Detailed information for compound 1156023

Basic information

Technical information
  • TDR Targets ID: 1156023
  • Name: [4-(octadecoxymethyl)oxolan-2-yl]methyl N-ace tyl-N-[(1-ethylpyridin-1-ium-3-yl)methyl]carb amate
  • MW: 589.869 | Formula: C35H61N2O5+
  • H donors: 0 H acceptors: 2 LogP: 9.76 Rotable bonds: 27
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCCCCCCCCCCCOCC1COC(C1)COC(=O)N(C(=O)C)Cc1ccc[n+](c1)CC
  • InChi: 1S/C35H61N2O5/c1-4-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-24-40-28-33-25-34(41-29-33)30-42-35(39)37(31(3)38)27-32-22-21-23-36(5-2)26-32/h21-23,26,33-34H,4-20,24-25,27-30H2,1-3H3/q+1
  • InChiKey: QLAUIMJZDQKTHG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-(octadecoxymethyl)tetrahydrofuran-2-yl]methyl N-acetyl-N-[(1-ethylpyridin-1-ium-3-yl)methyl]carbamate
  • N-acetyl-N-[(1-ethyl-3-pyridin-1-iumyl)methyl]carbamic acid [4-(octadecoxymethyl)-2-tetrahydrofuranyl]methyl ester
  • N-acetyl-N-[(1-ethylpyridin-1-ium-3-yl)methyl]carbamic acid [4-(stearyloxymethyl)tetrahydrofuran-2-yl]methyl ester
  • [4-(octadecoxymethyl)oxolan-2-yl]methyl N-ethanoyl-N-[(1-ethylpyridin-1-ium-3-yl)methyl]carbamate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.003 0.0033 0.0134
Loa Loa (eye worm) hypothetical protein 0.0031 0.0039 0.0106
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.0031 0.051
Echinococcus granulosus 6 phosphofructokinase 0.0218 0.1149 0.2964
Loa Loa (eye worm) glutaminase 2 0.0269 0.145 0.3953
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0092 0.0405 0.0405
Trypanosoma cruzi hypothetical protein, conserved 0.0441 0.2465 1
Toxoplasma gondii phosphofructokinase PFKII 0.0059 0.0207 0.3438
Onchocerca volvulus 0.0104 0.0471 0.1124
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0039 0.0106
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0408 0.0974
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1627 0.3879
Brugia malayi PHD-finger family protein 0.003 0.0033 0.009
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0051 0.0159 0.0644
Brugia malayi jmjC domain containing protein 0.0029 0.0031 0.0084
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0108 0.0294
Loa Loa (eye worm) hypothetical protein 0.004 0.0096 0.0261
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.009 0.0392 0.1012
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0096 0.0388
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1627 0.3879
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0108 0.0437
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0029 0.0031 0.0125
Loa Loa (eye worm) hypothetical protein 0.0155 0.0773 0.2108
Brugia malayi AF-10 protein 0.003 0.0033 0.009
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.1627 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0103 0.0246
Onchocerca volvulus 0.0055 0.0181 0.0432
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0405 0.1045
Trichomonas vaginalis phosphofructokinase, putative 0.0059 0.0207 0.0494
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0218 0.1149 0.6634
Loa Loa (eye worm) transcription factor SMAD2 0.0263 0.1413 0.3852
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0051 0.0159 0.1094
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0602 0.4156
Onchocerca volvulus 0.0733 0.4193 1
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0131 0.0312
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0218 0.1149 0.8238
Loa Loa (eye worm) hypothetical protein 0.0086 0.0369 0.1006
Loa Loa (eye worm) 6-phosphofructokinase 0.0218 0.1149 0.3132
Brugia malayi 6-phosphofructokinase 0.0218 0.1149 0.3132
Schistosoma mansoni lamin 0.0031 0.0039 0.01
Loa Loa (eye worm) jmjC domain-containing protein 0.0186 0.096 0.2618
Giardia lamblia Kinase, PLK 0.0093 0.0408 0.1418
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0602 0.4156
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0086 0.0205
Leishmania major hypothetical protein, conserved 0.004 0.0096 0.0388
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0096 0.0427 0.2592
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0107 0.049 0.3088
Schistosoma mansoni kinase 0.0047 0.0138 0.0356
Echinococcus multilocularis jumonji domain containing 1A 0.0029 0.0031 0.0031
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0092 0.0405 0.0405
Mycobacterium tuberculosis Probable oxidoreductase 0.0107 0.049 0.3088
Mycobacterium ulcerans hypothetical protein 0.0051 0.0159 0.1094
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0408 0.0974
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0053 0.0137
Plasmodium vivax 6-phosphofructokinase, putative 0.0059 0.0207 0.5116
Onchocerca volvulus Alhambra homolog 0.009 0.0392 0.0935
Echinococcus granulosus lamin dm0 0.0031 0.0039 0.01
