Detailed information for compound 1155437

Basic information

Technical information
  • TDR Targets ID: 1155437
  • Name: 2-[(3S)-6,8-dimethoxy-1,3-dimethyl-3,4-dihydr oisoquinolin-2-ium-2-yl]-8-methoxy-6-methylna phthalen-1-ol
  • MW: 406.494 | Formula: C25H28NO4+
  • H donors: 1 H acceptors: 1 LogP: 4.79 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)c2c(c1)C[C@@H]([N+](=C2C)c1ccc2c(c1O)c(OC)cc(c2)C)C
  • InChi: 1S/C25H27NO4/c1-14-9-17-7-8-20(25(27)24(17)21(10-14)29-5)26-15(2)11-18-12-19(28-4)13-22(30-6)23(18)16(26)3/h7-10,12-13,15H,11H2,1-6H3/p+1/t15-/m0/s1
  • InChiKey: WXOAABREETYYJH-HNNXBMFYSA-O  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(3S)-6,8-dimethoxy-1,3-dimethyl-3,4-dihydroisoquinolin-2-ium-2-yl]-8-methoxy-6-methyl-naphthalen-1-ol
  • 2-[(3S)-6,8-dimethoxy-1,3-dimethyl-3,4-dihydroisoquinolin-2-ium-2-yl]-8-methoxy-6-methyl-1-naphthalenol
  • 2-[(3S)-6,8-dimethoxy-1,3-dimethyl-3,4-dihydroisoquinolin-2-ium-2-yl]-8-methoxy-6-methyl-1-naphthol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0178 0.0628
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.014 0.0492
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.1862 0.6559
Brugia malayi Cathepsin L-like precursor 0.0019 0.0178 0.0628
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1782 0.1782
Schistosoma mansoni jumonji domain containing protein 0.0017 0.014 0.014
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0701 0.247
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0854 0.4585
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.01 0.2839 0.2985
Onchocerca volvulus 0.0031 0.0576 0.6054
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.1894 0.6671
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.1712 0.1712
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0178 0.0628
Brugia malayi jmjC domain containing protein 0.0065 0.1712 0.6031
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0701 0.247
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0228 0.703 0.8837
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0178 0.0628
Schistosoma mansoni jumonji domain containing protein 0.0065 0.1712 0.1712
Loa Loa (eye worm) thioredoxin reductase 0.01 0.2839 1
Toxoplasma gondii cathepsin CPL 0.0019 0.0178 0.0628
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.014 0.0492
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0701 0.247
Trichomonas vaginalis chromobox protein, putative 0.007 0.1862 1
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.014 0.014
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0797 0.2808
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.1782 0.6276
Brugia malayi chromobox protein homolog 3 0.0039 0.0854 0.3008
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.04 0.1411
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.014 0.0492
Loa Loa (eye worm) hypothetical protein 0.0019 0.0178 0.0628
Loa Loa (eye worm) hypothetical protein 0.0039 0.0854 0.3008
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.014 0.0492
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0914 0.3221
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0701 0.3936
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.1712 0.6031
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.014 0.0492
Leishmania major cathepsin L-like protease 0.0071 0.1894 0.6671
Brugia malayi jmjC domain containing protein 0.0017 0.014 0.0492
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0914 0.5133
Brugia malayi Peptidase family M1 containing protein 0.0038 0.0797 0.2808
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0178 0.0628
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0178 0.0628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1894 0.6671
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0797 0.2808
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.014 0.0492
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1894 0.6671
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0914 0.3221
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0701 0.247
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0701 0.247
Loa Loa (eye worm) cysteine protease 0.0019 0.0178 0.0628
Loa Loa (eye worm) hypothetical protein 0.0017 0.014 0.0492
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.014 0.0492
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0178 0.0957
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.014 0.0492
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0701 0.5
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0178 0.1873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0178 0.0957
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0228 0.703 0.8837
Mycobacterium ulcerans aminopeptidase N PepN 0.0038 0.0797 0.4474
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1782 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0178 0.0957
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0914 0.4911
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0228 0.703 0.8837
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0178 0.1873
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1894 0.6671
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1894 0.6671
Leishmania major trypanothione reductase 0.01 0.2839 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0178 0.0957
Loa Loa (eye worm) hypothetical protein 0.0017 0.014 0.0492
Echinococcus granulosus chromobox protein 1 0.007 0.1862 0.6559
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.04 0.1411
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0914 0.4911
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0701 0.247
Schistosoma mansoni phd/f-box containing protein 0.0017 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0178 0.0957
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0178 0.0628
Echinococcus granulosus phd:f box containing protein 0.0017 0.014 0.0492
Echinococcus multilocularis chromobox protein 1 0.007 0.1862 0.6559
Brugia malayi jmjC domain containing protein 0.0065 0.1712 0.6031
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.1712 0.6031
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0914 0.4911
Leishmania major cathepsin L-like protease 0.0071 0.1894 0.6671
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0952 0.511
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0044 0.1014 0.1014
Brugia malayi jmjC domain containing protein 0.0017 0.014 0.0492
