Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | high affinity choline transporter 1 | 0.041 | 0.8634 | 1 |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.0284 | 0.5658 | 0.5658 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0468 | 1 | 1 |
Echinococcus granulosus | furin | 0.0468 | 1 | 1 |
Schistosoma mansoni | high-affinity choline transporter | 0.041 | 0.8634 | 0.8634 |
Schistosoma mansoni | subfamily S8B non-peptidase homologue (S08 family) | 0.0111 | 0.1544 | 0.1544 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0261 | 0.5102 | 0.5102 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.3272 | 0.3272 |
Echinococcus granulosus | Furin 1 | 0.0111 | 0.1544 | 0.1544 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0111 | 0.1544 | 0.1032 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0111 | 0.1544 | 0.1032 |
Echinococcus multilocularis | 0.0377 | 0.7859 | 0.9102 | |
Brugia malayi | neuroendocrine convertase 1 precursor | 0.0294 | 0.5886 | 0.5886 |
Loa Loa (eye worm) | hypothetical protein | 0.041 | 0.8634 | 0.8634 |
Giardia lamblia | High cysteine membrane protein Group 2 | 0.0174 | 0.3043 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0111 | 0.1544 | 0.1032 |
Schistosoma mansoni | hypothetical protein | 0.0091 | 0.1071 | 0.1071 |
Brugia malayi | celfurPC protein | 0.0377 | 0.7859 | 0.7859 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0284 | 0.5658 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0266 | 0.5223 | 0.5223 |
Brugia malayi | GH02984p | 0.041 | 0.8634 | 0.8634 |
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.0284 | 0.5658 | 0.6553 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0111 | 0.1544 | 0.1032 |
Schistosoma mansoni | hypothetical protein | 0.02 | 0.366 | 0.366 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0294 | 0.5886 | 0.6818 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0111 | 0.1544 | 0.1032 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.5088 | 0.5088 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0294 | 0.5886 | 0.5886 |
Echinococcus multilocularis | Furin 1 | 0.0111 | 0.1544 | 0.1789 |
Schistosoma mansoni | hypothetical protein | 0.02 | 0.366 | 0.366 |
Schistosoma mansoni | hypothetical protein | 0.0222 | 0.4172 | 0.4172 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0284 | 0.5658 | 1 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0468 | 1 | 1 |
Schistosoma mansoni | furin-1 (S08 family) | 0.0204 | 0.3745 | 0.3745 |
Echinococcus granulosus | geminin | 0.02 | 0.366 | 0.366 |
Loa Loa (eye worm) | proprotein convertase 2 | 0.0111 | 0.1544 | 0.1544 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0261 | 0.5102 | 0.5102 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.041 | 0.8634 | 0.8634 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0111 | 0.1544 | 0.1032 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0261 | 0.5102 | 0.5102 |
Echinococcus multilocularis | geminin | 0.02 | 0.366 | 0.424 |
Trypanosoma brucei | RNA helicase, putative | 0.0222 | 0.4172 | 0.5 |
Brugia malayi | proprotein convertase 2 | 0.0294 | 0.5886 | 0.5886 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Survival (functional) | = 0 % | Histamine induced lethality, at 30-min pretreatment time when 30 mg/kg compound was administered intra peritonially in guinea pigs | ChEMBL. | 2570152 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.