Detailed information for compound 1154682

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 316.782 | Formula: C17H17ClN2O2
  • H donors: 1 H acceptors: 1 LogP: 2.86 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)C1(CCNCC1)CN2C(=O)c1ccco1
  • InChi: 1S/C17H17ClN2O2/c18-12-3-4-14-13(10-12)17(5-7-19-8-6-17)11-20(14)16(21)15-2-1-9-22-15/h1-4,9-10,19H,5-8,11H2
  • InChiKey: AZSNCQLMLNJFPG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0619 0.8768 0.9938
Brugia malayi Valyl-tRNA synthetase 0.0022 0.0137 0.0134
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0538 0.4366
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0018 0.0085 0.002
Echinococcus granulosus lamin 0.0026 0.0196 0.0222
Brugia malayi hypothetical protein 0.0022 0.0137 0.0134
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0156
Entamoeba histolytica hypothetical protein 0.0022 0.0137 0.0323
Echinococcus multilocularis tyrosine protein kinase Fyn 0.002 0.0109 0.0123
Brugia malayi Protein cec-1. 0.0022 0.0137 0.0134
Schistosoma mansoni hypothetical protein 0.0018 0.0084 0.0014
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0045 0.0468 0.053
Echinococcus multilocularis chromobox protein 1 0.0135 0.177 0.2007
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.002 0.0109 0.0042
Brugia malayi PHD-finger family protein 0.005 0.0536 0.059
Brugia malayi jmjC domain containing protein 0.0072 0.0862 0.0962
Onchocerca volvulus Alhambra homolog 0.0056 0.0635 0.0555
Schistosoma mansoni chromobox protein 0.0135 0.177 0.197
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.002 0.0109 0.0123
Schistosoma mansoni zinc finger protein 0.0031 0.0259 0.0216
Schistosoma mansoni phd finger protein 0.0023 0.0153 0.0093
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.002 0.0109 0.0123
Echinococcus multilocularis Chromobox protein 3 0.0022 0.0137 0.0156
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0022 0.0137 0.0075
Loa Loa (eye worm) hypothetical protein 0.0035 0.0322 0.0365
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0132 0.1722 1
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0081 0.001
Echinococcus multilocularis jumonji domain containing protein 0.0079 0.0955 0.1082
Trichomonas vaginalis esterase, putative 0.0035 0.0322 0.0188
Echinococcus granulosus growth factor receptor bound protein 2 0.0018 0.0073 0.0082
Brugia malayi jmjC domain containing protein 0.0018 0.0081 0.007
Echinococcus granulosus chromobox protein 2 0.0022 0.0137 0.0156
Schistosoma mansoni jumonji domain containing protein 0.0147 0.1944 0.2171
Loa Loa (eye worm) hypothetical protein 0.0443 0.6219 0.7049
Brugia malayi intermediate filament protein 0.0026 0.0196 0.0201
Echinococcus multilocularis PWWP domain containing protein 2A 0.0018 0.0084 0.0096
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0185 0.2494 0.2827
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0137 0.0534
Schistosoma mansoni tyrosine kinase 0.0614 0.8694 1
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0912 0.0786
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0669 0.0691
Loa Loa (eye worm) jmjC domain-containing protein 0.0117 0.1505 0.1706
Trichomonas vaginalis chromobox protein, putative 0.0081 0.0995 0.087
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0538 0.2785
Brugia malayi Sex muscle abnormal protein 5 0.0018 0.0073 0.006
Loa Loa (eye worm) hypothetical protein 0.0454 0.6385 0.7237
Echinococcus multilocularis growth factor receptor bound protein 2 0.0018 0.0073 0.0082
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0322 0.029
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0322 0.1468
Plasmodium vivax SET domain protein, putative 0.0091 0.1128 1
Schistosoma mansoni hypothetical protein 0.0018 0.0085 0.0014
Echinococcus granulosus phd:f box containing protein 0.0018 0.0081 0.0092
Loa Loa (eye worm) hypothetical protein 0.0236 0.3234 0.3665
Brugia malayi jmjC domain containing protein 0.0018 0.0081 0.007
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0185 0.2494 0.2827
Loa Loa (eye worm) hypothetical protein 0.0035 0.0322 0.0365
Loa Loa (eye worm) hypothetical protein 0.0085 0.1048 0.1187
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0156
Onchocerca volvulus 0.0035 0.0322 0.024
Schistosoma mansoni SET domain protein 0.0067 0.0783 0.0824
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.0192 0.0218
Loa Loa (eye worm) hypothetical protein 0.0125 0.162 0.1836
Loa Loa (eye worm) hypothetical protein 0.0022 0.014 0.0158
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0137 0.0323
Brugia malayi Heterochromatin protein 1 0.0135 0.177 0.2001
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.002 0.0109 0.0123
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0081 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0593 0.0462
Echinococcus granulosus PWWP domain containing protein 2A 0.0018 0.0084 0.0096
Echinococcus granulosus intermediate filament protein 0.0026 0.0196 0.0222