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0178 0.0628
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.014 0.0492
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0773 0.0101
Brugia malayi glutathione reductase 0.01 0.2839 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0365 0.1285
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.1396 0.4917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0178 0.0957
Loa Loa (eye worm) hypothetical protein 0.0024 0.0365 0.1285
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0701 0.247
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0952 0.511
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0701 0.247
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.1782 0.1509
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1894 0.6671
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0797 0.2808
Onchocerca volvulus 0.0019 0.0178 0.1873
Onchocerca volvulus 0.0038 0.0797 0.8377
Brugia malayi Heterochromatin protein 1 0.007 0.1862 0.6559
Loa Loa (eye worm) glutathione reductase 0.01 0.2839 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0178 0.0957
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0178 0.0628
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0178 0.0957
Toxoplasma gondii thioredoxin reductase 0.01 0.2839 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0178 0.0628
Brugia malayi Peptidase family M1 containing protein 0.0038 0.0797 0.2808
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0178 0.0628
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0178 0.0957
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0701 0.247
Leishmania major cathepsin L-like protease 0.0019 0.0178 0.0628
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0178 0.0957
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0914 0.3221
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0701 0.247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1894 0.6671
Leishmania major hypothetical protein, conserved 0.0017 0.014 0.0492
Plasmodium vivax JmjC domain containing protein 0.0017 0.014 0.0492
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.1782 0.6276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0178 0.0957
Treponema pallidum NADH oxidase 0.0035 0.0701 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0253 0.7862 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.014 0.0492
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.014 0.0492
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0178 0.0957
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0038 0.0797 0.2808
Loa Loa (eye worm) hypothetical protein 0.0024 0.0365 0.1285
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0701 0.247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0178 0.0957
Trypanosoma brucei trypanothione reductase 0.01 0.2839 1
Onchocerca volvulus 0.0038 0.0797 0.8377
Brugia malayi jmjC domain containing protein 0.0017 0.014 0.0492
Schistosoma mansoni inositol monophosphatase 0.0041 0.0914 0.0914
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0701 0.3766
Echinococcus granulosus cathepsin l1 0.0019 0.0178 0.0628
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.1782 0.6276
Brugia malayi Cathepsin L-like precursor 0.0019 0.0178 0.0628
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1894 0.6671
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0178 0.0628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1894 0.6671
Plasmodium falciparum glutathione reductase 0.0035 0.0701 0.247
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0038 0.0797 0.0797
Brugia malayi Cathepsin L-like precursor 0.0019 0.0178 0.0628
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0178 0.0957
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0178 0.0628
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0701 0.247
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1782 0.1782
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.014 0.0492
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.1692 0.596
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0701 0.247
Loa Loa (eye worm) fibroinase 0.0019 0.0178 0.0628
Schistosoma mansoni chromobox protein 0.007 0.1862 0.1862
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.1712 0.6031
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0701 0.3766
Mycobacterium tuberculosis Probable dehydrogenase 0.0228 0.703 0.8837
Leishmania major cathepsin L-like protease 0.0019 0.0178 0.0628
Plasmodium falciparum thioredoxin reductase 0.0035 0.0701 0.247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1894 0.6671
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0038 0.0797 0.2808
Trypanosoma brucei Aminopeptidase M1, putative 0.0038 0.0797 0.2808
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1894 0.6671
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0178 0.0178
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0701 0.247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0178 0.0957
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0365 0.1285
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0701 0.247
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.1712 0.1712
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0253 0.7862 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.014 0.0492
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0178 0.0957
Schistosoma mansoni protein phosphatase 2C 0.0017 0.014 0.014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0701 0.247
Brugia malayi Cathepsin L-like precursor 0.0019 0.0178 0.0628
Brugia malayi jmjC domain containing protein 0.0017 0.014 0.0492
Echinococcus granulosus chromobox protein 1 0.007 0.1862 0.6559
Plasmodium falciparum thioredoxin reductase 0.01 0.2839 1
Trypanosoma cruzi Aminopeptidase M1, putative 0.0038 0.0797 0.2808
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0038 0.0797 0.4281
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0038 0.0797 0.2808
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1894 0.6671
Brugia malayi Inositol-1 0.0041 0.0914 0.3221
Trichomonas vaginalis chromobox protein, putative 0.007 0.1862 1
Echinococcus multilocularis cysteine protease 0.0019 0.0178 0.0628
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0178 0.0178
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0914 0.3221
