Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0814 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0814 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0404 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0814 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0814 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0814 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0814 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0814 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0721 | 0.7743 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0814 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0503 | 0.2407 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0814 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0814 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0503 | 0.2407 | 0.2407 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0814 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0814 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.041 | 0.0151 | 0.0151 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0721 | 0.7743 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0404 | 0 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0814 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0814 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0814 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0814 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0814 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0814 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0814 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0814 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0814 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0814 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1 mM | In vitro reversible inhibition of eel acetylcholinesterase. | ChEMBL. | 3783578 |
IC50 (binding) | > 1 mM | Reactivation of human acetylcholinesterase | ChEMBL. | 3783578 |
IC50 (binding) | > 1 mM | In vitro reversible inhibition of eel acetylcholinesterase. | ChEMBL. | 3783578 |
IC50 (binding) | > 1 mM | Reactivation of human acetylcholinesterase | ChEMBL. | 3783578 |
kHOX (functional) | = 147 M-1 min-1 | In vitro rate of EPMP-inhibited acetylcholinesterase reactivation, by the protonated (oxime) form. | ChEMBL. | 3783578 |
kHOX (functional) | = 147 M-1 min-1 | In vitro rate of EPMP-inhibited acetylcholinesterase reactivation, by the protonated (oxime) form. | ChEMBL. | 3783578 |
kHOX (functional) | = 419 M-1 min-1 | In vitro rate of EPMP-inhibited acetylcholinesterase reactivation, by the protonated (oxime) form. | ChEMBL. | 3783578 |
kHOX (functional) | = 419 M-1 min-1 | In vitro rate of EPMP-inhibited acetylcholinesterase reactivation, by the protonated (oxime) form. | ChEMBL. | 3783578 |
KOX (functional) | = 761 M-1 min-1 | In vitro rate of EPMP-inhibited acetylcholinesterase reactivation, by anionic (oximate) form. | ChEMBL. | 3783578 |
KOX (functional) | = 761 M-1 min-1 | In vitro rate of EPMP-inhibited acetylcholinesterase reactivation, by anionic (oximate) form. | ChEMBL. | 3783578 |
KOX (functional) | = 2170 M-1 min-1 | In vitro rate of EPMP-inhibited acetylcholinesterase reactivation by anionic (oximate) form. | ChEMBL. | 3783578 |
KOX (functional) | = 2170 M-1 min-1 | In vitro rate of EPMP-inhibited acetylcholinesterase reactivation by anionic (oximate) form. | ChEMBL. | 3783578 |
logD | = 3 | Compound was tested for the ratio of octanol / buffer partition coefficient for 0.1M, pH 7.6 phosphate buffer | ChEMBL. | 3783578 |
pKa | = 8.22 | Compound as tested for the hydroxyimine methyl acid dissociation constant (pKa) | ChEMBL. | 3783578 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.