Detailed information for compound 115642

Basic information

Technical information
  • TDR Targets ID: 115642
  • Name: (4-hydroxyphenyl)-[9-[(3-hydroxyphenyl)methyl ]-3,4-dihydro-1H-pyrido[3,4-b]indol-2-yl]meth anone
  • MW: 398.454 | Formula: C25H22N2O3
  • H donors: 2 H acceptors: 3 LogP: 3.91 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)C(=O)N1CCc2c(C1)n(Cc1cccc(c1)O)c1c2cccc1
  • InChi: 1S/C25H22N2O3/c28-19-10-8-18(9-11-19)25(30)26-13-12-22-21-6-1-2-7-23(21)27(24(22)16-26)15-17-4-3-5-20(29)14-17/h1-11,14,28-29H,12-13,15-16H2
  • InChiKey: PURKDPDGYFFSOV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [9-(3-hydroxybenzyl)-3,4-dihydro-1H-$b-carbolin-2-yl]-(4-hydroxyphenyl)methanone
  • 1,2,3,4-Tetrahydropyrido[3,4-b]indole 11

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli enoyl-[acyl-carrier-protein] reductase, NADH-dependent Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase Get druggable targets OG5_130466 All targets in OG5_130466
Trichomonas vaginalis hypothetical protein Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) Get druggable targets OG5_130466 All targets in OG5_130466
Toxoplasma gondii enoyl-acyl carrier reductase ENR Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium falciparum enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium yoelii enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Neospora caninum enoyl-acyl carrier reductase, putative Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium knowlesi enoyl-acyl carrier reductase, putative Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium vivax enoyl-acyl carrier protein reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium berghei enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Chlamydia trachomatis enoyl-acyl-carrier protein reductase Get druggable targets OG5_130466 All targets in OG5_130466
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax vivapain-2 0.0444 0.1694 1
Onchocerca volvulus 0.017 0.057 0.3298
Loa Loa (eye worm) cysteine protease 0.0444 0.1694 0.2659
Giardia lamblia Cathepsin L precursor 0.0119 0.0361 0.1558
Entamoeba histolytica cysteine protease, putative 0.0119 0.0361 0.2129
Leishmania major cathepsin L-like protease 0.0444 0.1694 0.7633
Entamoeba histolytica cysteine protease, putative 0.0444 0.1694 1
Onchocerca volvulus Peroxidase homolog 0.0103 0.0296 0.1663
Toxoplasma gondii cathepsin CPC1 0.0119 0.0361 0.1625
Echinococcus granulosus cysteine protease 0.025 0.0901 0.1391
Schistosoma mansoni tar DNA-binding protein 0.0065 0.014 0.014
Onchocerca volvulus 0.0103 0.0296 0.1663
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0119 0.0361 0.2129
Onchocerca volvulus 0.0119 0.0361 0.2046
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0295 0.0464
Brugia malayi calpain family protein 1 0.0273 0.0993 0.1559
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0444 0.1694 0.7633
Onchocerca volvulus 0.0048 0.0068 0.0302
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0295 0.1331
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0018 0.0154
Loa Loa (eye worm) hypothetical protein 0.0444 0.1694 0.2659
Giardia lamblia Cathepsin L precursor 0.0119 0.0361 0.1558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.025 0.0901 0.4061
Entamoeba histolytica cysteine protease, putative 0.025 0.0901 0.532
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0295 0.1331
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0295 0.0464
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1583 0.637 0.637
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0018 0.0028
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0295 0.1331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0444 0.1694 0.7633
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0121 0.0369 0.0579
Loa Loa (eye worm) hypothetical protein 0.0119 0.0361 0.0566
Loa Loa (eye worm) hypothetical protein 0.0132 0.0414 0.0649
Brugia malayi RNA binding protein 0.0065 0.014 0.022
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0021 0.0005
Loa Loa (eye worm) animal heme peroxidase 0.0103 0.0296 0.0465
Brugia malayi MH2 domain containing protein 0.012 0.0365 0.0572
Giardia lamblia Cathepsin B precursor 0.0119 0.0361 0.1558
Brugia malayi Animal haem peroxidase family protein 0.0103 0.0296 0.0465
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0444 0.1694 0.7633