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1894 0.6671
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0701 0.247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0178 0.0957
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0024 0.0365 0.0365
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0797 0.2808
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0038 0.0797 0.2808
Echinococcus granulosus aminopeptidase N 0.0038 0.0797 0.2808
Schistosoma mansoni inositol monophosphatase 0.0041 0.0914 0.0914
Plasmodium vivax vivapain-2 0.0019 0.0178 0.0628
Brugia malayi Cathepsin L-like precursor 0.0019 0.0178 0.0628
Brugia malayi Cathepsin L-like precursor 0.0019 0.0178 0.0628
Plasmodium vivax glutathione reductase, putative 0.01 0.2839 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0178 0.0957
Brugia malayi hypothetical protein 0.0038 0.0797 0.2808
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1894 0.6671
Echinococcus multilocularis chromobox protein 1 0.007 0.1862 0.6559
Leishmania major cathepsin L-like protease 0.0071 0.1894 0.6671
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.1712 0.6031
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0797 0.2808
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0701 0.3936
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0701 0.247
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.014 0.0492
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0701 0.247
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0797 0.2808
Leishmania major cathepsin L-like protease 0.0019 0.0178 0.0628
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0952 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0701 0.3936
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.2839 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0854 0.8974
Trypanosoma cruzi trypanothione reductase, putative 0.01 0.2839 1
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0178 0.0628
Plasmodium vivax vivapain-2 0.0019 0.0178 0.0628
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.1712 0.6031
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0178 0.0628
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0178 0.0957
Onchocerca volvulus 0.0019 0.0178 0.1873
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0228 0.703 0.8825
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0701 0.247
Leishmania major cathepsin L-like protease 0.0019 0.0178 0.0628
Trypanosoma cruzi aminopeptidase, putative 0.0038 0.0797 0.2808
Entamoeba histolytica aminopeptidase, putative 0.0038 0.0797 0.8407
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0797 0.2808
Loa Loa (eye worm) aminopeptidase N 0.0038 0.0797 0.2808
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0178 0.0957
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0701 0.247
Echinococcus multilocularis phd:f box containing protein 0.0017 0.014 0.0492
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0701 0.247
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1782 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0178 0.0957
Loa Loa (eye worm) hypothetical protein 0.0017 0.014 0.0492
Onchocerca volvulus 0.0019 0.0178 0.1873
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0914 1
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1894 0.6671
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0701 0.247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0178 0.0957
Loa Loa (eye worm) hypothetical protein 0.0024 0.0365 0.1285
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.014 0.0492
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0701 0.0701
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.014 0.014
Schistosoma mansoni chromobox protein 0.007 0.1862 0.1862
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0914 0.3221
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0178 0.0957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0178 0.0957
Onchocerca volvulus 0.0019 0.0178 0.1873
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0701 0.247
Echinococcus multilocularis aminopeptidase N 0.0038 0.0797 0.2808
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0478 0.2569
Mycobacterium tuberculosis Probable reductase 0.0228 0.703 0.8837
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0797 0.2808
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.1782 0.6276
Trypanosoma brucei Aminopeptidase M1, putative 0.0038 0.0797 0.2808
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1782 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0914 0.3221
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.014 0.0492
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0228 0.703 0.8837
Brugia malayi Thioredoxin reductase 0.01 0.2839 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0038 0.0797 0.4281
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0253 0.7862 1
Loa Loa (eye worm) inositol-1 0.0041 0.0914 0.3221
Loa Loa (eye worm) ctsf protein 0.0019 0.0178 0.0628
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0038 0.0797 0.2808
Loa Loa (eye worm) hypothetical protein 0.0031 0.0576 0.2029
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0914 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0854 0.4585
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0701 0.247
Onchocerca volvulus 0.0019 0.0178 0.1873
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0178 0.0957
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0701 0.247
Onchocerca volvulus 0.0019 0.0178 0.1873
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0478 0.2569
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.014 0.0492
Plasmodium vivax thioredoxin reductase, putative 0.01 0.2839 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0797 0.2808
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0914 0.3221
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0253 0.7862 1
Plasmodium falciparum glutathione reductase 0.01 0.2839 1
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.2839 1
Leishmania major cathepsin L-like protease 0.0019 0.0178 0.0628
Echinococcus multilocularis cysteine protease 0.0019 0.0178 0.0628
Onchocerca volvulus 0.0019 0.0178 0.1873
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0178 0.1873
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0701 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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