Detailed information for compound 1154817

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 509.725 | Formula: C25H39N3O4S2
  • H donors: 3 H acceptors: 3 LogP: 1.44 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCc1ccc(cc1)O[C@@H]1CN([C@@H](C1)C(=O)N[C@H](C(=O)O)CCSC)C/C=C/[C@H](CS)N
  • InChi: 1S/C25H39N3O4S2/c1-3-4-6-18-8-10-20(11-9-18)32-21-15-23(28(16-21)13-5-7-19(26)17-33)24(29)27-22(25(30)31)12-14-34-2/h5,7-11,19,21-23,33H,3-4,6,12-17,26H2,1-2H3,(H,27,29)(H,30,31)/b7-5+/t19-,21+,22+,23+/m1/s1
  • InChiKey: LGUQFZZRDNTAAI-UZZQCTRBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum fructose-bisphosphate aldolase 0.0286 0.1019 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.1019 0.9296
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0224 0.0779 0.0777
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0011 0.0015
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0353 0.1277 0.3403
Schistosoma mansoni hypothetical protein 0.0334 0.1205 0.1203
Plasmodium falciparum carbamoyl phosphate synthetase 0.0224 0.0779 0.108
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0345 0.1245 0.1289
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0353 0.1277 0.3403
Entamoeba histolytica hypothetical protein 0.0026 0.0011 0.007
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0353 0.1277 0.3403
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.2606 1 1
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1886 0.7212 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0035 0.0035
Trichomonas vaginalis set domain proteins, putative 0.0266 0.094 0.8577
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0002 0.0003
Brugia malayi Carboxyl transferase domain containing protein 0.2515 0.9647 1
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0224 0.0779 0.0777
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0993 0.3753 0.3752
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0091 0.0263 0.0271
Loa Loa (eye worm) hypothetical protein 0.0091 0.0263 0.0271
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0091 0.0263 0.0263
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0042 0.004
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0353 0.1277 0.3403
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0061 0.0146 0.0144
Brugia malayi hypothetical protein 0.004 0.0066 0.0066
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0091 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0091 0.0263 0.0271
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.023 0.0228
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0224 0.0779 0.2075
Brugia malayi Importin beta-1 subunit 0.0032 0.0035 0.0034
Chlamydia trachomatis dihydrolipoamide acetyltransferase 0.0091 0.0263 0.0775
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0091 0.0263 0.0702
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0035 0.0033
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0224 0.0779 0.108
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.1019 0.9296
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0091 0.0263 0.0702
Onchocerca volvulus 0.0129 0.0411 0.4164
Echinococcus granulosus snurportin 1 0.0345 0.1245 0.1243
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0091 0.0263 0.0263
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.1019 0.9296
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0353 0.1277 0.3403
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0091 0.0263 0.0775
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0091 0.0263 0.0425
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.1019 0.9296
Toxoplasma gondii carbamoylphosphate synthetase 0.0224 0.0779 0.0779
Schistosoma mansoni importin beta-1 0.0032 0.0035 0.0033
Echinococcus multilocularis dnaJ subfamily B 0.0452 0.1659 0.1657
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0091 0.0263 0.0263
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.1019 0.9296
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0224 0.0779 0.1262
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0353 0.1277 0.1277
Schistosoma mansoni cpg binding protein 0.0034 0.004 0.0038
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.023 0.0228
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0353 0.1277 0.3403
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0353 0.1277 0.1277
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.2515 0.9647 1
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0993 0.3753 1
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0353 0.1277 0.2072
Leishmania major acetyl-CoA carboxylase, putative 0.2606 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0035 0.0034
Brugia malayi Pre-SET motif family protein 0.0034 0.0042 0.0042
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0091 0.0263 0.0702
Plasmodium vivax SET domain protein, putative 0.0034 0.0042 0.0058
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0353 0.1277 0.1276
Brugia malayi Pre-SET motif family protein 0.0234 0.0815 0.0843
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0091 0.0263 0.0702
Echinococcus granulosus geminin 0.0334 0.1205 0.1203
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0091 0.0263 0.0365
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0353 0.1277 0.3403
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0091 0.0263 0.0425
Onchocerca volvulus 0.0034 0.0042 0.0103
