactamase family protein 0.0079 0.0645 0.2008
Echinococcus multilocularis dna polymerase eta 0.0022 0.0087 0.0103
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0087 0.0216
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1011 0.3274
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0743 0.7106 0.8975
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0042 0.0073
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0645 0.0836
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0645 0.2066
Trichomonas vaginalis disulfide oxidoreductase, putative 0.003 0.0168 0.1327
Echinococcus granulosus dna polymerase eta 0.0022 0.0087 0.0113
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.003 0.0168 0.049
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0087 0.0216
Leishmania major hypothetical protein, conserved 0.003 0.0168 0.0275
Echinococcus multilocularis glutamate synthase 0.003 0.0168 0.02
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.003 0.0168 0.0157
Schistosoma mansoni ferritin 0.0017 0.0045 0.0045

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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