Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0214 | 0.804 | 0.8017 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.1195 | 0.1091 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0041 | 0.0638 | 0.0316 |
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.0782 | 0.0672 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0463 | 0.0466 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0162 | 0.5835 | 0.5875 |
Schistosoma mansoni | tar DNA-binding protein | 0.0214 | 0.804 | 0.8095 |
Echinococcus multilocularis | tar DNA binding protein | 0.0214 | 0.804 | 0.804 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0041 | 0.0638 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.5835 | 0.5875 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0596 | 0.014 |
Brugia malayi | TAR-binding protein | 0.0214 | 0.804 | 0.8017 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0085 | 0.2521 | 0.2521 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0071 | 0.1933 | 0.1447 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0596 | 0.014 |
Brugia malayi | hypothetical protein | 0.0162 | 0.5835 | 0.5785 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0041 | 0.0638 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0087 | 0.2604 | 0.2516 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0041 | 0.0638 | 0.0316 |
Loa Loa (eye worm) | fli-1 protein | 0.0258 | 0.9932 | 0.9928 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.1195 | 0.0768 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0107 | 0.3481 | 0.3505 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0596 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1993 | 0.1604 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0071 | 0.1933 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0107 | 0.3481 | 0.3505 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.1933 | 1 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0596 | 0.0484 |
Brugia malayi | Ets-domain containing protein | 0.0085 | 0.2521 | 0.2432 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0071 | 0.1933 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0041 | 0.0638 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2391 | 0.2022 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0041 | 0.0638 | 0.0638 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0107 | 0.3481 | 0.3404 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0786 | 0.0338 |
Schistosoma mansoni | tar DNA-binding protein | 0.0214 | 0.804 | 0.8095 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0107 | 0.3481 | 0.3165 |
Entamoeba histolytica | hypothetical protein | 0.0162 | 0.5835 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0085 | 0.2521 | 0.2432 |
Echinococcus multilocularis | geminin | 0.0184 | 0.6747 | 0.6747 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0596 | 0.014 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.1933 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0073 | 0.2022 | 0.2036 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0107 | 0.3481 | 0.3505 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0214 | 0.804 | 0.7945 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0042 | 0.0665 | 0.0665 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.1933 | 0.1946 |
Entamoeba histolytica | hypothetical protein | 0.0162 | 0.5835 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0162 | 0.5835 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0053 | 0.1149 | 0.1044 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0041 | 0.0638 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0041 | 0.0638 | 1 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0085 | 0.2521 | 0.2158 |
Onchocerca volvulus | 0.0053 | 0.1149 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0214 | 0.804 | 0.8095 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0069 | 0.1844 | 0.1844 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.1933 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0162 | 0.5835 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0107 | 0.3481 | 0.3481 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0041 | 0.0638 | 0.0527 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0463 | 0.035 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0041 | 0.0638 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0596 | 0.014 |
Schistosoma mansoni | ap endonuclease | 0.0041 | 0.0638 | 0.0643 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0162 | 0.5835 | 0.5835 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0596 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0041 | 0.0638 | 0.0046 |
Schistosoma mansoni | survival motor neuron protein | 0.0053 | 0.1149 | 0.1157 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0042 | 0.0665 | 0.0665 |
Schistosoma mansoni | ap endonuclease | 0.0041 | 0.0638 | 0.0643 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0041 | 0.0638 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0596 | 0.0596 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0071 | 0.1933 | 0.1933 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0071 | 0.1933 | 0.1933 |
Schistosoma mansoni | tar DNA-binding protein | 0.0214 | 0.804 | 0.8095 |
Schistosoma mansoni | gabp alpha | 0.0085 | 0.2521 | 0.2538 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0998 | 0.0561 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0596 | 0.06 |
Toxoplasma gondii | exonuclease III APE | 0.0041 | 0.0638 | 0.0316 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0596 | 0.0596 |
Loa Loa (eye worm) | TAR-binding protein | 0.0214 | 0.804 | 0.7945 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0107 | 0.3481 | 0.3481 |
Schistosoma mansoni | tar DNA-binding protein | 0.0214 | 0.804 | 0.8095 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0256 | 0.9838 | 1 |
Schistosoma mansoni | ets-related | 0.0258 | 0.9932 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0214 | 0.804 | 0.804 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0596 | 0.014 |
Brugia malayi | Fli-1 protein | 0.0258 | 0.9932 | 0.9931 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.1933 | 0.1946 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.1195 | 0.1091 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0596 | 0.0484 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.6747 | 0.6794 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0162 | 0.5835 | 0.5835 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0041 | 0.0638 | 0.0184 |
Brugia malayi | beta-lactamase | 0.004 | 0.0596 | 0.0484 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0596 | 0.0484 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0041 | 0.0638 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0041 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0596 | 0.014 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0041 | 0.0638 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0596 | 0.014 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0596 | 0.06 |
Loa Loa (eye worm) | RNA binding protein | 0.0214 | 0.804 | 0.7945 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.6747 | 0.6794 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1195 | 0.0768 |
Brugia malayi | RNA binding protein | 0.0214 | 0.804 | 0.8017 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0596 | 0.014 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0069 | 0.1844 | 0.1844 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.1149 | 0.1157 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0903 | 0.0461 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0041 | 0.0638 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0107 | 0.3481 | 0.3481 |
Echinococcus granulosus | geminin | 0.0184 | 0.6747 | 0.6747 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0107 | 0.3481 | 0.3481 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0085 | 0.2521 | 0.2521 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.