Trypanosoma cruzi cysteine peptidase, putative 0.0444 0.1694 0.2659
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0444 0.1694 0.2639
Schistosoma mansoni peroxidasin 0.0103 0.0296 0.0296
Toxoplasma gondii preprocathepsin c precursor, putative 0.0119 0.0361 0.1625
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0295 0.0464
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0295 0.1331
Echinococcus granulosus cathepsin l cysteine peptidase 0.0444 0.1694 0.2639
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0103 0.0295 0.1331
Schistosoma mansoni inositol monophosphatase 0.0036 0.0021 0.0021
Leishmania major pyruvate kinase 0.0035 0.0018 0.008
Plasmodium vivax unspecified product 0.0119 0.0361 0.2046
Brugia malayi Cathepsin L-like precursor 0.0132 0.0414 0.0649
Loa Loa (eye worm) hypothetical protein 0.0312 0.1153 0.1811
Trypanosoma brucei cysteine peptidase C (CPC) 0.0572 0.2219 1
Trypanosoma cruzi kinesin, putative 0.0072 0.0168 0.0264
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0021 0.0033
Giardia lamblia Cathepsin L precursor 0.0119 0.0361 0.1558
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0223 0.079 0.3561
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0119 0.0361 0.1625
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0119 0.0361 0.0361
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0069 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0361 0.1625
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.025 0.0901 0.4061
Plasmodium falciparum enoyl-acyl carrier reductase 0.0223 0.079 0.4665
Entamoeba histolytica cysteine protease, putative 0.0119 0.0361 0.2129
Giardia lamblia Cathepsin B precursor 0.0572 0.2219 1
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0223 0.079 0.4609
Schistosoma mansoni hypothetical protein 0.0179 0.0608 0.0608
Giardia lamblia Cysteine protease 0.0119 0.0361 0.1558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0119 0.0361 0.1625
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0061 0.0125 0.0196
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0068 0.0107
Entamoeba histolytica hypothetical protein 0.0119 0.0361 0.2129
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0119 0.0361 0.2046
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0119 0.0361 0.1558
Echinococcus multilocularis calpain 0.0103 0.0295 0.0437
Brugia malayi Peroxidasin 0.0103 0.0296 0.0465
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0273 0.0993 0.0993
Toxoplasma gondii cathepsin CPL 0.0444 0.1694 0.7633
Schistosoma mansoni tar DNA-binding protein 0.0065 0.014 0.014
Brugia malayi cathepsin F-like cysteine proteinase 0.0132 0.0414 0.0649
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0312 0.1153 0.1811
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0444 0.1694 0.7633
Echinococcus granulosus tar DNA binding protein 0.0065 0.014 0.0192
Loa Loa (eye worm) hypothetical protein 0.0132 0.0414 0.0649
Leishmania major cathepsin L-like protease 0.0444 0.1694 0.7633
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0119 0.0361 0.1625
Echinococcus granulosus calpain A 0.0285 0.1044 0.1615
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0021 0.0095
Trypanosoma cruzi cysteine peptidase, putative 0.025 0.0901 0.1415
Schistosoma mansoni survival motor neuron protein 0.0048 0.0068 0.0068
Schistosoma mansoni microtubule-associated protein tau 0.0729 0.2866 0.2866
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0444 0.1694 0.7633
Entamoeba histolytica cysteine protease, putative 0.0119 0.0361 0.2129
Brugia malayi cathepsin Z-like cysteine proteinase 0.0119 0.0361 0.0566
Brugia malayi Papain family cysteine protease containing protein 0.025 0.0901 0.1415
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0444 0.1694 0.7633
Echinococcus multilocularis calpain family protein 1, d 0.0201 0.0697 0.107
Brugia malayi cathepsin L-like precursor 0.0312 0.1153 0.1811
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0069 0.0069
Brugia malayi Cathepsin L-like precursor 0.0444 0.1694 0.2659
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.025 0.0901 0.0901
Toxoplasma gondii cathepsin CPC2 0.0119 0.0361 0.1625
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0295 0.1331
Plasmodium falciparum serine repeat antigen 8 0.0119 0.0361 0.2129
