Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0055 | 0.2149 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0055 | 0.2149 | 0.2557 |
Brugia malayi | MAP kinase sur-1 | 0.0055 | 0.2149 | 0.1906 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.1781 | 0.1669 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0064 | 0.2746 | 0.2647 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.2149 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0151 | 0.8406 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.1781 | 0.1669 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0055 | 0.2149 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1247 | 0.1247 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0039 | 0.1091 | 0.1829 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0039 | 0.1091 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.1091 | 0.1829 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0055 | 0.2149 | 0.2042 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0055 | 0.2149 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0055 | 0.2149 | 0.2042 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1781 | 0.2119 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.1091 | 0.1829 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0176 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.352 | 0.352 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0039 | 0.1091 | 0.1829 |
Trichomonas vaginalis | rotamase, putative | 0.0036 | 0.0909 | 0.0429 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0039 | 0.1091 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.1781 | 0.1669 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0039 | 0.1091 | 0.1829 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0036 | 0.0909 | 0.0628 |
Onchocerca volvulus | 0.0102 | 0.5172 | 0.5 | |
Schistosoma mansoni | rotamase | 0.0036 | 0.0909 | 0.1082 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0055 | 0.2149 | 0.2042 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0064 | 0.2746 | 0.2647 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0055 | 0.2149 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0055 | 0.2149 | 0.2149 |
Trypanosoma brucei | protein kinase, putative | 0.0055 | 0.2149 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0039 | 0.1091 | 0.1298 |
Schistosoma mansoni | alpha-glucosidase | 0.0151 | 0.8406 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0909 | 0.0429 |
Trypanosoma brucei | glucosidase, putative | 0.0039 | 0.1091 | 0.1829 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1075 | 0.0954 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0039 | 0.1091 | 0.1829 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0176 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.1091 | 0.1829 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0055 | 0.2149 | 0.2042 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.2149 | 1 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0039 | 0.1091 | 0.0969 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.1091 | 0.1829 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0055 | 0.2149 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.2149 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0055 | 0.2149 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0134 | 0.016 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.1781 | 0.1526 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0055 | 0.2149 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1075 | 0.0954 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.1781 | 0.1781 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1781 | 0.2119 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.1091 | 0.1829 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.2149 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0039 | 0.1091 | 0.0969 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.1091 | 0.1829 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1781 | 0.2119 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0176 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.1091 | 0.1829 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0055 | 0.2149 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1547 | 0.1547 |
Echinococcus granulosus | expressed protein | 0.0036 | 0.0909 | 0.0786 |
Echinococcus multilocularis | expressed protein | 0.0036 | 0.0909 | 0.0786 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1413 | 0.1413 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0039 | 0.1091 | 0.1829 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0176 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.1242 | 0.097 |
Schistosoma mansoni | bromodomain containing protein | 0.0068 | 0.2997 | 0.3566 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.1781 | 0.1669 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0039 | 0.1091 | 0.1091 |
Brugia malayi | Bromodomain containing protein | 0.0081 | 0.3821 | 0.3629 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0055 | 0.2149 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0039 | 0.1091 | 0.1829 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0036 | 0.0909 | 0.0909 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0039 | 0.1091 | 0.0815 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.