Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.4561 | 0.4561 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0638 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0638 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0638 | 0.0638 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.7163 | 0.7163 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.7163 | 0.7163 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0638 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0062 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0638 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.4561 | 0.4561 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0638 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0638 | 0.0638 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0638 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0638 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4561 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0638 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.3848 | 0.3848 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.4561 | 0.4561 |
Brugia malayi | hypothetical protein | 0.0037 | 0.4561 | 0.4561 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0638 | 0.0638 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0638 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0638 | 0.0638 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0638 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.7163 | 0.7163 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4561 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0638 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.4561 | 0.4561 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4561 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0638 | 0.0638 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4561 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.3848 | 0.3848 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0638 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.3848 | 0.3848 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.7163 | 0.7163 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0638 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0638 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.