Loa Loa (eye worm) TAR-binding protein 0.0065 0.014 0.022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0444 0.1694 0.7633
Leishmania major cysteine peptidase A (CPA) 0.0444 0.1694 0.7633
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0223 0.079 1
Entamoeba histolytica cysteine proteinase 1, putative 0.025 0.0901 0.532
Onchocerca volvulus 0.0444 0.1694 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0361 0.0566
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0444 0.1694 0.7633
Entamoeba histolytica cysteine proteinase, putative 0.0444 0.1694 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.025 0.0901 0.0901
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0119 0.0361 0.0361
Giardia lamblia Cysteine protease 0.0119 0.0361 0.1558
Plasmodium falciparum pyruvate kinase 0.0035 0.0018 0.0104
Onchocerca volvulus Cathepsin L homolog 0.0119 0.0361 0.2046
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0021 0.0095
Schistosoma mansoni cathepsin S (C01 family) 0.0119 0.0361 0.0361
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0223 0.079 1
Entamoeba histolytica cysteine protease, putative 0.025 0.0901 0.532
Giardia lamblia Cathepsin L precursor 0.0119 0.0361 0.1558
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0223 0.079 1
Entamoeba histolytica protein kinase, putative 0.0072 0.0168 0.0994
Echinococcus granulosus cathepsin l1 0.0312 0.1153 0.1788
Echinococcus granulosus calpain A 0.0103 0.0295 0.0437
Plasmodium falciparum cysteine proteinase falcipain 3 0.0444 0.1694 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0069 0.0109
Plasmodium vivax serine-repeat antigen (SERA) 0.0119 0.0361 0.2046
Loa Loa (eye worm) hypothetical protein 0.017 0.057 0.0896
Toxoplasma gondii cathepsin B 0.0572 0.2219 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0444 0.1694 0.7633
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1583 0.637 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0296 0.0465
Plasmodium falciparum serine repeat antigen 2 0.0119 0.0361 0.2129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0444 0.1694 0.7633
Onchocerca volvulus Cathepsin F homolog 0.0444 0.1694 1
Entamoeba histolytica cysteine protease, putative 0.025 0.0901 0.532
Brugia malayi calpain 5 0.0072 0.0168 0.0264
Loa Loa (eye worm) hypothetical protein 0.0103 0.0296 0.0465
Schistosoma mansoni cathepsin F (C01 family) 0.0312 0.1153 0.1153
Brugia malayi hypothetical protein 0.0233 0.083 0.1303
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0119 0.0361 0.0566
Brugia malayi calpain family protein 1 0.0273 0.0993 0.1559
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0119 0.0361 0.2046
Brugia malayi Cathepsin L-like precursor 0.0312 0.1153 0.1811
Echinococcus multilocularis cathepsin b 0.1583 0.637 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0119 0.0361 0.0566
Giardia lamblia Cathepsin B precursor 0.0572 0.2219 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0414 0.0649
Echinococcus multilocularis cathepsin L 0.0119 0.0361 0.054
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0444 0.1694 1
Trypanosoma cruzi cysteine peptidase, putative 0.0132 0.0414 0.0649
Plasmodium falciparum serine repeat antigen 5 0.0119 0.0361 0.2129
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0119 0.0361 0.1558
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0119 0.0361 0.0361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0444 0.1694 0.7633
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0119 0.0361 0.2046
Echinococcus granulosus calpain 5 0.0103 0.0295 0.0437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0119 0.0361 0.1625
Loa Loa (eye worm) hypothetical protein 0.0119 0.0361 0.0566
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0295 0.0464
Brugia malayi Cathepsin L-like precursor 0.0444 0.1694 0.2659
Echinococcus granulosus calpain 0.0103 0.0295 0.0437
Brugia malayi Inositol-1 0.0036 0.0021 0.0033
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0119 0.0361 0.2129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0069 0.0069
Brugia malayi Animal haem peroxidase family protein 0.0103 0.0296 0.0465
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0444 0.1694 0.7633
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0119 0.0361 0.2129
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0295 0.0464