Brugia malayi Variant SH3 domain containing protein 0.0018 0.0073 0.006
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0022 0.0137 0.1009
Onchocerca volvulus 0.0113 0.1447 0.1375
Brugia malayi MAP kinase sur-1 0.005 0.0538 0.0592
Echinococcus granulosus jumonji domain containing protein 0.0079 0.0955 0.1082
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0224 0.3054 0.3462
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0156
Loa Loa (eye worm) hypothetical protein 0.0076 0.0912 0.1034
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0137 0.0323
Brugia malayi beta-lactamase family protein 0.0035 0.0322 0.0345
Echinococcus multilocularis Chromo domain 0.0022 0.0137 0.0156
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0067 0.0783 0.0888
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0119 0.1539 0.1745
Echinococcus multilocularis lysine specific demethylase 5A 0.0068 0.0807 0.0914
Loa Loa (eye worm) hypothetical protein 0.0035 0.0322 0.0365
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0538 0.0407
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0132 0.1722 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0022 0.0137 0.0534
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0669 1
Onchocerca volvulus 0.0026 0.0196 0.0112
Entamoeba histolytica hypothetical protein 0.0022 0.0137 0.0323
Loa Loa (eye worm) SRC-1 0.002 0.0109 0.0123
Loa Loa (eye worm) hypothetical protein 0.0443 0.6219 0.7049
Schistosoma mansoni hypothetical protein 0.0018 0.0084 0.0014
Brugia malayi PHD-finger family protein 0.0022 0.014 0.0137
Echinococcus granulosus tyrosine protein kinase Src64B 0.002 0.0109 0.0123
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0024 0.0162 0.0184
Loa Loa (eye worm) runx1 0.0057 0.0641 0.0727
Trichomonas vaginalis set domain proteins, putative 0.0704 1 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0137 0.0323
Echinococcus multilocularis lamin dm0 0.0026 0.0196 0.0222
Echinococcus multilocularis tyrosine protein kinase Fyn 0.002 0.0109 0.0123
Echinococcus granulosus PWWP domain containing protein 2A 0.0018 0.0084 0.0096
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0538 0.2785
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0081 0.001
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.1722 1
Schistosoma mansoni tyrosine kinase 0.002 0.0109 0.0042
Schistosoma mansoni chromobox protein 0.0135 0.177 0.197
Schistosoma mansoni chromobox protein 0.0022 0.0137 0.0075
Loa Loa (eye worm) helicase 0.0022 0.0137 0.0156
Schistosoma mansoni lamin 0.0026 0.0196 0.0143
Brugia malayi beta-lactamase family protein 0.0035 0.0322 0.0345
Brugia malayi jmjC domain containing protein 0.0018 0.0081 0.007
Echinococcus multilocularis transcription factor Dp 1 0.0076 0.092 0.1042
Schistosoma mansoni zinc finger protein 0.0039 0.0382 0.0359
Trypanosoma brucei ISWI complex protein 0.0031 0.0259 0.1082
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0322 0.2302
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0056 0.0635 0.0652
Schistosoma mansoni tyrosine kinase 0.002 0.0109 0.0042
Echinococcus multilocularis tyrosine protein kinase Src64B 0.002 0.0109 0.0123
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0538 0.061
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0022 0.0137 0.1009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0073 0.0082
Brugia malayi Tyrosine-protein kinase abl-1 0.0254 0.3489 0.3965
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0084 0.0018
Toxoplasma gondii PHD-finger domain-containing protein 0.0018 0.0085 0.0032
Echinococcus multilocularis lamin 0.0026 0.0196 0.0222
Schistosoma mansoni bromodomain containing protein 0.0126 0.1643 0.1821
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0322 0.0188
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0196 0.0222
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0081 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0322 0.1468
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0538 0.2785
Trichomonas vaginalis chromobox protein, putative 0.0135 0.177 0.1656
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0669 0.358
Echinococcus granulosus tyrosine protein kinase Btk29A 0.002 0.0109 0.0123
Trypanosoma cruzi ISWI complex protein 0.0031 0.0259 0.1082
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.3041 1
Leishmania major hypothetical protein, conserved 0.0018 0.0084 0.0018
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.002 0.0109 0.0123
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0322 0.1468
Echinococcus granulosus histone lysine methyltransferase setb 0.0125 0.162 0.1836
Onchocerca volvulus 0.0022 0.0137 0.0053
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0022 0.0137 0.0075
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0538 0.061
Echinococcus granulosus transcription factor Dp 1 0.0076 0.092 0.1042
Brugia malayi photoreceptor-specific nuclear receptor 0.0252 0.3468 0.3941
Brugia malayi Bromodomain containing protein 0.0061 0.0703 0.0781