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0066 0.0064
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0147 0.0147
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0993 0.3753 1
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0224 0.0779 0.2075
Wolbachia endosymbiont of Brugia malayi branched-chain alpha-keto acid dehydrogenase subunit E2 0.0091 0.0263 0.0702
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0091 0.0263 0.0263
Schistosoma mansoni cpg binding protein 0.0032 0.0033 0.0031
Toxoplasma gondii pyruvate carboxylase 0.0993 0.3753 0.3753
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0234 0.0815 0.0843
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.1019 0.6246
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0091 0.0263 0.0365
Leishmania major GTP-binding protein, putative 0.0024 0.0002 0.0002
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0993 0.3753 1
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0993 0.3753 1
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0353 0.1277 0.1277
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0011 0.0086
Echinococcus granulosus importin subunit beta 1 0.0032 0.0035 0.0033
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0091 0.0263 0.0263
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0091 0.0263 0.0775
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0353 0.1277 0.3403
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0035 0.0035
Echinococcus multilocularis cpg binding protein 0.0034 0.004 0.0038
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0091 0.0263 0.0261
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.1019 0.9296
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0993 0.3753 0.3753
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.0452 0.1203
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0091 0.0263 0.0425
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0042 0.004
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0993 0.3753 1
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0091 0.0263 0.0702
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0353 0.1277 0.3403
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0444 0.1631 1
Plasmodium vivax importin-beta 2, putative 0.0032 0.0035 0.0049
Mycobacterium ulcerans glutaminase 0.0306 0.1096 0.2919
Schistosoma mansoni lipoxygenase 0.0061 0.0146 0.0144
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.1886 0.7212 1
Trichomonas vaginalis glutaminase, putative 0.0306 0.1096 1
Onchocerca volvulus 0.0266 0.094 1
Loa Loa (eye worm) glutaminase 0.0306 0.1096 0.1134
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0033 0.0032
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0175 0.0173
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0002 0.0002
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0224 0.0779 0.0779
Schistosoma mansoni pyruvate carboxylase 0.0993 0.3753 0.3752
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0066 0.0064
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0129 0.0411 0.4164
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.023 0.0236
Echinococcus granulosus dnaJ subfamily B 0.0452 0.1659 0.1657
Onchocerca volvulus 0.0129 0.0411 0.4164
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0002 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0042 0.004
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0091 0.0263 0.0702
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0091 0.0263 0.0261
Loa Loa (eye worm) hypothetical protein 0.0107 0.0325 0.0334
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0091 0.0263 0.0425
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component 0.0091 0.0263 0.0702
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0091 0.0263 0.0425
Schistosoma mansoni hypothetical protein 0.0345 0.1245 0.1243
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0042 0.004
Schistosoma mansoni glutaminase 0.0306 0.1096 0.1094
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0353 0.1277 0.3403
Onchocerca volvulus 0.0129 0.0411 0.4164
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0011 0.0086
Loa Loa (eye worm) hypothetical protein 0.0091 0.0263 0.0271
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0353 0.1277 0.1276
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0061 0.0146 0.0144
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0091 0.0263 0.0261
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0091 0.0263 0.0425
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0993 0.3753 0.3752
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0042 0.004
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0993 0.3753 1
Brugia malayi CXXC zinc finger family protein 0.0032 0.0033 0.0032
Entamoeba histolytica Ran family GTPase 0.0024 0.0002 0.0013
Entamoeba histolytica hypothetical protein 0.004 0.0066 0.0405
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0129 0.0411 0.0409
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0353 0.1277 0.1277
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0091 0.0263 0.0425
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0091 0.0263 0.0263
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0091 0.0263 0.0271
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0129 0.0411 0.0409
Brugia malayi RNA, U transporter 1 0.0092 0.0266 0.0273
Loa Loa (eye worm) hypothetical protein 0.0034 0.0042 0.0042