Loa Loa (eye worm) hypothetical protein 0.0103 0.0296 0.0465
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0018 0.008
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0119 0.0361 0.2129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0444 0.1694 0.7633
Onchocerca volvulus Dual oxidase homolog 0.0103 0.0296 0.1663
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0119 0.0361 0.1625
Loa Loa (eye worm) cathepsin B 0.0572 0.2219 0.3484
Echinococcus granulosus peroxidasin 0.0103 0.0296 0.0439
Entamoeba histolytica cysteine protease, putative 0.025 0.0901 0.532
Loa Loa (eye worm) hypothetical protein 0.0103 0.0296 0.0465
Giardia lamblia Cathepsin B precursor 0.0119 0.0361 0.1558
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0018 0.008
Echinococcus granulosus cathepsin b 0.1583 0.637 1
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0365 0.0572
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0444 0.1694 0.7633
Plasmodium vivax serine-repeat antigen (SERA) 0.0119 0.0361 0.2046
Giardia lamblia Encystation-specific protease 0.0119 0.0361 0.1558
Onchocerca volvulus Cathepsin L homolog 0.0444 0.1694 1
Plasmodium vivax vivapain-1 0.025 0.0901 0.527
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0444 0.1694 0.7633
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0119 0.0361 0.1558
Plasmodium vivax calpain, putative 0.0103 0.0295 0.1657
Brugia malayi cathepsin L-like cysteine proteinase 0.0119 0.0361 0.0566
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0444 0.1694 0.7633
Onchocerca volvulus Cathepsin L homolog 0.0444 0.1694 1
Leishmania major cathepsin L-like protease 0.0444 0.1694 0.7633
Brugia malayi Papain family cysteine protease containing protein 0.0119 0.0361 0.0566
Schistosoma mansoni tar DNA-binding protein 0.0065 0.014 0.014
Echinococcus multilocularis cysteine protease 0.0444 0.1694 0.2639
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0444 0.1694 0.7633
Brugia malayi Papain family cysteine protease containing protein 0.0119 0.0361 0.0566
Loa Loa (eye worm) hypothetical protein 0.0103 0.0296 0.0465
Giardia lamblia Cathepsin L precursor 0.0119 0.0361 0.1558
Echinococcus granulosus cathepsin b 0.1583 0.637 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0021 0.0045
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.083 0.1279
Echinococcus granulosus cathepsin L 0.025 0.0901 0.1391
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0069 0.0082
Echinococcus multilocularis tar DNA binding protein 0.0065 0.014 0.0192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0119 0.0361 0.1625
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0444 0.1694 0.7633
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0444 0.1694 1
Onchocerca volvulus 0.0103 0.0296 0.1663
Loa Loa (eye worm) hypothetical protein 0.0103 0.0296 0.0465
Schistosoma mansoni peroxidasin 0.0103 0.0296 0.0296
Trypanosoma cruzi cysteine protease, putative 0.025 0.0901 0.1415
Schistosoma mansoni calpain (C02 family) 0.0103 0.0295 0.0295
Onchocerca volvulus 0.0444 0.1694 1
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0365 0.0572
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0444 0.1694 0.7633
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0119 0.0361 0.2046
Echinococcus multilocularis geminin 0.0179 0.0608 0.0929
Onchocerca volvulus Peroxidase homolog 0.0103 0.0296 0.1663
Schistosoma mansoni Mername-AA248 (C02 family) 0.0103 0.0295 0.0295
Trypanosoma cruzi cysteine proteinase, putative 0.025 0.0901 0.1415
Onchocerca volvulus 0.0444 0.1694 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0296 0.0465
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0119 0.0361 0.0566
Brugia malayi Papain family cysteine protease containing protein 0.025 0.0901 0.1415
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0119 0.0361 0.2046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.025 0.0901 0.4061
Plasmodium falciparum serine repeat antigen 6 0.0119 0.0361 0.2129
Schistosoma mansoni cathepsin F (C01 family) 0.0444 0.1694 0.1694
Entamoeba histolytica cysteine protease, putative 0.025 0.0901 0.532
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0119 0.0361 0.0361
Brugia malayi Animal haem peroxidase family protein 0.0103 0.0296 0.0465
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0132 0.0414 0.0649
Entamoeba histolytica cysteine protease, putative 0.0119 0.0361 0.2129