Loa Loa (eye worm) hypothetical protein 0.003 0.0033 0.009
Schistosoma mansoni chromobox protein 0.0069 0.0264 0.0681
Brugia malayi jmjC domain containing protein 0.0029 0.0031 0.0084
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0181 0.0494
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0031 0.0125
Plasmodium vivax hypothetical protein, conserved 0.009 0.0392 0.9685
Toxoplasma gondii PHD-finger domain-containing protein 0.009 0.0392 0.6508
Echinococcus granulosus leukotriene A 4 hydrolase 0.0451 0.2521 0.6507
Brugia malayi jmjC domain containing protein 0.0029 0.0031 0.0084
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0602 0.4156
Brugia malayi MH2 domain containing protein 0.0263 0.1413 0.3852
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0451 0.2521 0.6876
Loa Loa (eye worm) hypothetical protein 0.004 0.0096 0.0261
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0096 0.0228
Trypanosoma brucei trypanothione reductase 0.0042 0.0108 0.0437
Brugia malayi beta-lactamase family protein 0.004 0.0096 0.0261
Mycobacterium ulcerans 6-phosphofructokinase 0.0218 0.1149 0.7924
Brugia malayi hypothetical protein 0.0268 0.144 0.3926
Plasmodium falciparum thioredoxin reductase 0.0042 0.0108 0.2748
Loa Loa (eye worm) hypothetical protein 0.0187 0.0962 0.2622
Schistosoma mansoni jumonji/arid domain-containing protein 0.0109 0.0504 0.1301
Schistosoma mansoni 6-phosphofructokinase 0.0218 0.1149 0.2964
Echinococcus granulosus lamin 0.0031 0.0039 0.01
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0096 0.066
Plasmodium falciparum phd finger protein, putative 0.009 0.0392 1
Brugia malayi 6-phosphofructokinase 0.0218 0.1149 0.3132
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0107 0.049 0.3088
Loa Loa (eye worm) hypothetical protein 0.0038 0.0086 0.0234
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0086 0.0369 0.0952
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1627 0.3879
Brugia malayi chromobox protein homolog 3 0.0038 0.0086 0.0234
Loa Loa (eye worm) hypothetical protein 0.0268 0.144 0.3926
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0408 0.0408
Echinococcus multilocularis PHD finger protein rhinoceros 0.009 0.0392 0.0392
Leishmania major ATP-dependent phosphofructokinase 0.0218 0.1149 0.4661
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0096 0.0247
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0051 0.0159 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0019 0.0046
Loa Loa (eye worm) hypothetical protein 0.003 0.0037 0.01
Schistosoma mansoni survival motor neuron protein 0.0055 0.0181 0.0467
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.0385 0.0993
Echinococcus multilocularis survival motor neuron protein 1 0.0268 0.144 0.144
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0059 0.0207 0.3438
Trypanosoma cruzi hypothetical protein, conserved 0.0441 0.2465 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1627 0.3879
Echinococcus granulosus microtubule associated protein 2 0.068 0.3875 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0273 0.1472 0.4014
Plasmodium vivax 6-phosphofructokinase, putative 0.0059 0.0207 0.5116
Trichomonas vaginalis phosphofructokinase, putative 0.0059 0.0207 0.0494
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0096 0.0228
Onchocerca volvulus 0.004 0.0096 0.0228
Loa Loa (eye worm) latrophilin receptor protein 2 0.0086 0.0369 0.1006
Loa Loa (eye worm) hypothetical protein 0.004 0.0096 0.0261
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0029 0.0031 0.0031
Trichomonas vaginalis phosphofructokinase, putative 0.0218 0.1149 0.2739
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0051 0.0159 0.0644
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0602 0.1555
Brugia malayi beta-lactamase 0.004 0.0096 0.0261
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.003 0.0033 0.0134
Loa Loa (eye worm) PHD-finger family protein 0.009 0.0392 0.1069
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0084
Leishmania major trypanothione reductase 0.0042 0.0108 0.0437
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0104 0.0471 0.1216
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0059 0.0207 0.5
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.1627 1
Trichomonas vaginalis glutaminase, putative 0.0269 0.145 0.3457
Plasmodium falciparum glutathione reductase 0.0042 0.0108 0.2748
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.003 0.0033 0.0546
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0408 0.1054
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0096 0.0427 0.2592
Leishmania major hypothetical protein, conserved 0.0029 0.0031 0.0125
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0408 0.0974