Echinococcus multilocularis NCK adaptor protein 0.0018 0.0073 0.0082
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0327 0.0371
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0136 0.0155
Echinococcus multilocularis zinc finger protein 0.0039 0.0382 0.0433
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0538 0.061
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0081 0.0092
Brugia malayi Tyrosine-protein kinase abl-1 0.0377 0.5277 0.601
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0322 0.0365
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0081 0.0995 0.0919
Mycobacterium leprae Probable lipase LipE 0.0035 0.0322 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.002 0.0109 0.0123
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0085 0.0032
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0136 0.0155
Loa Loa (eye worm) hypothetical protein 0.0081 0.0993 0.1125
Echinococcus granulosus peregrin 0.008 0.097 0.1099
Brugia malayi Pre-SET motif family protein 0.0091 0.1128 0.1266
Loa Loa (eye worm) PWWP domain-containing protein 0.0018 0.0084 0.0096
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0862 0.0977
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0018 0.0073 0.0082
Brugia malayi Bromodomain containing protein 0.015 0.1981 0.2241
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0132 0.1722 0.1951
Loa Loa (eye worm) hypothetical protein 0.0097 0.1219 0.1381
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0022 0.0137 0.0534
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0018 0.0085 0.006
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0022 0.0137 0.0156
Echinococcus multilocularis c src tyrosine kinase 0.002 0.0109 0.0123
Echinococcus granulosus tyrosine protein kinase Fyn 0.002 0.0109 0.0123
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0018 0.0085 0.0032
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0137 0.0534
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0156
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0081 0.001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0163 0.0104
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.1722 1
Echinococcus multilocularis muscleblind protein 0.0443 0.6219 0.7049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0092
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0081 0.0092
Brugia malayi hypothetical protein 0.0018 0.0084 0.0073
Echinococcus multilocularis Protein lozenge 0.0057 0.0641 0.0727
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0192 0.0139
Loa Loa (eye worm) hypothetical protein 0.0056 0.0635 0.0719
Echinococcus granulosus c src tyrosine kinase 0.002 0.0109 0.0123
Trichomonas vaginalis chromobox protein, putative 0.0081 0.0995 0.087
Loa Loa (eye worm) hypothetical protein 0.0035 0.0322 0.0365
Brugia malayi PWWP domain containing protein 0.0018 0.0084 0.0073
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0538 0.2785
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.162 0.1794
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.002 0.0109 0.0123
Loa Loa (eye worm) hypothetical protein 0.0141 0.1857 0.2105
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.002 0.0109 0.0123
Loa Loa (eye worm) hypothetical protein 0.0035 0.0322 0.0365
Toxoplasma gondii hypothetical protein 0.0018 0.0084 0.0028
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0024 0.0162 0.0184
Trypanosoma cruzi transcription elongation factor s-II, putative 0.0018 0.0084 0.0018
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0196 0.0222
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0084 0.0018
Schistosoma mansoni intermediate filament proteins 0.0026 0.0196 0.0143
Brugia malayi chromobox protein homolog 3 0.0076 0.0912 0.102
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0669 0.0758
Loa Loa (eye worm) hypothetical protein 0.0059 0.0676 0.0766
Brugia malayi AF-10 protein 0.0018 0.0085 0.0074
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.0018 0.0084 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0593 0.0462
Trichomonas vaginalis chromobox protein, putative 0.0135 0.177 0.1656
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0322 0.0365
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0022 0.0137 0.0156
Brugia malayi beta-lactamase 0.0035 0.0322 0.0345
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0196 0.0201
Brugia malayi CHD4 protein 0.0026 0.0192 0.0197
Echinococcus granulosus lysine specific demethylase 5A 0.0072 0.0862 0.0977
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0067 0.0783 0.0888
Echinococcus multilocularis tyrosine protein kinase Abl 0.0254 0.3489 0.3954
Echinococcus multilocularis peregrin 0.008 0.097 0.1099
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0538 0.061
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0322 0.0345
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0156
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0538 0.0407