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0228 0.0807 0.1267
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0119 0.0361 0.1625
Plasmodium vivax vivapain-2 0.0444 0.1694 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0444 0.1694 0.7633
Entamoeba histolytica cysteine protease, putative 0.0119 0.0361 0.2129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0119 0.0361 0.1625
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0119 0.0361 0.1625
Entamoeba histolytica cysteine protease, putative 0.025 0.0901 0.532
Giardia lamblia Cathepsin B precursor 0.0572 0.2219 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0296 0.0465
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0444 0.1694 0.2639
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0119 0.0361 0.1625
Onchocerca volvulus 0.0103 0.0296 0.1663
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0444 0.1694 0.7633
Loa Loa (eye worm) calpain family protein 1 0.0201 0.0697 0.1095
Brugia malayi Cathepsin L-like precursor 0.0444 0.1694 0.2659
Echinococcus multilocularis cysteine protease 0.0444 0.1694 0.2639
Brugia malayi Cathepsin L-like precursor 0.0444 0.1694 0.2659
Schistosoma mansoni pyruvate kinase 0.0035 0.0018 0.0018
Loa Loa (eye worm) fibroinase 0.0444 0.1694 0.2659
Trypanosoma cruzi cysteine peptidase, putative 0.0444 0.1694 0.2659
Loa Loa (eye worm) calpain 0.0103 0.0295 0.0464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0444 0.1694 0.7633
Leishmania major cathepsin L-like protease 0.0444 0.1694 0.7633
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0119 0.0361 0.2046
Plasmodium falciparum cysteine proteinase falcipain 1 0.025 0.0901 0.532
Entamoeba histolytica cysteine protease, putative 0.025 0.0901 0.532
Brugia malayi calpain 7 0.0103 0.0295 0.0464
Brugia malayi Cathepsin L-like precursor 0.0312 0.1153 0.1811
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0119 0.0361 0.1625
Loa Loa (eye worm) animal heme peroxidase 0.0103 0.0296 0.0465
Giardia lamblia Cysteine protease 0.0119 0.0361 0.1558
Loa Loa (eye worm) hypothetical protein 0.0103 0.0296 0.0465
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0119 0.0361 0.2046
Echinococcus multilocularis peroxidasin 0.0103 0.0296 0.0439
Plasmodium falciparum serine repeat antigen 1 0.0119 0.0361 0.2129
Echinococcus granulosus cathepsin L cysteine protease 0.025 0.0901 0.1391
Loa Loa (eye worm) ctsf protein 0.0444 0.1694 0.2659
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0444 0.1694 0.7633
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0295 0.0464
Plasmodium falciparum serine repeat antigen 7 0.0119 0.0361 0.2129
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0295 0.0464
Schistosoma mansoni hypothetical protein 0.0179 0.0608 0.0608
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0572 0.2219 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0119 0.0361 0.2046
Loa Loa (eye worm) hypothetical protein 0.0103 0.0296 0.0465
Loa Loa (eye worm) RNA binding protein 0.0065 0.014 0.022
Schistosoma mansoni calpain-7 (C02 family) 0.0103 0.0295 0.0295
Onchocerca volvulus 0.0444 0.1694 1
Echinococcus granulosus geminin 0.0179 0.0608 0.0929
Brugia malayi cathepsin L precursor 0.0119 0.0361 0.0566
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0444 0.1694 0.7633
Brugia malayi fibroinase precursor 0.0119 0.0361 0.0566
Entamoeba histolytica cysteine protease, putative 0.025 0.0901 0.532
Loa Loa (eye worm) blistered cuticle protein 3 0.0103 0.0296 0.0465
Leishmania major pyruvate kinase 0.0035 0.0018 0.008
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0449 0.1714 0.1714
Giardia lamblia Cathepsin L precursor 0.0119 0.0361 0.1558
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0103 0.0295 0.0464
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0444 0.1694 0.7633
Echinococcus granulosus cathepsin l1 0.0444 0.1694 0.2639
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0295 0.1331
Echinococcus granulosus microtubule associated protein 2 0.0729 0.2866 0.4484
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0021 0.0125
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0285 0.1044 0.1044
Loa Loa (eye worm) hypothetical protein 0.0233 0.083 0.1303
Brugia malayi cathepsin F-like cysteine proteinase 0.0119 0.0361 0.0566
Leishmania major cathepsin L-like protease 0.0444 0.1694 0.7633
