Detailed information for compound 1156567

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1715 | Formula: C80H131N17O24
  • H donors: 20 H acceptors: 23 LogP: -0.66 Rotable bonds: 69
    Rule of 5 violations (Lipinski): 4
  • SMILES: CCCCCCCCCCCCC[C@@H](OC(=O)[C@H](CCCN)C)CC(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1C[C@@H](C[C@H]1C(=O)N[C@@H](C(=O)N[C@H](C(=O)N1CC[C@@H]([C@H]1C(=O)N[C@@H]([C@@H](CC(=O)N)O)C(=O)NCC(=O)N[C@@H](C(=O)N)[C@H](O)C)O)[C@H](O)C)[C@H](O)C)O)C(C)C)Cc1ccc(cc1)OCC(=O)NCCCn1cncc1)C)[C@H](O)C
  • InChi: 1S/C80H131N17O24/c1-10-11-12-13-14-15-16-17-18-19-20-24-54(121-80(119)45(4)23-21-30-81)38-60(106)89-65(48(7)99)75(114)87-46(5)71(110)88-55(36-51-25-27-53(28-26-51)120-42-62(108)85-31-22-33-95-35-32-84-43-95)72(111)91-63(44(2)3)78(117)97-41-52(102)37-56(97)73(112)92-66(49(8)100)76(115)93-67(50(9)101)79(118)96-34-29-57(103)69(96)77(116)94-68(58(104)39-59(82)105)74(113)86-40-61(107)90-64(47(6)98)70(83)109/h25-28,32,35,43-50,52,54-58,63-69,98-104H,10-24,29-31,33-34,36-42,81H2,1-9H3,(H2,82,105)(H2,83,109)(H,85,108)(H,86,113)(H,87,114)(H,88,110)(H,89,106)(H,90,107)(H,91,111)(H,92,112)(H,93,115)(H,94,116)/t45-,46+,47+,48+,49+,50+,52+,54+,55-,56-,57-,58+,63-,64+,65+,66+,67-,68-,69-/m0/s1
  • InChiKey: XGNIPAZNMGOTMA-UCOVPCCSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0136 0.0026
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0116 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0136 0.0026
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0136 0.002
Loa Loa (eye worm) glutathione reductase 0.0095 0.2679 0.354
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0217 0.6952 0.8874
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0561 0.0603
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0561 0.0785
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0193 0.0103
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0116 0.0105
Plasmodium falciparum thioredoxin reductase 0.0095 0.2679 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0136 0.0131
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.3045 0.324
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0499 0.1748
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.1723 0.6048
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0499 0.0484
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0131
Entamoeba histolytica 60S ribosomal protein L19, putative 0.0029 0.037 0.0395
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0136 0.0023
Schistosoma mansoni hypothetical protein 0.0183 0.5784 0.5734
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0029 0.037 0.0395
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0068 0.1743 0.1646
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0499 0.0676
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0131
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0315
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0136 0.0034
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0068 0.1743 0.287
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1723 0.1626
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.3045 0.3967
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.1974 0.2517
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.144 0.188
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.2699 0.4557
Schistosoma mansoni lipoxygenase 0.0092 0.2575 0.2487
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0136 0.0034
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0136 0.0034
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0116 0.0297
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0499 0.086
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0273 0.035
Trypanosoma brucei trypanothione reductase 0.0095 0.2679 0.8685
Onchocerca volvulus 0.0023 0.0136 0.0023
Brugia malayi hypothetical protein 0.004 0.0754 0.0863
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.026 0.1303
Plasmodium falciparum 60S ribosomal protein L19 0.0029 0.037 0.1258
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0499 0.099
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.3045 0.2963
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0136 0.0131
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.3045 0.4031
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0136 0.0034
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0273 0.0017
Loa Loa (eye worm) hypothetical protein 0.0093 0.2602 0.3436
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0131
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.1723 0.2835
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0499 0.0484
Entamoeba histolytica hypothetical protein 0.004 0.0754 0.1772
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0132 0.3965 0.6791
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0499 0.0157
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0136 0.0026
Echinococcus multilocularis ribosomal protein L19 0.0029 0.037 0.0448
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0136 0.0023
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0561 0.0701
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0136 0.002
Trichomonas vaginalis set domain proteins, putative 0.0264 0.8626 1
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0136 0.0034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0116 0.0105
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0513 0.0701
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0136 0.0026
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.2679 0.8631
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0136 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.3045 0.324
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1723 0.1626
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0499 0.0388
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0273 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0136 0.0026
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0136 0.0131
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0499 0.0484
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0136 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0273 0.1377
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0273 0.0017
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0499 0.086
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0132 0.3965 0.6791
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0193 0.0103
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0499 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0068 0.1743 0.287
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0136 0.002
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0499 0.086
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0136 0.002
