Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.741 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0054 | 0.741 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.0005 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.741 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0689 | 0.0923 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.0005 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0689 | 0.0923 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0054 | 0.741 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0054 | 0.741 | 0.741 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0689 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0689 | 0.0923 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.0005 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0689 | 0.0689 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0689 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.3763 | 0.3763 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0689 | 0.0923 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0054 | 0.741 | 0.741 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.741 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.7007 | 0.7007 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0689 | 0.0689 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0689 | 0.0689 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0689 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0054 | 0.741 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0689 | 0.0923 |
Trypanosoma brucei | protein kinase, putative | 0.0054 | 0.741 | 1 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0689 | 0.0689 |
Brugia malayi | MAP kinase sur-1 | 0.0054 | 0.741 | 0.741 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0054 | 0.741 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0689 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.7007 | 0.7007 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0689 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.0005 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0054 | 0.741 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.3763 | 0.3763 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.741 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.0005 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0054 | 0.741 | 0.741 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0689 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.0005 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0689 | 0.0689 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0054 | 0.741 | 0.741 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.7007 | 0.7007 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0689 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0054 | 0.741 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0054 | 0.741 | 0.741 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.0005 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.741 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.0005 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.0005 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0054 | 0.741 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0054 | 0.741 | 0.741 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.741 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0689 | 0.0689 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.3763 | 0.3763 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.7007 | 0.7007 |
Brugia malayi | TAR-binding protein | 0.0067 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.