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0572 0.2219 0.3484
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0069 0.0082
Trypanosoma cruzi major cysteine proteinase, putative 0.0119 0.0361 0.0566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0444 0.1694 0.7633
Plasmodium vivax unspecified product 0.0132 0.0414 0.2362
Brugia malayi Papain family cysteine protease containing protein 0.0444 0.1694 0.2659
Entamoeba histolytica cysteine protease, putative 0.025 0.0901 0.532
Echinococcus granulosus cathepsin L 0.0119 0.0361 0.054
Brugia malayi hypothetical protein 0.0103 0.0296 0.0465
Schistosoma mansoni calpain-7 (C02 family) 0.0103 0.0295 0.0295
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0295 0.0464
Echinococcus multilocularis microtubule associated protein 2 0.0729 0.2866 0.4484
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0119 0.0361 0.2046
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0119 0.0361 0.1625
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0069 0.0069
Onchocerca volvulus 0.0444 0.1694 1
Plasmodium falciparum serine repeat antigen 4 0.0119 0.0361 0.2129
Onchocerca volvulus 0.0444 0.1694 1
Entamoeba histolytica cysteine proteinase, putative 0.0444 0.1694 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0444 0.1694 0.2639
Onchocerca volvulus 0.0444 0.1694 1
Loa Loa (eye worm) hypothetical protein 0.1583 0.637 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0119 0.0361 0.0566
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0444 0.1694 0.7633
Loa Loa (eye worm) hypothetical protein 0.0312 0.1153 0.1811
Brugia malayi TAR-binding protein 0.0065 0.014 0.022
Trypanosoma brucei antigen, putative 0.0103 0.0295 0.1331
Schistosoma mansoni dopamine-beta-monooxygenase 0.0121 0.0369 0.0369
Entamoeba histolytica cysteine proteinase, putative 0.0312 0.1153 0.6809
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0444 0.1694 0.7633
Loa Loa (eye worm) calpain 5 0.0072 0.0168 0.0264
Giardia lamblia Cathepsin B precursor 0.0119 0.0361 0.1558
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0444 0.1694 0.7633
Loa Loa (eye worm) hypothetical protein 0.0119 0.0361 0.0566
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0444 0.1694 0.2659
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1583 0.637 0.637
Trypanosoma cruzi cruzipain precursor, putative 0.0444 0.1694 0.2659
Leishmania major cathepsin L-like protease 0.0444 0.1694 0.7633
Entamoeba histolytica cysteine protease, putative 0.0119 0.0361 0.2129
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0223 0.079 1
Trypanosoma brucei kinesin, putative 0.0072 0.0168 0.0759
Loa Loa (eye worm) hypothetical protein 0.0119 0.0361 0.0566
Loa Loa (eye worm) hypothetical protein 0.0103 0.0296 0.0465
Brugia malayi Cathepsin L-like cysteine proteinase 0.0312 0.1153 0.1811
Schistosoma mansoni inositol monophosphatase 0.0036 0.0021 0.0021
Entamoeba histolytica cysteine protease, putative 0.025 0.0901 0.532
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0018 0.0028
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0285 0.1044 0.1615
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.083 0.1279
Schistosoma mansoni peptidylglycine monooxygenase 0.0121 0.0369 0.0369
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0444 0.1694 0.7633
Loa Loa (eye worm) hypothetical protein 0.0121 0.0369 0.0579
Loa Loa (eye worm) inositol-1 0.0036 0.0021 0.0033
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0119 0.0361 0.0361
Leishmania major cathepsin L-like protease 0.0444 0.1694 0.7633
Leishmania major kinesin, putative 0.0072 0.0168 0.0759
Entamoeba histolytica cysteine protease, putative 0.025 0.0901 0.532
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0444 0.1694 0.2659
Schistosoma mansoni cathepsin F (C01 family) 0.0444 0.1694 0.1694
Trypanosoma cruzi cysteine proteinase, putative 0.025 0.0901 0.1415
Giardia lamblia Cathepsin L-like protease 0.0119 0.0361 0.1558
Echinococcus multilocularis calpain 7 (C02 family) 0.0103 0.0295 0.0437
Loa Loa (eye worm) hypothetical protein 0.0119 0.0361 0.0566
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0069 0.0082
Giardia lamblia Cathepsin B precursor 0.0119 0.0361 0.1558
Schistosoma mansoni calpain C (C02 family) 0.0103 0.0295 0.0295
Plasmodium falciparum serine repeat antigen 9 0.0119 0.0361 0.2129