Brugia malayi Variant SH3 domain containing protein 0.0018 0.0073 0.006
Loa Loa (eye worm) beta-lactamase 0.0035 0.0322 0.0365
Schistosoma mansoni lozenge 0.0057 0.0641 0.066
Echinococcus granulosus c-Jun N-terminal kinases 0.0224 0.3054 0.3462
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.1128 0.1224
Plasmodium falciparum phd finger protein, putative 0.0056 0.0635 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0322 0.0188
Loa Loa (eye worm) heterochromatin protein 1 0.0135 0.177 0.2007
Brugia malayi PHD-finger family protein 0.0056 0.0635 0.0703
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0132 0.1722 0.1951
Schistosoma mansoni serine/threonine protein kinase 0.0224 0.3054 0.3459
Onchocerca volvulus 0.0022 0.0137 0.0053
Brugia malayi Associated with TFs and helicases family protein 0.0022 0.0137 0.0134
Schistosoma mansoni hypothetical protein 0.0041 0.0413 0.0395
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0085 0.105 0.119
Echinococcus granulosus tyrosine protein kinase ABL1 0.0623 0.8823 1
Schistosoma mansoni hepatoma derived growth factor 0.0018 0.0084 0.0014
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0045 0.0468 0.0459
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0214
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0322 0.029
Leishmania major hypothetical protein, conserved 0.0035 0.0322 0.1468
Echinococcus granulosus chromobox protein 1 0.0135 0.177 0.2007
Echinococcus granulosus tyrosine protein kinase Src42A 0.002 0.0109 0.0123
Echinococcus multilocularis PHD finger protein rhinoceros 0.0056 0.0635 0.0719
Echinococcus multilocularis tyrosine protein kinase Src42A 0.002 0.0109 0.0123
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0538 0.061
Brugia malayi hypothetical protein 0.0454 0.6385 0.7276
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0322 0.5
Echinococcus granulosus chromobox protein 1 0.0135 0.177 0.2007
Loa Loa (eye worm) PHD-finger family protein 0.0056 0.0635 0.0719
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0113 0.1447 0.1595
Schistosoma mansoni hypothetical protein 0.0018 0.0084 0.0014
Schistosoma mansoni tyrosine kinase 0.002 0.0109 0.0042
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0081 0.0092
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0538 0.0407
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0132 0.1722 0.1945
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.1128 1
Onchocerca volvulus 0.0035 0.0322 0.024
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0022 0.0137 0.0075
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0309 0.0275
Echinococcus multilocularis PWWP domain containing protein 2A 0.0018 0.0084 0.0096
Giardia lamblia PHD finger protein 15 0.0056 0.0635 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0924 0.1048
Echinococcus multilocularis chromobox protein 1 0.0135 0.177 0.2007
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0132 0.1722 0.1913
Schistosoma mansoni hypothetical protein 0.0056 0.0635 0.0652
Onchocerca volvulus 0.0059 0.0676 0.0596
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0224 0.3054 0.3462
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.0018 0.0084 0.0018
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.1722 1
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0081 0.001
Schistosoma mansoni tyrosine kinase 0.002 0.0109 0.0042
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0309 0.0351
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0538 0.2785
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0081 0.0092
Schistosoma mansoni chromobox protein 0.0022 0.0137 0.0075
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.002 0.0023
Plasmodium falciparum heterochromatin protein 1 0.0022 0.0137 0.1009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0156
Plasmodium vivax heterochromatin protein 1, putative 0.0022 0.0137 0.0534
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0092
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0862 0.0916
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0322 0.0188
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0081 0.0092
Toxoplasma gondii PHD-finger domain-containing protein 0.0056 0.0635 0.5289
Echinococcus granulosus PHD finger protein rhinoceros 0.0056 0.0635 0.0719
Loa Loa (eye worm) TK/ABL protein kinase 0.0623 0.8823 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0854 0.0968
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0309 0.0275
Brugia malayi Bromodomain containing protein 0.0076 0.0922 0.1031
Echinococcus multilocularis chromobox protein 2 0.0022 0.0137 0.0156
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0081 0.0092
Loa Loa (eye worm) hypothetical protein 0.0454 0.6385 0.7237
Brugia malayi Muscleblind-like protein 0.0443 0.6219 0.7087
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0635 0.5289
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0119 0.1539 0.1745
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0081 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.162 0.1794