Loa Loa (eye worm) DnaJ domain-containing protein 0.0068 0.1744 0.2287
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0093 0.2602 0.2515
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.3045 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0136 0.002
Schistosoma mansoni hypothetical protein 0.004 0.0754 0.0645
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0131
Leishmania major 60S ribosomal protein L19, putative 0.0029 0.037 0.0395
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0754 0.1124
Entamoeba histolytica 60S ribosomal protein L19, putative 0.0029 0.037 0.0395
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0093 0.2602 0.3366
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.2699 0.4557
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0136 0.0131
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0561 0.0785
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0499 0.0484
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0136 0.0034
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.026 0.0333
Mycobacterium tuberculosis Probable dehydrogenase 0.0217 0.6952 0.8912
Schistosoma mansoni hypothetical protein 0.0068 0.1744 0.1647
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0232 0.7499 1
Plasmodium vivax 60S ribosomal protein L19, putative 0.0029 0.037 0.1258
Loa Loa (eye worm) hypothetical protein 0.0033 0.0513 0.0637
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0029 0.037 0.0395
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0068 0.1743 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.3045 0.5168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0513 0.0402
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0068 0.1743 1
Loa Loa (eye worm) hypothetical protein 0.011 0.3192 0.4227
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0499 0.2707
Entamoeba histolytica hypothetical protein 0.004 0.0754 0.1772
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0136 0.0026
Leishmania major trypanothione reductase 0.0095 0.2679 0.8685
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0136 0.0034
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0136 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.3045 0.324
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0131
Brugia malayi nuclear hormone receptor 0.0023 0.0136 0.0026
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.1723 0.2209
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0499 0.086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0136 0.0131
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0038 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0136 0.0026
Toxoplasma gondii thioredoxin reductase 0.0095 0.2679 1
Echinococcus multilocularis ribosomal protein L19 0.0029 0.037 0.0448
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0136 0.0034
Echinococcus multilocularis geminin 0.0183 0.5784 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.3045 0.3442
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.3045 0.324
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0273 0.0046
Echinococcus granulosus dnaJ subfamily C 6 0.0068 0.1744 0.2872
Brugia malayi Pre-SET motif family protein 0.0232 0.7499 1
Brugia malayi nuclear receptor NHR-88 0.0023 0.0136 0.0026
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0754 0.0645
Echinococcus multilocularis L aminoadipate semialdehyde 0.0093 0.2602 0.4385
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0241 0.7801 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0136 0.002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0513 0.0701
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0136 0.002
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.026 0.0841
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0136 0.0034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0136 0.0026
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0136 0.0034
Plasmodium vivax SET domain protein, putative 0.0033 0.0513 0.1801
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0499 0.0484
Trichomonas vaginalis protein kinase inhibitor, putative 0.0068 0.1744 0.1664
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0136 0.0131
Giardia lamblia Kinase, PLK 0.0105 0.3045 1
Echinococcus granulosus GPCR family 2 0.0035 0.0561 0.0785
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.3045 0.5168
Mycobacterium ulcerans hypothetical protein 0.0026 0.0273 0.1377
Loa Loa (eye worm) hypothetical protein 0.0029 0.037 0.0445
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0241 0.7801 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0499 0.099
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0561 0.0785
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0273 0.0212
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0136 0.0034
Brugia malayi ecdysteroid receptor 0.0023 0.0136 0.0026
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.1723 0.2835
Brugia malayi Thioredoxin reductase 0.0095 0.2679 0.3471
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0136 0.0034
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0499 0.086
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0136 0.002
Leishmania major 60S ribosomal protein L19, putative 0.0029 0.037 0.0395
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0136 0.0034
Schistosoma mansoni kinase 0.0054 0.1225 0.1122
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.3045 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0513 0.0701
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0136 0.0026
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0273 0.1377
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0136 0.0026
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0499 0.086
Plasmodium falciparum glutathione reductase 0.0095 0.2679 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0499 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0136 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0136 0.0026
Schistosoma mansoni hypothetical protein 0.0035 0.0561 0.045
Loa Loa (eye worm) hypothetical protein 0.0035 0.0561 0.0701
Schistosoma mansoni hypothetical protein 0.0035 0.0561 0.045
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0499 0.086
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0499 0.2707
Echinococcus granulosus ribosomal protein L19 0.0029 0.037 0.0448
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0217 0.6952 0.8912
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.026 0.4813
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0136 0.002
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0273 0.0046
Brugia malayi 60S ribosomal protein L19 0.0029 0.037 0.0344
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0273 0.1377