Trypanosoma cruzi cruzipain precursor, putative 0.0132 0.0414 0.0649
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.025 0.0901 0.4061
Trypanosoma cruzi cysteine peptidase, putative 0.0444 0.1694 0.2659
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0021 0.0033
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1583 0.637 0.637
Schistosoma mansoni tar DNA-binding protein 0.0065 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0103 0.0296 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0361 0.1625
Giardia lamblia Cysteine protease 0.0119 0.0361 0.1558
Loa Loa (eye worm) animal heme peroxidase 0.0103 0.0296 0.0465
Schistosoma mansoni hypothetical protein 0.0048 0.0068 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0119 0.0361 0.1625
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0018 0.0028
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.025 0.0901 0.1415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0312 0.1153 0.5197
Brugia malayi Cathepsin L-like precursor 0.0444 0.1694 0.2659
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0119 0.0361 0.2129
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1583 0.637 0.637
Entamoeba histolytica cysteine protease, putative 0.025 0.0901 0.532
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0119 0.0361 0.1625
Echinococcus multilocularis cathepsin L 0.025 0.0901 0.1391
Echinococcus multilocularis cathepsin b 0.1583 0.637 1
Giardia lamblia Cathepsin L-like protease 0.0119 0.0361 0.1558
Loa Loa (eye worm) hypothetical protein 0.0103 0.0296 0.0465
Entamoeba histolytica cysteine proteinase, putative 0.025 0.0901 0.532
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0444 0.1694 0.7633
Loa Loa (eye worm) hypothetical protein 0.0273 0.0993 0.1559
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0021 0.0095
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0285 0.1044 0.1615
Loa Loa (eye worm) hypothetical protein 0.0312 0.1153 0.1811
Entamoeba histolytica cysteine proteinase, putative 0.025 0.0901 0.532
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0132 0.0414 0.0649
Schistosoma mansoni cathepsin B (C01 family) 0.0119 0.0361 0.0361
Entamoeba histolytica cysteine protease, putative 0.025 0.0901 0.532
Brugia malayi cathepsin B-like cysteine proteinase 0.1583 0.637 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0119 0.0361 0.0361
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0295 0.1331
Onchocerca volvulus Peroxidasin homolog 0.0103 0.0296 0.1663
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0021 0.0095
Loa Loa (eye worm) hypothetical protein 0.0228 0.0807 0.1267
Echinococcus granulosus calpain 7 C02 family 0.0103 0.0295 0.0437
Brugia malayi Animal haem peroxidase family protein 0.0103 0.0296 0.0465
Echinococcus multilocularis cathepsin L cysteine protease 0.0444 0.1694 0.2639
Trypanosoma cruzi cysteine peptidase, putative 0.0444 0.1694 0.2659
Echinococcus granulosus cathepsin L cysteine proteinase 0.0444 0.1694 0.2639
Schistosoma mansoni cathepsin C 0.0119 0.0361 0.0361
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0295 0.1331
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0572 0.2219 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0444 0.1694 0.7633
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.014 0.022
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0021 0.0095
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.006 0.0117 0.0184
Loa Loa (eye worm) animal heme peroxidase 0.0103 0.0296 0.0465
Plasmodium vivax unspecified product 0.025 0.0901 0.527
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0228 0.0807 0.1242
Entamoeba histolytica cysteine proteinase 2 0.025 0.0901 0.532
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.025 0.0901 0.0901
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0312 0.1153 0.5197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0444 0.1694 0.7633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0444 0.1694 0.7633
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0228 0.0807 0.1242
Echinococcus multilocularis hypothetical protein 0.0103 0.0295 0.0437
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0285 0.1044 0.1044
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0018 0.0028
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0119 0.0361 0.0361