Brugia malayi glutathione reductase 0.0042 0.0108 0.0294
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0256 0.1374 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0031 0.0784
Onchocerca volvulus 0.004 0.0096 0.0228
Schistosoma mansoni glutaminase 0.0269 0.145 0.3741
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0264 0.072
Brugia malayi PHD-finger family protein 0.009 0.0392 0.1069
Schistosoma mansoni jumonji domain containing protein 0.0029 0.0031 0.0079
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0042 0.0108 0.0094
Echinococcus multilocularis 6 phosphofructokinase 0.0218 0.1149 0.1149
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0051 0.0159 0.1094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0405 0.1045
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0096 0.0388
Echinococcus granulosus histone lysine methyltransferase setb 0.0092 0.0405 0.1045
Echinococcus granulosus PHD finger protein rhinoceros 0.009 0.0392 0.1012
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0408 0.0974
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0059 0.0207 0.5
Plasmodium vivax glutathione reductase, putative 0.0042 0.0108 0.2661
Schistosoma mansoni phosphatidylserine receptor 0.0029 0.0031 0.0079
Echinococcus granulosus jumonji domain containing 1A 0.0029 0.0031 0.0079
Onchocerca volvulus 0.0031 0.0039 0.0093
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0039 0.0106
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0108 0.2661
Brugia malayi jmjC domain containing protein 0.0109 0.0504 0.1375
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0126 0.0602 0.3964
Trichomonas vaginalis phosphofructokinase, putative 0.0218 0.1149 0.2739
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0097
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0029 0.0031 0.0079
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0451 0.2521 0.2521
Brugia malayi hypothetical protein 0.0207 0.1083 0.2953
Echinococcus multilocularis chromobox protein 1 0.0069 0.0264 0.0264
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0051 0.0159 0.0492
Entamoeba histolytica phosphofructokinase, putative 0.0218 0.1149 0.7062
Schistosoma mansoni hypothetical protein 0.009 0.0392 0.1012
Mycobacterium ulcerans beta-lactamase 0.004 0.0096 0.066
Brugia malayi jmjC domain containing protein 0.0029 0.0031 0.0084
Echinococcus granulosus jumonji domain containing protein 0.0126 0.0601 0.1551
Echinococcus multilocularis citrate lyase subunit beta protein 0.0051 0.0159 0.0159
Loa Loa (eye worm) MH2 domain-containing protein 0.0263 0.1413 0.3852
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0408 0.1113
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0096 0.0228
Echinococcus multilocularis lysine specific demethylase 6a 0.0029 0.0031 0.0031
Brugia malayi phosphofructokinase 0.0218 0.1149 0.3132
Mycobacterium ulcerans hypothetical protein 0.0051 0.0159 0.1094
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1627 0.3879
Onchocerca volvulus 0.004 0.0096 0.0228
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0086 0.0369 0.1006
Schistosoma mansoni phd/f-box containing protein 0.0029 0.0031 0.0079
Plasmodium vivax hypothetical protein, conserved 0.004 0.0096 0.2365
Toxoplasma gondii aldehyde dehydrogenase 0.0126 0.0602 1
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0051 0.0159 0.1094
Echinococcus granulosus GPCR family 2 0.0086 0.0369 0.0952
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0092 0.0405 0.672
Leishmania major hypothetical protein, conserved 0.0441 0.2465 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0109 0.0504 0.1375
Echinococcus multilocularis chromobox protein 1 0.0069 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.004 0.0096 0.0261
Echinococcus granulosus peregrin 0.009 0.0392 0.1012
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0039 0.0106
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0086 0.0369 0.0952
Echinococcus multilocularis peregrin 0.009 0.0392 0.0392
Schistosoma mansoni jumonji domain containing protein 0.0235 0.1247 0.3217
Mycobacterium tuberculosis Conserved protein 0.0051 0.0159 0.0492
Echinococcus granulosus phd:f box containing protein 0.0029 0.0031 0.0079
Brugia malayi Pre-SET motif family protein 0.0644 0.3667 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1627 0.3879
Loa Loa (eye worm) 6-phosphofructokinase 0.0218 0.1149 0.3132
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0096 0.0261
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0096 0.066
Trichomonas vaginalis phosphofructokinase, putative 0.0059 0.0207 0.0494
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0107 0.049 0.3748
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0602 0.1555