Schistosoma mansoni hypothetical protein 0.0075 0.1974 0.188
Schistosoma mansoni hypothetical protein 0.0183 0.5784 0.5734
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0499 0.1748
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0273 0.1377
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.026 0.1303
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0273 0.0046
Mycobacterium tuberculosis Probable reductase 0.0217 0.6952 0.8912
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0273 0.1377
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.3192 0.4166
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1723 0.9883
Entamoeba histolytica hypothetical protein 0.004 0.0754 0.1772
Onchocerca volvulus 0.0264 0.8626 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.047 0.0625
Schistosoma mansoni coup transcription factor 0.0023 0.0136 0.002
Schistosoma mansoni lipoxygenase 0.0132 0.3965 0.3894
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0273 0.0046
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0499 0.1748
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0136 0.0034
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.026 0.0841
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0499 1
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.1176 0.0976
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.1176 0.0976
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0513 0.1048
Plasmodium falciparum thioredoxin reductase 0.0033 0.0499 0.1748
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0273 0.1377
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1723 0.9883
Echinococcus multilocularis GPCR, family 2 0.0035 0.0561 0.0785
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0241 0.7801 1
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0136 0.002
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0217 0.6952 0.8912
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0217 0.6952 0.8912
Echinococcus multilocularis dnaJ subfamily C 6 0.0068 0.1744 0.2872
Echinococcus granulosus L aminoadipate semialdehyde 0.0093 0.2602 0.4385
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0499 0.2707
Loa Loa (eye worm) hypothetical protein 0.0022 0.0116 0.0105
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.2679 0.3434
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0561 0.0785
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0499 0.0484
Brugia malayi glutathione reductase 0.0095 0.2679 0.3471
Brugia malayi DnaJ domain containing protein 0.0068 0.1744 0.2205
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.3045 0.324
Entamoeba histolytica hypothetical protein 0.004 0.0754 0.1772
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0499 0.0484
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.3192 0.4227
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.2679 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0131
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0136 0.0026
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0499 0.0484
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0273 0.0046
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0136 0.002
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0136 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0136 0.0026
Mycobacterium tuberculosis Probable oxidoreductase 0.0241 0.7801 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0499 0.1748
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0068 0.1743 0.5325
Echinococcus granulosus ribosomal protein L19 0.0029 0.037 0.0448
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0136 0.0023
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0513 0.0402
Toxoplasma gondii ribosomal protein RPL19 0.0029 0.037 0.0455
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.3045 1
Plasmodium falciparum glutathione reductase 0.0033 0.0499 0.1748
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0136 0.0131
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0499 0.0676
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0513 0.0402
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0273 0.1377
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0217 0.6952 0.8912
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.3045 0.324
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0499 0.086
Onchocerca volvulus 0.0093 0.2602 0.2921
Plasmodium vivax glutathione reductase, putative 0.0095 0.2679 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.1974 0.2595
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0513 0.0402
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0136 0.0131
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0273 0.0212
Echinococcus granulosus geminin 0.0183 0.5784 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0754 0.1124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0499 0.0484
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.1723 0.5253
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0315
Schistosoma mansoni hypothetical protein 0.0035 0.0561 0.045
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0136 0.002
Treponema pallidum NADH oxidase 0.0033 0.0499 1
Brugia malayi Pre-SET motif family protein 0.0033 0.0513 0.0538
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.3045 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0499 0.0484
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0068 0.1743 0.2234
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0499 0.0519
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0499 0.0157
Trypanosoma brucei polo-like protein kinase 0.0105 0.3045 1
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.2679 0.354
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0136 0.0034
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.3192 0.4166
Brugia malayi steroid hormone receptor 0.0023 0.0136 0.0026
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0273 0.0046
Onchocerca volvulus 0.0026 0.0273 0.0184
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0068 0.1743 0.2203
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0561 0.0603
Onchocerca volvulus 0.0033 0.0513 0.0467
Schistosoma mansoni hypothetical protein 0.0035 0.0561 0.045
Schistosoma mansoni 60S ribosomal protein L19 0.0029 0.037 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.3045 0.324
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0136 0.0034
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0499 0.064
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1723 0.9883
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0273 0.035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0273 0.0315

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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