Entamoeba histolytica calpain large subunit domain III containing protein 0.0072 0.0168 0.0994
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0444 0.1694 0.7633
Echinococcus multilocularis calpain A 0.0285 0.1044 0.1615
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0018 0.0028
Loa Loa (eye worm) hypothetical protein 0.0103 0.0296 0.0465
Giardia lamblia Cathepsin B precursor 0.0119 0.0361 0.1558
Schistosoma mansoni cathepsin s 0.0132 0.0414 0.0414
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0119 0.0361 0.1558
Loa Loa (eye worm) calpain family protein 1 0.0273 0.0993 0.1559
Onchocerca volvulus Chorion peroxidase homolog 0.0103 0.0296 0.1663
Loa Loa (eye worm) hypothetical protein 0.0035 0.0018 0.0028
Brugia malayi Cathepsin L-like precursor 0.0444 0.1694 0.2659
Plasmodium falciparum serine repeat antigen 3 0.0119 0.0361 0.2129
Plasmodium vivax vivapain-3 0.025 0.0901 0.527
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0444 0.1694 0.7633
Echinococcus multilocularis calpain 5 0.0103 0.0295 0.0437
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0018 0.0028
Trichomonas vaginalis hypothetical protein 0.0223 0.079 0.3561
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0228 0.0807 0.0807
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0069 0.0109
Schistosoma mansoni tar DNA-binding protein 0.0065 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0242 0.0866 0.1359
Loa Loa (eye worm) hypothetical protein 0.0201 0.0697 0.1095
Entamoeba histolytica cysteine proteinase, putative 0.025 0.0901 0.532
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0119 0.0361 0.1625
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0021 0.0095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0119 0.0361 0.1625
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0018 0.0154
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0223 0.079 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0119 0.0361 0.1625
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0018 0.0028
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0018 0.008
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0119 0.0361 0.2046
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0572 0.2219 0.2219
Brugia malayi cathepsin Z-like cysteine proteinase 0.0119 0.0361 0.0566
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0021 0.0005
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0119 0.0361 0.0361
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0018 0.008
Brugia malayi Animal haem peroxidase family protein 0.0103 0.0296 0.0465
Trypanosoma cruzi kinesin, putative 0.0072 0.0168 0.0264
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.014 0.022
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0119 0.0361 0.0361
Leishmania major cathepsin L-like protease 0.0444 0.1694 0.7633
Brugia malayi Papain family cysteine protease containing protein 0.0119 0.0361 0.0566
Schistosoma mansoni pyruvate kinase 0.0035 0.0018 0.0018
Entamoeba histolytica cysteine proteinase, putative 0.025 0.0901 0.532
Giardia lamblia Hypothetical protein 0.0119 0.0361 0.1558
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0119 0.0361 0.0566
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0018 0.008
Onchocerca volvulus 0.0312 0.1153 0.6775
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0295 0.0464
Brugia malayi Blistered cuticle protein 3 0.0103 0.0296 0.0465
Onchocerca volvulus Peroxidasin homolog 0.0103 0.0296 0.1663
Giardia lamblia Hypothetical protein 0.0119 0.0361 0.1558

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.42 uM Antibacterial activity of the compound against Staphylococcus aureus Enoyl-[acyl-carrier-protein] reductase was determined ChEMBL. 11527706
IC50 (binding) = 0.42 uM Antibacterial activity of the compound against Staphylococcus aureus Enoyl-[acyl-carrier-protein] reductase was determined ChEMBL. 11527706
IC50 (binding) = 8.8 uM Antibacterial activity of the compound against Escherichia coli Enoyl-[acyl-carrier-protein] reductase was determined ChEMBL. 11527706
IC50 (binding) = 8.8 uM Antibacterial activity of the compound against Escherichia coli Enoyl-[acyl-carrier-protein] reductase was determined ChEMBL. 11527706

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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