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0031 0.0125
Toxoplasma gondii PHD-finger domain-containing protein 0.009 0.0392 0.6508
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0111 0.0111
Loa Loa (eye worm) glutaminase 0.0269 0.145 0.3953
Echinococcus multilocularis lysine specific demethylase 5A 0.0109 0.0504 0.0504
Echinococcus multilocularis lamin 0.0031 0.0039 0.0039
Mycobacterium ulcerans lipase LipD 0.004 0.0096 0.066
Mycobacterium ulcerans glutaminase 0.0269 0.145 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.0405 0.1104
Brugia malayi Latrophilin receptor protein 2 0.0086 0.0369 0.1006
Entamoeba histolytica phosphofructokinase, putative 0.0218 0.1149 0.7062
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0029 0.0031 0.0079
Loa Loa (eye worm) beta-lactamase 0.004 0.0096 0.0261
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0086 0.0205
Schistosoma mansoni hypothetical protein 0.0086 0.0369 0.0952
Schistosoma mansoni hypothetical protein 0.0187 0.0962 0.2481
Giardia lamblia PHD finger protein 15 0.009 0.0392 0.1303
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0264 0.063
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0096 0.0228
Loa Loa (eye worm) phosphofructokinase 0.0218 0.1149 0.3132
Plasmodium vivax JmjC domain containing protein 0.0029 0.0031 0.0759
Echinococcus multilocularis lamin dm0 0.0031 0.0039 0.0039
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0296 0.1606 0.1606
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0408 0.251
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0031 0.0084
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0126 0.0602 0.0602
Schistosoma mansoni hypothetical protein 0.003 0.0033 0.0085
Toxoplasma gondii thioredoxin reductase 0.0042 0.0108 0.1788
Echinococcus multilocularis microtubule associated protein 2 0.068 0.3875 0.3875
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0051 0.0159 0.0378
Entamoeba histolytica phosphofructokinase, putative 0.0218 0.1149 0.7062
Echinococcus granulosus survival motor neuron protein 1 0.0268 0.144 0.3715
Toxoplasma gondii ABC1 family protein 0.004 0.0096 0.1589
Echinococcus granulosus lysine specific demethylase 5A 0.0109 0.0504 0.1301
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0126 0.0602 0.1555
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0096 0.0247
Schistosoma mansoni microtubule-associated protein tau 0.068 0.3875 1
Schistosoma mansoni hypothetical protein 0.0086 0.0369 0.0952
Trypanosoma brucei polo-like protein kinase 0.0093 0.0408 0.1657
Echinococcus multilocularis JmjC domain containing protein 4 0.0029 0.0031 0.0031
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0086 0.0369 0.0369
Trichomonas vaginalis phosphofructokinase, putative 0.0218 0.1149 0.2739
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0264 0.063
Echinococcus multilocularis jumonji domain containing protein 0.0126 0.0601 0.0601
Echinococcus granulosus chromobox protein 1 0.0069 0.0264 0.0681
Onchocerca volvulus 0.0031 0.0039 0.0093
Brugia malayi Heterochromatin protein 1 0.0069 0.0264 0.072
Schistosoma mansoni hypothetical protein 0.0086 0.0369 0.0952
Toxoplasma gondii 6-phosphofructokinase 0.0059 0.0207 0.3438
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0408 0.0974
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0408 0.0974
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0296 0.1606 0.4144
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.003 0.0033 0.0839
Schistosoma mansoni protein phosphatase 2C 0.0029 0.0031 0.0079
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.0722 0.4982
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0218 0.1149 0.4661
Brugia malayi beta-lactamase family protein 0.004 0.0096 0.0261
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.0722 0.595
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0086 0.0205
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0408 0.1657
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0019 0.0046
Loa Loa (eye worm) hypothetical protein 0.004 0.0096 0.0261
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0031 0.0084
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.0722 0.4901
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0103 0.0246
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0096 0.0427 0.2592
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0131 0.0312
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0408 0.1054
Loa Loa (eye worm) hypothetical protein 0.0273 0.1472 0.4014
Brugia malayi glutaminase DH11.1 0.0269 0.145 0.3953
Trichomonas vaginalis esterase, putative 0.004 0.0096 0.0228
Loa Loa (eye worm) hypothetical protein 0.009 0.0392 0.1069
Schistosoma mansoni hypothetical protein 0.0086 0.0369 0.0952
