Detailed information for compound 1155482

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 321.459 | Formula: C21H27N3
  • H donors: 1 H acceptors: 0 LogP: 4.2 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCNCCN1c2ccccc2N2c3c(C1C)cccc3CC2
  • InChi: 1S/C21H27N3/c1-3-12-22-13-15-23-16(2)18-8-6-7-17-11-14-24(21(17)18)20-10-5-4-9-19(20)23/h4-10,16,22H,3,11-15H2,1-2H3
  • InChiKey: BARWJTWZDLAEEY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0029
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0029 0.0029
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.0029 0.5
Schistosoma mansoni tar DNA-binding protein 0.0057 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0029 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0029 0.0029
Echinococcus granulosus GPCR family 2 0.0012 0.072 0.072
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0029 0.0029
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0012 0.072 0.072
Schistosoma mansoni coup transcription factor 0.0009 0.0029 0.0029
Brugia malayi nuclear receptor NHR-88 0.0009 0.0029 0.0029
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0057 1 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0012 0.0603 0.5
Schistosoma mansoni tar DNA-binding protein 0.0057 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0029 0.0029
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0012 0.0603 0.0603
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0029 0.0029
Brugia malayi ecdysteroid receptor 0.0009 0.0029 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0029 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0029 0.0029
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0029 0.0029
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0012 0.0603 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0029 0.0029
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0029 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0029
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0012 0.0603 0.5
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0012 0.0603 0.0603
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0029 0.0029
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0029 0.0029
Echinococcus multilocularis tar DNA binding protein 0.0057 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0029 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0027 0.3718 0.3718
Brugia malayi exodeoxyribonuclease III family protein 0.0012 0.0603 0.0603
Schistosoma mansoni ap endonuclease 0.0012 0.0603 0.0603
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0029 0.0029
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0012 0.0603 0.0603
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0029 0.0029
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0012 0.0603 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0029 0.0029
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0029 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0029 0.0029
Loa Loa (eye worm) latrophilin receptor protein 2 0.0012 0.072 0.072
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0029 0.0029
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0029 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0029 0.0029
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0029 0.0029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0029 0.0029
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0029 0.0029
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0029 0.0029
Echinococcus multilocularis GPCR, family 2 0.0012 0.072 0.072
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0029 0.0029
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0012 0.072 0.072
Brugia malayi nuclear hormone receptor 0.0009 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0012 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0029
Brugia malayi latrophilin 2 splice variant baaae 0.0027 0.3718 0.3718
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0029 0.0029
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0029 0.0029
Schistosoma mansoni ap endonuclease 0.0012 0.0603 0.0603
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0029
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0029 0.0029
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0012 0.0603 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0039 0.6302 0.6302
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0057 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0039 0.6302 0.6302
Brugia malayi steroid hormone receptor 0.0009 0.0029 0.0029
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0012 0.072 0.072
Loa Loa (eye worm) TAR-binding protein 0.0057 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0029 0.0029
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0012 0.0603 0.5
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0012 0.0603 1
Schistosoma mansoni hypothetical protein 0.0012 0.072 0.072
Trichomonas vaginalis ap endonuclease, putative 0.0012 0.0603 0.5
Onchocerca volvulus 0.0009 0.0029 0.5
Echinococcus granulosus tar DNA binding protein 0.0057 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.072 0.072
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0029 0.0029
Brugia malayi TAR-binding protein 0.0057 1 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0012 0.0603 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.0029 0.5
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0012 0.0603 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0029 0.0029
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0029 0.0029
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.0029 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0029 0.0029
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0029 0.0029
Brugia malayi RNA recognition motif domain containing protein 0.0057 1 1
Schistosoma mansoni tar DNA-binding protein 0.0057 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0029 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0029 0.0029
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0029 0.0029
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0012 0.072 0.072
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0029 0.0029
Brugia malayi Latrophilin receptor protein 2 0.0012 0.072 0.072
Brugia malayi Calcitonin receptor-like protein seb-1 0.0039 0.6302 0.6302
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0039 0.6302 0.6302
Toxoplasma gondii exonuclease III APE 0.0012 0.0603 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0029 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0029
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0029 0.0029
Treponema pallidum exodeoxyribonuclease (exoA) 0.0012 0.0603 0.5
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0603 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0029 0.0029
Loa Loa (eye worm) RNA binding protein 0.0057 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0012 0.0603 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0029 0.0029
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0012 0.072 0.072
Schistosoma mansoni hypothetical protein 0.0012 0.072 0.072
Schistosoma mansoni tar DNA-binding protein 0.0057 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.3718 0.3718
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0029 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0029 0.0029
Trichomonas vaginalis ap endonuclease, putative 0.0012 0.0603 0.5
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0012 0.072 0.072

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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