Echinococcus multilocularis tyrosine protein kinase Fgr 0.002 0.0109 0.0123
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0018 0.0085 0.002
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0669 0.0691
Trypanosoma brucei protein kinase, putative 0.005 0.0538 0.2785
Brugia malayi hypothetical protein 0.0018 0.0084 0.0073
Leishmania major hypothetical protein, conserved 0.0031 0.0259 0.1082
Schistosoma mansoni lamin 0.0026 0.0196 0.0143
Schistosoma mansoni SET domain protein 0.0028 0.0217 0.0168
Brugia malayi jmjC domain containing protein 0.0018 0.0081 0.007
Trypanosoma cruzi ISWI complex protein 0.0031 0.0259 0.1082
Echinococcus multilocularis muscleblind protein 1 0.0443 0.6219 0.7049
Brugia malayi Stress-activated protein kinase jnk-1 0.0224 0.3054 0.3469
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0669 0.5612
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0912 0.0786
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0623 0.8823 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0018 0.0073 0.0082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0322 0.0365
Entamoeba histolytica hypothetical protein 0.0022 0.0137 0.0323
Loa Loa (eye worm) hypothetical protein 0.0252 0.3468 0.393
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0538 0.0407
Brugia malayi SET domain containing protein 0.0027 0.0215 0.0223
Loa Loa (eye worm) hypothetical protein 0.0026 0.0196 0.0222
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0538 0.2785
Echinococcus granulosus lamin dm0 0.0026 0.0196 0.0222
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0854 0.0968
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0538 0.2785
Echinococcus granulosus Chromobox protein 3 0.0022 0.0137 0.0156
Echinococcus granulosus tyrosine protein kinase Fyn 0.002 0.0109 0.0123
Echinococcus granulosus zinc finger protein 0.0039 0.0382 0.0433
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0125 0.162 0.1836
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0156
Echinococcus granulosus hepatoma derived growth factor protein 0.0018 0.0084 0.0096
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0669 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0669 0.1274
Schistosoma mansoni hepatoma derived growth factor 0.0018 0.0084 0.0014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0669 1
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0413 0.0468
Toxoplasma gondii PHD-finger domain-containing protein 0.0056 0.0635 0.5289
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0322 0.0365
Echinococcus multilocularis musashi 0.0026 0.0196 0.0222
Brugia malayi M-phase phosphoprotein, mpp8 0.0022 0.0137 0.0134
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.0192 0.0218
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0081 0.0092
Echinococcus granulosus NCK adaptor protein 0.0018 0.0073 0.0082
Onchocerca volvulus 0.0454 0.6385 0.6354
Echinococcus granulosus muscleblind protein 0.0443 0.6219 0.7049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0096
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0218 0.0226
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.1128 0.1278
Toxoplasma gondii ABC1 family protein 0.0035 0.0322 0.2302
Onchocerca volvulus 0.0035 0.0322 0.024
Brugia malayi Pre-SET motif family protein 0.0619 0.8768 1
Schistosoma mansoni hypothetical protein 0.0031 0.0259 0.0216
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0322 0.0188
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0669 0.0758
Echinococcus granulosus tyrosine protein kinase Fyn 0.002 0.0109 0.0123
Onchocerca volvulus 0.0026 0.0196 0.0112
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0076 0.0912 0.0835
Echinococcus multilocularis hepatoma derived growth factor protein 0.0018 0.0084 0.0096
Trypanosoma brucei transcription elongation factor s-II, putative 0.0018 0.0084 0.0018
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0192 0.0218
Echinococcus granulosus Chromo domain 0.0022 0.0137 0.0156
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0132 0.1722 0.1951
Schistosoma mansoni hypothetical protein 0.0022 0.0137 0.0075
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0322 0.0188
Brugia malayi SRC-1 0.002 0.0109 0.0101
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0538 0.054
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0081 0.0092
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0022 0.0137 0.0134
Echinococcus granulosus fetal alzheimer antigen falz 0.0045 0.0468 0.053
Brugia malayi jmjC domain containing protein 0.0185 0.2494 0.2828
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0862 0.0916
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0022 0.0137 0.0534
Echinococcus granulosus tyrosine protein kinase Lyn 0.0021 0.0122 0.0138
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0309 0.0351

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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