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.2606 1 1
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0091 0.0263 0.0261
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0993 0.3753 0.3752
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0002 0.0002
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0444 0.1631 1
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0993 0.3753 0.6095
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0091 0.0263 0.0261
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0011 0.0086
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0993 0.3753 0.3752
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0042 0.0042
Brugia malayi glutaminase DH11.1 0.0306 0.1096 0.1134
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0042 0.004
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.0452 0.1203
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0091 0.0263 0.0261
Trypanosoma cruzi acetyl-CoA carboxylase 0.1613 0.6157 1
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0993 0.3753 1
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0091 0.0263 0.0263
Leishmania major carboxylase, putative 0.0993 0.3753 0.3753
Schistosoma mansoni hypothetical protein 0.004 0.0066 0.0064
Entamoeba histolytica hypothetical protein 0.004 0.0066 0.0405
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0091 0.0263 0.0271
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.1019 0.9296
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.2606 1 1
Loa Loa (eye worm) glutaminase 2 0.0306 0.1096 0.1134
Leishmania major importin beta-1 subunit, putative 0.0026 0.0011 0.0011
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0353 0.1277 0.2072
Echinococcus granulosus cpg binding protein 0.0034 0.004 0.0038
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0035 0.0033
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0353 0.1277 0.1276
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0129 0.0411 0.0409
Schistosoma mansoni aspartate carbamoyltransferase 0.0224 0.0779 0.0777
Leishmania major carbamoyl-phosphate synthase, putative 0.0224 0.0779 0.0779
Echinococcus multilocularis Biotin lipoyl attachment 0.0091 0.0263 0.0261
Entamoeba histolytica hypothetical protein 0.004 0.0066 0.0405
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0091 0.0263 0.0263
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0091 0.0263 0.0263
Entamoeba histolytica hypothetical protein 0.004 0.0066 0.0405
Chlamydia trachomatis biotin carboxylase 0.0901 0.34 1
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0993 0.3753 0.6095
Echinococcus granulosus Biotin lipoyl attachment 0.0091 0.0263 0.0261
Trypanosoma brucei unspecified product 0.0653 0.2437 0.2437
Schistosoma mansoni cpg binding protein 0.0034 0.004 0.0038
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0091 0.0263 0.0261
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0353 0.1277 0.3403
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0993 0.3753 0.3753
Schistosoma mansoni hypothetical protein 0.0452 0.1659 0.1657
Trypanosoma brucei acetyl-CoA carboxylase 0.2606 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0042 0.004
Plasmodium falciparum importin beta, putative 0.0032 0.0035 0.0049
Onchocerca volvulus 0.0129 0.0411 0.4164
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.1019 0.6246
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0035 0.0035
Treponema pallidum pyruvate carboxylase subunit B 0.0091 0.0263 0.2586
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0353 0.1277 0.3757
Giardia lamblia Fructose-bisphosphate aldolase 0.0286 0.1019 0.6242
Echinococcus multilocularis snurportin 1 0.0345 0.1245 0.1243
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.1019 0.9296
Mycobacterium ulcerans pyruvate carboxylase 0.0993 0.3753 1
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0091 0.0263 0.0702
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0091 0.0263 0.0365
Chlamydia trachomatis acetyl-CoA carboxylase biotin carboxyl carrier protein 0.0091 0.0263 0.0775
Mycobacterium ulcerans hypothetical protein 0.0091 0.0263 0.0702
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0066 0.0064
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0353 0.1277 0.3403
Loa Loa (eye worm) hypothetical protein 0.0083 0.023 0.0236
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0091 0.0263 0.0261
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.023 0.0228
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0091 0.0263 0.0263
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0993 0.3753 0.3753
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0353 0.1277 0.2072
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0224 0.0779 0.1262
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.0452 0.1203
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0091 0.0263 0.0263
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0091 0.0263 0.0365
Echinococcus multilocularis geminin 0.0334 0.1205 0.1203
Onchocerca volvulus 0.0083 0.023 0.2174
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0091 0.0263 0.0263
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0091 0.0263 0.0365
Schistosoma mansoni acetyl-CoA carboxylase 0.2606 1 1
Schistosoma mansoni hypothetical protein 0.0334 0.1205 0.1203

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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