Schistosoma mansoni intermediate filament proteins 0.0031 0.0039 0.01
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.0031 0.051
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0126 0.0602 0.2444
Mycobacterium tuberculosis Probable dehydrogenase 0.0096 0.0427 0.2592
Schistosoma mansoni jumonji/arid domain-containing protein 0.0109 0.0504 0.1301
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0059 0.0207 0.5282
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0218 0.1149 1
Plasmodium vivax SET domain protein, putative 0.0092 0.0405 1
Trichomonas vaginalis phosphofructokinase, putative 0.0059 0.0207 0.0494
Loa Loa (eye worm) glutathione reductase 0.0042 0.0108 0.0294
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0644 0.3667 1
Trichomonas vaginalis phosphofructokinase, putative 0.0218 0.1149 0.2739
Echinococcus multilocularis phd:f box containing protein 0.0029 0.0031 0.0031
Trichomonas vaginalis phosphofructokinase, putative 0.0059 0.0207 0.0494
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0084
Trypanosoma brucei hypothetical protein, conserved 0.0441 0.2465 1
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0451 0.2521 0.6507
Brugia malayi jmjC domain containing protein 0.0296 0.1606 0.4379
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0059 0.0207 0.1273
Brugia malayi latrophilin 2 splice variant baaae 0.0187 0.0962 0.2622
Echinococcus multilocularis GPCR, family 2 0.0086 0.0369 0.0369
Brugia malayi Bromodomain containing protein 0.009 0.0392 0.1069
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1627 0.3879
Brugia malayi Thioredoxin reductase 0.0042 0.0108 0.0294
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0096 0.0247
Echinococcus granulosus JmjC domain containing protein 4 0.0029 0.0031 0.0079
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.1627 1
Trichomonas vaginalis set domain proteins, putative 0.0733 0.4193 1
Schistosoma mansoni hypothetical protein 0.0055 0.0181 0.0467
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0408 0.1113
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0096 0.0261
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0096 0.0388
Echinococcus granulosus lysine specific demethylase 6a 0.0029 0.0031 0.0079
Mycobacterium ulcerans hypothetical protein 0.004 0.0096 0.066
Brugia malayi intermediate filament protein 0.0031 0.0039 0.0106
Brugia malayi Pre-SET motif family protein 0.0092 0.0405 0.1104
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0408 0.0974
Echinococcus granulosus intermediate filament protein 0.0031 0.0039 0.01
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0059 0.0207 0.0494
Plasmodium vivax hypothetical protein, conserved 0.003 0.0033 0.0813
Mycobacterium tuberculosis Probable reductase 0.0096 0.0427 0.2592
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0031 0.0084
Brugia malayi F/Y-rich N-terminus family protein 0.0033 0.0053 0.0145
Echinococcus granulosus citrate lyase subunit beta protein 0.0051 0.0159 0.0409
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0103 0.0246
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0059 0.0207 0.5282
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1627 0.3879
Schistosoma mansoni lamin 0.0031 0.0039 0.01
Brugia malayi Calcitonin receptor-like protein seb-1 0.0273 0.1472 0.4014
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0408 0.1657
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0096 0.0427 0.2592
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0408 0.0974
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0218 0.1149 0.4661
Schistosoma mansoni 6-phosphofructokinase 0.0218 0.1149 0.2964
Echinococcus multilocularis musashi 0.0031 0.0039 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0405 0.1045
Onchocerca volvulus 0.003 0.0037 0.0088
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0086 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.004 0.0096 0.0261
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0096 0.0427 0.3146
Schistosoma mansoni chromobox protein 0.0069 0.0264 0.0681
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0273 0.1472 0.4014
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0408 0.1657
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.1627 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0096 0.0096
Trichomonas vaginalis phosphofructokinase, putative 0.0059 0.0207 0.0494
Echinococcus granulosus chromobox protein 1 0.0069 0.0264 0.0681
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0096 0.0228
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0111 0.0287
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0033 0.0546

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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